PE20080144A1 - Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa - Google Patents

Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa

Info

Publication number
PE20080144A1
PE20080144A1 PE2007000292A PE2007000292A PE20080144A1 PE 20080144 A1 PE20080144 A1 PE 20080144A1 PE 2007000292 A PE2007000292 A PE 2007000292A PE 2007000292 A PE2007000292 A PE 2007000292A PE 20080144 A1 PE20080144 A1 PE 20080144A1
Authority
PE
Peru
Prior art keywords
halo
compounds
alkyl
tetrahydropyridotienopyrimidine
antiproliferative activity
Prior art date
Application number
PE2007000292A
Other languages
English (en)
Inventor
Chengzhi Zhang
Kanwar Sidhu
Mario Lobell
Gaetan Ladouceur
Qian Zhao
Zheng Liu
Kristen Allegue
Chetan Darne
Jason Newcom
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of PE20080144A1 publication Critical patent/PE20080144A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A COMPUESTOS TETRAHIDROPIRIDOTIENOPIRIMIDINA DE FORMULA (I), DONDE m ES DE 0 A 2; n ES DE 0 A 3; q ES 0 O 1; R1 ES H, ALQUILO(C1-C4) O HALO; R2 ES H, CN, HALO, ENTRE OTROS; R3 ES H, CN, HALO, ALQUILO(C1-C4), *-O(CH2)pAr, ENTRE OTROS; O R2 Y R3 JUNTOS PUEDEN FORMAR UN CARBO O HETEROCICLO; R4 ES CN, ALQUENILO(C2-C4), HALO, ENTRE OTROS; R5 ES H O HALO; R9 ES H O CH2-Y; O R10 ES H; R9 Y R10 JUNTOS PUEDEN FORMAR UN LIGAMIENTO ACETILENICO, R8 ES HALO, HIDROXILO O ALQUILO(C1-C4); R7 ES UN GRUPO MONO- O DI-(ALQUILO(CI-C4))AMINO. SON SELECCIONADOS: N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIMETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENE ACTIVIDAD ANTIPROLIFERATIVA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS ASOCIADOS A HIPERPROLIFERACION Y TRATAMIENTO DEL CANCER
PE2007000292A 2006-03-20 2007-03-19 Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa PE20080144A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78414606P 2006-03-20 2006-03-20

Publications (1)

Publication Number Publication Date
PE20080144A1 true PE20080144A1 (es) 2008-04-06

Family

ID=38523058

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000292A PE20080144A1 (es) 2006-03-20 2007-03-19 Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa

Country Status (29)

Country Link
US (1) US8501755B2 (es)
EP (1) EP2001890B1 (es)
JP (1) JP5282026B2 (es)
KR (1) KR20080110834A (es)
CN (1) CN101448840B (es)
AR (1) AR059901A1 (es)
AT (1) ATE495179T1 (es)
AU (1) AU2007227317A1 (es)
BR (1) BRPI0711045A2 (es)
CA (1) CA2647036C (es)
CR (1) CR10304A (es)
DE (1) DE602007011906D1 (es)
DO (1) DOP2007000053A (es)
EC (1) ECSP088749A (es)
ES (1) ES2357654T3 (es)
GT (1) GT200800187A (es)
IL (1) IL194028A0 (es)
MA (1) MA30351B1 (es)
MX (1) MX2008012006A (es)
NZ (1) NZ571326A (es)
PA (1) PA8719401A1 (es)
PE (1) PE20080144A1 (es)
RU (1) RU2008141239A (es)
SV (1) SV2008003032A (es)
TN (1) TNSN08370A1 (es)
TW (1) TW200804397A (es)
UY (1) UY30220A1 (es)
WO (1) WO2007109279A2 (es)
ZA (1) ZA200808017B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8524722B2 (en) * 2007-09-14 2013-09-03 Bayer Intellectual Property Gmbh Substituted tricyclic compounds and methods of use thereof
MX2010012814A (es) 2008-05-23 2010-12-20 Amira Pharmaceuticals Inc Inhibidor de proteina activadora de 5-lipoxigenasa.
US8507502B2 (en) 2008-11-10 2013-08-13 National Health Research Institutes Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
JP2015513317A (ja) * 2012-01-25 2015-05-07 プロテオステイシス セラピューティクス，インコーポレイテッド プロテアソーム活性を増強する化合物
EP3149004A1 (en) * 2014-05-26 2017-04-05 Bayer Pharma Aktiengesellschaft Substituted tetrahydropyridothienopyrimidines
EP3111960B1 (en) * 2015-07-03 2019-12-11 Kyoto University Nuclear medicine diagnostic imaging agent
PE20190446A1 (es) 2016-06-22 2019-03-29 Univ Vanderbilt Moduladores alostericos positivos del receptor muscarinico de acetilcolina m4
CN109863139B (zh) 2016-11-07 2023-02-17 范德比尔特大学 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂
US11008335B2 (en) 2016-11-07 2021-05-18 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M4
US10961253B2 (en) 2016-11-07 2021-03-30 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M4
WO2019113174A1 (en) 2017-12-05 2019-06-13 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
TW201930311A (zh) 2017-12-05 2019-08-01 泛德比爾特大學 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑
WO2020191151A1 (en) * 2019-03-19 2020-09-24 Oncovalent Therapeutics Inc. Sumo inhibitor compounds and uses thereof
EP4380941A1 (en) * 2021-08-05 2024-06-12 Bristol-Myers Squibb Company Tricyclic fused pyrimidine compounds for use as her2 inhibitors
CN114736154B (zh) * 2022-03-15 2023-07-21 安庆朗坤药业有限公司 N-（3-氯-4-（2-吡啶甲氧基）苯基）-2-氰基乙酰胺的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3453900A (en) * 1999-03-30 2000-10-23 Nippon Soda Co., Ltd. Thienopyrimidine compounds and salts thereof and process for the preparation of the same
DE19944604A1 (de) * 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
JPWO2003035653A1 (ja) * 2001-10-26 2005-02-10 日本曹達株式会社 ピリドチエノピリミジン化合物およびその塩
JP4712702B2 (ja) 2003-07-24 2011-06-29 バイエル・シエリング・フアーマ・アクチエンゲゼルシヤフト 高増殖性疾患を処置するために有用な置換されたテトラヒドロベンゾチエノピリミジンアミン化合物

