PE20050336A1 - Compuestos triciclicos como inhibidores de la proteina farnesil transferasa - Google Patents

Compuestos triciclicos como inhibidores de la proteina farnesil transferasa

Info

Publication number
PE20050336A1
PE20050336A1 PE2004000760A PE2004000760A PE20050336A1 PE 20050336 A1 PE20050336 A1 PE 20050336A1 PE 2004000760 A PE2004000760 A PE 2004000760A PE 2004000760 A PE2004000760 A PE 2004000760A PE 20050336 A1 PE20050336 A1 PE 20050336A1
Authority
PE
Peru
Prior art keywords
methyl
alkyl
cycloalkyl
group
inhibitors
Prior art date
Application number
PE2004000760A
Other languages
English (en)
Inventor
Ronald J Doll
Alan B Cooper
James J-S Wang
Viyyoor M Girijavallabhan
F George Njoroge
Hugh Y Zhu
Dinanath F Rane
Jagdish A Desai
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34138747&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050336(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20050336A1 publication Critical patent/PE20050336A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE LA FORMULA I, EN DONDE R1 ES UN GRUPO a ENTRE OTROS, DONDE n ES 1-6; X ES O, S o N; R2, R3, R4 Y R5 SON H, Br, Cl o F; R5A ES H, ALQUILO C1-C6 o CICLOALQUILO C3-C6; R6 Y R7 SON H, ALQUILO C1-C4 o CICLOALQUILO C3-C7, ENTRE OTROS; R8 SE SELECCIONA DEL GRUPO CONSISTENTE EN LOS RADICALES 2.0, 3.0, ENTRE OTROS; R9 ES ALQUILO C1-C6, ARILO, HETEROARILO, CICLOALQUILO, ENTRE OTROS, CON LA CONDICION DE QUE EL ATOMO DE C, MEDIANTE EL CUAL DICHO GRUPO R9 ESTA UNIDO AL SUSTITUYENTE X, NO ESTA SUSTITUIDO CON UN GRUPO -OH, NH2, NH(ALQUILO C1-C6)2 o N(ALQUILO C1-C6)2; R10 ES ARILO, HETEROARILO, CICLOALQUILO, HETEROCICLOALQUILO, ENTRE OTROS; R11 ES ALQUILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: ESTER ISOPROPILICO DEL ACIDO 4-{8-CLORO-6-[[(1-METOXI-CICLOPROPANOCARBONIL)-AMINO]-(3-METIL-3H-IMIDAZOL-4-IL)-METIL]-11H-BENZO[5,6]CICLOHEPTA[1,2-b]PIRIDIN-11-IL-PIPERAZIN}-1-CARBOXILICO; ESTER ISOPROPILICO DEL ACIDO 4-{8-CLORO-6-[[(1-HIDROXI-CICLOPROPANOCARBONIL)-AMINO]-(3-METIL-3H-IMIDAZOL-4-IL)-METIL]-11H-BENZO[5,6]CICLOHEPTA[1,2-b]PIRIDIN-11-IL-PIPERAZIN}-1-CARBOXILICO; ESTER CICLOPENTILICO DEL ACIDO 4-{6-[(BICICLOPROPIL-1-ILOXICARBONILAMINO)-(3-METIL-3H-IMIDAZOL-4-IL)-METIL]-8-CLORO-11H-BENZO[5,6]CICLOHEPTA[1,2-b]PIRIDIN-11-IL}-PIPERAZIN-1-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UN KIT Y UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA FARNESILO TRANSFERASA Y SON UTILES EN EL TRATAMIENTO DE TUMORES
PE2004000760A 2003-08-07 2004-08-05 Compuestos triciclicos como inhibidores de la proteina farnesil transferasa PE20050336A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49326903P 2003-08-07 2003-08-07
US49850903P 2003-08-28 2003-08-28

Publications (1)

Publication Number Publication Date
PE20050336A1 true PE20050336A1 (es) 2005-05-30

Family

ID=34138747

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000760A PE20050336A1 (es) 2003-08-07 2004-08-05 Compuestos triciclicos como inhibidores de la proteina farnesil transferasa

Country Status (19)

