HN2001000013A - PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - KINASE INHIBITING DIAMINES - Google Patents
PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - KINASE INHIBITING DIAMINESInfo
- Publication number
- HN2001000013A HN2001000013A HN2001000013A HN2001000013A HN2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A HN 2001000013 A HN2001000013 A HN 2001000013A
- Authority
- HN
- Honduras
- Prior art keywords
- pirido
- pirimidin
- diamines
- kinase inhibiting
- enzymes
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 102000020233 phosphotransferase Human genes 0.000 title abstract 2
- 150000004985 diamines Chemical class 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A PIRIDO [2, 3-D] PIRIMIDIN 2,7- DIAMINAS QUE INHIBEN ENZIMAS DE SERINA/TREONINA CINASAS DEPENDIENTES DE CICLINA Y ENZIMAS DE TIROSSINA-CINASAS MEDIADAS POR FACTOR DE CRECIMIENTO Y COMO TALES SON UTILES PARA TRATAR ENFERMEDADES Y TRASTORNOS DE LA PROLIFERACION CELULAR.THE PRESENT INVENTION REFERS TO PIRIDO [2, 3-D] PIRIMIDIN 2,7- DIAMINES INHIBITING SERINE / TREONIN ENZYMES CYCLINE-DEPENDENT KINASES AND THYROSSINE-KINAS ENZYMES MEDIATED BY GROWTH FACTOR AND AS THESE ARE UTILITY AND DISORDERS OF CELL PROLIFERATION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17826100P | 2000-01-25 | 2000-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
HN2001000013A true HN2001000013A (en) | 2001-06-18 |
Family
ID=22651853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN2001000013A HN2001000013A (en) | 2000-01-25 | 2001-01-24 | PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - KINASE INHIBITING DIAMINES |
Country Status (34)
Country | Link |
---|---|
EP (1) | EP1254137A1 (en) |
JP (1) | JP4047010B2 (en) |
KR (1) | KR20020065939A (en) |
CN (1) | CN1395578A (en) |
AP (1) | AP2002002586A0 (en) |
AR (1) | AR030044A1 (en) |
AU (1) | AU2542501A (en) |
BG (1) | BG106850A (en) |
BR (1) | BR0107751A (en) |
CA (1) | CA2397961C (en) |
CO (1) | CO5261549A1 (en) |
CR (1) | CR6706A (en) |
CZ (1) | CZ20022475A3 (en) |
DZ (1) | DZ3266A1 (en) |
EA (1) | EA200200643A1 (en) |
EE (1) | EE200200405A (en) |
GT (1) | GT200100016A (en) |
HN (1) | HN2001000013A (en) |
HU (1) | HUP0204141A3 (en) |
IL (1) | IL150545A0 (en) |
IS (1) | IS6443A (en) |
MA (1) | MA26868A1 (en) |
MX (1) | MXPA02007221A (en) |
NO (1) | NO20023527L (en) |
OA (1) | OA12161A (en) |
PA (1) | PA8510701A1 (en) |
PE (1) | PE20011066A1 (en) |
PL (1) | PL356802A1 (en) |
SK (1) | SK10632002A3 (en) |
SV (1) | SV2002000294A (en) |
TN (1) | TNSN01014A1 (en) |
WO (1) | WO2001055147A1 (en) |
YU (1) | YU50402A (en) |
ZA (1) | ZA200205879B (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
NZ524806A (en) | 2000-10-23 | 2006-03-31 | Smithkline Beecham Corp | Tri-substituted 8H-pyrido[2,3-d]pyrimidin-7-one compounds |
PE20030008A1 (en) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | DUAL INHIBITORS OF PDE 7 AND PDE 4 |
WO2003088972A1 (en) | 2002-04-19 | 2003-10-30 | Smithkline Beecham Corporation | Novel compounds |
CN1717396A (en) * | 2002-11-28 | 2006-01-04 | 舍林股份公司 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
US7157455B2 (en) * | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
TW200502236A (en) | 2003-03-28 | 2005-01-16 | Hoffmann La Roche | Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents |
FR2873118B1 (en) | 2004-07-15 | 2007-11-23 | Sanofi Synthelabo | PYRIDO-PYRIMIDINE DERIVATIVES, THEIR APPLICATION IN THERAPEUTICS |
CA2579406A1 (en) * | 2004-09-21 | 2006-03-30 | F.Hoffmann-La Roche Ag | 6-(2-alkyl-phenyl) - pyrido[2,3-d] pyrimidines useful as protein kinase inhibitors |
CN101495475A (en) | 2005-03-25 | 2009-07-29 | 葛兰素集团有限公司 | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives |
US7423042B2 (en) | 2005-03-25 | 2008-09-09 | Glaxo Group Limited | Compounds |
PE20061193A1 (en) | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVATIVES OF 3,4-DIHYDROPYRIMIDO [4,5-d] PYRIMIDIN-2- [1H] -0NA AS KINASE INHIBITORS p38 |
PE20100737A1 (en) | 2005-03-25 | 2010-11-27 | Glaxo Group Ltd | NEW COMPOUNDS |
FR2887882B1 (en) | 2005-07-01 | 2007-09-07 | Sanofi Aventis Sa | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION |
WO2007009911A1 (en) * | 2005-07-21 | 2007-01-25 | F. Hoffmann-La Roche Ag | PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS |
MX2008001969A (en) | 2005-08-09 | 2008-04-11 | Irm Llc | Compounds and compositions as protein kinase inhibitors. |
FR2896246B1 (en) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | PYRIDO-PYRIMIDONE DERIVATIVES, THEIR PREPARATION, THEIR THERAPEUTIC APPLICATION |
EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
JO2985B1 (en) | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | MAPK/ERK Kinase Inhibitors |
FR2910813B1 (en) * | 2006-12-28 | 2009-02-06 | Sanofi Aventis Sa | NEW THERAPEUTIC USE FOR THE TREATMENT OF LEUKEMIA |
EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
CN102216299B (en) * | 2008-12-01 | 2015-02-11 | 默克专利有限公司 | 2, 5-diamino-substituted pyrido [4, 3-d] pyrimidines as autotaxin inhibitors |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
US9815847B2 (en) | 2013-03-14 | 2017-11-14 | Icahn School Of Medicine At Mount Sinai | Pyrimidine compounds as kinase inhibitors |
