PE20080144A1 - Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa - Google Patents

Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa

Info

Publication number
PE20080144A1
PE20080144A1 PE2007000292A PE2007000292A PE20080144A1 PE 20080144 A1 PE20080144 A1 PE 20080144A1 PE 2007000292 A PE2007000292 A PE 2007000292A PE 2007000292 A PE2007000292 A PE 2007000292A PE 20080144 A1 PE20080144 A1 PE 20080144A1
Authority
PE
Peru
Prior art keywords
halo
compounds
alkyl
tetrahydropyridotienopyrimidine
antiproliferative activity
Prior art date
Application number
PE2007000292A
Other languages
English (en)
Inventor
Chengzhi Zhang
Kanwar Sidhu
Mario Lobell
Gaetan Ladouceur
Qian Zhao
Zheng Liu
Kristen Allegue
Chetan Darne
Jason Newcom
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of PE20080144A1 publication Critical patent/PE20080144A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A COMPUESTOS TETRAHIDROPIRIDOTIENOPIRIMIDINA DE FORMULA (I), DONDE m ES DE 0 A 2; n ES DE 0 A 3; q ES 0 O 1; R1 ES H, ALQUILO(C1-C4) O HALO; R2 ES H, CN, HALO, ENTRE OTROS; R3 ES H, CN, HALO, ALQUILO(C1-C4), *-O(CH2)pAr, ENTRE OTROS; O R2 Y R3 JUNTOS PUEDEN FORMAR UN CARBO O HETEROCICLO; R4 ES CN, ALQUENILO(C2-C4), HALO, ENTRE OTROS; R5 ES H O HALO; R9 ES H O CH2-Y; O R10 ES H; R9 Y R10 JUNTOS PUEDEN FORMAR UN LIGAMIENTO ACETILENICO, R8 ES HALO, HIDROXILO O ALQUILO(C1-C4); R7 ES UN GRUPO MONO- O DI-(ALQUILO(CI-C4))AMINO. SON SELECCIONADOS: N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIMETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENE ACTIVIDAD ANTIPROLIFERATIVA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS ASOCIADOS A HIPERPROLIFERACION Y TRATAMIENTO DEL CANCER
PE2007000292A 2006-03-20 2007-03-19 Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa PE20080144A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78414606P 2006-03-20 2006-03-20

Publications (1)

Publication Number Publication Date
PE20080144A1 true PE20080144A1 (es) 2008-04-06

Family

ID=38523058

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000292A PE20080144A1 (es) 2006-03-20 2007-03-19 Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa

Country Status (29)

Country Link
US (1) US8501755B2 (es)
EP (1) EP2001890B1 (es)
JP (1) JP5282026B2 (es)
KR (1) KR20080110834A (es)
CN (1) CN101448840B (es)
AR (1) AR059901A1 (es)
AT (1) ATE495179T1 (es)
AU (1) AU2007227317A1 (es)
BR (1) BRPI0711045A2 (es)
CA (1) CA2647036C (es)
CR (1) CR10304A (es)
DE (1) DE602007011906D1 (es)
DO (1) DOP2007000053A (es)
EC (1) ECSP088749A (es)
ES (1) ES2357654T3 (es)
GT (1) GT200800187A (es)
IL (1) IL194028A0 (es)
MA (1) MA30351B1 (es)
MX (1) MX2008012006A (es)
NZ (1) NZ571326A (es)
PA (1) PA8719401A1 (es)
PE (1) PE20080144A1 (es)
RU (1) RU2008141239A (es)
SV (1) SV2008003032A (es)
TN (1) TNSN08370A1 (es)
TW (1) TW200804397A (es)
UY (1) UY30220A1 (es)
WO (1) WO2007109279A2 (es)
ZA (1) ZA200808017B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8524722B2 (en) * 2007-09-14 2013-09-03 Bayer Intellectual Property Gmbh Substituted tricyclic compounds and methods of use thereof
CA2724726C (en) 2008-05-23 2018-02-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein inhibitor
JP5781934B2 (ja) * 2008-11-10 2015-09-24 ナショナル ヘルス リサーチ インスティテューツ チロシンキナーゼ阻害剤としての融合２環および３環ピリミジン化合物
AU2013202373B2 (en) * 2012-01-25 2016-04-14 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
WO2015181063A1 (en) * 2014-05-26 2015-12-03 Bayer Pharma Aktiengesellschaft Substituted tetrahydropyridothienopyrimidines
US10561749B2 (en) 2015-07-03 2020-02-18 Kyoto University Nuclear medicine diagnostic imaging agent
KR102474326B1 (ko) 2016-06-22 2022-12-05 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m4의 양성 알로스테릭 조절제
US11008335B2 (en) 2016-11-07 2021-05-18 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M4
JP7097623B2 (ja) 2016-11-07 2022-07-08 ヴァンダービルト ユニヴァーシティ ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子
WO2018085808A1 (en) 2016-11-07 2018-05-11 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
EP3720859A1 (en) 2017-12-05 2020-10-14 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
TW201930311A (zh) 2017-12-05 2019-08-01 泛德比爾特大學 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑
EP3941905A1 (en) * 2019-03-19 2022-01-26 Suvalent Therapeutics, Inc. Sumo inhibitor compounds and uses thereof
CN117980309A (zh) * 2021-08-05 2024-05-03 百时美施贵宝公司 用作her2抑制剂的三环稠合嘧啶化合物
CN114736154B (zh) * 2022-03-15 2023-07-21 安庆朗坤药业有限公司 N-（3-氯-4-（2-吡啶甲氧基）苯基）-2-氰基乙酰胺的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482948B1 (en) * 1999-03-30 2002-11-19 Nippon Soda Co., Ltd. Thienopyrimidine compounds and salts thereof and process for the preparation of the same
DE19944604A1 (de) * 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
US6608053B2 (en) * 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
WO2003035653A1 (fr) * 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Compose pyridothienopyrimidine et son sel
DE602004003952T2 (de) * 2003-07-24 2007-11-08 Bayer Pharmaceuticals Corp., West Haven Substituierte tetrahydrobenzothienopyrimidinamine verbindungen geeignet zur behandlung von hyper-proliferative disorders

Also Published As

Publication number Publication date
JP5282026B2 (ja) 2013-09-04
CN101448840B (zh) 2011-12-14
CA2647036C (en) 2015-06-23
KR20080110834A (ko) 2008-12-19
RU2008141239A (ru) 2010-04-27
IL194028A0 (en) 2009-09-22
TW200804397A (en) 2008-01-16
NZ571326A (en) 2011-07-29
ECSP088749A (es) 2008-10-31
CR10304A (es) 2009-01-27
BRPI0711045A2 (pt) 2012-06-26
CA2647036A1 (en) 2007-09-27
MX2008012006A (es) 2008-10-03
EP2001890A2 (en) 2008-12-17
UY30220A1 (es) 2007-10-31
ATE495179T1 (de) 2011-01-15
US8501755B2 (en) 2013-08-06
TNSN08370A1 (en) 2009-12-29
WO2007109279A3 (en) 2007-12-21
GT200800187A (es) 2009-04-07
ZA200808017B (en) 2009-11-25
EP2001890B1 (en) 2011-01-12
US20100298297A1 (en) 2010-11-25
AR059901A1 (es) 2008-05-07
MA30351B1 (fr) 2009-04-01
DE602007011906D1 (de) 2011-02-24
WO2007109279A2 (en) 2007-09-27
AU2007227317A1 (en) 2007-09-27
PA8719401A1 (es) 2009-02-09
DOP2007000053A (es) 2007-09-30
CN101448840A (zh) 2009-06-03
SV2008003032A (es) 2009-11-26
JP2009530387A (ja) 2009-08-27
ES2357654T3 (es) 2011-04-28

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