CO5080785A1 - Derivados heterociclicos - Google Patents
Derivados heterociclicosInfo
- Publication number
- CO5080785A1 CO5080785A1 CO99035699A CO99035699A CO5080785A1 CO 5080785 A1 CO5080785 A1 CO 5080785A1 CO 99035699 A CO99035699 A CO 99035699A CO 99035699 A CO99035699 A CO 99035699A CO 5080785 A1 CO5080785 A1 CO 5080785A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- carbon atoms
- alkyl
- hydrogen
- amino
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052757 nitrogen Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Un compuesto de la fórmula (I)<EMI FILE="99035699_1" ID="1" IMF=JPEG >o una sal o ésteres lábiles metabólicamente no tóxicos de los mismos, en donde Y representa un átomo de carbono;Z es el grupo CH el cual está unido al grupo Y por medio de un doble enlace y X es CH o Z es metileno o NR11 y X es un átomo de carbono unido al grupo Y por medio de un doble enlace;A representa una cadena de alquileno con 1 a 2 átomos de carbono y la cual puede estar substituida por uno o dos grupos seleccionados de alquilo con 1 a 6 átomos de carbono substituido opcionalmente por hidroxi, amino, C1-4 alquil amino o C1-4 dialquil amino o tal cadena puede estar substituida por el grupo=0;R representa un átomo de halógeno o un grupo alquilo con 1 a 4 átomos de carbono;R1 representa un hidrógeno, un átomo de halógeno o un grupo alquilo con 1 a 4 átomos de carbono;R2 representa fenilo el cual puede estar substituido con hasta 3 grupos seleccionados de halógeno, hidrógeno, o (CH2)nR3 en donde R3 es COR4, NR6R5, NHCOR7, NHCOR9R8 o el grupo NH SO2 R10 o R2 es un grupo heteroarilo de 5 elementos que contiene 1 a 3 heteroátomos seleccionados de oxígeno, azufre y nitrógeno; o un grupo heteroarilo de 6 elementos que contiene 1 a 3 átomos de nitrógeno R4 representa un amino, un hidroxilo o un grupo alcoxi con C1-4 o R5 y R6 cada uno representan independientemente hidrógeno o un grupo alquilo con C1-4 o R5 y R6 junto con el átomo de nitrógeno al cual los mismos están unidos representan un grupo heterocíclico de 5-7 elemento saturado, que contiene opcionalmente un heteroátomo adicional seleccionado de oxígeno, azufre o nitrógeno. R7 representa un átomo de hidrógeno o alquilo con 1 a 4 átomos de carbono, alcoxi con 1 a 4 átomos de carbono, o fenilo;R8 representa hidrógeno o un grupo alquilo con 1 a 4 átomos de carbono; R9 representa, hidrógeno con alquilo con 1 a 4 átomos de carbono substituido opcionalmente (substituido opcionalmente por uno o más grupos de hidroxi carbilo y amino), fenilo; R11 representa hidrógeno o un grupo alquilo con 1 a 4 átomos de carbono; R10 representa hidrógeno, alquilo con 1 a 4 átomos de carbono o un grupo protector de nitrógeno, n es cero o un número entero desde 1 hasta 2.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812410.0A GB9812410D0 (en) | 1998-06-10 | 1998-06-10 | Heterocyclic derivatives |
| GBGB9812408.4A GB9812408D0 (en) | 1998-06-10 | 1998-06-10 | Heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5080785A1 true CO5080785A1 (es) | 2001-09-25 |
Family
ID=26313826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99035699A CO5080785A1 (es) | 1998-06-10 | 1999-06-08 | Derivados heterociclicos |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US6362199B1 (es) |
| EP (1) | EP1086093B1 (es) |
| JP (1) | JP2002517492A (es) |
| KR (1) | KR100586762B1 (es) |
| CN (1) | CN1173970C (es) |
| AP (1) | AP2000002008A0 (es) |
| AR (1) | AR018632A1 (es) |
| AT (1) | ATE301650T1 (es) |
| AU (1) | AU753867B2 (es) |
| BG (1) | BG105123A (es) |
| BR (1) | BR9911145A (es) |
| CA (1) | CA2334727C (es) |
| CO (1) | CO5080785A1 (es) |
| CZ (1) | CZ293605B6 (es) |
| DE (1) | DE69926632T2 (es) |
| DK (1) | DK1086093T3 (es) |
| EA (1) | EA003276B1 (es) |
| EE (1) | EE200000733A (es) |
| ES (1) | ES2249010T3 (es) |
| HK (1) | HK1034079A1 (es) |
| HR (1) | HRP20000845A2 (es) |
| HU (1) | HUP0102767A3 (es) |
| ID (1) | ID27845A (es) |
| IL (2) | IL140062A0 (es) |
| IS (1) | IS5746A (es) |
| MY (1) | MY125037A (es) |
| NO (1) | NO321904B1 (es) |
| NZ (1) | NZ508638A (es) |
| OA (1) | OA11564A (es) |
| PE (1) | PE20000724A1 (es) |
| PL (1) | PL197160B1 (es) |
| TR (1) | TR200003652T2 (es) |
| TW (1) | TWI229079B (es) |
| WO (1) | WO1999064411A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY125037A (en) * | 1998-06-10 | 2006-07-31 | Glaxo Wellcome Spa | 1,2,3,4 tetrahydroquinoline derivatives |
| US6455734B1 (en) | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| GB9929037D0 (en) | 1999-12-08 | 2000-02-02 | Glaxo Wellcome Spa | Heterocyclic derivatives |
| DE10000311A1 (de) | 2000-01-05 | 2001-07-12 | Gruenenthal Gmbh | Aminomethyl-Phonyl-Cyclohexanonderivate |
| DE10005302A1 (de) * | 2000-02-07 | 2002-01-17 | Gruenenthal Gmbh | Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate |
| DE10137487A1 (de) * | 2001-08-03 | 2003-03-27 | Gruenenthal Gmbh | Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate |
| DE10137488A1 (de) * | 2001-08-03 | 2003-02-20 | Gruenenthal Gmbh | Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate |
| US20090181966A1 (en) * | 2002-10-04 | 2009-07-16 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| US7504508B2 (en) * | 2002-10-04 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | PGD2 receptor antagonists for the treatment of inflammatory diseases |
| MXPA05003456A (es) * | 2002-10-04 | 2005-07-05 | Millennium Pharm Inc | Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias. |
| GB0327912D0 (en) * | 2003-12-02 | 2004-01-07 | Glaxo Group Ltd | Medicament |
| UA90706C2 (ru) * | 2005-02-24 | 2010-05-25 | Милленниум Фармасьютикалз, Инк. | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2024516C1 (ru) * | 1989-02-02 | 1994-12-15 | Яманути Фармасьютикал Ко., Лтд. | Способ получения производного тетрагидробензимидазола или его фармацевтически приемлемой соли |
| US4902695A (en) * | 1989-02-13 | 1990-02-20 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5231102A (en) * | 1989-03-08 | 1993-07-27 | Merck Sharp & Dohme, Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| DE69029668T2 (de) * | 1989-03-08 | 1997-08-07 | Merck Sharp & Dohme | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| US5529999A (en) | 1994-03-04 | 1996-06-25 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
| TR199800531T1 (xx) * | 1995-09-29 | 1998-06-22 | Glaxo Wellcome Spa | NMDA antagonistleri olarak tetrahidrokinolinler. |
| GB9617305D0 (en) * | 1996-08-17 | 1996-09-25 | Glaxo Wellcome Spa | Heterocyclic compounds |
| MY125037A (en) * | 1998-06-10 | 2006-07-31 | Glaxo Wellcome Spa | 1,2,3,4 tetrahydroquinoline derivatives |
-
1999
- 1999-06-07 MY MYPI99002298A patent/MY125037A/en unknown
- 1999-06-08 ID IDW20010061A patent/ID27845A/id unknown
- 1999-06-08 US US09/719,188 patent/US6362199B1/en not_active Expired - Fee Related
- 1999-06-08 OA OA1200000335A patent/OA11564A/en unknown
- 1999-06-08 DE DE69926632T patent/DE69926632T2/de not_active Expired - Lifetime
- 1999-06-08 CO CO99035699A patent/CO5080785A1/es unknown
- 1999-06-08 KR KR1020007013994A patent/KR100586762B1/ko not_active IP Right Cessation
- 1999-06-08 EP EP99927911A patent/EP1086093B1/en not_active Expired - Lifetime
- 1999-06-08 AT AT99927911T patent/ATE301650T1/de active
- 1999-06-08 BR BR9911145-4A patent/BR9911145A/pt not_active Application Discontinuation
- 1999-06-08 EA EA200001165A patent/EA003276B1/ru not_active IP Right Cessation
- 1999-06-08 EE EEP200000733A patent/EE200000733A/xx unknown
- 1999-06-08 IL IL14006299A patent/IL140062A0/xx active IP Right Grant
- 1999-06-08 AR ARP990102714A patent/AR018632A1/es active IP Right Grant
- 1999-06-08 CN CNB998094145A patent/CN1173970C/zh not_active Expired - Fee Related
- 1999-06-08 PE PE1999000511A patent/PE20000724A1/es not_active Application Discontinuation
- 1999-06-08 AU AU45092/99A patent/AU753867B2/en not_active Ceased
- 1999-06-08 JP JP2000553420A patent/JP2002517492A/ja active Pending
- 1999-06-08 CZ CZ20004587A patent/CZ293605B6/cs not_active IP Right Cessation
- 1999-06-08 CA CA002334727A patent/CA2334727C/en not_active Expired - Fee Related
- 1999-06-08 PL PL344694A patent/PL197160B1/pl not_active IP Right Cessation
- 1999-06-08 NZ NZ508638A patent/NZ508638A/en not_active IP Right Cessation
- 1999-06-08 DK DK99927911T patent/DK1086093T3/da active
- 1999-06-08 AP APAP/P/2000/002008A patent/AP2000002008A0/en unknown
- 1999-06-08 ES ES99927911T patent/ES2249010T3/es not_active Expired - Lifetime
- 1999-06-08 HU HU0102767A patent/HUP0102767A3/hu unknown
- 1999-06-08 WO PCT/EP1999/003936 patent/WO1999064411A1/en active IP Right Grant
- 1999-06-08 TR TR2000/03652T patent/TR200003652T2/xx unknown
- 1999-06-17 TW TW088110159A patent/TWI229079B/zh not_active IP Right Cessation
-
2000
- 2000-11-30 IS IS5746A patent/IS5746A/is unknown
- 2000-12-04 IL IL140062A patent/IL140062A/en not_active IP Right Cessation
- 2000-12-07 NO NO20006227A patent/NO321904B1/no not_active IP Right Cessation
- 2000-12-08 HR HR20000845A patent/HRP20000845A2/hr not_active Application Discontinuation
-
2001
- 2001-01-08 BG BG105123A patent/BG105123A/xx unknown
- 2001-07-03 HK HK01104579A patent/HK1034079A1/xx not_active IP Right Cessation
- 2001-11-16 US US09/990,513 patent/US6413985B1/en not_active Expired - Fee Related
-
2002
- 2002-05-14 US US10/145,258 patent/US6495566B2/en not_active Expired - Fee Related
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