EA200200337A1 - ПРОИЗВОДНЫЕ ПИРАЗОЛО[4,3-d]ПИРИМИДИНА - Google Patents

ПРОИЗВОДНЫЕ ПИРАЗОЛО[4,3-d]ПИРИМИДИНА

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Publication number
EA200200337A1
EA200200337A1 EA200200337A EA200200337A EA200200337A1 EA 200200337 A1 EA200200337 A1 EA 200200337A1 EA 200200337 A EA200200337 A EA 200200337A EA 200200337 A EA200200337 A EA 200200337A EA 200200337 A1 EA200200337 A1 EA 200200337A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutically
veterinary acceptable
pyrazolo
pyrimidine
derivatives
Prior art date
Application number
EA200200337A
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English (en)
Other versions
EA004982B1 (ru
Inventor
Марк Эдвард Баннейдж
Кит Майкл Девриз
Лоренс Джеймс Харрис
Филип Чарлз Леветт
Джон Пол Матайас
Джоанна Териза Негри
Стивен Дерек Алберт Стрит
Алберт Шо Вуд
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9924063.2A external-priority patent/GB9924063D0/en
Priority claimed from GB0018656A external-priority patent/GB0018656D0/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200200337A1 publication Critical patent/EA200200337A1/ru
Publication of EA004982B1 publication Critical patent/EA004982B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/06—Antiabortive agents; Labour repressants
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Соединения формулы (I), где R, R, Rи Rявляются такими, как определено, либо их фармацевтически или ветеринарно приемлемые соль или полиморф, либо их фармацевтически или ветеринарно приемлемые сольват или пролекарство являются сильнодействующими и избирательными ингибиторами фосфодиэстеразы циклического гуанозин-3',5'-монофосфата (цГМФ-ФДЭ5) и полезны при лечении, среди прочего, мужской эректильной дисфункции (МЭД) и женской половой дисфункции (ЖПД).Отчет о международном поиске был опубликован 2001.10.25.
EA200200337A 1999-10-11 2000-10-11 ПРОИЗВОДНЫЕ ПИРАЗОЛО [4,3-d]ПИРИМИДИНА EA004982B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9924063.2A GB9924063D0 (en) 1999-10-11 1999-10-11 Pharmaceutically active compounds
GB0018656A GB0018656D0 (en) 2000-07-28 2000-07-28 Pharmaceutically active compounds
PCT/IB2000/001457 WO2001027113A2 (en) 1999-10-11 2000-10-11 PYRAZOLO `4,3-d! PYRIMIDINE DERIVATIVES

Publications (2)

Publication Number Publication Date
EA200200337A1 true EA200200337A1 (ru) 2002-10-31
EA004982B1 EA004982B1 (ru) 2004-10-28

Family

ID=26244757

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200337A EA004982B1 (ru) 1999-10-11 2000-10-11 ПРОИЗВОДНЫЕ ПИРАЗОЛО [4,3-d]ПИРИМИДИНА

Country Status (49)

Country Link
US (4) US6677335B1 (ru)
EP (1) EP1220856B1 (ru)
JP (1) JP3834236B2 (ru)
KR (1) KR100549152B1 (ru)
CN (3) CN100378100C (ru)
AP (1) AP1238A (ru)
AT (1) ATE284404T1 (ru)
AU (1) AU779065B2 (ru)
BG (1) BG106678A (ru)
BR (1) BR0014698A (ru)
CA (1) CA2387357C (ru)
CO (1) CO5251477A1 (ru)
CR (2) CR6617A (ru)
CU (1) CU23198A3 (ru)
CZ (1) CZ20021158A3 (ru)
DE (1) DE60016615T2 (ru)
DK (1) DK1220856T3 (ru)
DZ (1) DZ3220A1 (ru)
EA (1) EA004982B1 (ru)
EE (1) EE05181B1 (ru)
EG (1) EG24411A (ru)
ES (1) ES2232502T3 (ru)
GE (2) GEP20033142B (ru)
GT (1) GT200000171A (ru)
HK (3) HK1050367A1 (ru)
HR (1) HRP20020317B1 (ru)
HU (1) HUP0203450A3 (ru)
IL (2) IL149026A0 (ru)
IN (4) IN2002MU00385A (ru)
IS (1) IS2181B (ru)
MA (1) MA26825A1 (ru)
MX (1) MX228340B (ru)
MY (1) MY130319A (ru)
NO (1) NO322856B1 (ru)
NZ (1) NZ518078A (ru)
OA (1) OA12061A (ru)
PA (1) PA8504501A1 (ru)
PE (1) PE20010737A1 (ru)
PH (1) PH12000002783B1 (ru)
PL (1) PL357536A1 (ru)
PT (1) PT1220856E (ru)
RS (1) RS50476B (ru)
SI (1) SI1220856T1 (ru)
SK (1) SK4602002A3 (ru)
SV (1) SV2002000195A (ru)
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TR (1) TR200200989T2 (ru)
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WO (1) WO2001027113A2 (ru)

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GB0000561D0 (en) * 2000-01-11 2000-03-01 Pfizer Ltd Treatment of diabetic ulcers
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DE10229778A1 (de) * 2002-07-03 2004-01-29 Bayer Ag Neue Verwendung von Imidazotriazinonen
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