GB201403536D0 (en) | 2014-02-28 | 2014-04-16 | Cancer Rec Tech Ltd | Inhibitor compounds |
KR101671404B1 (en) * | 2014-09-02 | 2016-11-02 | 한국원자력의학원 | Pyrimidine derivatives having anti-cancer effect, combination therapeutic effect with radiation, and anti-diabetic effect, and PPAR activity, and medical use thereof |
CN107286180B (en) * | 2016-04-11 | 2019-07-02 | 上海勋和医药科技有限公司 | Miscellaneous generation Pyridopyrimidinone derivatives are as CDK inhibitor and its application |
GB201709840D0 (en) | 2017-06-20 | 2017-08-02 | Inst Of Cancer Research: Royal Cancer Hospital | Methods and medical uses |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GEP20012444B (en) * | 1994-11-14 | 2001-05-25 | Warner Lambert Company Us | 6-Aryl Pyrido[2,3-d]Pyrimidines and Naphthyridines, Pharmaceutical Composition on Their Basis and Application for Inhibiting Cellular Proliferation |
IL115256A0 (en) * | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
US5620981A (en) * | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
BR9911590A (en) * | 1998-05-26 | 2001-02-13 | Warner Lambert Co | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cell proliferation |
-
2001
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Application Discontinuation
- 2001-01-23 IL IL15054501A patent/IL150545A0/en unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 YU YU50402A patent/YU50402A/en unknown
- 2001-01-23 PL PL01356802A patent/PL356802A1/en not_active Application Discontinuation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/en not_active Application Discontinuation
- 2001-01-23 EE EEP200200405A patent/EE200200405A/en unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/en unknown
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/en unknown
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 CN CN01804048A patent/CN1395578A/en active Pending
- 2001-01-23 AR ARP010100285A patent/AR030044A1/en not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/en active
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/en not_active Application Discontinuation
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/en not_active IP Right Cessation
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/en not_active Application Discontinuation
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/en not_active Expired - Fee Related
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/en not_active Application Discontinuation
- 2001-01-23 EA EA200200643A patent/EA200200643A1/en unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 GT GT200100016A patent/GT200100016A/en unknown
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/en unknown
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/en not_active Application Discontinuation
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/en unknown
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/en unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/en not_active Application Discontinuation
-
2002
- 2002-06-20 BG BG106850A patent/BG106850A/en unknown
- 2002-06-25 IS IS6443A patent/IS6443A/en unknown
- 2002-07-17 CR CR6706A patent/CR6706A/en not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/en unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/en not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HN2001000013A (en) | PIRIDO [2,3 - d] PIRIMIDIN - 2, 7 - KINASE INHIBITING DIAMINES | |
USD538050S1 (en) | Substrate with camouflage pattern | |
IS7319A (en) | Multiple synthetic clopidogrel hydrogen sulphate | |
CR6736A (en) | 5-ALQUILPIRIDO [2,3-D [PIRIDINES AS INHIBITORS OF TYPOSINE KINASA | |
HN1999000083A (en) | PIRROLO COMPOUNDS (2,3-D) PYRIMIDINE | |
BR0010616A (en) | Nucleic acid sequences to proteins involved in isoprenoid synthesis | |
BG106035A (en) | Heterocyclically substituted benzimidazoles, the production and utilization thereof | |
NZ593182A (en) | Use of beta-hydroxy-beta-methylbutyrate to modulate the imbalance in type 1 and type 2 cytokine production | |
IL198270A0 (en) | Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol | |
BRPI0414598A (en) | replaced indoles | |
MXPA04002247A (en) | Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol. | |
BRPI0407282A (en) | Process for preparing pyrrolotriazine kinase inhibitors | |
HN1997000098A (en) | COMPOSITION OF INDOL 2, 3 REPLACED AS ANTI-INFLAMMATORY AND ANALGESICAL AGENTS. | |
AU1783201A (en) | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors | |
AU5354301A (en) | Nucleic acid sequences to proteins involved in tocopherol synthesis | |
USD583604S1 (en) | Front face of a mat | |
WO2002056929A3 (en) | Implant with porous calcium phosphate surface layer | |
AU1781601A (en) | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors | |
MY141606A (en) | N-alkoxyalkyl-substituted benzimidazoles, their preparation and their use as agents against parasitic protozoa | |
USD479281S1 (en) | Board game for teaching DNA concepts | |
AR023979A1 (en) | PROCESSES TO PREPARE INTERMEDIATE PESTICIDE COMPOUNDS | |
WO2002022848A3 (en) | Compositions comprising mixtures of human cytokines and methods of producing the same | |
USD506316S1 (en) | Surface pattern for fabric | |
CA104399S (en) | Tape dispenser | |
BR0211893A (en) | Homogeneous alkaline earth peroxide with boron |