PL319758A1 - Bicyclic tetrahydropyrasole pyridines and their application as medicines - Google Patents

Bicyclic tetrahydropyrasole pyridines and their application as medicines

Info

Publication number
PL319758A1
PL319758A1 PL95319758A PL31975895A PL319758A1 PL 319758 A1 PL319758 A1 PL 319758A1 PL 95319758 A PL95319758 A PL 95319758A PL 31975895 A PL31975895 A PL 31975895A PL 319758 A1 PL319758 A1 PL 319758A1
Authority
PL
Poland
Prior art keywords
tetrahydropyrasole
pyridines
bicyclic
medicines
application
Prior art date
Application number
PL95319758A
Inventor
Allen J Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PL319758A1 publication Critical patent/PL319758A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PL95319758A 1994-10-20 1995-10-06 Bicyclic tetrahydropyrasole pyridines and their application as medicines PL319758A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32643494A 1994-10-20 1994-10-20
PCT/IB1995/000847 WO1996012720A1 (en) 1994-10-20 1995-10-06 Bicyclic tetrahydro pyrazolopyridines and their use as medicaments

Publications (1)

Publication Number Publication Date
PL319758A1 true PL319758A1 (en) 1997-08-18

Family

ID=23272184

Family Applications (1)

Application Number Title Priority Date Filing Date
PL95319758A PL319758A1 (en) 1994-10-20 1995-10-06 Bicyclic tetrahydropyrasole pyridines and their application as medicines

Country Status (16)

Country Link
EP (1) EP0787132A1 (en)
JP (1) JPH09511758A (en)
KR (1) KR970707124A (en)
CN (1) CN1050129C (en)
AU (1) AU702105B2 (en)
BR (1) BR9504491A (en)
CZ (1) CZ120097A3 (en)
FI (1) FI954991A (en)
HU (1) HUT77517A (en)
IL (1) IL115667A0 (en)
MX (1) MX9504422A (en)
NO (1) NO971811L (en)
NZ (1) NZ292991A (en)
PL (1) PL319758A1 (en)
WO (1) WO1996012720A1 (en)
ZA (1) ZA958839B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2001002304A0 (en) * 1996-05-03 2001-12-31 Pfizer Substituted indazole derivatives and related compounds
EP0934307B1 (en) 1996-06-19 2011-04-27 Aventis Pharma Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
DE69723447T2 (en) * 1996-06-25 2003-12-24 Pfizer SUBSTITUTED INDAZOL DERIVATIVES AND THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE (PDE) TYPE 4 AND THE TUMOR NECROSIN FACTOR (TNF)
ATE214373T1 (en) * 1997-05-08 2002-03-15 Pfizer Prod Inc METHOD AND INTERMEDIATE PRODUCTS FOR PRODUCING SUBSTITUTED INDAZOLE DERIVATIVES
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
PT1140941E (en) 1998-12-23 2005-02-28 Bristol Myers Squibb Pharma Co HETEROCYCLICS CONTAINING NITROX AS FACTOR XA INHIBITORS
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
ATE320800T1 (en) 1999-08-21 2006-04-15 Altana Pharma Ag SYNERGISTIC COMBINATION OF ROFLUMILAST AND SALMETEROL
NZ524475A (en) * 2000-08-10 2004-11-26 Pharmacia Italia S Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US6998408B2 (en) 2001-03-23 2006-02-14 Bristol-Myers Squibb Pharma Company 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
EP1379244A4 (en) 2001-04-18 2006-03-15 Bristol Myers Squibb Co 1,4,5,6-tetrahydropyrazolo- 3,4-c]-pyridin-7-ones as factor xa inhibitors
WO2002085356A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]-pyrid in-7-ones as factor xa inhibitors
WO2002088122A1 (en) * 2001-04-26 2002-11-07 Ajinomoto Co., Inc. Heterocyclic compounds
TWI320039B (en) 2001-09-21 2010-02-01 Lactam-containing compounds and derivatives thereof as factor xa inhibitors
MXPA04002526A (en) 2001-09-21 2004-05-31 Bristol Myers Squibb Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors.
MXPA05000947A (en) * 2002-07-25 2005-05-16 Pharmacia Italia Spa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them.
FR2857363B1 (en) * 2003-07-10 2007-09-07 Aventis Pharma Sa SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO [3,4-C] PYRIDINES COMPOSITIONS CONTAINING SAME AND USE THEREOF
AR045037A1 (en) * 2003-07-10 2005-10-12 Aventis Pharma Sa TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE.
TW200736255A (en) * 2005-12-01 2007-10-01 Elan Pharm Inc 5-(Substituted)-pyrazolopiperidines
CA2722938A1 (en) * 2008-04-30 2009-11-05 Fredrik Almqvist New peptidomimetic compounds
US7741350B1 (en) 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
CN102282147B (en) 2009-01-28 2015-09-30 卡拉治疗学股份有限公司 Bicyclic pyrazolo-heterocycles
US10144732B2 (en) 2014-06-06 2018-12-04 Biogen Ma Inc. ATX modulating agents
CN115043768A (en) * 2022-06-20 2022-09-13 新乡市润宇新材料科技有限公司 Method for synthesizing N-aryl pyrrolidine-2-ketone by acid-promoted ring opening of cyclopropyl

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
FR1463883A (en) * 1964-09-08 1966-07-22 Ciba Geigy Process for the preparation of bicyclic triaza-compounds
CA2166721C (en) * 1993-07-06 1999-07-27 Allen Jacob Duplantier Bicyclic tetrahydro pyrazolopyridines

Also Published As

Publication number Publication date
KR970707124A (en) 1997-12-01
ZA958839B (en) 1997-04-21
AU702105B2 (en) 1999-02-11
NO971811L (en) 1997-06-18
IL115667A0 (en) 1996-01-19
FI954991A0 (en) 1995-10-19
NO971811D0 (en) 1997-04-18
BR9504491A (en) 1997-05-20
JPH09511758A (en) 1997-11-25
WO1996012720A1 (en) 1996-05-02
NZ292991A (en) 1999-02-25
HUT77517A (en) 1998-05-28
CN1161040A (en) 1997-10-01
FI954991A (en) 1996-04-21
CN1050129C (en) 2000-03-08
AU3531795A (en) 1996-05-15
MX9504422A (en) 1997-04-30
CZ120097A3 (en) 1998-01-14
EP0787132A1 (en) 1997-08-06

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