Also Published As

Publication number Publication date
NZ571326A (en) 2011-07-29
US8501755B2 (en) 2013-08-06
US20100298297A1 (en) 2010-11-25
DE602007011906D1 (de) 2011-02-24
WO2007109279A3 (en) 2007-12-21
ATE495179T1 (de) 2011-01-15
TW200804397A (en) 2008-01-16
EP2001890A2 (en) 2008-12-17
CA2647036A1 (en) 2007-09-27
AR059901A1 (es) 2008-05-07
CN101448840B (zh) 2011-12-14
CN101448840A (zh) 2009-06-03
CR10304A (es) 2009-01-27
EP2001890B1 (en) 2011-01-12
IL194028A0 (en) 2009-09-22
ECSP088749A (es) 2008-10-31
UY30220A1 (es) 2007-10-31
GT200800187A (es) 2009-04-07
TNSN08370A1 (en) 2009-12-29
MA30351B1 (fr) 2009-04-01
CA2647036C (en) 2015-06-23
RU2008141239A (ru) 2010-04-27
DOP2007000053A (es) 2007-09-30
ZA200808017B (en) 2009-11-25
WO2007109279A2 (en) 2007-09-27
MX2008012006A (es) 2008-10-03
SV2008003032A (es) 2009-11-26
ES2357654T3 (es) 2011-04-28
JP2009530387A (ja) 2009-08-27
JP5282026B2 (ja) 2013-09-04
PA8719401A1 (es) 2009-02-09
AU2007227317A1 (en) 2007-09-27
BRPI0711045A2 (pt) 2012-06-26
KR20080110834A (ko) 2008-12-19

Similar Documents

Publication Publication Date Title
PE20080144A1 (es) Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa
AR061008A1 (es) Inhibidores ns5b de vhc de indolobenzazepina fusionados a ciclopropilo
SV2005002102A (es) Compuestos de metil-aril o heteroaril-amida sustituida ref. pc32241a
PL1613315T3 (pl) Pochodne chinolino-2-onu do leczenia chorób dróg oddechowych
AR078542A1 (es) Moduladores de gpr40 de pirrolidina
TW200612936A (en) Indole derivatives
TW200801003A (en) Novel compounds
TW200718422A (en) 1,6-Dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
BRPI0408353A (pt) composto, composição farmacêutica, métodos para o tratamento de neoplasias suscetìveis e para o tratamento de infecções virais, e, uso de um composto
PE20090648A1 (es) Compuestos para el tratamiento de la hepatitis c
UA84208C2 (en) Tetraazabenzo(e)azulene derivatives and analogs thereof
BRPI0617436B8 (pt) derivado heterocíclico fundido, composição farmacêutica compreendendo o mesmo e usos do dito derivado na prevenção ou tratamento de doença dependente de hormônio sexual e na regulação da reprodução, contracepção ou indução de ovulação
ECSP077402A (es) Derivados de 2-amido-4-feniltiazol, su preparación y su aplicación en terapéutica
GB0517191D0 (en) Compounds
TW200616979A (en) Non-nucleoside reverse transcriptase inhibitors
TW200745122A (en) New compounds I
TW200833670A (en) Novel compounds 569
TW200626158A (en) Naphthaline derivatives
MX2007007027A (es) Derivados piperazinilpiridina como agentes anti-obesidad.
MX2010009022A (es) Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
TNSN07419A1 (en) Methods for treating drug resistant cancer
TW200639156A (en) New compounds
AR064253A1 (es) Compuestos de biciclocarboxiamida sustituidos composiciones farmaceuticas y una combinacion que los incluye y su uso en fabaricacion de un medicamento para el tratamiento de enfermedades mediadas por la actividad del receptor vr1
AR061438A1 (es) Derivados de entacapone
TW200740781A (en) Novel compounds

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed