AR035401A1 - El uso de compuestos derivados de feniletenilo y feniletinilo; compuestos derivados de feniletinilo; compuestos derivados de feniletenilo; un procedimiento para la elaboracion de los mismos; y medicamentos que los contienen - Google Patents

El uso de compuestos derivados de feniletenilo y feniletinilo; compuestos derivados de feniletinilo; compuestos derivados de feniletenilo; un procedimiento para la elaboracion de los mismos; y medicamentos que los contienen

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Publication number
AR035401A1
AR035401A1 ARP010105602A ARP010105602A AR035401A1 AR 035401 A1 AR035401 A1 AR 035401A1 AR P010105602 A ARP010105602 A AR P010105602A AR P010105602 A ARP010105602 A AR P010105602A AR 035401 A1 AR035401 A1 AR 035401A1
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Argentina
Prior art keywords
lower alkyl
hydrogen
halogen
compounds derived
phenylethynyl
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ARP010105602A
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English (en)
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Vincent Mutel
Juergen Wichmann
Jens-Uwe Peters
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Hoffmann La Roche
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Publication of AR035401A1 publication Critical patent/AR035401A1/es

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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Abstract

El uso de compuestos derivados de feniletenilo y feniletinilo de fórmula general (1) donde: R1, R2, R3, R4 y R5 significan, independientemente entre sí, hidrógeno, alquilo inferior, -(CH2)n-halógeno, alcoxi inferior, -(CH2)n-NRR', -(CH2)n-N(R)-C(O)-alquilo inferior, arilo o heteroarilo que está insustituido o sustituido por uno o más residuos de alquilo inferior; R, R' y R'' significan, independientemente entre sí, hidrógeno o alquilo inferior; A significa -CH=CH-o -C:::C; y B significa (B1), (B2), (B3), (B4), (B5) o (B6), donde R6 significa hidrógeno, alquilo inferior, -(CH2)n-C(O)OR o halógeno; R7 significa hidrógeno, alquilo inferior, -(CH2)n-C(O)OR', halógeno, nitro o heteroarilo que está insustituido o sustituido por cicloalquilo o alquilo inferior; R8 significa hidrógeno, alquilo inferior, -(CH2)n-OH, -(CH2)n-C(O)OR'' o arilo; R9 significa alquilo inferior; R10 significa hidrógeno, halógeno o alquilo inferior; R11 significa hidrógeno o alquilo; R12 significa -(CH2)n-N(R)-C(O)-alquilo inferior; R13 significa hidrógeno o alquilo inferior; R14, R15, R16 y R17 significan, independientemente entre sí, hidrógeno, alquilo inferior, -(CH2)n-halógeno o alcoxi inferior; R18, R19 y R20 significan, independientemente entre sí, hidrógeno, alquilo inferior, -(CH2)n-halógeno o alcoxi Inferior; R21 significa hidrógeno o alquilo inferior; R22 significa hidrógeno, alquilo inferior o alquilo inferior que lleva uno o más sustituyentes seleccionados entre hidroxi o halógeno; R23 significa hidrógeno, alquilo inferior, alcanoílo inferior o nitro; R24, R25 y R26 significan, independientemente entre sí, hidrógeno o alquilo inferior; n es 0, 1, 2, 3, 4, 5 o 6; X es -CH2-, -O- o -S-; e Y es -CH= o -N=; y sus sales farmacéuticamente aceptables para la elaboración de medicamentos para el tratamiento o para la prevención de trastornos mediados por receptor de mGluR5. Compuestos derivados de feniletinilo de fórmula (2) donde: R1, R2, R3, R4, R5 y B tienen los significados dados anteriormente; y sus sales farmacéuticamente aceptables; con excepción de: 1-metil-2-feniletinil-1H-imidazol, 1-metil-2-(4-metoxi-feniletinil)-1H-imidazol, 1-metil-5-feniletinil-1H-imidazol, y 1-metil-4-feniletinil-1H-imidazol. Compuestos derivados de feniletenilo de fórmula (3) en la cual: R1, R2, R3, R4, R5, R6, R7 y R8 tienen los significados dados anteriormente; y sus sales farmacéuticamente aceptables. Compuestos derivados de feniletenilo de fórmula (4) en la cual: R1, R2, R3, R4, R5, R9 y R11 tienen los significados dados anteriormente; R10 significa halógeno y sus sales farmacéuticamente aceptables. Un procedimiento para la elaboración de los compuestos de fórmulas (2), (3) y (4), así como también, de sus sales farmacéuticamente aceptables, y medicamentos que los contienen.
ARP010105602A 2000-12-04 2001-12-03 El uso de compuestos derivados de feniletenilo y feniletinilo; compuestos derivados de feniletinilo; compuestos derivados de feniletenilo; un procedimiento para la elaboracion de los mismos; y medicamentos que los contienen AR035401A1 (es)

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EP00126615 2000-12-04

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AR035401A1 true AR035401A1 (es) 2004-05-26

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US (4) US6706707B2 (es)
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JP (2) JP4077317B2 (es)
KR (1) KR100515549B1 (es)
CN (1) CN1257894C (es)
AR (1) AR035401A1 (es)
AT (1) ATE288898T1 (es)
AU (2) AU2956702A (es)
BG (1) BG107877A (es)
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