PL1963304T3 - Pochodne izochinoliny - Google Patents

Pochodne izochinoliny

Info

Publication number
PL1963304T3
PL1963304T3 PL06830425T PL06830425T PL1963304T3 PL 1963304 T3 PL1963304 T3 PL 1963304T3 PL 06830425 T PL06830425 T PL 06830425T PL 06830425 T PL06830425 T PL 06830425T PL 1963304 T3 PL1963304 T3 PL 1963304T3
Authority
PL
Poland
Prior art keywords
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
PL06830425T
Other languages
English (en)
Inventor
Peter Christopher Ray
Original Assignee
N V Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36569955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1963304(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by N V Organon filed Critical N V Organon
Publication of PL1963304T3 publication Critical patent/PL1963304T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL06830425T 2005-12-08 2006-12-06 Pochodne izochinoliny PL1963304T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05111813 2005-12-08
EP20060830425 EP1963304B2 (en) 2005-12-08 2006-12-06 Isoquinoline derivatives
PCT/EP2006/069392 WO2007065916A1 (en) 2005-12-08 2006-12-06 Isoquinoline derivatives

Publications (1)

Publication Number Publication Date
PL1963304T3 true PL1963304T3 (pl) 2009-12-31

Family

ID=36569955

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06830425T PL1963304T3 (pl) 2005-12-08 2006-12-06 Pochodne izochinoliny

Country Status (17)

Country Link
EP (1) EP1963304B2 (pl)
JP (1) JP5313682B2 (pl)
CN (1) CN101321748B (pl)
AR (1) AR058287A1 (pl)
AT (1) ATE434613T1 (pl)
CA (1) CA2629915C (pl)
CY (1) CY1110489T1 (pl)
DE (1) DE602006007488D1 (pl)
DK (1) DK1963304T3 (pl)
ES (1) ES2327677T3 (pl)
HR (1) HRP20090400T1 (pl)
PE (1) PE20070808A1 (pl)
PL (1) PL1963304T3 (pl)
PT (1) PT1963304E (pl)
SI (1) SI1963304T1 (pl)
TW (1) TW200738682A (pl)
WO (1) WO2007065916A1 (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007000240A1 (en) 2005-06-28 2007-01-04 Sanofi-Aventis Isoquinoline derivatives as inhibitors of rho-kinase
ES2580108T3 (es) 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Compuestos de isoquinolina
UA93882C2 (ru) * 2005-07-26 2011-03-25 Санофи-Авентис Пиперидинил-замещенные производные изохинолона kak ингибиторы rho-киназы
JP5049970B2 (ja) 2005-07-26 2012-10-17 サノフイ Ｒｈｏ−キナーゼ阻害剤としてのシクロヘキシルアミンイソキノロン誘導体
EP2068878B1 (en) 2006-09-20 2019-04-10 Aerie Pharmaceuticals, Inc. Rho kinase inhibitors
JP5405316B2 (ja) 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノリン誘導体
WO2008077556A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
NZ577980A (en) 2006-12-27 2012-01-12 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
WO2008077552A1 (en) * 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
MY150746A (en) * 2006-12-27 2014-02-28 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
KR101545533B1 (ko) 2006-12-27 2015-08-19 사노피 치환된 이소퀴놀린 및 Ｒｈｏ-키나아제 억제제로서의 이의 용도
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
NZ586335A (en) * 2007-12-26 2011-08-26 Sanofi Aventis Process for the preparation of 6-substituted-1-(2h)-isoquinolinones
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
HUE026617T2 (en) 2008-06-24 2016-06-28 Sanofi Sa Substituted isoquinolines and isoquinolinones as RHO kinase inhibitors
ES2434121T3 (es) 2008-06-24 2013-12-13 Sanofi Derivados de isoquinolina e isoquinolinona bi- y policíclicos sustituidos como inhibidores de rho cinasa
WO2009156099A1 (en) 2008-06-24 2009-12-30 Sanofi-Aventis 6-substituted isoquinolines and isoquinolinones
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
JP6030644B2 (ja) 2011-07-08 2016-11-24 サノフイ 置換されたフェニル化合物
HRP20160358T1 (hr) 2011-07-08 2016-05-06 Sanofi Polimorfi 6-(piperidin-4-iloksi)-2h-izokinolin-1-on hidroklorida
SG2014007520A (en) 2011-07-08 2014-07-30 Sanofi Sa Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride
EP2740458B1 (en) 2012-12-06 2016-08-03 IP Gesellschaft für Management mbH Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide
PT3811943T (pt) 2013-03-15 2023-03-15 Aerie Pharmaceuticals Inc Composto para uso no tratamento de distúrbios oculares
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US10550087B2 (en) 2015-11-17 2020-02-04 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US11389441B2 (en) 2016-08-31 2022-07-19 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
TWI795381B (zh) * 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
JP2020515583A (ja) 2017-03-31 2020-05-28 アエリエ ファーマシューティカルズ インコーポレイテッド アリールシクロプロピル−アミノ−イソキノリニルアミド化合物
JP6906105B2 (ja) * 2017-06-16 2021-07-21 成都先導薬物開発股▲ふん▼有限公司Ｈｉｔｇｅｎ Ｌｔｄ． Ｒｏｃｋを阻害する化合物及びその使用
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN113877483B (zh) * 2021-07-20 2023-11-24 烟台宁远药业有限公司 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法
EP4402129A1 (en) * 2022-08-01 2024-07-24 Valo Health, Inc. <smallcaps/>? ? ?h? ? ? ? ?process for preparing 6-substituted-1-(2)-isoquinolinones and intermediate compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2002100833A1 (ja) * 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
EP1541559A4 (en) * 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE
US7615564B2 (en) * 2002-09-12 2009-11-10 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
UA93882C2 (ru) * 2005-07-26 2011-03-25 Санофи-Авентис Пиперидинил-замещенные производные изохинолона kak ингибиторы rho-киназы

Also Published As

Publication number Publication date
ATE434613T1 (de) 2009-07-15
AR058287A1 (es) 2008-01-30
EP1963304B2 (en) 2015-05-13
HRP20090400T1 (hr) 2009-08-31
CY1110489T1 (el) 2015-04-29
ES2327677T3 (es) 2009-11-02
WO2007065916A1 (en) 2007-06-14
PT1963304E (pt) 2009-09-14
CA2629915A1 (en) 2007-06-14
CA2629915C (en) 2014-03-18
CN101321748B (zh) 2013-03-27
EP1963304A1 (en) 2008-09-03
PE20070808A1 (es) 2007-08-27
JP5313682B2 (ja) 2013-10-09
DK1963304T3 (da) 2009-10-12
SI1963304T1 (sl) 2009-12-31
EP1963304B1 (en) 2009-06-24
DE602006007488D1 (de) 2009-08-06
JP2009518360A (ja) 2009-05-07
TW200738682A (en) 2007-10-16
CN101321748A (zh) 2008-12-10

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