ATE434613T1 - Isochinolinderivate - Google Patents

Isochinolinderivate

Info

Publication number
ATE434613T1
ATE434613T1 AT06830425T AT06830425T ATE434613T1 AT E434613 T1 ATE434613 T1 AT E434613T1 AT 06830425 T AT06830425 T AT 06830425T AT 06830425 T AT06830425 T AT 06830425T AT E434613 T1 ATE434613 T1 AT E434613T1
Authority
AT
Austria
Prior art keywords
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
AT06830425T
Other languages
English (en)
Inventor
Peter Ray
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36569955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE434613(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE434613T1 publication Critical patent/ATE434613T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06830425T 2005-12-08 2006-12-06 Isochinolinderivate ATE434613T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05111813 2005-12-08
PCT/EP2006/069392 WO2007065916A1 (en) 2005-12-08 2006-12-06 Isoquinoline derivatives

Publications (1)

Publication Number Publication Date
ATE434613T1 true ATE434613T1 (de) 2009-07-15

Family

ID=36569955

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06830425T ATE434613T1 (de) 2005-12-08 2006-12-06 Isochinolinderivate

Country Status (17)

Country Link
EP (1) EP1963304B2 (de)
JP (1) JP5313682B2 (de)
CN (1) CN101321748B (de)
AR (1) AR058287A1 (de)
AT (1) ATE434613T1 (de)
CA (1) CA2629915C (de)
CY (1) CY1110489T1 (de)
DE (1) DE602006007488D1 (de)
DK (1) DK1963304T3 (de)
ES (1) ES2327677T3 (de)
HR (1) HRP20090400T1 (de)
PE (1) PE20070808A1 (de)
PL (1) PL1963304T3 (de)
PT (1) PT1963304E (de)
SI (1) SI1963304T1 (de)
TW (1) TW200738682A (de)
WO (1) WO2007065916A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1899322E (pt) 2005-06-28 2009-11-09 Sanofi Aventis Derivados de isoquinolina como inibidores de rho-cinase
ES2580108T3 (es) 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Compuestos de isoquinolina
HRP20110839T1 (hr) 2005-07-26 2011-12-31 Sanofi Derivati cikloheksaminizokinolona kao inhibitori rho-kinaze
PT1910333E (pt) * 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
CA2664335C (en) 2006-09-20 2014-12-02 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
BRPI0721180A2 (pt) 2006-12-27 2014-03-18 Sanofi Aventis Derivados de isoquinolina substituídos com cicloalquilamina
JP5405314B2 (ja) 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノロン誘導体
KR101545533B1 (ko) 2006-12-27 2015-08-19 사노피 치환된 이소퀴놀린 및 Ｒｈｏ-키나아제 억제제로서의 이의 용도
RU2468011C2 (ru) 2006-12-27 2012-11-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолина и изохинолинона
MY150746A (en) * 2006-12-27 2014-02-28 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
RU2009128693A (ru) 2006-12-27 2011-02-10 Санофи-Авентис (Fr) Замещенные производные изохинолина и изохинолинона
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
RU2010131010A (ru) * 2007-12-26 2012-02-10 Санофи-Авентис (Fr) Способ получения 6-замещенных-1-(2н)-изохинолинонов
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
AU2009262516B8 (en) 2008-06-24 2014-01-30 Sanofi 6-substituted isoquinolines and isoquinolinones
MX2010013867A (es) 2008-06-24 2011-02-24 Sanofi Aventis Derivados de isoquinolina e isoquinolinona bi- y policiclicos sustituidos.
RU2538588C2 (ru) 2008-06-24 2015-01-10 Санофи-Авентис ЗАМЕЩЕННЫЕ ИЗИХИНОЛИНЫ И ИЗОХИНОЛИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
RU2619129C2 (ru) 2011-07-08 2017-05-12 Санофи Кристаллические сольваты гидрохлорида 6-(пиперидин-4-илокси)-2н-изохинолин-1-oha
IN2014CN00834A (de) 2011-07-08 2015-04-03 Sanofi Sa
EP2729463B1 (de) 2011-07-08 2015-07-29 Sanofi Substituierte phenylverbindungen
EP3141235A1 (de) 2012-12-06 2017-03-15 IP Gesellschaft für Management mbH N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorbenzylthio)pyrimidin-4-yl)-3-methylazetidin-l-sulfonamid
EP2976080B1 (de) 2013-03-15 2019-12-25 Aerie Pharmaceuticals, Inc. Konjugate von isoquinolinverbindungen und prostaglandinen
EP3376870B1 (de) 2015-11-17 2021-08-11 Aerie Pharmaceuticals, Inc. Verfahren zur herstellung von kinaseinhibitoren und zwischenprodukten davon
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
MX2019002396A (es) 2016-08-31 2019-07-08 Aerie Pharmaceuticals Inc Composiciones oftalmicas.
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
JP2020515583A (ja) 2017-03-31 2020-05-28 アエリエ ファーマシューティカルズ インコーポレイテッド アリールシクロプロピル−アミノ−イソキノリニルアミド化合物
WO2018228452A1 (zh) * 2017-06-16 2018-12-20 成都先导药物开发有限公司 一种抑制 rock 的化合物及其用途
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN113877483B (zh) * 2021-07-20 2023-11-24 烟台宁远药业有限公司 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法
JP2025525162A (ja) * 2022-08-01 2025-08-01 ヴァロ ヘルス インコーポレイテッド ６－置換－１－（２ｈ）－イソキノリノン及び中間体化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199147B2 (en) * 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
AU2003281623B8 (en) * 2002-07-22 2009-06-11 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivative
CA2502583A1 (en) * 2002-09-12 2004-03-25 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinase inhibitory activity and medicament containing the same
PT1910333E (pt) * 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase

Also Published As

Publication number Publication date
CN101321748A (zh) 2008-12-10
EP1963304A1 (de) 2008-09-03
AR058287A1 (es) 2008-01-30
TW200738682A (en) 2007-10-16
WO2007065916A1 (en) 2007-06-14
ES2327677T3 (es) 2009-11-02
CA2629915A1 (en) 2007-06-14
PL1963304T3 (pl) 2009-12-31
SI1963304T1 (sl) 2009-12-31
PE20070808A1 (es) 2007-08-27
PT1963304E (pt) 2009-09-14
JP2009518360A (ja) 2009-05-07
JP5313682B2 (ja) 2013-10-09
CY1110489T1 (el) 2015-04-29
EP1963304B2 (de) 2015-05-13
CN101321748B (zh) 2013-03-27
HRP20090400T1 (hr) 2009-08-31
EP1963304B1 (de) 2009-06-24
CA2629915C (en) 2014-03-18
DK1963304T3 (da) 2009-10-12
DE602006007488D1 (de) 2009-08-06

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