HRP20090400T1 - Izokinolinski derivati - Google Patents
Izokinolinski derivati Download PDFInfo
- Publication number
- HRP20090400T1 HRP20090400T1 HR20090400T HRP20090400T HRP20090400T1 HR P20090400 T1 HRP20090400 T1 HR P20090400T1 HR 20090400 T HR20090400 T HR 20090400T HR P20090400 T HRP20090400 T HR P20090400T HR P20090400 T1 HRP20090400 T1 HR P20090400T1
- Authority
- HR
- Croatia
- Prior art keywords
- isoquinolin
- yloxy
- piperidin
- ylamine
- alkyl
- Prior art date
Links
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 title abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 10
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 10
- 229910052736 halogen Inorganic materials 0.000 claims abstract 9
- 150000002367 halogens Chemical class 0.000 claims abstract 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 7
- 125000005842 heteroatom Chemical group 0.000 claims abstract 7
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 3
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 2
- 150000002537 isoquinolines Chemical class 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 102100039313 Rho-associated protein kinase 1 Human genes 0.000 claims 1
- 101710088411 Rho-associated protein kinase 1 Proteins 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111813 | 2005-12-08 | ||
| PCT/EP2006/069392 WO2007065916A1 (en) | 2005-12-08 | 2006-12-06 | Isoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090400T1 true HRP20090400T1 (hr) | 2009-08-31 |
Family
ID=36569955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090400T HRP20090400T1 (hr) | 2005-12-08 | 2009-07-15 | Izokinolinski derivati |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1963304B2 (es) |
| JP (1) | JP5313682B2 (es) |
| CN (1) | CN101321748B (es) |
| AR (1) | AR058287A1 (es) |
| AT (1) | ATE434613T1 (es) |
| CA (1) | CA2629915C (es) |
| CY (1) | CY1110489T1 (es) |
| DE (1) | DE602006007488D1 (es) |
| DK (1) | DK1963304T3 (es) |
| ES (1) | ES2327677T3 (es) |
| HR (1) | HRP20090400T1 (es) |
| PE (1) | PE20070808A1 (es) |
| PL (1) | PL1963304T3 (es) |
| PT (1) | PT1963304E (es) |
| SI (1) | SI1963304T1 (es) |
| TW (1) | TW200738682A (es) |
| WO (1) | WO2007065916A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008000017A (es) | 2005-06-28 | 2008-03-26 | Sanofi Aventis | Derivados de isoquinolina como inhibidores de rho-cinasa. |
| ES2580108T3 (es) | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
| PT1910333E (pt) * | 2005-07-26 | 2013-08-01 | Sanofi Sa | Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase |
| MX2008000956A (es) | 2005-07-26 | 2008-03-27 | Sanofi Aventis | Derivados de ciclohexilaminisoquinolona en calidad de inhibidores de rho-quinasa. |
| CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| JP5405316B2 (ja) | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノリン誘導体 |
| BRPI0720909A2 (pt) | 2006-12-27 | 2016-11-01 | Sanofi Aventis | derivados de isoquinolina e isoquinolinona substituídos |
| BRPI0720862A2 (pt) | 2006-12-27 | 2014-02-25 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona substituídos como inibidores de rho-cinase |
| AU2007338408B2 (en) * | 2006-12-27 | 2012-07-26 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
| PT2102164E (pt) | 2006-12-27 | 2011-01-21 | Sanofi Aventis | Derivados de isoquinolina e de isoquinolinona substituída com cicloalquilamina |
| MY155009A (en) | 2006-12-27 | 2015-08-28 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| KR20100103646A (ko) * | 2007-12-26 | 2010-09-27 | 사노피-아벤티스 | ６치환된１（２ｈ）이소퀴놀리논의 제조 방법 |
| US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| CN102131785B (zh) | 2008-06-24 | 2014-10-29 | 赛诺菲-安万特 | 6-取代的异喹啉和异喹啉酮 |
| EP2303845B1 (en) | 2008-06-24 | 2013-09-18 | Sanofi | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors |
| JP5713893B2 (ja) | 2008-06-24 | 2015-05-07 | サノフイ | Ｒｈｏ−キナーゼ阻害剤としての置換イソキノリン類及びイソキノリノン類 |
| TW201006821A (en) * | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| BR112014000279B1 (pt) | 2011-07-08 | 2020-11-24 | Sanofi | composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i) |
| US8598201B2 (en) | 2011-07-08 | 2013-12-03 | Sanofi | Polymorphs of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride |
| KR102013566B1 (ko) | 2011-07-08 | 2019-08-23 | 사노피 | ６-(피페리딘-４-일옥시)-２ｈ-이소퀴놀린-１-온 하이드로클로라이드의 결정성 용매화물 |
| EP3141235A1 (en) | 2012-12-06 | 2017-03-15 | IP Gesellschaft für Management mbH | N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-l -sulfonamide |
| CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| KR102579582B1 (ko) | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
| CA3035566A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| TWI795381B (zh) * | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| CN110506037A (zh) | 2017-03-31 | 2019-11-26 | 爱瑞制药公司 | 芳基环丙基-氨基-异喹啉酰胺化合物 |
| WO2018228452A1 (zh) * | 2017-06-16 | 2018-12-20 | 成都先导药物开发有限公司 | 一种抑制 rock 的化合物及其用途 |
| US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN113877483B (zh) * | 2021-07-20 | 2023-11-24 | 烟台宁远药业有限公司 | 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1403255A4 (en) * | 2001-06-12 | 2005-04-06 | Sumitomo Pharma | INHIBITORS OF RHO KINASE |
| WO2004009555A1 (ja) * | 2002-07-22 | 2004-01-29 | Asahi Kasei Pharma Corporation | ５−置換イソキノリン誘導体 |
| CN100383140C (zh) * | 2002-09-12 | 2008-04-23 | 麒麟麦酒株式会社 | 具有激酶抑制活性的异喹啉衍生物和包含异喹啉衍生物的药剂 |
| PT1910333E (pt) * | 2005-07-26 | 2013-08-01 | Sanofi Sa | Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase |
-
2006
- 2006-11-29 TW TW095144093A patent/TW200738682A/zh unknown
- 2006-12-06 DE DE602006007488T patent/DE602006007488D1/de active Active
- 2006-12-06 WO PCT/EP2006/069392 patent/WO2007065916A1/en active Application Filing
- 2006-12-06 JP JP2008543829A patent/JP5313682B2/ja not_active Expired - Fee Related
- 2006-12-06 CN CN2006800457133A patent/CN101321748B/zh not_active Expired - Fee Related
- 2006-12-06 SI SI200630399T patent/SI1963304T1/sl unknown
- 2006-12-06 PL PL06830425T patent/PL1963304T3/pl unknown
- 2006-12-06 PE PE2006001566A patent/PE20070808A1/es not_active Application Discontinuation
- 2006-12-06 AT AT06830425T patent/ATE434613T1/de active
- 2006-12-06 CA CA2629915A patent/CA2629915C/en not_active Expired - Fee Related
- 2006-12-06 ES ES06830425T patent/ES2327677T3/es active Active
- 2006-12-06 EP EP20060830425 patent/EP1963304B2/en active Active
- 2006-12-06 DK DK06830425T patent/DK1963304T3/da active
- 2006-12-06 PT PT06830425T patent/PT1963304E/pt unknown
- 2006-12-07 AR ARP060105404A patent/AR058287A1/es unknown
-
2009
- 2009-07-15 HR HR20090400T patent/HRP20090400T1/hr unknown
- 2009-09-08 CY CY20091100933T patent/CY1110489T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1963304T3 (pl) | 2009-12-31 |
| SI1963304T1 (sl) | 2009-12-31 |
| JP2009518360A (ja) | 2009-05-07 |
| CA2629915A1 (en) | 2007-06-14 |
| EP1963304B2 (en) | 2015-05-13 |
| CA2629915C (en) | 2014-03-18 |
| CY1110489T1 (el) | 2015-04-29 |
| PT1963304E (pt) | 2009-09-14 |
| JP5313682B2 (ja) | 2013-10-09 |
| WO2007065916A1 (en) | 2007-06-14 |
| CN101321748B (zh) | 2013-03-27 |
| DK1963304T3 (da) | 2009-10-12 |
| EP1963304A1 (en) | 2008-09-03 |
| TW200738682A (en) | 2007-10-16 |
| AR058287A1 (es) | 2008-01-30 |
| PE20070808A1 (es) | 2007-08-27 |
| DE602006007488D1 (de) | 2009-08-06 |
| ES2327677T3 (es) | 2009-11-02 |
| EP1963304B1 (en) | 2009-06-24 |
| ATE434613T1 (de) | 2009-07-15 |
| CN101321748A (zh) | 2008-12-10 |
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