ZA958839B - Bicyclic tetrahydro pyrazolopyridines - Google Patents

Bicyclic tetrahydro pyrazolopyridines

Info

Publication number
ZA958839B
ZA958839B ZA958839A ZA958839A ZA958839B ZA 958839 B ZA958839 B ZA 958839B ZA 958839 A ZA958839 A ZA 958839A ZA 958839 A ZA958839 A ZA 958839A ZA 958839 B ZA958839 B ZA 958839B
Authority
ZA
South Africa
Prior art keywords
pyrazolopyridines
bicyclic
bicyclic tetrahydro
tetrahydro pyrazolopyridines
tetrahydro
Prior art date
Application number
ZA958839A
Inventor
Allen J Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA958839B publication Critical patent/ZA958839B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
ZA958839A 1994-10-20 1995-10-19 Bicyclic tetrahydro pyrazolopyridines ZA958839B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32643494A 1994-10-20 1994-10-20

Publications (1)

Publication Number Publication Date
ZA958839B true ZA958839B (en) 1997-04-21

Family

ID=23272184

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA958839A ZA958839B (en) 1994-10-20 1995-10-19 Bicyclic tetrahydro pyrazolopyridines

Country Status (16)

Country Link
EP (1) EP0787132A1 (en)
JP (1) JPH09511758A (en)
KR (1) KR970707124A (en)
CN (1) CN1050129C (en)
AU (1) AU702105B2 (en)
BR (1) BR9504491A (en)
CZ (1) CZ120097A3 (en)
FI (1) FI954991A (en)
HU (1) HUT77517A (en)
IL (1) IL115667A0 (en)
MX (1) MX9504422A (en)
NO (1) NO971811L (en)
NZ (1) NZ292991A (en)
PL (1) PL319758A1 (en)
WO (1) WO1996012720A1 (en)
ZA (1) ZA958839B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1147A (en) * 1996-05-03 2003-02-25 Pfizer Substituted indazole derivatives and related compounds.
CA2258728C (en) * 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
IL127036A (en) * 1996-06-25 2001-06-14 Pfizer Substituted indazole derivatives and pharmaceutical compositions for the inhibition of phosphodiesterase type iv (pde) and tumor necrosis factor (tnf) comprising the same
EP0983249B1 (en) * 1997-05-08 2002-03-13 Pfizer Products Inc. Processes and intermediates for preparing substituted indazole derivatives
IL126745A (en) * 1997-11-04 2003-09-17 Pfizer Prod Inc Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors
ES2232202T3 (en) * 1998-12-23 2005-05-16 Bristol-Myers Squibb Pharma Company HETEROBICICLES CONTAINING NITROGEN AS INHIBITORS OF THE XA FACTOR.
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
PL200923B1 (en) 1999-08-21 2009-02-27 Nycomed Gmbh SYNERGISTIC COMBINATION OF PDE INHIBITORS AND ß₂ ADRENOCEPTOR AGONIST
PL213199B1 (en) * 2000-08-10 2013-01-31 Pharmacia Italia Spa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
US6998408B2 (en) 2001-03-23 2006-02-14 Bristol-Myers Squibb Pharma Company 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
EP1379245A4 (en) 2001-04-18 2006-07-26 Bristol Myers Squibb Co 1, 4, 5, 6-tetrahydropyrazolo- 3, 4-c|-pyrid in-7-ones as factor xa inhibitors
WO2002085353A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor xa inhibitors
JP4196678B2 (en) 2001-04-26 2008-12-17 味の素株式会社 Heterocyclic compounds
AU2002341693B2 (en) 2001-09-21 2008-05-29 Bristol-Myers Squibb Holdings Ireland Unlimited Company Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
US20060100233A1 (en) * 2002-07-25 2006-05-11 Manuela Villa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
FR2857363B1 (en) * 2003-07-10 2007-09-07 Aventis Pharma Sa SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H-PYRAZOLO [3,4-C] PYRIDINES COMPOSITIONS CONTAINING SAME AND USE THEREOF
AR045037A1 (en) * 2003-07-10 2005-10-12 Aventis Pharma Sa TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE.
EP1957458A2 (en) * 2005-12-01 2008-08-20 Elan Pharmaceuticals Inc. 5-(arylsulfonyl)-pyrazolopiperidines
AU2009243232A1 (en) * 2008-04-30 2009-11-05 Fredrik Almqvist New peptidomimetic compounds
US7741350B1 (en) 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
CN102282147B (en) 2009-01-28 2015-09-30 卡拉治疗学股份有限公司 Bicyclic pyrazolo-heterocycles
WO2015188051A1 (en) * 2014-06-06 2015-12-10 Biogen Ma Inc. Atx modulating agents
CN115043768A (en) * 2022-06-20 2022-09-13 新乡市润宇新材料科技有限公司 Method for synthesizing N-aryl pyrrolidine-2-ketone by acid-promoted ring opening of cyclopropyl

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463883A (en) * 1964-09-08 1966-07-22 Ciba Geigy Process for the preparation of bicyclic triaza-compounds
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
BR9406946A (en) * 1993-07-06 1996-08-06 Pfizer Bicyclic tetrahydro-pyrazolpyridines

Also Published As

Publication number Publication date
NO971811D0 (en) 1997-04-18
CN1161040A (en) 1997-10-01
NO971811L (en) 1997-06-18
AU3531795A (en) 1996-05-15
JPH09511758A (en) 1997-11-25
CN1050129C (en) 2000-03-08
FI954991A (en) 1996-04-21
CZ120097A3 (en) 1998-01-14
FI954991A0 (en) 1995-10-19
WO1996012720A1 (en) 1996-05-02
PL319758A1 (en) 1997-08-18
IL115667A0 (en) 1996-01-19
NZ292991A (en) 1999-02-25
BR9504491A (en) 1997-05-20
EP0787132A1 (en) 1997-08-06
KR970707124A (en) 1997-12-01
HUT77517A (en) 1998-05-28
MX9504422A (en) 1997-04-30
AU702105B2 (en) 1999-02-11

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