IL115113A0 - Pyridinium derivatives and pharmaceutical compositions containing them - Google Patents

Pyridinium derivatives and pharmaceutical compositions containing them

Info

Publication number
IL115113A0
IL115113A0 IL11511395A IL11511395A IL115113A0 IL 115113 A0 IL115113 A0 IL 115113A0 IL 11511395 A IL11511395 A IL 11511395A IL 11511395 A IL11511395 A IL 11511395A IL 115113 A0 IL115113 A0 IL 115113A0
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
pyridinium derivatives
pyridinium
derivatives
Prior art date
Application number
IL11511395A
Other versions
IL115113A (en
Original Assignee
Israel State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Israel State filed Critical Israel State
Priority to IL11511395A priority Critical patent/IL115113A/en
Publication of IL115113A0 publication Critical patent/IL115113A0/en
Priority to CA002230578A priority patent/CA2230578A1/en
Priority to EP96928661A priority patent/EP0851859A1/en
Priority to JP9510076A priority patent/JPH11511456A/en
Priority to AU68359/96A priority patent/AU6835996A/en
Priority to PCT/IL1996/000089 priority patent/WO1997008146A1/en
Publication of IL115113A publication Critical patent/IL115113A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/559—Redox delivery systems, e.g. dihydropyridine pyridinium salt redox systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
IL11511395A 1995-08-31 1995-08-31 3-carbamoyloxy pyridinium derivatives and pharmaceutical compositions containing them IL115113A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL11511395A IL115113A (en) 1995-08-31 1995-08-31 3-carbamoyloxy pyridinium derivatives and pharmaceutical compositions containing them
CA002230578A CA2230578A1 (en) 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing them
EP96928661A EP0851859A1 (en) 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing them
JP9510076A JPH11511456A (en) 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing the derivatives
AU68359/96A AU6835996A (en) 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing them
PCT/IL1996/000089 WO1997008146A1 (en) 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11511395A IL115113A (en) 1995-08-31 1995-08-31 3-carbamoyloxy pyridinium derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
IL115113A0 true IL115113A0 (en) 1995-12-08
IL115113A IL115113A (en) 2002-11-10

Family

ID=11067933

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11511395A IL115113A (en) 1995-08-31 1995-08-31 3-carbamoyloxy pyridinium derivatives and pharmaceutical compositions containing them

Country Status (6)

Country Link
EP (1) EP0851859A1 (en)
JP (1) JPH11511456A (en)
AU (1) AU6835996A (en)
CA (1) CA2230578A1 (en)
IL (1) IL115113A (en)
WO (1) WO1997008146A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE990286A1 (en) * 1999-04-07 2000-11-01 Malope Company Ltd Diagnosis of irritable bowel syndrome based on demonstrated central cholinergic supersensitivity.
FR2795412B1 (en) * 1999-06-23 2001-07-13 Adir NOVEL QUATERNARY AMMONIUM DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP1414464A4 (en) * 2001-05-30 2005-06-22 Alteon Inc Method for treating glaucoma v
DK1868998T3 (en) 2005-04-01 2016-08-29 Vfp Therapies NEW HETEROCYCLIC COMPOUNDS, MANUFACTURING THEM, AND USE THEREOF AS MEDICINES, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS
EP1731507A1 (en) * 2005-04-26 2006-12-13 Institut National des Sciences Appliquees de Rouen (INSA) New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
WO2012111021A1 (en) 2011-02-14 2012-08-23 Council Of Scientific & Industrial Research (An Indian Registered Body Incorporated Under The Registration Of Societies Act (Act Xxi Of 1860) Substituted 1, 2, 3, 4-tetrahydroquinolin-7-yl carbamates as acetylcholinesterase inhibitors for treatment of alzheimer's disease
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2759536A1 (en) 2013-01-25 2014-07-30 INSA (Institut National des Sciences Appliquees) de Rouen Oxidisable pyridine derivatives, their preparation and use as anti-Alzheimer agents
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
CN105142623A (en) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 Methods and compositions for improving cognitive function
GR1008233B (en) * 2013-03-28 2014-06-23 Αλεξανδρος Δημητριου Βαμβακιδης Optimization and therapeutic valorization of the symptomatic treatment of alzheimer's disease with rivastigmine, galantamine or donepezil, by selected aminotetrafurans acting as mixed sigma-1 / muscarinic ligands
EA034167B8 (en) 2015-05-22 2021-04-27 Эйджинбайо, Инк. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2839536A (en) * 1958-06-17 Salts of disubstituted carbamic acid
FR2517307A1 (en) * 1981-11-27 1983-06-03 France Etat Alkyl imidazolium di:methyl carbamoyl pyridinium double salts - for prevention of phosphorus pesticide intoxication
IT1169873B (en) * 1983-10-21 1987-06-03 Prodotti Formenti Srl PHARMACEUTICAL COMPOSITION WITH SYSTEMIC ANTI-COLINESTERASIC, AGONISTIC-COLINERGIC AND ANTI-MUSCARINIC ACTIVITY

Also Published As

Publication number Publication date
IL115113A (en) 2002-11-10
WO1997008146A1 (en) 1997-03-06
JPH11511456A (en) 1999-10-05
EP0851859A1 (en) 1998-07-08
AU6835996A (en) 1997-03-19
CA2230578A1 (en) 1997-03-06

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees