EP0796252A4 - Antagonistes du fibrinogene a cycle double - Google Patents

Antagonistes du fibrinogene a cycle double

Info

Publication number
EP0796252A4
EP0796252A4 EP95942590A EP95942590A EP0796252A4 EP 0796252 A4 EP0796252 A4 EP 0796252A4 EP 95942590 A EP95942590 A EP 95942590A EP 95942590 A EP95942590 A EP 95942590A EP 0796252 A4 EP0796252 A4 EP 0796252A4
Authority
EP
European Patent Office
Prior art keywords
fibrinogen antagonists
bicyclic fibrinogen
bicyclic
antagonists
fibrinogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95942590A
Other languages
German (de)
English (en)
Other versions
EP0796252A1 (fr
Inventor
James Francis Callahan
James Martin Samanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0796252A1 publication Critical patent/EP0796252A1/fr
Publication of EP0796252A4 publication Critical patent/EP0796252A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
EP95942590A 1994-12-09 1995-12-07 Antagonistes du fibrinogene a cycle double Withdrawn EP0796252A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35304594A 1994-12-09 1994-12-09
US353045 1994-12-09
PCT/US1995/015932 WO1996017833A1 (fr) 1994-12-09 1995-12-07 Antagonistes du fibrinogene a cycle double

Publications (2)

Publication Number Publication Date
EP0796252A1 EP0796252A1 (fr) 1997-09-24
EP0796252A4 true EP0796252A4 (fr) 1998-02-04

Family

ID=23387541

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95942590A Withdrawn EP0796252A4 (fr) 1994-12-09 1995-12-07 Antagonistes du fibrinogene a cycle double

Country Status (3)

Country Link
EP (1) EP0796252A4 (fr)
JP (1) JPH11505509A (fr)
WO (1) WO1996017833A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
JP4615727B2 (ja) 1998-12-24 2011-01-19 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Ａβタンパク質生成の阻害剤としてのスクシノイルアミノベンゾジアゼピン
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
CA2387493A1 (fr) 1999-10-08 2001-04-19 Lorin Andrew Thompson Amino sulfonamides de lactame utilises comme inhibiteurs de la production de proteine a.beta.
EP1261610A2 (fr) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company CARBOCYCLES ET HETEROCYCLES SUCCINOYLAMINO UTILISES EN TANT QU'INHIBITEURS DE LA PRODUCTION DE LA PROTEINE A$g(b)
US6495540B2 (en) 2000-03-28 2002-12-17 Bristol - Myers Squibb Pharma Company Lactams as inhibitors of A-β protein production
CA2404023A1 (fr) 2000-04-03 2001-10-11 Richard E. Olson Lactames cycliques utilises comme inhibiteurs de la production de la proteine beta-amyloide
JP2004508289A (ja) 2000-04-03 2004-03-18 デュポン　ファーマシューティカルズ　カンパニー Ａβタンパク質産生の阻害剤としての環状ラクタム
WO2001077086A1 (fr) 2000-04-11 2001-10-18 Dupont Pharmaceuticals Company LACTAMES SUBSTITUES UTILISES EN TANT QU'INHIBITEURS DE PRODUCTION DE PROTEINE A$g(b)
IL147629A0 (en) 2000-06-01 2002-08-14 Bristol Myers Squibb Pharma Co LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
WO2002036587A2 (fr) 2000-11-01 2002-05-10 Cor Therapeutics, Inc. Composes heterocycliques azotes et procede de fabrication de ces composes et de leurs intermediaires
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923821A1 (de) * 1969-05-09 1970-11-19 Wuelfing J A Fa 1,2,4,5-Tetrahydro-[3H]-benzo-1,4-diazepin-2,5-dion-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten
US3898214A (en) * 1974-07-22 1975-08-05 Squibb & Sons Inc Benzazepine diones
US4746657A (en) * 1987-07-13 1988-05-24 A. H. Robins Company, Incorporated Fused aromatic tetrahydroazepinones (and thiones)
EP0444924A1 (fr) * 1990-02-28 1991-09-04 Suntory Limited Composés condensés contenant un cycle à sept chaînons et préparations antipsychotiques les contenant
WO1993000095A2 (fr) * 1991-06-28 1993-01-07 Smithkline Beecham Corporation Antagonistes bicycliques de fibrinogene
WO1993008174A1 (fr) * 1991-10-18 1993-04-29 Genentech, Inc. INHIBITEURS NON PEPTIDYLES A BASE D'INTEGRINE SPECIFIQUES DU RECEPTEUR GPIIbIII¿a?
WO1994014776A2 (fr) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Antagonistes bicycliques du fibrinogene

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US5389631A (en) * 1991-10-29 1995-02-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5441952A (en) * 1993-04-05 1995-08-15 Merck & Co., Inc. Fibrinogen receptor antagonists

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923821A1 (de) * 1969-05-09 1970-11-19 Wuelfing J A Fa 1,2,4,5-Tetrahydro-[3H]-benzo-1,4-diazepin-2,5-dion-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten
US3898214A (en) * 1974-07-22 1975-08-05 Squibb & Sons Inc Benzazepine diones
US4746657A (en) * 1987-07-13 1988-05-24 A. H. Robins Company, Incorporated Fused aromatic tetrahydroazepinones (and thiones)
EP0444924A1 (fr) * 1990-02-28 1991-09-04 Suntory Limited Composés condensés contenant un cycle à sept chaînons et préparations antipsychotiques les contenant
WO1993000095A2 (fr) * 1991-06-28 1993-01-07 Smithkline Beecham Corporation Antagonistes bicycliques de fibrinogene
WO1993008174A1 (fr) * 1991-10-18 1993-04-29 Genentech, Inc. INHIBITEURS NON PEPTIDYLES A BASE D'INTEGRINE SPECIFIQUES DU RECEPTEUR GPIIbIII¿a?
WO1994014776A2 (fr) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Antagonistes bicycliques du fibrinogene

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
M. REIFFEN ET AL.: "Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 5, May 1990 (1990-05-01), WASHINGTON DC, US, pages 1496 - 1504, XP002047919 *
See also references of WO9617833A1 *

Also Published As

Publication number Publication date
JPH11505509A (ja) 1999-05-21
EP0796252A1 (fr) 1997-09-24
WO1996017833A1 (fr) 1996-06-13

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Legal Events

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