UA96970C2 - Polymorphs of a mglur5 receptor antagonist - Google Patents

Polymorphs of a mglur5 receptor antagonist

Info

Publication number
UA96970C2
UA96970C2 UAA200907474A UAA200907474A UA96970C2 UA 96970 C2 UA96970 C2 UA 96970C2 UA A200907474 A UAA200907474 A UA A200907474A UA A200907474 A UAA200907474 A UA A200907474A UA 96970 C2 UA96970 C2 UA 96970C2
Authority
UA
Ukraine
Prior art keywords
mglur5 receptor
polymorphs
treatment
receptor antagonist
receptor
Prior art date
Application number
UAA200907474A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Томас П. Клири
Александер ГЛОММЕ
Олаф Грассманн
Шань-Мин Гуан
Роланд Майер
Дорин Миллер
Регина Мог
Франциска Э. Рорер
Джейсон Ян
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39186951&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96970(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of UA96970C2 publication Critical patent/UA96970C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Present invention relates to mono-sulfate and hemi-sulfate salts of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine, to crystalline and amorphous forms thereof and to their use in pharmaceutical formulations. Present compounds are active on the mGluR5 receptor for the treatment of diseases, related to this receptor, such acute and/or chronic neurological disorders, in particular anxiety, or for the treatment of chronic and acute pain, protection against liver damage, failure whether drug or disease induced, urinary incontinence, obesity, Fragile-X or Autism.
UAA200907474A 2006-12-21 2007-12-11 Polymorphs of a mglur5 receptor antagonist UA96970C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87639806P 2006-12-21 2006-12-21

Publications (1)

Publication Number Publication Date
UA96970C2 true UA96970C2 (en) 2011-12-26

Family

ID=39186951

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200907474A UA96970C2 (en) 2006-12-21 2007-12-11 Polymorphs of a mglur5 receptor antagonist

Country Status (33)

Country Link
US (2) US8063076B2 (en)
EP (1) EP2125779B1 (en)
JP (1) JP5405311B2 (en)
KR (1) KR101148580B1 (en)
CN (1) CN101568531B (en)
AR (1) AR064654A1 (en)
AU (1) AU2007336369B2 (en)
BR (1) BRPI0720954A2 (en)
CA (1) CA2673444C (en)
CL (1) CL2007003695A1 (en)
CO (1) CO6210731A2 (en)
CY (1) CY1117810T1 (en)
DK (1) DK2125779T3 (en)
EC (1) ECSP099431A (en)
ES (1) ES2577391T3 (en)
HR (1) HRP20160950T1 (en)
HU (1) HUE029324T2 (en)
IL (1) IL199181A (en)
MA (1) MA31008B1 (en)
MX (1) MX2009006694A (en)
MY (1) MY148217A (en)
NO (1) NO342451B1 (en)
NZ (1) NZ577440A (en)
PE (1) PE20081484A1 (en)
PL (1) PL2125779T3 (en)
PT (1) PT2125779T (en)
RS (1) RS54853B1 (en)
RU (1) RU2460728C2 (en)
SI (1) SI2125779T1 (en)
TW (1) TWI347320B (en)
UA (1) UA96970C2 (en)
WO (1) WO2008074697A1 (en)
ZA (1) ZA200904289B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2125779B1 (en) 2006-12-21 2016-04-27 F. Hoffmann-La Roche AG Polymorphs of a mglur5 receptor antagonist
US20120039999A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
WO2012127393A1 (en) 2011-03-18 2012-09-27 Novartis Ag COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
EP2837631A1 (en) * 2013-08-14 2015-02-18 Merck & Cie New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid
GB201317022D0 (en) * 2013-09-25 2013-11-06 Addex Pharmaceuticals Sa Polymorphs
US10548985B2 (en) 2014-01-10 2020-02-04 Birdie Biopharmaceuticals, Inc. Compounds and compositions for treating EGFR expressing tumors
CN106943597A (en) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 Anti-EGFR for treating tumour is combined
CN108794467A (en) 2017-04-27 2018-11-13 博笛生物科技有限公司 2- amino-quinoline derivatives
CN116056701A (en) * 2020-06-05 2023-05-02 诺埃玛制药公司 Methods for treating tuberous sclerosis complex
CN115989024A (en) * 2020-07-30 2023-04-18 诺埃玛制药公司 Method for treating trigeminal neuralgia

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303199A (en) * 1963-07-15 1967-02-07 Geigy Chem Corp Certain imidazolone derivatives and process for making same
US3341548A (en) * 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
DE2035905A1 (en) 1970-07-20 1972-02-03 Chemische Fabrik Stockhausen & Cie.,4150Krefeld Imidazole compounds and their manufacturing process
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
EP0079312A3 (en) * 1981-11-11 1984-04-25 Ciba-Geigy Ag Heterocyclic acetylene compounds
US4711962A (en) * 1984-10-18 1987-12-08 Stauffer Chemical Company Process for selective preparation of ratios of isomers formed on N-substitution of asymmetric imidazoles
WO1991000277A1 (en) 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
NZ502463A (en) 1997-08-14 2002-05-31 F 1-Phenyl vinyl substituted imidazole, triazole or tetrazole derivatives useful for controlling or preventing acute or chronic neurological disorders
AU780009B2 (en) 1999-08-31 2005-02-24 Merck Sharp & Dohme Corp. Heterocyclic compounds and methods of use thereof
DK1303495T3 (en) 2000-07-24 2010-09-20 Krenitsky Pharmaceuticals Inc Substituted 5-alkylnylpyrimidines with neurotrophic activity
WO2002046166A1 (en) 2000-12-04 2002-06-13 F. Hoffmann-La Roche Ag Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
US20040259917A1 (en) * 2001-12-19 2004-12-23 Cosford Nicholas D.P. Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
UA80888C2 (en) * 2003-06-05 2007-11-12 Hoffmann La Roche Imidazole derivatives as glutmate receptor antagonists
US7091222B2 (en) 2003-07-03 2006-08-15 Hoffmann-La Roche Inc. Imidazole derivatives
US7452909B2 (en) 2003-09-04 2008-11-18 Hoffman-La Roche Inc. Imidazole derivatives
CN1960984B (en) * 2004-06-01 2010-05-12 弗·哈夫曼-拉罗切有限公司 Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists
EP2125779B1 (en) 2006-12-21 2016-04-27 F. Hoffmann-La Roche AG Polymorphs of a mglur5 receptor antagonist

Also Published As

Publication number Publication date
RS54853B1 (en) 2016-10-31
EP2125779A1 (en) 2009-12-02
CA2673444A1 (en) 2008-06-26
CO6210731A2 (en) 2010-10-20
WO2008074697A1 (en) 2008-06-26
AR064654A1 (en) 2009-04-15
SI2125779T1 (en) 2016-07-29
TWI347320B (en) 2011-08-21
RU2009123135A (en) 2011-01-27
HRP20160950T1 (en) 2016-10-07
NO20092357L (en) 2009-07-15
ES2577391T3 (en) 2016-07-14
CN101568531A (en) 2009-10-28
IL199181A (en) 2016-02-29
HUE029324T2 (en) 2017-02-28
JP2010513378A (en) 2010-04-30
PL2125779T3 (en) 2016-11-30
PT2125779T (en) 2016-07-19
MA31008B1 (en) 2009-12-01
DK2125779T3 (en) 2016-07-04
KR101148580B1 (en) 2012-05-24
RU2460728C2 (en) 2012-09-10
AU2007336369B2 (en) 2013-01-17
PE20081484A1 (en) 2008-10-18
US8329912B2 (en) 2012-12-11
CA2673444C (en) 2015-01-20
CL2007003695A1 (en) 2008-07-04
EP2125779B1 (en) 2016-04-27
MY148217A (en) 2013-03-29
CN101568531B (en) 2013-11-13
BRPI0720954A2 (en) 2014-03-18
US20080312288A1 (en) 2008-12-18
MX2009006694A (en) 2009-06-30
CY1117810T1 (en) 2017-05-17
TW200833679A (en) 2008-08-16
ECSP099431A (en) 2009-07-31
AU2007336369A1 (en) 2008-06-26
US8063076B2 (en) 2011-11-22
NO342451B1 (en) 2018-05-22
ZA200904289B (en) 2010-04-28
US20120035222A1 (en) 2012-02-09
NZ577440A (en) 2011-12-22
KR20090081026A (en) 2009-07-27
JP5405311B2 (en) 2014-02-05

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