TR200402656T4 - Antikanser ajanları olarak faydalı tiyofen türevleri - Google Patents
Antikanser ajanları olarak faydalı tiyofen türevleriInfo
- Publication number
- TR200402656T4 TR200402656T4 TR2004/02656T TR200402656T TR200402656T4 TR 200402656 T4 TR200402656 T4 TR 200402656T4 TR 2004/02656 T TR2004/02656 T TR 2004/02656T TR 200402656 T TR200402656 T TR 200402656T TR 200402656 T4 TR200402656 T4 TR 200402656T4
- Authority
- TR
- Turkey
- Prior art keywords
- anticancer agents
- derivatives useful
- thiophene derivatives
- formula
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Bulus, formül (1) bilesikleri veya bunlarin farmasötik açidan kabul gören bir tuzu ve farmasötik açidan kabul gören tuzlari ve hidratlari ile ilgilidir; buradaki X,Y,R1,R2 ve R11, burada tanimlandigi gibidir. Bulus ayrica formül (1) bilesikleri içeren farmasötik kompozisyonlarla ve bir memelide hiperproliferatif bozukluklarin formül (1) bilesikleri uygulanarak tedavi edilmesine yönelik metotlarla da ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20968600P | 2000-06-06 | 2000-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200402656T4 true TR200402656T4 (tr) | 2004-11-22 |
Family
ID=22779830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/02656T TR200402656T4 (tr) | 2000-06-06 | 2001-05-02 | Antikanser ajanları olarak faydalı tiyofen türevleri |
Country Status (22)
Country | Link |
---|---|
US (1) | US6964961B2 (tr) |
EP (1) | EP1287001B1 (tr) |
JP (1) | JP2003535867A (tr) |
AR (1) | AR032621A1 (tr) |
AT (1) | ATE277933T1 (tr) |
AU (1) | AU2001252463A1 (tr) |
BR (1) | BR0111377A (tr) |
CA (1) | CA2411084A1 (tr) |
DE (1) | DE60106022T2 (tr) |
DO (1) | DOP2001000170A (tr) |
EC (1) | ECSP014097A (tr) |
ES (1) | ES2223827T3 (tr) |
GT (1) | GT200100104A (tr) |
MX (1) | MXPA02012034A (tr) |
PA (1) | PA8518701A1 (tr) |
PE (1) | PE20011373A1 (tr) |
PT (1) | PT1287001E (tr) |
SV (1) | SV2002000478A (tr) |
TN (1) | TNSN01082A1 (tr) |
TR (1) | TR200402656T4 (tr) |
UY (1) | UY26750A1 (tr) |
WO (1) | WO2001094353A1 (tr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0012046A (pt) * | 1999-07-01 | 2002-05-14 | Ajinomoto Kk | Composto heterocìclico, composição farmacêutica, inibidor de ativação de ap-1 ou um inibidor da ativação de nf-kappab, inibidor da produção de citocina inflamatória, e, inibidor da produção de metaloprotease de matriz ou inibidor da expressão do fator de adesão de célula inflamatória |
EP1311500A2 (en) * | 2000-08-09 | 2003-05-21 | AstraZeneca AB | Indole, azaindole and indazole derivatives having vegf inhibiting activity |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
US7101898B2 (en) | 2002-02-01 | 2006-09-05 | Novo Nordisk A/S | Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes |
RU2366652C2 (ru) * | 2002-02-01 | 2009-09-10 | ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Амиды аминоалкилзамещенных азетидинов, пирролидинов, пиперидинов и азепанов |
JP2005527511A (ja) | 2002-03-01 | 2005-09-15 | ファイザー インコーポレイテッド | 抗血管形成剤として有用なチエノピリジンのインドリル−尿素誘導体およびその使用法 |
EP1513516B1 (en) * | 2002-06-06 | 2008-12-03 | Boehringer Ingelheim Pharmaceuticals Inc. | SUBSTITUTED 3-AMINO-THIENO(2,3-b) PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES |
UA77303C2 (en) * | 2002-06-14 | 2006-11-15 | Pfizer | Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use |
US7488823B2 (en) * | 2003-11-10 | 2009-02-10 | Array Biopharma, Inc. | Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors |
CL2003002287A1 (es) * | 2002-11-25 | 2005-01-14 | Wyeth Corp | COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS |
US7276519B2 (en) * | 2002-11-25 | 2007-10-02 | Wyeth | Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors |
CL2004000398A1 (es) | 2003-02-27 | 2005-03-18 | Uriach Y Compania S A J | Compuestos derivados de pirazolopiridinas, sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades mediadas por quinasas p38, en especial por citocinas, tnf-alfa, il-1, il-6 y/o il-8, tales como enfermedad |
EP1620094A4 (en) * | 2003-05-06 | 2010-04-28 | Glaxosmithkline Llc | NEW CHEMICAL COMPOUNDS |
US7501427B2 (en) | 2003-08-14 | 2009-03-10 | Array Biopharma, Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
CN102432552B (zh) | 2003-08-14 | 2016-01-20 | 阿雷生物药品公司 | 作为受体酪氨酸激酶抑制剂的喹唑啉类似物 |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
TW200538453A (en) | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
US7432373B2 (en) | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
US7772247B2 (en) | 2004-07-30 | 2010-08-10 | Methylgene Inc. | Substituted thieno[3,2-d]pyridines as inhibitors of the VEGF receptor and HGF receptor |
MX2007014616A (es) | 2005-05-20 | 2009-08-12 | Methylgene Inc | Inhibidores de señalizacion del receptor del factor a de crecimiento endotelial vascular y del receptor del factor de crecimiento de hepatocitos. |
MX2007014617A (es) | 2005-05-20 | 2008-02-11 | Methylgene Inc | Inhibidores de senalizacion de receptor de factor de crecimiento endotelial bascular y receptor de factor de crecimiento de hepatocitos. |
WO2007035428A1 (en) | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
AR056200A1 (es) * | 2005-09-27 | 2007-09-26 | Wyeth Corp | Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa |
US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
ES2364901T3 (es) * | 2005-11-15 | 2011-09-16 | Array Biopharma, Inc. | Procesos e intermedios para la preparación de derivados de n4-fenil-quinazolin-4-amina. |
JP2009526761A (ja) * | 2006-01-30 | 2009-07-23 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環式チオフェン化合物および使用の方法 |
AU2008236670B2 (en) | 2007-04-05 | 2011-12-01 | Amgen Inc. | Aurora kinase modulators and method of use |
RU2498988C2 (ru) | 2008-03-05 | 2013-11-20 | Метилджин, Инк. | Ингибиторы активности протеинтирозинкиназы |
US8404694B2 (en) | 2008-03-20 | 2013-03-26 | Amgen Inc. | Aurora kinase modulators and method of use |
WO2010019473A1 (en) | 2008-08-14 | 2010-02-18 | Amgen Inc. | Aurora kinase modulators and methods of use |
PL2540297T3 (pl) | 2008-11-19 | 2015-12-31 | Forum Pharmaceuticals Inc | Leczenie zaburzeń funkcji poznawczych(R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidem i jego farmaceutyczne dopuszczalnymi solami |
BRPI1014793A2 (pt) * | 2009-05-11 | 2016-04-05 | Envivo Pharmaceuticals Inc | tratamento de distúrbios de cognição com determinados receptores de ácido alfa-7-nicotínico em combinação com inibidores de acetil-colinesterase |
PL3029039T3 (pl) | 2010-05-17 | 2018-04-30 | Forum Pharmaceuticals Inc. | Formulacje farmaceutyczne zawierające postacie krystaliczne jednowodnego chlorowodorku (R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidu |
AU2013259871A1 (en) | 2012-05-08 | 2014-11-20 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
FR3080620B1 (fr) * | 2018-04-27 | 2021-11-12 | Univ Paris Sud | Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices |
CN113648307B (zh) * | 2021-09-23 | 2022-09-30 | 河南大学 | MII-tt-DTT及其在制备抗结直肠癌药物中的应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3277623D1 (en) | 1981-07-31 | 1987-12-17 | Sloan Kettering Inst Cancer | Anti-leukemic beta-glycosyl c-nucleosides |
EP0364598A4 (en) | 1988-03-02 | 1992-01-15 | Yoshitomi Pharmaceutical Industries, Ltd. | 3,4-dihydrothieno 2,3-d¨pyrimidine compounds and pharmaceutical application thereof |
JPH02256667A (ja) * | 1988-12-27 | 1990-10-17 | Masatoshi Yamato | 縮合キノリン系化合物およびその製造方法 |
BR9101256A (pt) | 1990-03-30 | 1991-11-05 | Dowelanco | Composto,composicao fungicida,processo fungicida,composicao inseticida ou acaricida e processo inseticida ou acaricida |
US5187168A (en) | 1991-10-24 | 1993-02-16 | American Home Products Corporation | Substituted quinazolines as angiotensin II antagonists |
US5583137A (en) | 1992-02-19 | 1996-12-10 | Pfizer Inc. | Heterocyclic compounds for enhancing antitumor activity |
US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
PT831829E (pt) | 1995-06-07 | 2003-12-31 | Pfizer | Derivados de pirimidina heterociclicos de aneis fundidos |
AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
ATE243697T1 (de) | 1995-12-08 | 2003-07-15 | Pfizer | Substitutierte heterozyclische derivate als crf antagonisten |
DE69708059T2 (de) | 1996-02-07 | 2002-07-18 | Janssen Pharmaceutica Nv | Thiophenopyrimidine |
KR20000057228A (ko) | 1996-11-27 | 2000-09-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 축합된 비사이클릭 피리미딘 유도체 |
ZA986729B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
HUP0100287A3 (en) * | 1997-11-11 | 2003-04-28 | Pfizer Prod Inc | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
-
2001
- 2001-05-02 AT AT01925786T patent/ATE277933T1/de not_active IP Right Cessation
- 2001-05-02 MX MXPA02012034A patent/MXPA02012034A/es active IP Right Grant
- 2001-05-02 PT PT01925786T patent/PT1287001E/pt unknown
- 2001-05-02 ES ES01925786T patent/ES2223827T3/es not_active Expired - Lifetime
- 2001-05-02 JP JP2002501902A patent/JP2003535867A/ja active Pending
- 2001-05-02 AU AU2001252463A patent/AU2001252463A1/en not_active Abandoned
- 2001-05-02 EP EP01925786A patent/EP1287001B1/en not_active Expired - Lifetime
- 2001-05-02 BR BR0111377-1A patent/BR0111377A/pt not_active IP Right Cessation
- 2001-05-02 CA CA002411084A patent/CA2411084A1/en not_active Abandoned
- 2001-05-02 TR TR2004/02656T patent/TR200402656T4/tr unknown
- 2001-05-02 DE DE60106022T patent/DE60106022T2/de not_active Expired - Fee Related
- 2001-05-02 WO PCT/IB2001/000766 patent/WO2001094353A1/en active IP Right Grant
- 2001-05-23 DO DO2001000170A patent/DOP2001000170A/es unknown
- 2001-06-01 PE PE2001000510A patent/PE20011373A1/es not_active Application Discontinuation
- 2001-06-04 AR ARP010102655A patent/AR032621A1/es unknown
- 2001-06-04 US US09/873,555 patent/US6964961B2/en not_active Expired - Fee Related
- 2001-06-05 SV SV2001000478A patent/SV2002000478A/es not_active Application Discontinuation
- 2001-06-05 GT GT200100104A patent/GT200100104A/es unknown
- 2001-06-05 UY UY26750A patent/UY26750A1/es not_active Application Discontinuation
- 2001-06-05 EC EC2001004097A patent/ECSP014097A/es unknown
- 2001-06-05 TN TNTNSN01082A patent/TNSN01082A1/fr unknown
- 2001-06-06 PA PA20018518701A patent/PA8518701A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE60106022D1 (de) | 2004-11-04 |
EP1287001B1 (en) | 2004-09-29 |
DOP2001000170A (es) | 2002-05-15 |
US20020042409A1 (en) | 2002-04-11 |
DE60106022T2 (de) | 2006-03-09 |
ES2223827T3 (es) | 2005-03-01 |
PE20011373A1 (es) | 2002-01-18 |
CA2411084A1 (en) | 2001-12-13 |
BR0111377A (pt) | 2003-06-03 |
AU2001252463A1 (en) | 2001-12-17 |
MXPA02012034A (es) | 2003-04-25 |
EP1287001A1 (en) | 2003-03-05 |
WO2001094353A1 (en) | 2001-12-13 |
ECSP014097A (es) | 2003-02-06 |
US6964961B2 (en) | 2005-11-15 |
UY26750A1 (es) | 2002-01-31 |
ATE277933T1 (de) | 2004-10-15 |
JP2003535867A (ja) | 2003-12-02 |
TNSN01082A1 (fr) | 2005-11-10 |
PA8518701A1 (es) | 2002-09-17 |
SV2002000478A (es) | 2002-07-03 |
GT200100104A (es) | 2002-01-31 |
PT1287001E (pt) | 2004-12-31 |
AR032621A1 (es) | 2003-11-19 |
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