PE20020406A1 - 7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6-DISUSTITUTED AS INHIBITORS OF PROTEIN KINASES - Google Patents

7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6-DISUSTITUTED AS INHIBITORS OF PROTEIN KINASES

Info

Publication number
PE20020406A1
PE20020406A1 PE2001000860A PE2001000860A PE20020406A1 PE 20020406 A1 PE20020406 A1 PE 20020406A1 PE 2001000860 A PE2001000860 A PE 2001000860A PE 2001000860 A PE2001000860 A PE 2001000860A PE 20020406 A1 PE20020406 A1 PE 20020406A1
Authority
PE
Peru
Prior art keywords
disustituted
pyrido
pyrimidines
oxo
inhibitors
Prior art date
Application number
PE2001000860A
Other languages
Spanish (es)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Julie Anne Lim
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20020406A1 publication Critical patent/PE20020406A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A 7-OXO-PIRIDO[2,3-d]PIRIMIDINAS 2,6 DISUSTITUIDAS DE FORMULA I DONDE R1 ES H, ALQUILO; R2 ES CICLOALQUILO, CICLOALQUILO HETEROSUSTITUIDO, ARALCOXI, ALCOXI, HETEROCICLICLO, ENTRE OTROS; R3 ES H, AMINO, MONOALQUILOAMINO, DIALQUILAMINO, ACILAMINO, ALQUILO, CICLOLAQUILO, -NRa-C(=O)-Rb, ENTRE OTROS DONDE Ra ES H, ALQUILO; Rb ES HETEROCICLILO, HETEROALQUILO; AR1 Y AR2 SON ARILO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA II DONDE AR1 ES FENILO. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LAS PROTEINA CINASAS Y SON UTILES PARA EL TRATAMIENTO DE ARTRITIS, ENFERMEDAD DE CROHN, ALZHEIMERREFERS TO 7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6 DISUSTITUTED OF FORMULA I WHERE R1 IS H, ALKYL; R2 IS CYCLOALKYL, HETEROSUSTITUTED CYCLOALKYL, ARALCOXI, ALCOXI, HETERO CYCLE, AMONG OTHERS; R3 IS H, AMINO, MONOALKYLAMINE, DIALKYLAMINE, ACILAMINE, ALKYL, CYCLOLAKYL, -NRa-C (= O) -Rb, AMONG OTHERS WHERE Ra IS H, ALKYL; Rb IS HETEROCYCLYL, HETEROALKYL; AR1 AND AR2 ARE ARYL. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE PREFERRED COMPOUNDS ARE THE COMPOUNDS OF FORMULA II WHERE AR1 IS PHENYL. THE MENTIONED COMPOUNDS ARE INHIBITORS OF PROTEIN KINASES AND ARE USEFUL FOR THE TREATMENT OF ARTHRITIS, CROHN'S DISEASE, ALZHEIMER

PE2001000860A 2000-08-31 2001-08-28 7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6-DISUSTITUTED AS INHIBITORS OF PROTEIN KINASES PE20020406A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22958400P 2000-08-31 2000-08-31

Publications (1)

Publication Number Publication Date
PE20020406A1 true PE20020406A1 (en) 2002-05-17

Family

ID=22861859

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000860A PE20020406A1 (en) 2000-08-31 2001-08-28 7-OXO-PYRIDO [2,3-d] PYRIMIDINES 2,6-DISUSTITUTED AS INHIBITORS OF PROTEIN KINASES

Country Status (15)

Country Link
EP (1) EP1315726A1 (en)
JP (1) JP4141830B2 (en)
KR (1) KR100571339B1 (en)
CN (1) CN1275964C (en)
AR (1) AR033681A1 (en)
AU (2) AU9378401A (en)
BR (1) BR0113628A (en)
CA (1) CA2420286A1 (en)
GT (1) GT200100191A (en)
MX (1) MXPA03001821A (en)
PA (1) PA8527301A1 (en)
PE (1) PE20020406A1 (en)
UY (1) UY26918A1 (en)
WO (1) WO2002018380A1 (en)
ZA (1) ZA200301079B (en)

Families Citing this family (34)

