AU6835996A - Pyridinium derivatives and pharmaceutical compositions containing them - Google Patents

Pyridinium derivatives and pharmaceutical compositions containing them

Info

Publication number
AU6835996A
AU6835996A AU68359/96A AU6835996A AU6835996A AU 6835996 A AU6835996 A AU 6835996A AU 68359/96 A AU68359/96 A AU 68359/96A AU 6835996 A AU6835996 A AU 6835996A AU 6835996 A AU6835996 A AU 6835996A
Authority
AU
Australia
Prior art keywords
pharmaceutical compositions
compositions containing
pyridinium derivatives
pyridinium
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU68359/96A
Inventor
Rachel Adani
Gabriel Amitai
Eliahu Heldman
Eliezer Rachaman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STATE OF ISRAEL
Original Assignee
State of Israel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by State of Israel filed Critical State of Israel
Publication of AU6835996A publication Critical patent/AU6835996A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/559—Redox delivery systems, e.g. dihydropyridine pyridinium salt redox systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU68359/96A 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing them Abandoned AU6835996A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11511395A IL115113A (en) 1995-08-31 1995-08-31 3-carbamoyloxy pyridinium derivatives and pharmaceutical compositions containing them
IL115113 1995-08-31
PCT/IL1996/000089 WO1997008146A1 (en) 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing them

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU61228/00A Division AU6122800A (en) 1995-08-31 2000-09-21 Pyridinium derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
AU6835996A true AU6835996A (en) 1997-03-19

Family

ID=11067933

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68359/96A Abandoned AU6835996A (en) 1995-08-31 1996-08-29 Pyridinium derivatives and pharmaceutical compositions containing them

Country Status (6)

Country Link
EP (1) EP0851859A1 (en)
JP (1) JPH11511456A (en)
AU (1) AU6835996A (en)
CA (1) CA2230578A1 (en)
IL (1) IL115113A (en)
WO (1) WO1997008146A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE990286A1 (en) * 1999-04-07 2000-11-01 Malope Company Ltd Diagnosis of irritable bowel syndrome based on demonstrated central cholinergic supersensitivity.
FR2795412B1 (en) * 1999-06-23 2001-07-13 Adir NOVEL QUATERNARY AMMONIUM DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2448317A1 (en) * 2001-05-30 2002-12-05 Alteon Inc. Method for treating glaucoma v
CA2603345C (en) 2005-04-01 2017-05-02 Insa Rouen New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
EP1731507A1 (en) * 2005-04-26 2006-12-13 Institut National des Sciences Appliquees de Rouen (INSA) New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US8946261B2 (en) 2011-02-14 2015-02-03 Council Of Scientific & Industrial Research Substituted 1, 2, 3, 4-tetrahydroquinolin-7-yl carbamates as acetylcholinesterase inhibitors for treatment of Alzheimer's disease
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP2759536A1 (en) 2013-01-25 2014-07-30 INSA (Institut National des Sciences Appliquees) de Rouen Oxidisable pyridine derivatives, their preparation and use as anti-Alzheimer agents
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
JP6433482B2 (en) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド Methods and compositions for improving cognitive function
GR1008233B (en) * 2013-03-28 2014-06-23 Αλεξανδρος Δημητριου Βαμβακιδης Optimization and therapeutic valorization of the symptomatic treatment of alzheimer's disease with rivastigmine, galantamine or donepezil, by selected aminotetrafurans acting as mixed sigma-1 / muscarinic ligands
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2839536A (en) * 1958-06-17 Salts of disubstituted carbamic acid
FR2517307A1 (en) * 1981-11-27 1983-06-03 France Etat Alkyl imidazolium di:methyl carbamoyl pyridinium double salts - for prevention of phosphorus pesticide intoxication
IT1169873B (en) * 1983-10-21 1987-06-03 Prodotti Formenti Srl PHARMACEUTICAL COMPOSITION WITH SYSTEMIC ANTI-COLINESTERASIC, AGONISTIC-COLINERGIC AND ANTI-MUSCARINIC ACTIVITY

Also Published As

Publication number Publication date
IL115113A (en) 2002-11-10
EP0851859A1 (en) 1998-07-08
IL115113A0 (en) 1995-12-08
WO1997008146A1 (en) 1997-03-06
CA2230578A1 (en) 1997-03-06
JPH11511456A (en) 1999-10-05

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted