HUP0301311A2 - N-oxidok mint 4-fenil-piridin-származékok előgyógyszerei, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
N-oxidok mint 4-fenil-piridin-származékok előgyógyszerei, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0301311A2 HUP0301311A2 HU0301311A HUP0301311A HUP0301311A2 HU P0301311 A2 HUP0301311 A2 HU P0301311A2 HU 0301311 A HU0301311 A HU 0301311A HU P0301311 A HUP0301311 A HU P0301311A HU P0301311 A2 HUP0301311 A2 HU P0301311A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- lower alkyl
- compounds
- hydrogen atom
- hydrogen
- Prior art date
Links
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title abstract 2
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 150000005362 4-phenylpyridines Chemical class 0.000 title 1
- 150000001204 N-oxides Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001302 tertiary amino group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A találmány (I) általános képletű vegyületekre[mely képletben Rjelentése hidrogénatom, kis szénatomszámú alkil-, kis szénatomszámúalkoxicsoport, halogénatom vagy trifluor-metil-csoport; R1 jelentésehidrogén- vagy halogénatom; vagy R és R1 a gyűrűszénatomokkal együtt,amelyekhez kapcsolódnak -CH=CH-CH=CH-csoportot képeznek; R2 és R2'jelentése egymástól függetlenül hidrogénatom, halogénatom, trifluor-metil-, kis szénatomszámú alkoxi- vagy cianocsoport; vagy R2 és R2'együtt -CH=CH-CH=CH- csoportot képez, amely adott esetben egy vagy kétkis szénatomszámú alkil- és/vagy kis szénatomszámú alkoxicsoporttalhelyettesítve lehet; R3 és R3' jelentése egymástól függetlenülhidrogénatom, kis szénatomszámú alkil- vagy cikloalkilcsoport; R4 ésR4' jelentése egymástól függetlenül -(CH2)mOR6 vagy kis szénatomszámúalkilcsoport; vagy R4 és R4' a nitrogénatommal együtt, amelyhezkapcsolódik, (A) általános képletű gyűrűs tercier-amino-csoportotképez; R5 jelentése hidrogénatom, hidroxil-, kis szénatomszámú alkil-,kis szénatomszámú alkoxicsoport, -(CH2)mQH, -COOR3, -CON(R3)2, -N(R3)CO-kis szénatomszámú alkil- vagy -C(O)R3 csoport; R6 jelentésehidrogénatom, kis szénatomszámú alkil- vagy fenilcsoport; X jelentése-C(O)N(R6)- , -N(R6)C(O)- , -(CH2)mO- vagy -O(CH2)m-; n értéke 0, 1,2, 3 vagy 4; és m értéke 1, 2 vagy 3] és gyógyászatilag alkalmassavaddíciós sóikra és a vegyületek előállítására vonatkozik. Atalálmány kiterjed a vegyületeket tartalmazó gyógyszerkészítményekreis. A fenti vegyületek NK-1 receptorral összefüggő betegségekkezelésénél vagy megelőzésénél előgyógyszerként (prodrug)alkalmazhatók. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00115287 | 2000-07-14 | ||
EP00115287.5 | 2000-07-14 | ||
PCT/EP2001/007850 WO2002006236A1 (en) | 2000-07-14 | 2001-07-09 | N-oxides as nk1 receptor antagonist prodrugs of 4-phenyl-pyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301311A2 true HUP0301311A2 (hu) | 2003-08-28 |
HU230316B1 HU230316B1 (hu) | 2016-01-28 |
Family
ID=8169262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301311A HU230316B1 (hu) | 2000-07-14 | 2001-07-09 | N-oxidok, mint 4-fenil-piridin-származékok előgyógyszerei, eljárás és előállításukra és az ezeket tartalmazó gyógyszerkészítmények |
Country Status (39)
Country | Link |
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US (4) | US6593472B2 (hu) |
EP (1) | EP1303490B1 (hu) |
JP (1) | JP3950044B2 (hu) |
KR (1) | KR100501608B1 (hu) |
CN (1) | CN1178917C (hu) |
AR (1) | AR029717A1 (hu) |
AT (1) | ATE400556T1 (hu) |
AU (1) | AU7061901A (hu) |
BR (1) | BRPI0112475B8 (hu) |
CA (1) | CA2415890C (hu) |
CY (1) | CY1108557T1 (hu) |
CZ (1) | CZ303639B6 (hu) |
DE (1) | DE60134749D1 (hu) |
DK (1) | DK1303490T3 (hu) |
EC (1) | ECSP034431A (hu) |
EG (1) | EG24968A (hu) |
ES (1) | ES2309075T3 (hu) |
GT (1) | GT200100137A (hu) |
HK (1) | HK1058198A1 (hu) |
HR (1) | HRP20030003B1 (hu) |
HU (1) | HU230316B1 (hu) |
IL (2) | IL153834A0 (hu) |
JO (1) | JO2372B1 (hu) |
MA (1) | MA26929A1 (hu) |
ME (1) | ME01311B (hu) |
MX (1) | MXPA03000366A (hu) |
MY (1) | MY154976A (hu) |
NO (1) | NO324700B1 (hu) |
NZ (1) | NZ523273A (hu) |
PA (1) | PA8522001A1 (hu) |
PE (1) | PE20020272A1 (hu) |
PL (1) | PL205207B1 (hu) |
PT (1) | PT1303490E (hu) |
RS (1) | RS50932B (hu) |
RU (1) | RU2266284C2 (hu) |
SI (1) | SI1303490T1 (hu) |
UY (1) | UY26839A1 (hu) |
WO (1) | WO2002006236A1 (hu) |
ZA (1) | ZA200210207B (hu) |
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CZ303639B6 (cs) * | 2000-07-14 | 2013-01-23 | F. Hoffmann-La Roche Ag | N-Oxid derivátu 4-fenylpyridinu, zpusob jeho prípravy a lécivo s jeho obsahem |
TWI287003B (en) * | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
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SI3102208T1 (sl) | 2014-02-07 | 2021-07-30 | Global Blood Therapeutics, Inc. | Kristalinični polimorf proste baze 2-hidroksi-6-((2-(1-izopropil-1H-pirazol-5-IL)piridin-3-IL)metoksi)- benzaldehida |
TWI649307B (zh) | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
CN106588899B (zh) * | 2015-10-15 | 2019-11-15 | 江苏恒瑞医药股份有限公司 | 吡啶基取代的6-氧杂螺[4.5]癸烷类衍生物、其制备方法及其在医药上的应用 |
MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
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US11160809B2 (en) | 2017-04-10 | 2021-11-02 | Chase Therapeutics Corporation | NK1-antagonist combination and method for treating synucleinopathies |
BR112019028034A2 (pt) | 2017-06-30 | 2020-07-07 | Chase Therapeutics Corporation | composições de antagonista de nk-1 e métodos para uso no tratamento da depressão |
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JPS56106286A (en) | 1980-01-28 | 1981-08-24 | Nippon Musical Instruments Mfg | Electronic musical instrument |
EP0103545A3 (en) | 1982-09-13 | 1984-10-03 | Arc Technologies Systems, Ltd. | Electrode for arc furnaces |
IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
PL181214B1 (pl) | 1993-12-29 | 2001-06-29 | Merck Sharp & Dohme | Podstawione związki morfolinowe, sposób ich wytwarzania oraz zawierające je kompozycje farmaceutyczne |
TW385308B (en) | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
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AR008789A1 (es) * | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
CZ20013046A3 (cs) * | 1999-02-24 | 2002-02-13 | F. Hoffmann-La Roche Ag | Fenylové a pyridinylové deriváty |
ATE277905T1 (de) * | 1999-02-24 | 2004-10-15 | Hoffmann La Roche | 4-phenylpyridinderivate und deren verwendung als nk-1 rezeptorantagonisten |
ES2208205T3 (es) * | 1999-11-29 | 2004-06-16 | F. Hoffmann-La Roche Ag | 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il-4-otolil-piridin-3-il)-isobutiramida. |
CZ303639B6 (cs) * | 2000-07-14 | 2013-01-23 | F. Hoffmann-La Roche Ag | N-Oxid derivátu 4-fenylpyridinu, zpusob jeho prípravy a lécivo s jeho obsahem |
US20030083345A1 (en) * | 2001-07-10 | 2003-05-01 | Torsten Hoffmann | Method of treatment and/or prevention of brain, spinal or nerve injury |
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