HUP0400570A2 - Feniletenil- vagy feniletinil-heteroaril-származékok mint glutamát receptor antagonisták, alkalmazásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Feniletenil- vagy feniletinil-heteroaril-származékok mint glutamát receptor antagonisták, alkalmazásuk, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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HUP0400570A2
HUP0400570A2 HU0400570A HUP0400570A HUP0400570A2 HU P0400570 A2 HUP0400570 A2 HU P0400570A2 HU 0400570 A HU0400570 A HU 0400570A HU P0400570 A HUP0400570 A HU P0400570A HU P0400570 A2 HUP0400570 A2 HU P0400570A2
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hydrogen atom
alkyl
alkyl group
atom
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Vincent Mutel
Jens-Uwe Peters
Jürgen Wichmann
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F.Hoffmann-La Roche Ag.
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Publication of HUP0400570A3 publication Critical patent/HUP0400570A3/hu

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    • C07D513/14—Ortho-condensed systems

Abstract

A találmány tárgya (I) általános képletű vegyületek[mely képletbenRl, R2, R3, R4 és R5 jelentése egymástól függetlenül hidrogénatom, 1-6szénatomos alkil-, -(CH2)n halogén-, 1-6 szénatomos alkoxi-, -(CH2)nNRR1, -(CH2)n-N(R)-C(O)-1-6 szénatomos alkil-, aril-csoport vagyhelyettesítetlen vagy egy vagy több 1-6 szénatomos alkilcsoporttalhelyettesített heteroaril-csoport; R, R' és R" jelentése egymástólfüggetlenül hidrogénatom vagy 1-6 szénatomos alkilcsoport; A jelentése-CH=CH- vagy -C<C-; és B jelentése (Bl), (B2), (B3), (B4), (B5) vagy(B6) általános képletű csoport; ahol R6 jelentése hidrogénatom, 1-6szénatomos alkilcsoport, -(CH2)n-C(O)OR csoport vagy halogénatom; R7jelentése hidrogénatom, 1-6 szénatomos alkilcsoport, -(CH2)n-C(O)OR'csoport, halogénatom, nitrocsoport vagy helyettesítetlen vagy 1-6szénatomos alkil- vagy cikloalkilcsoporttal helyettesített heteroaril-csoport; R8 jelentése hidrogénatom, 1-6 szénatomos alkilcsoport, -(CH2)n-OH, -(CH2)n-C(O)OR" csoport vagy arilcsoport; R9 jelentése 1-6szénatomos alkilcsoport; Rl0 jelentése hidrogénatom, 1-6 szénatomosalkilcsoport vagy halogénatom; Rl1 jelentése hidrogénatom vagy 1-6szénatomos alkilcsoport; R12 jelentése -(CH2)n-N(R)-C(O)-(1-6szénatomos)- alkilcsoport; R13 jelentése hidrogénatom vagy 1-6szénatomos alkilcsoport; R14, R15, R16 és Rl7 jelentése egymástólfüggetlenül hidrogénatom, 1-6 szénatomos alkilcsoport, -(CH2)nhalogéncsoport vagy 1-6 szénatomos alkoxicsoport; R18, Rl9 és R20jelentése egymástól függetlenül hidrogénatom, 1-6 szénatomosalkilcsoport, -(CH2)n halogéncsoport vagy 1-6 szénatomosalkoxicsoport; R21 jelentése hidrogénatom vagy 1-6 szénatomosalkilcsoport; R22 jelentése hidrogénatom, 1-6 szénatomos alkilcsoportvagy egy vagy több hidroxilcsoporttal és/vagy halogénatommalhelyettesített 1-6 szénatomos alkilcsoport; R23 jelentésehidrogénatom, 1-6 szénatomos alkil-, 1-6 szénatomos alkanoil- vagynitrocsoport; R24, R25 és R26 jelentése egymástól függetlenülhidrogénatom vagy 1-6 szénatomos alkilcsoport] és gyógyászatilagalkalmas sóik felhasználása mGluR5 receptor által közvetítettrendellenességek kezelésére vagy megelőzésére alkalmas gyógyászatikészítmények előállítására. A találmány kiterjed a vegyületekelőállítási eljárására is. Ó
HU0400570A 2000-12-04 2001-11-26 Phenylethenyl or phenylethinyl heteroaril derivatives as glutamate receptor antagonists, their use, process for their preparation and pharmaceutical compositions containing them HUP0400570A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00126615 2000-12-04
PCT/EP2001/013714 WO2002046166A1 (en) 2000-12-04 2001-11-26 Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists

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HUP0400570A2 true HUP0400570A2 (hu) 2004-06-28
HUP0400570A3 HUP0400570A3 (en) 2004-09-28

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US (4) US6706707B2 (hu)
EP (1) EP1349839B8 (hu)
JP (2) JP4077317B2 (hu)
KR (1) KR100515549B1 (hu)
CN (1) CN1257894C (hu)
AR (1) AR035401A1 (hu)
AT (1) ATE288898T1 (hu)
AU (2) AU2956702A (hu)
BG (1) BG107877A (hu)
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CA (1) CA2430696C (hu)
CZ (1) CZ20031795A3 (hu)
DE (1) DE60108900T2 (hu)
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HU (1) HUP0400570A3 (hu)
IL (2) IL155999A0 (hu)
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