EP0796252A4 - Bicyclic fibrinogen antagonists - Google Patents

Bicyclic fibrinogen antagonists

Info

Publication number
EP0796252A4
EP0796252A4 EP95942590A EP95942590A EP0796252A4 EP 0796252 A4 EP0796252 A4 EP 0796252A4 EP 95942590 A EP95942590 A EP 95942590A EP 95942590 A EP95942590 A EP 95942590A EP 0796252 A4 EP0796252 A4 EP 0796252A4
Authority
EP
European Patent Office
Prior art keywords
fibrinogen antagonists
bicyclic fibrinogen
bicyclic
antagonists
fibrinogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95942590A
Other languages
German (de)
French (fr)
Other versions
EP0796252A1 (en
Inventor
James Francis Callahan
James Martin Samanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0796252A1 publication Critical patent/EP0796252A1/en
Publication of EP0796252A4 publication Critical patent/EP0796252A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
EP95942590A 1994-12-09 1995-12-07 Bicyclic fibrinogen antagonists Withdrawn EP0796252A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35304594A 1994-12-09 1994-12-09
US353045 1994-12-09
PCT/US1995/015932 WO1996017833A1 (en) 1994-12-09 1995-12-07 Bicyclic fibrinogen antagonists

Publications (2)

Publication Number Publication Date
EP0796252A1 EP0796252A1 (en) 1997-09-24
EP0796252A4 true EP0796252A4 (en) 1998-02-04

Family

ID=23387541

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95942590A Withdrawn EP0796252A4 (en) 1994-12-09 1995-12-07 Bicyclic fibrinogen antagonists

Country Status (3)

Country Link
EP (1) EP0796252A4 (en)
JP (1) JPH11505509A (en)
WO (1) WO1996017833A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
BR9917082A (en) 1998-12-24 2001-11-06 Du Pont Pharm Co Compounds that inhibit the production of "beta" proteins, a method of treating neurological disorders associated with the production of "beta" -amyloid, pharmaceutical composition and, method of inhibiting y-secretase activity
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
EP1222176A1 (en) 1999-10-08 2002-07-17 Bristol-Myers Squibb Pharma Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION
US6525044B2 (en) 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
US6495540B2 (en) 2000-03-28 2002-12-17 Bristol - Myers Squibb Pharma Company Lactams as inhibitors of A-β protein production
AU2001253108A1 (en) 2000-04-03 2001-10-15 Bristol-Myers Squibb Pharma Company Cyclic lactams as inhibitors of a-beta protein production
IL151576A0 (en) 2000-04-03 2003-04-10 Bristol Myers Squibb Pharma Co Cyclic lactams as inhibitors of a-beta protein production
US6632812B2 (en) 2000-04-11 2003-10-14 Dupont Pharmaceuticals Company Substituted lactams as inhibitors of Aβ protein production
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
JP4564713B2 (en) 2000-11-01 2010-10-20 ミレニアム・ファーマシューティカルズ・インコーポレイテッド Nitrogen heterocyclic compounds, and methods for making nitrogen heterocyclic compounds and intermediates thereof
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923821A1 (en) * 1969-05-09 1970-11-19 Wuelfing J A Fa Tetrahydrobenzodiazepinedione derivs with - valuable cns properties
US3898214A (en) * 1974-07-22 1975-08-05 Squibb & Sons Inc Benzazepine diones
US4746657A (en) * 1987-07-13 1988-05-24 A. H. Robins Company, Incorporated Fused aromatic tetrahydroazepinones (and thiones)
EP0444924A1 (en) * 1990-02-28 1991-09-04 Suntory Limited Fused 7-membered cyclic compound and antipsychotic preparation containing the same
WO1993000095A2 (en) * 1991-06-28 1993-01-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
WO1993008174A1 (en) * 1991-10-18 1993-04-29 Genentech, Inc. NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR
WO1994014776A2 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US5389631A (en) * 1991-10-29 1995-02-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5441952A (en) * 1993-04-05 1995-08-15 Merck & Co., Inc. Fibrinogen receptor antagonists

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923821A1 (en) * 1969-05-09 1970-11-19 Wuelfing J A Fa Tetrahydrobenzodiazepinedione derivs with - valuable cns properties
US3898214A (en) * 1974-07-22 1975-08-05 Squibb & Sons Inc Benzazepine diones
US4746657A (en) * 1987-07-13 1988-05-24 A. H. Robins Company, Incorporated Fused aromatic tetrahydroazepinones (and thiones)
EP0444924A1 (en) * 1990-02-28 1991-09-04 Suntory Limited Fused 7-membered cyclic compound and antipsychotic preparation containing the same
WO1993000095A2 (en) * 1991-06-28 1993-01-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
WO1993008174A1 (en) * 1991-10-18 1993-04-29 Genentech, Inc. NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR
WO1994014776A2 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
M. REIFFEN ET AL.: "Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 5, May 1990 (1990-05-01), WASHINGTON DC, US, pages 1496 - 1504, XP002047919 *
See also references of WO9617833A1 *

Also Published As

Publication number Publication date
JPH11505509A (en) 1999-05-21
WO1996017833A1 (en) 1996-06-13
EP0796252A1 (en) 1997-09-24

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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