PE20020406A1 - 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDAS COMO INHIBIDORES DE LAS PROTEINAS CINASAS - Google Patents
7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDAS COMO INHIBIDORES DE LAS PROTEINAS CINASASInfo
- Publication number
- PE20020406A1 PE20020406A1 PE2001000860A PE2001000860A PE20020406A1 PE 20020406 A1 PE20020406 A1 PE 20020406A1 PE 2001000860 A PE2001000860 A PE 2001000860A PE 2001000860 A PE2001000860 A PE 2001000860A PE 20020406 A1 PE20020406 A1 PE 20020406A1
- Authority
- PE
- Peru
- Prior art keywords
- disustituted
- pyrido
- pyrimidines
- oxo
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6 DISUSTITUIDAS DE FORMULA I DONDE R1 ES H, ALQUILO; R2 ES CICLOALQUILO, CICLOALQUILO HETEROSUSTITUIDO, ARALCOXI, ALCOXI, HETEROCICLICLO, ENTRE OTROS; R3 ES H, AMINO, MONOALQUILOAMINO, DIALQUILAMINO, ACILAMINO, ALQUILO, CICLOLAQUILO, -NRa-C(=O)-Rb, ENTRE OTROS DONDE Ra ES H, ALQUILO; Rb ES HETEROCICLILO, HETEROALQUILO; AR1 Y AR2 SON ARILO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA II DONDE AR1 ES FENILO. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LAS PROTEINA CINASAS Y SON UTILES PARA EL TRATAMIENTO DE ARTRITIS, ENFERMEDAD DE CROHN, ALZHEIMER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22958400P | 2000-08-31 | 2000-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020406A1 true PE20020406A1 (es) | 2002-05-17 |
Family
ID=22861859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001000860A PE20020406A1 (es) | 2000-08-31 | 2001-08-28 | 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6-DISUSTITUIDAS COMO INHIBIDORES DE LAS PROTEINAS CINASAS |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1315726A1 (es) |
JP (1) | JP4141830B2 (es) |
KR (1) | KR100571339B1 (es) |
CN (1) | CN1275964C (es) |
AR (1) | AR033681A1 (es) |
AU (2) | AU9378401A (es) |
BR (1) | BR0113628A (es) |
CA (1) | CA2420286A1 (es) |
GT (1) | GT200100191A (es) |
MX (1) | MXPA03001821A (es) |
PA (1) | PA8527301A1 (es) |
PE (1) | PE20020406A1 (es) |
UY (1) | UY26918A1 (es) |
WO (1) | WO2002018380A1 (es) |
ZA (1) | ZA200301079B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2243568T3 (es) * | 2000-08-31 | 2005-12-01 | F. Hoffmann-La Roche Ag | 7-oxo-piridopirimidinas. |
US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
CA2479644A1 (en) * | 2002-04-03 | 2003-10-09 | F. Hoffmann-La Roche Ag | Imidazo fused compounds |
PL373339A1 (en) * | 2002-04-19 | 2005-08-22 | Smithkline Beecham Corporation | Novel compounds |
US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
KR20050075028A (ko) * | 2002-11-18 | 2005-07-19 | 에프. 호프만-라 로슈 아게 | 다이아지노피리미딘 |
US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
RU2350617C2 (ru) | 2003-04-10 | 2009-03-27 | Ф.Хоффманн-Ля Рош Аг | Пиримидиновые соединения, обладающие свойствами селективного ингибирования активности кдр и фрфр |
DE602004024536D1 (de) * | 2003-07-07 | 2010-01-21 | Van Andel Res Inst | Hemmung der tumor-angiogenese durch eine kombination von thrombospondin-1 und hemmern des vaskulären endothel-wachstumsfaktors |
ATE356124T1 (de) * | 2003-11-13 | 2007-03-15 | Hoffmann La Roche | Hydroxyalkylsubstituierte pyrido-7-pyrimidin-7- one |
WO2005105097A2 (en) * | 2004-04-28 | 2005-11-10 | Gpc Biotech Ag | Pyridopyrimidines for treating inflammatory and other diseases |
US20070054916A1 (en) * | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
EP1831215A1 (en) * | 2004-11-23 | 2007-09-12 | Ranbaxy Laboratories Limited | Pyrido[2,3-d]pyrimidines as anti-inflamatory agents |
EP1846403A1 (en) * | 2005-02-02 | 2007-10-24 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
WO2007036791A1 (en) * | 2005-09-28 | 2007-04-05 | Ranbaxy Laboratories Limited | Pyrido-pyridimidine derivatives useful as antiinflammatory agents |
ATE439361T1 (de) | 2006-01-31 | 2009-08-15 | Hoffmann La Roche | 7h-pyridoä3,4-düpyrimidin-8-one, ihre herstellung und ihre verwendung als proteinkinaseinhibitoren |
KR100661523B1 (ko) * | 2006-06-09 | 2006-12-26 | 주식회사 청용산기 | 포장박스 제조장치에 장착되는 개선된 비틀림 교정 장치 |
EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
EP2094698A1 (en) | 2006-11-09 | 2009-09-02 | F. Hoffmann-Roche AG | Substituted 6-phenyl-pyrido [2,3-d]pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same |
WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
KR101106162B1 (ko) * | 2010-04-20 | 2012-01-20 | 주식회사 청용산기 | 포장박스 제조장치용 스티칭 장치에 있어서의 하역가이드 지지유닛 |
CA2868156C (en) * | 2012-03-22 | 2020-07-28 | Genosco | Substituted pyridopyrimidine compounds and their use as flt3 inhibitors |
AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
KR102219695B1 (ko) | 2013-03-15 | 2021-02-25 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
UA120248C2 (uk) | 2013-03-15 | 2019-11-11 | Селджен Кар Ллс | Гетероарильні сполуки та їх застосування |
WO2016037255A2 (en) | 2014-09-12 | 2016-03-17 | Biolab Sanus Farmacêutica Ltda. | New pyridopyrimidines derivatives compounds |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
CN114732910A (zh) | 2017-10-05 | 2022-07-12 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
TWI748317B (zh) | 2019-01-03 | 2021-12-01 | 美商建南德克公司 | 吡啶并-嘧啶酮與喋啶酮化合物及使用方法 |
EP3976611A1 (en) * | 2019-05-31 | 2022-04-06 | Les Laboratoires Servier | Heterobicyclic inhibitors of mat2a and methods of use for treating cancer |
CN115960098A (zh) * | 2020-09-11 | 2023-04-14 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物的制备方法和用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TJ342B (en) * | 1994-11-14 | 2002-10-06 | Warner Lambert Co | Derivatives of 6-aryl pyrido Ä2,3-dÜ pyrimidines and naphthyridines pharmaceutical composition possess inhibiting effect of cellular proliferation pr ovoking protein tyrosine kinase and method of inhibiting cellular proliferation |
IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
EP1080092B1 (en) * | 1998-05-26 | 2008-07-23 | Warner-Lambert Company LLC | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
-
2001
- 2001-08-22 CN CNB018150306A patent/CN1275964C/zh not_active Expired - Fee Related
- 2001-08-22 KR KR1020037002936A patent/KR100571339B1/ko not_active IP Right Cessation
- 2001-08-22 MX MXPA03001821A patent/MXPA03001821A/es active IP Right Grant
- 2001-08-22 WO PCT/EP2001/009689 patent/WO2002018380A1/en not_active Application Discontinuation
- 2001-08-22 AU AU9378401A patent/AU9378401A/xx active Pending
- 2001-08-22 BR BR0113628-3A patent/BR0113628A/pt not_active Application Discontinuation
- 2001-08-22 EP EP01974206A patent/EP1315726A1/en not_active Withdrawn
- 2001-08-22 CA CA002420286A patent/CA2420286A1/en not_active Abandoned
- 2001-08-22 AU AU2001293784A patent/AU2001293784B2/en not_active Ceased
- 2001-08-22 JP JP2002523895A patent/JP4141830B2/ja not_active Expired - Fee Related
- 2001-08-28 PE PE2001000860A patent/PE20020406A1/es not_active Application Discontinuation
- 2001-08-28 PA PA20018527301A patent/PA8527301A1/es unknown
- 2001-08-30 AR ARP010104132A patent/AR033681A1/es unknown
- 2001-08-30 UY UY26918A patent/UY26918A1/es not_active Application Discontinuation
- 2001-09-18 GT GT200100191A patent/GT200100191A/es unknown
-
2003
- 2003-02-07 ZA ZA200301079A patent/ZA200301079B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2420286A1 (en) | 2002-03-07 |
UY26918A1 (es) | 2002-02-28 |
KR100571339B1 (ko) | 2006-04-17 |
KR20030022422A (ko) | 2003-03-15 |
PA8527301A1 (es) | 2002-07-30 |
JP4141830B2 (ja) | 2008-08-27 |
BR0113628A (pt) | 2003-07-01 |
AU2001293784B2 (en) | 2007-08-30 |
CN1275964C (zh) | 2006-09-20 |
WO2002018380A1 (en) | 2002-03-07 |
CN1451005A (zh) | 2003-10-22 |
AR033681A1 (es) | 2004-01-07 |
ZA200301079B (en) | 2004-05-07 |
MXPA03001821A (es) | 2003-06-04 |
AU9378401A (en) | 2002-03-13 |
EP1315726A1 (en) | 2003-06-04 |
GT200100191A (es) | 2002-05-16 |
JP2004507541A (ja) | 2004-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |