PE20080144A1 - Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa - Google Patents
Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativaInfo
- Publication number
- PE20080144A1 PE20080144A1 PE2007000292A PE2007000292A PE20080144A1 PE 20080144 A1 PE20080144 A1 PE 20080144A1 PE 2007000292 A PE2007000292 A PE 2007000292A PE 2007000292 A PE2007000292 A PE 2007000292A PE 20080144 A1 PE20080144 A1 PE 20080144A1
- Authority
- PE
- Peru
- Prior art keywords
- halo
- compounds
- alkyl
- tetrahydropyridotienopyrimidine
- antiproliferative activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A COMPUESTOS TETRAHIDROPIRIDOTIENOPIRIMIDINA DE FORMULA (I), DONDE m ES DE 0 A 2; n ES DE 0 A 3; q ES 0 O 1; R1 ES H, ALQUILO(C1-C4) O HALO; R2 ES H, CN, HALO, ENTRE OTROS; R3 ES H, CN, HALO, ALQUILO(C1-C4), *-O(CH2)pAr, ENTRE OTROS; O R2 Y R3 JUNTOS PUEDEN FORMAR UN CARBO O HETEROCICLO; R4 ES CN, ALQUENILO(C2-C4), HALO, ENTRE OTROS; R5 ES H O HALO; R9 ES H O CH2-Y; O R10 ES H; R9 Y R10 JUNTOS PUEDEN FORMAR UN LIGAMIENTO ACETILENICO, R8 ES HALO, HIDROXILO O ALQUILO(C1-C4); R7 ES UN GRUPO MONO- O DI-(ALQUILO(CI-C4))AMINO. SON SELECCIONADOS: N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, N-[3-CLORO-4(PIRIDIN-2-ILMETOXI)FENIL]-7[(2E)-4-(DIMETILAMINO)BUT-2-ENOIL]-5,6,7,8-TETRAHIDROPIRIDO[4',3':4,5]TIENO[2,3-d]PIRIMIDIN-4-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENE ACTIVIDAD ANTIPROLIFERATIVA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS ASOCIADOS A HIPERPROLIFERACION Y TRATAMIENTO DEL CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78414606P | 2006-03-20 | 2006-03-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080144A1 true PE20080144A1 (es) | 2008-04-06 |
Family
ID=38523058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000292A PE20080144A1 (es) | 2006-03-20 | 2007-03-19 | Compuestos de tetrahidropiridotienopirimidina con actividad antiproliferativa |
Country Status (29)
Country | Link |
---|---|
US (1) | US8501755B2 (es) |
EP (1) | EP2001890B1 (es) |
JP (1) | JP5282026B2 (es) |
KR (1) | KR20080110834A (es) |
CN (1) | CN101448840B (es) |
AR (1) | AR059901A1 (es) |
AT (1) | ATE495179T1 (es) |
AU (1) | AU2007227317A1 (es) |
BR (1) | BRPI0711045A2 (es) |
CA (1) | CA2647036C (es) |
CR (1) | CR10304A (es) |
DE (1) | DE602007011906D1 (es) |
DO (1) | DOP2007000053A (es) |
EC (1) | ECSP088749A (es) |
ES (1) | ES2357654T3 (es) |
GT (1) | GT200800187A (es) |
IL (1) | IL194028A0 (es) |
MA (1) | MA30351B1 (es) |
MX (1) | MX2008012006A (es) |
NZ (1) | NZ571326A (es) |
PA (1) | PA8719401A1 (es) |
PE (1) | PE20080144A1 (es) |
RU (1) | RU2008141239A (es) |
SV (1) | SV2008003032A (es) |
TN (1) | TNSN08370A1 (es) |
TW (1) | TW200804397A (es) |
UY (1) | UY30220A1 (es) |
WO (1) | WO2007109279A2 (es) |
ZA (1) | ZA200808017B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US8524722B2 (en) * | 2007-09-14 | 2013-09-03 | Bayer Intellectual Property Gmbh | Substituted tricyclic compounds and methods of use thereof |
CA2724726C (en) | 2008-05-23 | 2018-02-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein inhibitor |
JP5781934B2 (ja) * | 2008-11-10 | 2015-09-24 | ナショナル ヘルス リサーチ インスティテューツ | チロシンキナーゼ阻害剤としての融合2環および3環ピリミジン化合物 |
AU2013202373B2 (en) * | 2012-01-25 | 2016-04-14 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
WO2015181063A1 (en) * | 2014-05-26 | 2015-12-03 | Bayer Pharma Aktiengesellschaft | Substituted tetrahydropyridothienopyrimidines |
US10561749B2 (en) | 2015-07-03 | 2020-02-18 | Kyoto University | Nuclear medicine diagnostic imaging agent |
KR102474326B1 (ko) | 2016-06-22 | 2022-12-05 | 반더빌트유니버시티 | 무스카린성 아세틸콜린 수용체 m4의 양성 알로스테릭 조절제 |
US11008335B2 (en) | 2016-11-07 | 2021-05-18 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
JP7097623B2 (ja) | 2016-11-07 | 2022-07-08 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターm4のポジティブアロステリック調節因子 |
WO2018085808A1 (en) | 2016-11-07 | 2018-05-11 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
EP3720859A1 (en) | 2017-12-05 | 2020-10-14 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
EP3941905A1 (en) * | 2019-03-19 | 2022-01-26 | Suvalent Therapeutics, Inc. | Sumo inhibitor compounds and uses thereof |
CN117980309A (zh) * | 2021-08-05 | 2024-05-03 | 百时美施贵宝公司 | 用作her2抑制剂的三环稠合嘧啶化合物 |
CN114736154B (zh) * | 2022-03-15 | 2023-07-21 | 安庆朗坤药业有限公司 | N-(3-氯-4-(2-吡啶甲氧基)苯基)-2-氰基乙酰胺的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6482948B1 (en) * | 1999-03-30 | 2002-11-19 | Nippon Soda Co., Ltd. | Thienopyrimidine compounds and salts thereof and process for the preparation of the same |
DE19944604A1 (de) * | 1999-09-17 | 2001-03-22 | Merck Patent Gmbh | Aminderivate |
US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
WO2003035653A1 (fr) * | 2001-10-26 | 2003-05-01 | Nippon Soda Co.,Ltd. | Compose pyridothienopyrimidine et son sel |
DE602004003952T2 (de) * | 2003-07-24 | 2007-11-08 | Bayer Pharmaceuticals Corp., West Haven | Substituierte tetrahydrobenzothienopyrimidinamine verbindungen geeignet zur behandlung von hyper-proliferative disorders |
-
2007
- 2007-03-15 AR ARP070101057A patent/AR059901A1/es not_active Application Discontinuation
- 2007-03-19 UY UY30220A patent/UY30220A1/es not_active Application Discontinuation
- 2007-03-19 TW TW096109309A patent/TW200804397A/zh unknown
- 2007-03-19 PE PE2007000292A patent/PE20080144A1/es not_active Application Discontinuation
- 2007-03-20 EP EP07753547A patent/EP2001890B1/en not_active Not-in-force
- 2007-03-20 ES ES07753547T patent/ES2357654T3/es active Active
- 2007-03-20 BR BRPI0711045-6A patent/BRPI0711045A2/pt not_active IP Right Cessation
- 2007-03-20 WO PCT/US2007/006927 patent/WO2007109279A2/en active Application Filing
- 2007-03-20 US US12/225,285 patent/US8501755B2/en not_active Expired - Fee Related
- 2007-03-20 AT AT07753547T patent/ATE495179T1/de not_active IP Right Cessation
- 2007-03-20 CN CN2007800178021A patent/CN101448840B/zh not_active Expired - Fee Related
- 2007-03-20 PA PA20078719401A patent/PA8719401A1/es unknown
- 2007-03-20 MX MX2008012006A patent/MX2008012006A/es active IP Right Grant
- 2007-03-20 DE DE602007011906T patent/DE602007011906D1/de active Active
- 2007-03-20 RU RU2008141239/04A patent/RU2008141239A/ru not_active Application Discontinuation
- 2007-03-20 AU AU2007227317A patent/AU2007227317A1/en not_active Abandoned
- 2007-03-20 KR KR1020087025480A patent/KR20080110834A/ko not_active Application Discontinuation
- 2007-03-20 CA CA2647036A patent/CA2647036C/en not_active Expired - Fee Related
- 2007-03-20 NZ NZ571326A patent/NZ571326A/en not_active IP Right Cessation
- 2007-03-20 DO DO2007000053A patent/DOP2007000053A/es unknown
- 2007-03-20 JP JP2009501517A patent/JP5282026B2/ja not_active Expired - Fee Related
-
2008
- 2008-09-11 IL IL194028A patent/IL194028A0/en unknown
- 2008-09-18 GT GT200800187A patent/GT200800187A/es unknown
- 2008-09-18 ZA ZA200808017A patent/ZA200808017B/xx unknown
- 2008-09-18 SV SV2008003032A patent/SV2008003032A/es not_active Application Discontinuation
- 2008-09-19 CR CR10304A patent/CR10304A/es not_active Application Discontinuation
- 2008-09-19 EC EC2008008749A patent/ECSP088749A/es unknown
- 2008-09-22 TN TNP2008000370A patent/TNSN08370A1/en unknown
- 2008-10-20 MA MA31320A patent/MA30351B1/fr unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |