PE20091095A1 - Moduladores de gamma secretasa - Google Patents
Moduladores de gamma secretasaInfo
- Publication number
- PE20091095A1 PE20091095A1 PE2008002022A PE2008002022A PE20091095A1 PE 20091095 A1 PE20091095 A1 PE 20091095A1 PE 2008002022 A PE2008002022 A PE 2008002022A PE 2008002022 A PE2008002022 A PE 2008002022A PE 20091095 A1 PE20091095 A1 PE 20091095A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridine
- pirrolo
- fluorobenzyl
- imidazol
- aryl
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 6
- -1 4-FLUOROBENZYL Chemical class 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical group C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 206010044688 Trisomy 21 Diseases 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 150000002476 indolines Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE FORMULA (I) DONDE R1 ES ALQUILO, CICLOALQUILO, ARILO, ENTRE OTROS; R2 ES INDOLINA, PIRROLO[3,2-c]PIRIDINA, PIRROLO[2,3-b]PIRIDINA, ENTRE OTROS; R3 ES -ARIL, -HETEROARIL, CICLOALQUILO, ENTRE OTROS; R4 ES -ARILALCOXI, -ARILALQUILAMINO, ARILO, ENTRE OTROS; L ES ENLACE DIRECTO, -O-, -N(R5)-, ENTRE OTROS; R5 ES H, ALQUILO, ALQUENILO, ENTRE OTROS. SON COMPUESTOS SELECCIONADOS: 1-(4-FLUOROBENCIL)-4-(4-(4-METIL-1H-IMIDAZOL-1-IL)FENIL)INDOLINA, 1-(4-FLUOROBENCIL)-4-(4-(4-METIL-1H-IMIDAZOL-1-IL)FENIL)-1H-PIRROLO[3,2c]PIRIDINA, 1-(4-FLUOROBENCIL)-4-(4-(4-METIL-1H-IMIDAZOL-1-IL)FENIL)-1H-PIRROLO[2,3b]PIRIDINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE GAMMA SECRETASA, SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDAD DE ALZHEIMER, SINDROME DE DOWN, DEFICIENCIA COGNITIVA SUAVE, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99283907P | 2007-12-06 | 2007-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091095A1 true PE20091095A1 (es) | 2009-07-25 |
Family
ID=40351934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008002022A PE20091095A1 (es) | 2007-12-06 | 2008-12-05 | Moduladores de gamma secretasa |
Country Status (13)
Country | Link |
---|---|
US (1) | US8450343B2 (es) |
EP (1) | EP2229381A1 (es) |
JP (1) | JP2011506335A (es) |
KR (1) | KR20100094554A (es) |
CN (1) | CN101939315A (es) |
AR (1) | AR069635A1 (es) |
AU (1) | AU2008333865A1 (es) |
CA (1) | CA2707712A1 (es) |
IL (1) | IL206172A0 (es) |
MX (1) | MX2010006243A (es) |
PE (1) | PE20091095A1 (es) |
TW (1) | TW200930366A (es) |
WO (1) | WO2009073777A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2008002542A1 (es) | 2007-08-31 | 2009-01-02 | Eisai R&D Man Co Ltd | Compuestos derivados de imidazolil piridina ligados a un heterociclo mediante un vinilo, moduladores de la actividad de amiloide-beta; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de enfermedades tales como alzheimer, demencia, sindrome de down o amiloidosis. |
CA2742897A1 (en) | 2008-11-06 | 2010-05-14 | Astrazeneca Ab | Modulators of amyloid beta. |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
CN102325765B (zh) | 2009-02-06 | 2014-12-24 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的双环杂环化合物 |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
EP2401276B1 (en) * | 2009-02-26 | 2013-06-05 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
CN102439005B (zh) | 2009-05-07 | 2015-07-22 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的吲唑和氮杂-吲唑衍生物 |
WO2010140339A1 (ja) * | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
CN102482276A (zh) * | 2009-07-13 | 2012-05-30 | 武田药品工业株式会社 | 杂环化合物及其用途 |
KR20120050450A (ko) * | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
TWI468402B (zh) * | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β-類澱粉生成之化合物 |
US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
US9145399B2 (en) | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
TW201206946A (en) * | 2010-07-15 | 2012-02-16 | Bristol Myers Squibb Co | Compounds for the reduction of beta-amyloid production |
IN2013CN01326A (es) * | 2010-07-22 | 2015-04-24 | Kowa Co | |
MA34556B1 (fr) | 2010-09-02 | 2013-09-02 | Takeda Pharmaceutcal Company Ltd | Triazoles fusionnés pour le traitement ou la prophylaxie du trouble cognitif léger |
KR20140025326A (ko) * | 2011-01-07 | 2014-03-04 | 다이호야쿠힌고교 가부시키가이샤 | 신규 인돌, 인다졸 유도체 또는 그 염 |
AU2012204651A1 (en) | 2011-01-07 | 2013-08-01 | Taiho Pharmaceutical Co., Ltd. | Novel bicyclic compound or salt thereof |
AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
IN2014MN00258A (es) * | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc | |
EP2755976B1 (en) | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
US9096582B2 (en) | 2011-10-31 | 2015-08-04 | Merck Sharp & Dohme Corp | Gamma secretase modulators |
JP6106745B2 (ja) | 2012-05-16 | 2017-04-05 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | (特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体 |
EP2687528A1 (en) * | 2012-07-17 | 2014-01-22 | Ares Trading S.A. | Fused triazole derivatives as gamma secretase modulators |
EP2914597B1 (en) * | 2012-10-31 | 2017-12-06 | RaQualia Pharma Inc | Pyrazolopyridine derivatives as ttx-s blockers |
CN104837839A (zh) | 2012-11-08 | 2015-08-12 | 辉瑞公司 | 作为多巴胺d1配体的杂芳族化合物 |
US20150291625A1 (en) | 2012-11-08 | 2015-10-15 | Pfizer Inc. | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands |
US10112943B2 (en) | 2012-12-20 | 2018-10-30 | Janssen Pharmaceutica Nv | Substituted imidazoles as gamma secretase modulators |
AU2014206834B2 (en) | 2013-01-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
JP2016540024A (ja) * | 2013-12-12 | 2016-12-22 | チョン クン ダン ファーマシューティカル コーポレーション | 新規な選択的ヒストン脱アセチル化酵素阻害剤としてのアザインドール誘導体およびこれを含む薬剤学的組成物 |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
NZ736055A (en) * | 2015-04-29 | 2023-05-26 | Janssen Pharmaceutica Nv | Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators |
MX2017013886A (es) | 2015-04-29 | 2018-03-12 | Janssen Pharmaceutica Nv | Azabenzimidazoles y su uso como moduladores del receptor ampa. |
TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗rsv活性之吡唑并嘧啶 |
SG11202006141RA (en) | 2018-01-31 | 2020-07-29 | Janssen Sciences Ireland Unlimited Co | Cycloalkyl substituted pyrazolopyrimidines having activity against rsv |
WO2019206828A1 (en) | 2018-04-23 | 2019-10-31 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against rsv |
US20220048987A1 (en) * | 2020-08-13 | 2022-02-17 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treatment to prevent or reverse age-associated inflammation, cognitive decline, and neurodegeneration |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5026712A (en) * | 1985-06-05 | 1991-06-25 | Schering Ag | Novel imidazo[1,5-a]pyridines, useful as cardiovascular and CNS agents |
US4937258A (en) * | 1989-09-12 | 1990-06-26 | Berlex Laboratories, Inc. | Pyrrolo[1,2-c]imidazolone derivatives as PDE inhibitors |
EP1603548A4 (en) | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS |
BRPI0410348A (pt) * | 2003-05-14 | 2006-05-30 | Torreypines Therapeutics Inc | compostos e usos dos mesmos na modulação de amilóide-beta |
KR20060040676A (ko) * | 2003-07-11 | 2006-05-10 | 미리어드 제네틱스, 인크. | 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형 |
WO2005063756A1 (en) | 2003-12-22 | 2005-07-14 | Sb Pharmco Puerto Rico Inc | Crf receptor antagonists and methods relating thereto |
US20070293538A1 (en) | 2004-04-13 | 2007-12-20 | Myriad Genetics, Incorporated | Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders |
MY149038A (en) * | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
EP1650183A1 (en) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
-
2008
- 2008-12-04 MX MX2010006243A patent/MX2010006243A/es not_active Application Discontinuation
- 2008-12-04 AU AU2008333865A patent/AU2008333865A1/en not_active Abandoned
- 2008-12-04 US US12/746,041 patent/US8450343B2/en not_active Expired - Fee Related
- 2008-12-04 WO PCT/US2008/085515 patent/WO2009073777A1/en active Application Filing
- 2008-12-04 EP EP08856462A patent/EP2229381A1/en not_active Withdrawn
- 2008-12-04 KR KR1020107014784A patent/KR20100094554A/ko not_active Application Discontinuation
- 2008-12-04 JP JP2010537047A patent/JP2011506335A/ja not_active Withdrawn
- 2008-12-04 CN CN2008801266240A patent/CN101939315A/zh active Pending
- 2008-12-04 CA CA2707712A patent/CA2707712A1/en not_active Abandoned
- 2008-12-05 TW TW097147548A patent/TW200930366A/zh unknown
- 2008-12-05 PE PE2008002022A patent/PE20091095A1/es not_active Application Discontinuation
- 2008-12-05 AR ARP080105315A patent/AR069635A1/es not_active Application Discontinuation
-
2010
- 2010-06-03 IL IL206172A patent/IL206172A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2010006243A (es) | 2010-08-31 |
AR069635A1 (es) | 2010-02-10 |
AU2008333865A1 (en) | 2009-06-11 |
CN101939315A (zh) | 2011-01-05 |
TW200930366A (en) | 2009-07-16 |
US8450343B2 (en) | 2013-05-28 |
CA2707712A1 (en) | 2009-06-11 |
AU2008333865A2 (en) | 2010-07-29 |
KR20100094554A (ko) | 2010-08-26 |
JP2011506335A (ja) | 2011-03-03 |
US20110015190A1 (en) | 2011-01-20 |
WO2009073777A1 (en) | 2009-06-11 |
IL206172A0 (en) | 2010-12-30 |
EP2229381A1 (en) | 2010-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |