DE602007011906D1 - Tetrahydropyridothienpyrimidin-verbindungen und verwendung zur behandlung proliferativer erkrankungen - Google Patents

Tetrahydropyridothienpyrimidin-verbindungen und verwendung zur behandlung proliferativer erkrankungen

Info

Publication number
DE602007011906D1
DE602007011906D1 DE602007011906T DE602007011906T DE602007011906D1 DE 602007011906 D1 DE602007011906 D1 DE 602007011906D1 DE 602007011906 T DE602007011906 T DE 602007011906T DE 602007011906 T DE602007011906 T DE 602007011906T DE 602007011906 D1 DE602007011906 D1 DE 602007011906D1
Authority
DE
Germany
Prior art keywords
tetrahydropyridothia
treatment
proliferative diseases
pyrimidine compounds
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007011906T
Other languages
English (en)
Inventor
Chengzhi Zhang
Kanwar Sidhu
Mario Lobell
Gaetan Ladouceur
Qian Zhao
Zheng Liu
Kristen M Allegue
Chetan P Darne
Jason Newcom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of DE602007011906D1 publication Critical patent/DE602007011906D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
DE602007011906T 2006-03-20 2007-03-20 Tetrahydropyridothienpyrimidin-verbindungen und verwendung zur behandlung proliferativer erkrankungen Active DE602007011906D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78414606P 2006-03-20 2006-03-20
PCT/US2007/006927 WO2007109279A2 (en) 2006-03-20 2007-03-20 Tetrahydropyridothienopyrimidine compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
DE602007011906D1 true DE602007011906D1 (de) 2011-02-24

Family

ID=38523058

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007011906T Active DE602007011906D1 (de) 2006-03-20 2007-03-20 Tetrahydropyridothienpyrimidin-verbindungen und verwendung zur behandlung proliferativer erkrankungen

Country Status (29)

Country Link
US (1) US8501755B2 (de)
EP (1) EP2001890B1 (de)
JP (1) JP5282026B2 (de)
KR (1) KR20080110834A (de)
CN (1) CN101448840B (de)
AR (1) AR059901A1 (de)
AT (1) ATE495179T1 (de)
AU (1) AU2007227317A1 (de)
BR (1) BRPI0711045A2 (de)
CA (1) CA2647036C (de)
CR (1) CR10304A (de)
DE (1) DE602007011906D1 (de)
DO (1) DOP2007000053A (de)
EC (1) ECSP088749A (de)
ES (1) ES2357654T3 (de)
GT (1) GT200800187A (de)
IL (1) IL194028A0 (de)
MA (1) MA30351B1 (de)
MX (1) MX2008012006A (de)
NZ (1) NZ571326A (de)
PA (1) PA8719401A1 (de)
PE (1) PE20080144A1 (de)
RU (1) RU2008141239A (de)
SV (1) SV2008003032A (de)
TN (1) TNSN08370A1 (de)
TW (1) TW200804397A (de)
UY (1) UY30220A1 (de)
WO (1) WO2007109279A2 (de)
ZA (1) ZA200808017B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
EP2212332B1 (de) * 2007-09-14 2012-10-24 Bayer Intellectual Property GmbH Substituierte tricyclische verbindungen und verfahren zu deren anwendung
KR20160129109A (ko) 2008-05-23 2016-11-08 아미라 파마슈티칼스 인코포레이티드 5-리폭시게나아제 활성화 단백질 억제제
KR101703941B1 (ko) * 2008-11-10 2017-02-07 내셔날 헬스 리서치 인스티튜트 티로신 키나아제 억제제로서의 접합 이환 및 삼환 피리미딘 화합물
AU2013202373B2 (en) * 2012-01-25 2016-04-14 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
WO2015181063A1 (en) * 2014-05-26 2015-12-03 Bayer Pharma Aktiengesellschaft Substituted tetrahydropyridothienopyrimidines
EP3111960B1 (de) * 2015-07-03 2019-12-11 Kyoto University Nuklearmedizinisches diagnostisches bildgebungsmittel
MA45463A (fr) 2016-06-22 2019-05-01 Univ Vanderbilt Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
JP7099725B2 (ja) 2016-11-07 2022-07-12 ヴァンダービルト ユニヴァーシティ ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子
EP3534901B1 (de) 2016-11-07 2022-06-22 Vanderbilt University Positive allosterische modulatoren des muskarinischen acetylcholinrezeptors m4
MA46899A (fr) 2016-11-07 2021-04-14 Univ Vanderbilt Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
US11376254B2 (en) 2017-12-05 2022-07-05 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M4
TW201930311A (zh) 2017-12-05 2019-08-01 泛德比爾特大學 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑
EP3941905A1 (de) * 2019-03-19 2022-01-26 Suvalent Therapeutics, Inc. Sumo-inhibitorverbindungen und verwendungen davon
KR20240044458A (ko) * 2021-08-05 2024-04-04 브리스톨-마이어스 스큅 컴퍼니 Her2 억제제로서 사용하기 위한 트리시클릭 융합된 피리미딘 화합물
CN114736154B (zh) * 2022-03-15 2023-07-21 安庆朗坤药业有限公司 N-（3-氯-4-（2-吡啶甲氧基）苯基）-2-氰基乙酰胺的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1167367A4 (de) * 1999-03-30 2002-04-24 Nippon Soda Co Thienopyrimidin-verbindungen und verfahren zu ihrer herstellung
DE19944604A1 (de) 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
JPWO2003035653A1 (ja) * 2001-10-26 2005-02-10 日本曹達株式会社 ピリドチエノピリミジン化合物およびその塩
EP1651652B1 (de) 2003-07-24 2006-12-27 Bayer Pharmaceuticals Corporation Substituierte tetrahydrobenzothienopyrimidinamine verbindungen geeignet zur behandlung von hyper-proliferative disorders

Also Published As

Publication number Publication date
PE20080144A1 (es) 2008-04-06
CA2647036C (en) 2015-06-23
CR10304A (es) 2009-01-27
NZ571326A (en) 2011-07-29
GT200800187A (es) 2009-04-07
WO2007109279A2 (en) 2007-09-27
CN101448840A (zh) 2009-06-03
ZA200808017B (en) 2009-11-25
CA2647036A1 (en) 2007-09-27
BRPI0711045A2 (pt) 2012-06-26
KR20080110834A (ko) 2008-12-19
CN101448840B (zh) 2011-12-14
ES2357654T3 (es) 2011-04-28
JP2009530387A (ja) 2009-08-27
AU2007227317A1 (en) 2007-09-27
DOP2007000053A (es) 2007-09-30
RU2008141239A (ru) 2010-04-27
US8501755B2 (en) 2013-08-06
EP2001890B1 (de) 2011-01-12
US20100298297A1 (en) 2010-11-25
MA30351B1 (fr) 2009-04-01
PA8719401A1 (es) 2009-02-09
SV2008003032A (es) 2009-11-26
EP2001890A2 (de) 2008-12-17
JP5282026B2 (ja) 2013-09-04
AR059901A1 (es) 2008-05-07
ATE495179T1 (de) 2011-01-15
UY30220A1 (es) 2007-10-31
IL194028A0 (en) 2009-09-22
TNSN08370A1 (en) 2009-12-29
WO2007109279A3 (en) 2007-12-21
ECSP088749A (es) 2008-10-31
TW200804397A (en) 2008-01-16
MX2008012006A (es) 2008-10-03

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