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US6518276B2 (en) 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
AU2002212147B2 (en) * 2000-08-31 2007-10-18 F. Hoffmann-La Roche Ag 7-OXO pyridopyrimidines
JP2006503802A (en) * 2002-04-03 2006-02-02 エフ．ホフマン−ラ　ロシュ　アーゲー Imidazo condensation compounds
DE60315826T2 (en) * 2002-04-19 2008-05-21 Smithkline Beecham Corp. NEW CONNECTIONS
US7084270B2 (en) 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
UY27939A1 (en) 2002-08-21 2004-03-31 Glaxo Group Ltd COMPOUNDS
US7129351B2 (en) 2002-11-04 2006-10-31 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
MXPA05005028A (en) * 2002-11-18 2005-08-03 Hoffmann La Roche Diazinopyrimidines.
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
CN100497339C (en) 2003-04-10 2009-06-10 霍夫曼-拉罗奇有限公司 Pyrimido compounds
WO2005007193A2 (en) * 2003-07-07 2005-01-27 Vande Woude, George, F. Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor
PL1685131T3 (en) * 2003-11-13 2007-08-31 Hoffmann La Roche Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
WO2005105097A2 (en) * 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
US20090131430A1 (en) * 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
EP1846403A1 (en) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
EP1931667A1 (en) * 2005-09-28 2008-06-18 Ranbaxy Laboratories Limited Pyrido-pyridimidine derivatives useful as antiinflammatory agents
JP2009525292A (en) 2006-01-31 2009-07-09 エフ．ホフマン−ラ ロシュ アーゲー 7H-pyrido [3,4-D] pyrimidin-8-ones, their preparation and use as protein kinase inhibitors
KR100661523B1 (en) * 2006-06-09 2006-12-26 주식회사 청용산기 Box correcting device of stitching progress for carton box erecting
EP1914234A1 (en) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
WO2008055842A1 (en) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Substituted 6-phenyl-pyrido [2,3-d] pyrimidin-7-one derivatives as kinase inhibitors and methods for using the same
WO2008078249A1 (en) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Anti-inflammatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
KR101106162B1 (en) * 2010-04-20 2012-01-20 주식회사 청용산기 Stitching device for packing box making apparatus
AU2013235344B2 (en) * 2012-03-22 2017-03-16 Oscotec Inc. Substituted pyridopyrimidine compounds and their use as FLT3 inhibitors
NZ711376A (en) 2013-03-15 2020-01-31 Sanofi Sa Heteroaryl compounds and uses thereof
TWI647220B (en) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 Heteroaryl compound and its use
AU2014228746B2 (en) 2013-03-15 2018-08-30 Celgene Car Llc Heteroaryl compounds and uses thereof
WO2016037255A2 (en) 2014-09-12 2016-03-17 Biolab Sanus Farmacêutica Ltda. New pyridopyrimidines derivatives compounds
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
PT3691620T (en) 2017-10-05 2022-10-06 Fulcrum Therapeutics Inc P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
EP3941919A1 (en) * 2019-01-03 2022-01-26 Genentech, Inc. Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases
US20220251081A1 (en) * 2019-05-31 2022-08-11 Les Laboratoires Servier Heterobicyclic inhibitors of mat2a and methods of use for treating cancer
WO2022052924A1 (en) * 2020-09-11 2022-03-17 上海凌达生物医药有限公司 Preparation method for class of nitrogen-containing fused ring compounds and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2146782T3 (en) * 1994-11-14 2000-08-16 Warner Lambert Co 6-ARYL-PIRIDO (2,3-D) PIRIMIDINAS AND NAFTIRIDINAS FOR THE INHIBITION OF THE CELL PROLIFERATION INDUCED BY THE PROTEIN TIROSINA QUINASA.
IL117923A (en) * 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
AU763839B2 (en) * 1998-05-26 2003-07-31 Warner-Lambert Company Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation

Also Published As

Publication number Publication date
KR20030022422A (en) 2003-03-15
KR100571339B1 (en) 2006-04-17
WO2002018380A1 (en) 2002-03-07
AR033681A1 (en) 2004-01-07
JP4141830B2 (en) 2008-08-27
CN1275964C (en) 2006-09-20
CN1451005A (en) 2003-10-22
GT200100191A (en) 2002-05-16
CA2420286A1 (en) 2002-03-07
AU9378401A (en) 2002-03-13
UY26918A1 (en) 2002-02-28
PA8527301A1 (en) 2002-07-30
MXPA03001821A (en) 2003-06-04
BR0113628A (en) 2003-07-01
ZA200301079B (en) 2004-05-07
EP1315726A1 (en) 2003-06-04
JP2004507541A (en) 2004-03-11
AU2001293784B2 (en) 2007-08-30

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