PE20060525A1 - Compuestos heterociclicos como inhibidores de cetp - Google Patents

Compuestos heterociclicos como inhibidores de cetp

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Publication number
PE20060525A1
PE20060525A1 PE2005000763A PE2005000763A PE20060525A1 PE 20060525 A1 PE20060525 A1 PE 20060525A1 PE 2005000763 A PE2005000763 A PE 2005000763A PE 2005000763 A PE2005000763 A PE 2005000763A PE 20060525 A1 PE20060525 A1 PE 20060525A1
Authority
PE
Peru
Prior art keywords
alkyl
metoxy
isopropyl
heterocyclic compounds
cetp inhibitors
Prior art date
Application number
PE2005000763A
Other languages
English (en)
Inventor
Amjad Ali
Joann M Napolitano
Zhijian Lu
Peter J Sinclair
Christopher F Thompson
Julianne A Hunt
Cameron J Smith
Gayle E Taylor
Nazia Quraishi
Qiaolin Deng
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20060525A1 publication Critical patent/PE20060525A1/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
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    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
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    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

REFERIDA A UN COMPUESTO DE FORMULA 1e, DONDE X ES O, NH, N-ALQUILO c1-C5, ENTRE OTROS; Z ES C(=O), S(O)2, ENTRE OTROS; R ES H Y CH3; B ES A1 Y A2; R1 ES H, ALQUILO C1-C5, ENTRE OTROS; R2 ES H, ALQUILO C1-C5, HALOGENO, ENTRE OTROS; A2 ES FENILO, CICLOHEXILO, PIRIDILO, ENTRE OTROS; Ra ES ALQUILO C1-C3, HALOGENO, ENTRE OTROS; Rb ES F, ALQUILO C1-C4, O, ENTRE OTROS; n ES 0 O 1; p ES 0, 1 O 2; q ES 0, 1, 2 O 3. SON COMPUESTOS PREFERIDOS: 1-[5'-ISOPROPIL-2'-METOXI-4-(TRIFLUOROMETIL)BIFENIL-2-IL]METANAMINA, ACIDO 5'-ISOPROPIL-2'-METOXI-4-(TRIFLUOROMETIL)BIFENIL-2-CARBOXILICO, [5'-ISOPROPIL-2'-METOXI-4-(TRIFLUOROMETIL9BIFENIL-2-IL]METANOL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN LA PROTEINA DE TRANSFERENCIA DE ESTER DE COLESTEROL (CETP) Y SON UTILES PARA EL TRATAMIENTO Y PREVENCION DE LA ATEROSCLEROSIS
PE2005000763A 2004-07-02 2005-06-30 Compuestos heterociclicos como inhibidores de cetp PE20060525A1 (es)

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