PL1963304T3 - Pochodne izochinoliny - Google Patents

Pochodne izochinoliny

Info

Publication number
PL1963304T3
PL1963304T3 PL06830425T PL06830425T PL1963304T3 PL 1963304 T3 PL1963304 T3 PL 1963304T3 PL 06830425 T PL06830425 T PL 06830425T PL 06830425 T PL06830425 T PL 06830425T PL 1963304 T3 PL1963304 T3 PL 1963304T3
Authority
PL
Poland
Prior art keywords
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
PL06830425T
Other languages
English (en)
Inventor
Peter Christopher Ray
Original Assignee
N V Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36569955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1963304(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by N V Organon filed Critical N V Organon
Publication of PL1963304T3 publication Critical patent/PL1963304T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL06830425T 2005-12-08 2006-12-06 Pochodne izochinoliny PL1963304T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05111813 2005-12-08
PCT/EP2006/069392 WO2007065916A1 (en) 2005-12-08 2006-12-06 Isoquinoline derivatives
EP20060830425 EP1963304B2 (en) 2005-12-08 2006-12-06 Isoquinoline derivatives

Publications (1)

Publication Number Publication Date
PL1963304T3 true PL1963304T3 (pl) 2009-12-31

Family

ID=36569955

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06830425T PL1963304T3 (pl) 2005-12-08 2006-12-06 Pochodne izochinoliny

Country Status (17)

Country Link
EP (1) EP1963304B2 (pl)
JP (1) JP5313682B2 (pl)
CN (1) CN101321748B (pl)
AR (1) AR058287A1 (pl)
AT (1) ATE434613T1 (pl)
CA (1) CA2629915C (pl)
CY (1) CY1110489T1 (pl)
DE (1) DE602006007488D1 (pl)
DK (1) DK1963304T3 (pl)
ES (1) ES2327677T3 (pl)
HR (1) HRP20090400T1 (pl)
PE (1) PE20070808A1 (pl)
PL (1) PL1963304T3 (pl)
PT (1) PT1963304E (pl)
SI (1) SI1963304T1 (pl)
TW (1) TW200738682A (pl)
WO (1) WO2007065916A1 (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE441641T1 (de) 2005-06-28 2009-09-15 Sanofi Aventis Isochinolinderivate als inhibitoren von rho- kinase
US7470787B2 (en) 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
BRPI0613861B8 (pt) 2005-07-26 2021-05-25 Sanofi Aventis derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase
NI200800024A (es) 2005-07-26 2009-03-03 Derivados de ciclohexilaminisoquinolona en calidad inhibidores de rho-quinasa
WO2008036540A2 (en) 2006-09-20 2008-03-27 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
KR20090092303A (ko) 2006-12-27 2009-08-31 사노피-아벤티스 사이클로알킬아민 치환된 이소퀴놀린 유도체
DE602007010981D1 (de) 2006-12-27 2011-01-13 Sanofi Aventis Cycloalkylaminsubstituierte isochinolin- und isochinolinonderivate
CA2673917C (en) 2006-12-27 2015-01-27 Sanofi-Aventis Cycloalkylamine substituted isoquinolone derivatives
CA2673918C (en) * 2006-12-27 2015-02-17 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
MX2009005825A (es) * 2006-12-27 2009-06-16 Sanofi Aventis Derivados de isoquinolina e isoquinolinona sustituidos en calidad de inhibidores de rho-quinasa.
DK2132194T3 (da) 2006-12-27 2011-06-27 Sanofi Aventis Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
BRPI0821837A2 (pt) * 2007-12-26 2015-06-16 Sanofi Aventis Processo para a preparação de 6-substituídas-1-(2h)-isoquinolinonas
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
PT2313374E (pt) 2008-06-24 2013-11-29 Sanofi Sa Isoquinolinas e isoquinolinonas 6-substituídas
DK2303845T3 (da) 2008-06-24 2013-12-16 Sanofi Sa Bi- og polycyklisk substitueret isoquinolin og bi- og polycykliske substituerede isoquinolinderivater som rho-kinasehæmmere
KR101638326B1 (ko) 2008-06-24 2016-07-12 사노피 Ｒｈｏ 키나제 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3354643B1 (en) 2009-05-01 2020-10-28 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
SG2014007520A (en) 2011-07-08 2014-07-30 Sanofi Sa Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride
CN103649078B (zh) 2011-07-08 2015-08-19 赛诺菲 取代的苯基化合物
IN2014CN00834A (pl) 2011-07-08 2015-04-03 Sanofi Sa
EP2740458B1 (en) 2012-12-06 2016-08-03 IP Gesellschaft für Management mbH Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide
ES2942898T3 (es) 2013-03-15 2023-06-07 Aerie Pharmaceuticals Inc Compuesto para uso en el tratamiento de trastornos oculares
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
EP3376870B1 (en) 2015-11-17 2021-08-11 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102568082B1 (ko) 2016-08-31 2023-08-17 에어리 파마슈티컬즈, 인코포레이티드 안과용 조성물
TWI795381B (zh) * 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
US10858339B2 (en) 2017-03-31 2020-12-08 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2018228452A1 (zh) * 2017-06-16 2018-12-20 成都先导药物开发有限公司 一种抑制 rock 的化合物及其用途
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN113877483B (zh) * 2021-07-20 2023-11-24 烟台宁远药业有限公司 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法
EP4402129A1 (en) * 2022-08-01 2024-07-24 Valo Health, Inc. <smallcaps/>? ? ?h? ? ? ? ?process for preparing 6-substituted-1-(2)-isoquinolinones and intermediate compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199147B2 (en) * 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
JPWO2004009555A1 (ja) * 2002-07-22 2005-11-17 旭化成ファーマ株式会社 ５−置換イソキノリン誘導体
AU2003264427A1 (en) * 2002-09-12 2004-04-30 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
BRPI0613861B8 (pt) * 2005-07-26 2021-05-25 Sanofi Aventis derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase

Also Published As

Publication number Publication date
EP1963304A1 (en) 2008-09-03
EP1963304B1 (en) 2009-06-24
WO2007065916A1 (en) 2007-06-14
CA2629915A1 (en) 2007-06-14
CN101321748B (zh) 2013-03-27
CY1110489T1 (el) 2015-04-29
DK1963304T3 (da) 2009-10-12
SI1963304T1 (sl) 2009-12-31
PE20070808A1 (es) 2007-08-27
ATE434613T1 (de) 2009-07-15
ES2327677T3 (es) 2009-11-02
JP5313682B2 (ja) 2013-10-09
CA2629915C (en) 2014-03-18
HRP20090400T1 (hr) 2009-08-31
JP2009518360A (ja) 2009-05-07
CN101321748A (zh) 2008-12-10
EP1963304B2 (en) 2015-05-13
AR058287A1 (es) 2008-01-30
TW200738682A (en) 2007-10-16
DE602006007488D1 (de) 2009-08-06
PT1963304E (pt) 2009-09-14

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