PE20070808A1 - COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA - Google Patents

COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA

Info

Publication number
PE20070808A1
PE20070808A1 PE2006001566A PE2006001566A PE20070808A1 PE 20070808 A1 PE20070808 A1 PE 20070808A1 PE 2006001566 A PE2006001566 A PE 2006001566A PE 2006001566 A PE2006001566 A PE 2006001566A PE 20070808 A1 PE20070808 A1 PE 20070808A1
Authority
PE
Peru
Prior art keywords
rho
isoquinoline
kinase
inhibitors
compounds derived
Prior art date
Application number
PE2006001566A
Other languages
English (en)
Inventor
Peter Christopher Ray
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36569955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070808(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon Nv filed Critical Organon Nv
Publication of PE20070808A1 publication Critical patent/PE20070808A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ISOQUINOLINA DE FORMULA (I) DONDE X ES O, S O NH; Y ES OH O NH2; m ES DE 0 A 2; n ES 1 O 2; R1 ES H, HALOGENO O ALQUILO(C1-C4); R2 Y R3 SON CADA UNO H, HALOGENO O ALQUILO(C1-C4); R ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON OH, ALQUILOXI(C1-C4), ALQUILOXICARBONILO(C1-C4), ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: (S)-6-(PIPERIDIN-3-ILOXI)-2H-ISOQUINOLIN-1-ONA, (S)-7-METIL-6-(PIPERIDIN-3-ILOXI)-2H-ISOQUINOLIN-1-ONA, (S)-6-[1-(1H-PIRROL-2-ILMETIL)-PIPERIDIN-3-ILOXI]-ISOQUINOLIN-1-ILAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA Rho-QUINASA SIENDO UTILES PARA EL TRATAMIENTO DE HIPERTENSION, ARTERIOSCLEROSIS, GLAUCOMA
PE2006001566A 2005-12-08 2006-12-06 COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA PE20070808A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05111813 2005-12-08

Publications (1)

Publication Number Publication Date
PE20070808A1 true PE20070808A1 (es) 2007-08-27

Family

ID=36569955

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001566A PE20070808A1 (es) 2005-12-08 2006-12-06 COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA

Country Status (17)

Country Link
EP (1) EP1963304B2 (es)
JP (1) JP5313682B2 (es)
CN (1) CN101321748B (es)
AR (1) AR058287A1 (es)
AT (1) ATE434613T1 (es)
CA (1) CA2629915C (es)
CY (1) CY1110489T1 (es)
DE (1) DE602006007488D1 (es)
DK (1) DK1963304T3 (es)
ES (1) ES2327677T3 (es)
HR (1) HRP20090400T1 (es)
PE (1) PE20070808A1 (es)
PL (1) PL1963304T3 (es)
PT (1) PT1963304E (es)
SI (1) SI1963304T1 (es)
TW (1) TW200738682A (es)
WO (1) WO2007065916A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006264043B2 (en) 2005-06-28 2012-04-26 Sanofi-Aventis Isoquinoline derivatives as inhibitors of Rho-kinase
WO2007008926A1 (en) 2005-07-11 2007-01-18 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
RS52241B (en) 2005-07-26 2012-10-31 Sanofi CYCLOHEXYLAMINE ISOHINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS
CN101228149B (zh) 2005-07-26 2013-01-02 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的哌啶基取代的异喹啉酮衍生物
CA2664335C (en) 2006-09-20 2014-12-02 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
WO2008077550A1 (en) * 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
CN101611012B (zh) 2006-12-27 2012-11-14 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹啉衍生物
AU2007338412B2 (en) 2006-12-27 2013-03-14 Sanofi-Aventis Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
CA2673918C (en) * 2006-12-27 2015-02-17 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
NZ577980A (en) 2006-12-27 2012-01-12 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
CA2673921C (en) 2006-12-27 2015-10-20 Sanofi-Aventis New substituted isoquinoline and isoquinolinone derivatives
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
AU2008340601A1 (en) * 2007-12-26 2009-07-02 Sanofi-Aventis Process for the preparation of 6-substituted-1-(2H)-isoquinolinones
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
NZ590067A (en) 2008-06-24 2012-09-28 Sanofi Aventis Bi-and polycyclic substituted isoquinoline and isoquinolinone derivatives as rho kinase inhibitors
PL2303846T3 (pl) 2008-06-24 2015-10-30 Sanofi Sa Podstawione izochinoliny i izochinolinony jako inhibitory kinazy Rho
DK2313374T3 (da) 2008-06-24 2013-12-16 Sanofi Sa 6-substituerede isoquinoliner og isoquinolinoner
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
CA2929545C (en) 2009-05-01 2019-04-09 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
HUE027309T2 (en) 2011-07-08 2016-10-28 Sanofi Sa Crystalline solvates of 6- (Piperidin-4-ylix) -2H-isoquinolin-1-one hydrochloride
BR112014000279B1 (pt) 2011-07-08 2020-11-24 Sanofi composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i)
ES2567317T3 (es) 2011-07-08 2016-04-21 Sanofi Polimorfos de hidrocloruro de 6-(piperidin-4-iloxi)-2H-isoquinolin-1-ona
EP3141235A1 (en) 2012-12-06 2017-03-15 IP Gesellschaft für Management mbH N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-l -sulfonamide
EP3461484B9 (en) 2013-03-15 2021-06-09 Aerie Pharmaceuticals, Inc. Dimesylate salts of 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl, their combinations with prostaglandins and the use thereof in the treatment of ocular disorders
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP6832946B2 (ja) 2015-11-17 2021-02-24 アエリエ ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤およびその中間体の調製方法
BR112019003945A2 (pt) 2016-08-31 2019-05-21 Aerie Pharmaceuticals, Inc. composições oftálmicas
TWI795381B (zh) * 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
CN110506037A (zh) 2017-03-31 2019-11-26 爱瑞制药公司 芳基环丙基-氨基-异喹啉酰胺化合物
WO2018228452A1 (zh) * 2017-06-16 2018-12-20 成都先导药物开发有限公司 一种抑制 rock 的化合物及其用途
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN113877483B (zh) * 2021-07-20 2023-11-24 烟台宁远药业有限公司 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1403255A4 (en) * 2001-06-12 2005-04-06 Sumitomo Pharma INHIBITORS OF RHO KINASE
CN100354264C (zh) * 2002-07-22 2007-12-12 旭化成制药株式会社 5－取代异喹啉衍生物及含有它们的药物
US7615564B2 (en) * 2002-09-12 2009-11-10 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
CN101228149B (zh) * 2005-07-26 2013-01-02 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的哌啶基取代的异喹啉酮衍生物

Also Published As

Publication number Publication date
CA2629915C (en) 2014-03-18
CA2629915A1 (en) 2007-06-14
JP2009518360A (ja) 2009-05-07
EP1963304A1 (en) 2008-09-03
DE602006007488D1 (de) 2009-08-06
EP1963304B2 (en) 2015-05-13
DK1963304T3 (da) 2009-10-12
CN101321748A (zh) 2008-12-10
JP5313682B2 (ja) 2013-10-09
EP1963304B1 (en) 2009-06-24
CN101321748B (zh) 2013-03-27
HRP20090400T1 (hr) 2009-08-31
PL1963304T3 (pl) 2009-12-31
SI1963304T1 (sl) 2009-12-31
ES2327677T3 (es) 2009-11-02
ATE434613T1 (de) 2009-07-15
WO2007065916A1 (en) 2007-06-14
TW200738682A (en) 2007-10-16
AR058287A1 (es) 2008-01-30
CY1110489T1 (el) 2015-04-29
PT1963304E (pt) 2009-09-14

Similar Documents

Publication Publication Date Title
PE20070808A1 (es) COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA
PE20060777A1 (es) Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
TN2009000107A1 (en) New sulfonamide derivatives as bradykinin antagonists
PE20060334A1 (es) Derivados de piridina como antagonistas del receptor a2b de adenosina
PE20120058A1 (es) Derivados de imidazopirazina como inhibidores de syk
PE20070141A1 (es) Derivados de isoquinolina como inhibidores de rho-cinasa
PE20090895A1 (es) Derivados de triazol como inhibidores de la jak quinasa
NO20070529L (no) Kinazolindionderivater som parp-inhibitorer
PE20120635A1 (es) Dihidropirazolonas sustituidas como inhibidores de hif-propil-4-hidroxilasas
PE20090601A1 (es) Derivados de piridin-il-oxi-piridinas como inhibidores de alk5
PE20061106A1 (es) Derivados de 2-(4-oxo-4h-quinazolin-3-il)acetamida
PT1940839E (pt) Inibidores de piridopirimidinona pi3k alfa
UA83875C2 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
MX2011011485A (es) Sulfonamidas nematocidas.
HU0400405D0 (en) Novel compounds
PE20090326A1 (es) Compuestos heterociclos como inhibidores de erk
SG153811A1 (en) Quinazolinone derivatives useful as vanilloid antagonists
WO2005070884A3 (en) Heterocyclic compounds useful as growth hormone secretagogues
NO20070532L (no) Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer
PE20060525A1 (es) Compuestos heterociclicos como inhibidores de cetp
ATE503755T1 (de) Cgrp-rezeptorantagonisten
UY31750A (es) Compuestos y composiciones como inhibidores de quinasa
MX2009004526A (es) Nuevos derivados de benzamida como antagonistas de la bradiqunina.
MX2010004498A (es) Derivados de ciclohexenoamida y su uso como antagonistas de trpv1.
EP1856100A4 (en) CGRP RECEPTOR ANTAGONISTS

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed