PE20011066A1 - PYRID [2,3-d] PYRIMIDIN-2,7-DIAMINES KINE INHIBITORS - Google Patents

PYRID [2,3-d] PYRIMIDIN-2,7-DIAMINES KINE INHIBITORS

Info

Publication number
PE20011066A1
PE20011066A1 PE2001000072A PE2001000072A PE20011066A1 PE 20011066 A1 PE20011066 A1 PE 20011066A1 PE 2001000072 A PE2001000072 A PE 2001000072A PE 2001000072 A PE2001000072 A PE 2001000072A PE 20011066 A1 PE20011066 A1 PE 20011066A1
Authority
PE
Peru
Prior art keywords
pyrimidin
cyane
nr9r10
halo
pyrid
Prior art date
Application number
PE2001000072A
Other languages
Spanish (es)
Inventor
Richard John Booth
Ellen Myra Dobrusin
Peter Laurence Toogood
Dennis Joseph Mcnamara
Vara Prasad Venkata Nagendra Josyula
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20011066A1 publication Critical patent/PE20011066A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

SE REFIERE A UN COMPUESTO PIRIDO [2,3-d] PIRIMIDIN-2,7-DIAMINAS DE FORMULA I ENTRE OTROS COMPUESTOS DONDE R2, R7, R13, R14 Y R15 SON H, ALQUILO, ALQUENILO, ALQUINILO CON HALO, CIANO, R9, NR9R10, -(CH2)nSO2R11, ENTRE OTROS; R5 ES HALO, CIANO,NITRO, R9, NR9R10, OR9; R6 ES HALO, CIANO, NITRO, R9, NR9R10, ENTRE OTROS ; R8 ES H, CO2R13, COR13 ,CONR13R14, -C(NR13)NR14R15, ENTRE OTROS; R9 Y R10 SON H, ALQUILO, HALOGENO, AMINO, HIDROXI ,ALCOXI, ENTRE OTROS; R11 ES HETEROARILO, HETEROCICLICO; R12 ES CICLOALQUILO, HETEROCICLICO, ARILO, HETEROARILO; n ES 0-3. SON COMPUESTOS PREFERIDOS 1-t-BUTIL-3-[2-(4-PIPERAZIN-1-IL-FENILAMINO)-PIRIDO-[2,3-d]PIRIMIDIN-7-IL]-UREA, 1-t-BUTIL-3-[2-(3-CLORO-4-PIPERAZIN-1-IL-FENILAMINO)-PIRIDO-[2,3-d]PIRIMIDIN-7-IL]-UREA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. EL COMPUESTO DE FORMULA I INHIBE LA ENZIMA TIROSINA CINASA POR LO QUE ES UTIL PARA EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR PROLIFERACION CELULAR TAL COMO CANCERREFERS TO A PYRID [2,3-d] PYRIMIDIN-2,7-DIAMINES COMPOUND OF FORMULA I AMONG OTHER COMPOUNDS WHERE R2, R7, R13, R14 AND R15 ARE H, ALKYL, ALKENYL, ALKINYL WITH HALO, CYANE, R9 , NR9R10, - (CH2) nSO2R11, AMONG OTHERS; R5 IS HALO, CYANE, NITRO, R9, NR9R10, OR9; R6 IS HALO, CYANE, NITRO, R9, NR9R10, AMONG OTHERS; R8 IS H, CO2R13, COR13, CONR13R14, -C (NR13) NR14R15, AMONG OTHERS; R9 AND R10 ARE H, ALKYL, HALOGEN, AMINO, HYDROXY, ALCOXY, AMONG OTHERS; R11 IS HETEROARYL, HETEROCYCLIC; R12 IS CYCLOALKYL, HETEROCICLIC, ARYL, HETEROARYL; n IS 0-3. PREFERRED COMPOUNDS ARE 1-t-BUTYL-3- [2- (4-PIPERAZIN-1-IL-PHENYLAMINE) -PYRIDO- [2,3-d] PYRIMIDIN-7-IL] -UREA, 1-t-BUTYL- 3- [2- (3-CHLORO-4-PIPERAZIN-1-IL-PHENYLAMINE) -PYRIDO- [2,3-d] PYRIMIDIN-7-IL] -UREA, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE FORMULA I COMPOUND INHIBITS THE ENZYME TYROSINE KINASE SO IT IS USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY CELLULAR PROLIFERATION SUCH AS CANCER

PE2001000072A 2000-01-25 2001-01-23 PYRID [2,3-d] PYRIMIDIN-2,7-DIAMINES KINE INHIBITORS PE20011066A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17826100P 2000-01-25 2000-01-25

Publications (1)

Publication Number Publication Date
PE20011066A1 true PE20011066A1 (en) 2001-10-22

Family

ID=22651853

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000072A PE20011066A1 (en) 2000-01-25 2001-01-23 PYRID [2,3-d] PYRIMIDIN-2,7-DIAMINES KINE INHIBITORS

Country Status (34)

Country Link
EP (1) EP1254137A1 (en)
JP (1) JP4047010B2 (en)
KR (1) KR20020065939A (en)
CN (1) CN1395578A (en)
AP (1) AP2002002586A0 (en)
AR (1) AR030044A1 (en)
AU (1) AU2542501A (en)
BG (1) BG106850A (en)
BR (1) BR0107751A (en)
CA (1) CA2397961C (en)
CO (1) CO5261549A1 (en)
CR (1) CR6706A (en)
CZ (1) CZ20022475A3 (en)
DZ (1) DZ3266A1 (en)
EA (1) EA200200643A1 (en)
EE (1) EE200200405A (en)
GT (1) GT200100016A (en)
HN (1) HN2001000013A (en)
HU (1) HUP0204141A3 (en)
IL (1) IL150545A0 (en)
IS (1) IS6443A (en)
MA (1) MA26868A1 (en)
MX (1) MXPA02007221A (en)
NO (1) NO20023527L (en)
OA (1) OA12161A (en)
PA (1) PA8510701A1 (en)
PE (1) PE20011066A1 (en)
PL (1) PL356802A1 (en)
SK (1) SK10632002A3 (en)
SV (1) SV2002000294A (en)
TN (1) TNSN01014A1 (en)
WO (1) WO2001055147A1 (en)
YU (1) YU50402A (en)
ZA (1) ZA200205879B (en)

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US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CA2426654C (en) 2000-10-23 2010-12-21 Smithkline Beecham Corporation 2,4,8-trisubstituted-8h-pyrido[2,3-d}pyrimidin-7-one compounds
PE20030008A1 (en) * 2001-06-19 2003-01-22 Bristol Myers Squibb Co DUAL INHIBITORS OF PDE 7 AND PDE 4
CN1646131A (en) 2002-04-19 2005-07-27 史密丝克莱恩比彻姆公司 Novel compounds
EA200500721A1 (en) * 2002-11-28 2005-12-29 Шеринг Акциенгезельшафт Pyrimidines inhibiting CHK, PDK and ACT, THEIR RECEIVING AND USING AS MEDICINES
US7157455B2 (en) * 2003-02-10 2007-01-02 Hoffmann-La Roche Inc. 4-Aminopyrimidine-5-one derivatives
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (en) 2004-07-15 2007-11-23 Sanofi Synthelabo PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS
CN101014600A (en) * 2004-09-21 2007-08-08 霍夫曼-拉罗奇有限公司 6-(2-alkyl-phenyl) - pyrido[2,3-d] pyrimidines useful as proteine kinase inhibitors
PE20061351A1 (en) 2005-03-25 2007-01-14 Glaxo Group Ltd 8H-PYRID [2,3-d] PYRIMIDIN-7-ONA 2,4,8-TRISUSTITUTED COMPOUNDS AS CSBP / RK / p38 KINASE INHIBITORS
PE20100741A1 (en) 2005-03-25 2010-11-25 Glaxo Group Ltd COMPOUNDS DERIVED FROM 3,4-DIHYDROPYRIMIDE [4,5-d] PYRIMIDIN-2 (1H) -ONE AS KINASE INHIBITORS p38
MX2007012951A (en) 2005-03-25 2008-01-11 Glaxo Group Ltd Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives.
JP2008535822A (en) 2005-03-25 2008-09-04 グラクソ グループ リミテッド New compounds
FR2887882B1 (en) * 2005-07-01 2007-09-07 Sanofi Aventis Sa PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
ATE449097T1 (en) * 2005-07-21 2009-12-15 Hoffmann La Roche PYRIDOÄ2,3-DÜPYRIMIDINE-2,4-DIAMINE COMPOUNDS AS PTPIB INHIBITORS
CA2617359A1 (en) * 2005-08-09 2007-02-22 Irm Llc Compounds and compositions as protein kinase inhibitors
FR2896246B1 (en) 2006-01-13 2008-08-15 Sanofi Aventis Sa PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION
EP1914234A1 (en) 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (en) 2006-12-20 2016-09-05 Takeda Pharmaceuticals Co MAPK/ERK Kinase Inhibitors
FR2910813B1 (en) * 2006-12-28 2009-02-06 Sanofi Aventis Sa NEW THERAPEUTIC USE FOR THE TREATMENT OF LEUKEMIA
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
CN102216299B (en) * 2008-12-01 2015-02-11 默克专利有限公司 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
WO2014151682A1 (en) * 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
KR101671404B1 (en) * 2014-09-02 2016-11-02 한국원자력의학원 Pyrimidine derivatives having anti-cancer effect, combination therapeutic effect with radiation, and anti-diabetic effect, and PPAR activity, and medical use thereof
CN107286180B (en) * 2016-04-11 2019-07-02 上海勋和医药科技有限公司 Miscellaneous generation Pyridopyrimidinone derivatives are as CDK inhibitor and its application
GB201709840D0 (en) 2017-06-20 2017-08-02 Inst Of Cancer Research: Royal Cancer Hospital Methods and medical uses

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20012444B (en) * 1994-11-14 2001-05-25 Warner Lambert Company Us 6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) * 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
YU73300A (en) * 1998-05-26 2003-08-29 Warner-Lambert Company Bicyclic pyrimidines and bicyclic 3,4-dihydro-pyrimidines as inhibitors of cellular proliferation

Also Published As

Publication number Publication date
AU2542501A (en) 2001-08-07
NO20023527L (en) 2002-09-10
CN1395578A (en) 2003-02-05
WO2001055147A1 (en) 2001-08-02
BG106850A (en) 2003-02-28
NO20023527D0 (en) 2002-07-24
CA2397961C (en) 2008-08-26
SK10632002A3 (en) 2003-06-03
OA12161A (en) 2006-05-08
PA8510701A1 (en) 2002-12-11
BR0107751A (en) 2002-11-12
IL150545A0 (en) 2003-02-12
GT200100016A (en) 2001-10-19
ZA200205879B (en) 2003-09-29
AP2002002586A0 (en) 2002-09-30
JP4047010B2 (en) 2008-02-13
IS6443A (en) 2002-06-25
PL356802A1 (en) 2004-07-12
SV2002000294A (en) 2002-07-16
EA200200643A1 (en) 2002-12-26
HUP0204141A3 (en) 2005-03-29
CZ20022475A3 (en) 2003-03-12
CA2397961A1 (en) 2001-08-02
MXPA02007221A (en) 2002-11-29
MA26868A1 (en) 2004-12-20
EP1254137A1 (en) 2002-11-06
EE200200405A (en) 2003-12-15
AR030044A1 (en) 2003-08-13
HUP0204141A2 (en) 2003-04-28
CO5261549A1 (en) 2003-03-31
CR6706A (en) 2005-04-04
TNSN01014A1 (en) 2005-11-10
DZ3266A1 (en) 2001-08-02
JP2003523357A (en) 2003-08-05
KR20020065939A (en) 2002-08-14
HN2001000013A (en) 2001-06-18
YU50402A (en) 2005-11-28

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