BR0113628A - 7-oxopyridopyrimidines as inhibitors of cell proliferation - Google Patents

7-oxopyridopyrimidines as inhibitors of cell proliferation

Info

Publication number
BR0113628A
BR0113628A BR0113628-3A BR0113628A BR0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A BR 0113628 A BR0113628 A BR 0113628A
Authority
BR
Brazil
Prior art keywords
alkyl
cycloalkyl
hydrogen
heterocyclyl
aryl
Prior art date
Application number
BR0113628-3A
Other languages
Portuguese (pt)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0113628A publication Critical patent/BR0113628A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"7-OXO-PIRIDOPIRIMIDINAS COMO INIBIDORES DE UMA PROLIFERAçãO CELULAR". Compostos de fórmula (I) nos quais R^ 1^ é hidrogênio ou alquila; R^ 2^ é cicloalquila substituída, cicloalquila heterossubstituída, cicloalquila heteroalquilsubstituída, cicloalquil-arila heterossubstituída, heterociclila, heterociclil espiro cicloalquila, aralcóxi, alcóxi, -alquileno-S(O)~ n~-alquila (onde n é 1 ou 2) ou -SO~ 2~Ar^ 2^; R^ 3^ é hidrogênio, amino, monoalquilamino, dialquilamino, acilamino, -NR^ a^-C(=O)-R^ b^ (onde R^ a^ é hidrogênio ou alquila e R^ b^ heterociclila ou heteroalquila), alquila, cicloalquila, arila, aralquila, haloalquila, heteroalquila, cianoalquila, -alquileno-C(O)-R (onde R é hidrogênio, alquila, hidróxi, alcóxi, amino, monoalquilamino ou dialquilamino), acila, ou ftalimidoalquila; e cada um dentre Ar^ 1^ e Ar^ 2^ é independentemente arila, e seu emprego para o tratamento de distúrbios selecionados do grupo consistindo em artrite, doença de Crohn, doença de Alzheimer, síndrome do intestino irritável, síndrome da dificuldade respiratória do adulto, e doença pulmonar obstrutiva crónica."7-OXYPYROPYPYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION". Compounds of formula (I) wherein R2 is hydrogen or alkyl; R 2 is substituted cycloalkyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkyl, heterosubstituted cycloalkyl aryl, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, S (O) n -alkyl (where n is 1 or 2) -SO-2-Ar ^ 2 ^; R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, -NR4 a4 -C (= O) -R4b4 (where R4a4 is hydrogen or alkyl and R4b4 heterocyclyl or heteroalkyl) alkyl, cycloalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -C (O) alkylene -R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), acyl, or phthalimidoalkyl; and each of Ar ^ 1 ^ and Ar ^ 2 ^ is independently aryl, and its use for the treatment of disorders selected from the group consisting of arthritis, Crohn's disease, Alzheimer's disease, irritable bowel syndrome, respiratory distress syndrome. adult, and chronic obstructive pulmonary disease.

BR0113628-3A 2000-08-31 2001-08-22 7-oxopyridopyrimidines as inhibitors of cell proliferation BR0113628A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22958400P 2000-08-31 2000-08-31
PCT/EP2001/009689 WO2002018380A1 (en) 2000-08-31 2001-08-22 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation

Publications (1)

Publication Number Publication Date
BR0113628A true BR0113628A (en) 2003-07-01

Family

ID=22861859

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113628-3A BR0113628A (en) 2000-08-31 2001-08-22 7-oxopyridopyrimidines as inhibitors of cell proliferation

Country Status (15)

Country Link
EP (1) EP1315726A1 (en)
JP (1) JP4141830B2 (en)
KR (1) KR100571339B1 (en)
CN (1) CN1275964C (en)
AR (1) AR033681A1 (en)
AU (2) AU9378401A (en)
BR (1) BR0113628A (en)
CA (1) CA2420286A1 (en)
GT (1) GT200100191A (en)
MX (1) MXPA03001821A (en)
PA (1) PA8527301A1 (en)
PE (1) PE20020406A1 (en)
UY (1) UY26918A1 (en)
WO (1) WO2002018380A1 (en)
ZA (1) ZA200301079B (en)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
EP1315727B1 (en) * 2000-08-31 2005-06-29 F. Hoffmann-La Roche Ag 7-oxo pyridopyrimidines
US6518276B2 (en) 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
BR0308937A (en) * 2002-04-03 2005-01-04 Hoffmann La Roche Fused imidazo compounds
DE60315826T2 (en) * 2002-04-19 2008-05-21 Smithkline Beecham Corp. NEW CONNECTIONS
US7084270B2 (en) 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
UY27939A1 (en) 2002-08-21 2004-03-31 Glaxo Group Ltd COMPOUNDS
US7112676B2 (en) 2002-11-04 2006-09-26 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
RU2340618C2 (en) * 2002-11-18 2008-12-10 Ф.Хоффманн-Ля Рош Аг Diazinopyrimidines and pharmaceutical composition containing them
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
RU2350617C2 (en) 2003-04-10 2009-03-27 Ф.Хоффманн-Ля Рош Аг Pyrimidine compounds with selective inhibition of "¦-¦" and "l¦l¦" activity
ATE451115T1 (en) * 2003-07-07 2009-12-15 Van Andel Res Inst INHIBITION OF TUMOR ANGIOGENESIS BY A COMBINATION OF THROMBOSPONDIN-1 AND VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS
KR100816321B1 (en) * 2003-11-13 2008-03-24 에프. 호프만-라 로슈 아게 Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
WO2005105097A2 (en) * 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
US20090131430A1 (en) * 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
EP1846403A1 (en) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Azabicyclo derivatives as anti-inflammatory agents
WO2007036791A1 (en) * 2005-09-28 2007-04-05 Ranbaxy Laboratories Limited Pyrido-pyridimidine derivatives useful as antiinflammatory agents
KR20080083046A (en) 2006-01-31 2008-09-12 에프. 호프만-라 로슈 아게 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors
KR100661523B1 (en) * 2006-06-09 2006-12-26 주식회사 청용산기 Box correcting device of stitching progress for carton box erecting
EP1914234A1 (en) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
CA2668731A1 (en) 2006-11-09 2008-05-15 Tobias Gabriel Kinase inhibitors and methods for using the same
WO2008078249A1 (en) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Anti-inflammatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
KR101106162B1 (en) * 2010-04-20 2012-01-20 주식회사 청용산기 Stitching device for packing box making apparatus
ES2694223T3 (en) * 2012-03-22 2018-12-19 Oscotec, Inc. Pyridopyrimidine compounds and their use as FLT3 inhibitors
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
KR102350704B1 (en) 2013-03-15 2022-01-13 셀젠 카르 엘엘씨 Heteroaryl compounds and uses thereof
EA036160B1 (en) 2013-03-15 2020-10-08 Селджен Кар Ллс Heteroaryl compounds and uses thereof
CN107074847A (en) 2014-09-12 2017-08-18 生物实验萨纽斯药物有限公司 New Pyridopyrimidine derivatives compound
CA3128468A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2020142612A1 (en) * 2019-01-03 2020-07-09 Genentech, Inc. Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases.
PE20220387A1 (en) * 2019-05-31 2022-03-18 Servier Lab HETEROBICYCLIC MAT2A INHIBITORS AND METHODS OF USE FOR THE TREATMENT OF CANCER
WO2022052924A1 (en) * 2020-09-11 2022-03-17 上海凌达生物医药有限公司 Preparation method for class of nitrogen-containing fused ring compounds and use thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT790997E (en) * 1994-11-14 2000-06-30 Warner Lambert Co 6-ARYL PYRIDINE-2,3-D | PYRIMIDINES AND NAFTIRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION
IL117923A (en) * 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
AU763839B2 (en) * 1998-05-26 2003-07-31 Warner-Lambert Company Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation

Also Published As

Publication number Publication date
AU2001293784B2 (en) 2007-08-30
CN1275964C (en) 2006-09-20
GT200100191A (en) 2002-05-16
JP2004507541A (en) 2004-03-11
JP4141830B2 (en) 2008-08-27
CA2420286A1 (en) 2002-03-07
WO2002018380A1 (en) 2002-03-07
KR100571339B1 (en) 2006-04-17
UY26918A1 (en) 2002-02-28
EP1315726A1 (en) 2003-06-04
AR033681A1 (en) 2004-01-07
MXPA03001821A (en) 2003-06-04
PE20020406A1 (en) 2002-05-17
ZA200301079B (en) 2004-05-07
PA8527301A1 (en) 2002-07-30
CN1451005A (en) 2003-10-22
KR20030022422A (en) 2003-03-15
AU9378401A (en) 2002-03-13

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Legal Events

Date Code Title Description
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.