Country Link
US (1) US7557107B2 (es)
EP (1) EP1660477B1 (es)
JP (1) JP2007501791A (es)
KR (1) KR20060057599A (es)
AR (1) AR045447A1 (es)
AT (1) ATE417041T1 (es)
AU (1) AU2004263493A1 (es)
BR (1) BRPI0413384A (es)
CA (1) CA2535210A1 (es)
DE (1) DE602004018332D1 (es)
EC (1) ECSP066349A (es)
ES (1) ES2317047T3 (es)
HK (1) HK1087122A1 (es)
IL (1) IL173514A0 (es)
MX (1) MXPA06001483A (es)
PE (1) PE20050336A1 (es)
RU (1) RU2006106768A (es)
TW (1) TW200510384A (es)
WO (1) WO2005014577A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342016B2 (en) * 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
WO2003100008A2 (en) 2002-05-24 2003-12-04 Schering Corporation Neutralizing human anti-igfr antibody
AU2003272767A1 (en) * 2002-09-30 2004-04-23 Schering Corporation Use of tricyclic amides for the treatment of disorders of calcium homeostasis
TW200526684A (en) * 2003-11-21 2005-08-16 Schering Corp Anti-IGFR1 antibody therapeutic combinations
US20060205810A1 (en) * 2004-11-24 2006-09-14 Schering Corporation Platinum therapeutic combinations
MX2007007611A (es) * 2004-12-21 2007-09-04 Schering Corp Nuevos inhibidores de la farnesil protein-transferasa como agentes antitumorales.
BRPI0607537A2 (pt) * 2005-04-12 2009-09-15 Elan Pharma Int Ltd formulações de derivado de quinazolina nanoparticulado
CA2604393A1 (en) * 2005-04-15 2006-10-26 Schering Corporation Methods and compositions for treating or preventing cancer
US20070213340A1 (en) * 2006-01-19 2007-09-13 Kelly Joseph M Farnesyl protein transferase inhibitors
EP1854465A1 (en) 2006-05-12 2007-11-14 Alexander Tobias Teichmann Use of 4,17 beta-dihydroxyandrost-4-ene-3-one for treating cancers
CA2683109A1 (en) * 2006-10-11 2008-04-17 Fusion Antibodies Limited Combination therapy
AU2008317057B8 (en) 2007-10-22 2014-02-13 Merck Sharp & Dohme Corp. Bicyclic Heterocycle Derivatives and their use as modulators of the activity of GPR119
GB0807018D0 (en) 2008-04-17 2008-05-21 Fusion Antibodies Ltd Antibodies and treatment
CN104797267A (zh) 2012-06-26 2015-07-22 德玛医药 使用卫康醇、二乙酰二脱水卫矛醇、二溴卫矛醇或类似物或其衍生物治疗具有基因多型性或ahi1失调或突变患者的抗酪氨酸激酶抑制剂的恶性肿瘤的方法
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
US5874442A (en) * 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
EP1019392B1 (en) 1995-12-22 2005-11-09 Schering Corporation Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases
CA2397425A1 (en) 2000-02-29 2001-09-07 Ivan David Horak Farnesyl protein transferase inhibitor combinations with taxane compounds
AR033680A1 (es) * 2000-08-30 2004-01-07 Schering Corp Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales
US7342016B2 (en) * 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
US20030229099A1 (en) 2000-08-30 2003-12-11 Zhu Hugh Y. Novel farnesyl protein transferase inhibitors as antitumor agents
JP2005515201A (ja) * 2001-12-03 2005-05-26 シェーリング　コーポレイション 癌の処置におけるｆｐｔインヒビターおよび少なくとも２つの抗腫瘍性剤の使用
AU2003272767A1 (en) * 2002-09-30 2004-04-23 Schering Corporation Use of tricyclic amides for the treatment of disorders of calcium homeostasis
MX2007007611A (es) * 2004-12-21 2007-09-04 Schering Corp Nuevos inhibidores de la farnesil protein-transferasa como agentes antitumorales.

Also Published As

Publication number Publication date
EP1660477A1 (en) 2006-05-31
US20050059672A1 (en) 2005-03-17
ECSP066349A (es) 2006-08-30
KR20060057599A (ko) 2006-05-26
JP2007501791A (ja) 2007-02-01
AR045447A1 (es) 2005-10-26
HK1087122A1 (en) 2006-10-06
AU2004263493A1 (en) 2005-02-17
TW200510384A (en) 2005-03-16
ATE417041T1 (de) 2008-12-15
US7557107B2 (en) 2009-07-07
WO2005014577A1 (en) 2005-02-17
ES2317047T3 (es) 2009-04-16
DE602004018332D1 (de) 2009-01-22
EP1660477B1 (en) 2008-12-10
CA2535210A1 (en) 2005-02-17
MXPA06001483A (es) 2006-05-15
IL173514A0 (en) 2006-07-05
BRPI0413384A (pt) 2006-10-17
RU2006106768A (ru) 2007-09-20
WO2005014577A9 (en) 2006-03-23

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