TNSN01082A1 - Derives de thiophene nouveaux, procede pour leur preparation et compositions les contenant - Google Patents

Derives de thiophene nouveaux, procede pour leur preparation et compositions les contenant

Info

Publication number
TNSN01082A1
TNSN01082A1 TNTNSN01082A TNSN01082A TNSN01082A1 TN SN01082 A1 TNSN01082 A1 TN SN01082A1 TN TNSN01082 A TNTNSN01082 A TN TNSN01082A TN SN01082 A TNSN01082 A TN SN01082A TN SN01082 A1 TNSN01082 A1 TN SN01082A1
Authority
TN
Tunisia
Prior art keywords
preparation
compositions containing
compounds
thiophene derivatives
novel thiophene
Prior art date
Application number
TNTNSN01082A
Other languages
English (en)
Inventor
Joseph Luzzio Michael
Arnold Marx Matthew
Vera Yang Bingwei
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN01082A1 publication Critical patent/TNSN01082A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE I : DANS LAQUELLE X ET Y REPRESENTENT N OU UN RADICAL ORGANIQUE, R1 REPRESENTE H OU UN RADICAL ORGANIQUE, R2 REPRESENTE UN GROUPE HETEROCYCLIQUE DE 5 A 13 ATOMES, ET R11 REPRESENTE UN RADICAL ORGANIQUE. ELLE CONCERNE EGALEMENT DES COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITS COMPOSES ET DES PROCEDES POUR LA PREPARATION DE CES COMPOSES. APPLICATION : TRAITEMENT DE TROUBLES HYPERPROLIFERATIFS CHEZ UN MAMMIFERE PAR ADMINISTRATION DESDITS COMPOSES OU DESDITES COMPOSITIONS.
TNTNSN01082A 2000-06-06 2001-06-05 Derives de thiophene nouveaux, procede pour leur preparation et compositions les contenant TNSN01082A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20968600P 2000-06-06 2000-06-06

Publications (1)

Publication Number Publication Date
TNSN01082A1 true TNSN01082A1 (fr) 2005-11-10

Family

ID=22779830

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN01082A TNSN01082A1 (fr) 2000-06-06 2001-06-05 Derives de thiophene nouveaux, procede pour leur preparation et compositions les contenant

Country Status (22)

Country Link
US (1) US6964961B2 (fr)
EP (1) EP1287001B1 (fr)
JP (1) JP2003535867A (fr)
AR (1) AR032621A1 (fr)
AT (1) ATE277933T1 (fr)
AU (1) AU2001252463A1 (fr)
BR (1) BR0111377A (fr)
CA (1) CA2411084A1 (fr)
DE (1) DE60106022T2 (fr)
DO (1) DOP2001000170A (fr)
EC (1) ECSP014097A (fr)
ES (1) ES2223827T3 (fr)
GT (1) GT200100104A (fr)
MX (1) MXPA02012034A (fr)
PA (1) PA8518701A1 (fr)
PE (1) PE20011373A1 (fr)
PT (1) PT1287001E (fr)
SV (1) SV2002000478A (fr)
TN (1) TNSN01082A1 (fr)
TR (1) TR200402656T4 (fr)
UY (1) UY26750A1 (fr)
WO (1) WO2001094353A1 (fr)

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DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US7101898B2 (en) 2002-02-01 2006-09-05 Novo Nordisk A/S Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
CA2473468C (fr) * 2002-02-01 2011-06-21 Novo Nordisk A/S Amides d'azetidines, de pyrrolidines, de piperidines et d'azepanes aminoalkyle substitues
MXPA04008403A (es) 2002-03-01 2004-11-26 Pfizer Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso.
WO2003103661A1 (fr) * 2002-06-06 2003-12-18 Boehringer Ingelheim Pharmaceuticals, Inc. COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIQUE SUBSTITUES ET PROCESSUS DE PREPARATION ET D'UTILISATION DE CES COMPOSES
UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7488823B2 (en) 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
CL2003002287A1 (es) * 2002-11-25 2005-01-14 Wyeth Corp COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
US7276519B2 (en) 2002-11-25 2007-10-02 Wyeth Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
AU2004215644B2 (en) 2003-02-27 2010-09-02 Palau Pharma, S.A. Pyrazolopyridine derivates
US7592352B2 (en) * 2003-05-06 2009-09-22 Smithkline Beecham Corporation Substituted thieno and furo-pyridines
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
DK1660090T3 (da) 2003-08-14 2012-12-17 Array Biopharma Inc Quinazolin-analoger som receptor-tyrosinkinase-inhibitorer
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
KR101257343B1 (ko) 2004-07-30 2013-04-23 메틸진 인코포레이티드 Ｖｅｇｆ 수용체 및 ｈｇｆ 수용체 신호전달 억제제
BRPI0610322B8 (pt) 2005-05-20 2021-05-25 Methylgene Inc inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica
ES2473341T3 (es) 2005-05-20 2014-07-04 Methylgene Inc Inhibidores de la se�alizaci�n del receptor del VEGF y del receptor del HGF
WO2007035428A1 (fr) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Inhibiteurs de la kinase met
AR056200A1 (es) * 2005-09-27 2007-09-26 Wyeth Corp Tieno [2,3-b]piridin-5-carbonitrilos como inhibidores de proteina quinasa
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
EP1971601B1 (fr) 2005-11-15 2009-10-21 Array Biopharma Inc. Derivés de la n4-phényl-quinazoline-4-amine et composés similaires en tant que inhibiteurs de la kinase tyrosine erbb type i pour le traitement de maladies hyperproliferatives
CA2636242A1 (fr) * 2006-01-30 2008-05-29 Array Biopharma, Inc. Composes heterobicycliques de thiophene et leurs methodes d'utilisation
WO2008124083A2 (fr) 2007-04-05 2008-10-16 Amgen Inc. Modulateurs de la kinase aurora et méthode d'utilisation
BRPI0923670A2 (pt) 2008-03-05 2013-07-30 Methylgene Inc inibidores da atividade de proteÍna tirosina quinase e seu uso, bem como composiÇço compreendendo os mesmos
WO2009117157A1 (fr) 2008-03-20 2009-09-24 Amgen Inc. Modulateurs d’aurora kinase et procédé d’utilisation
WO2010019473A1 (fr) 2008-08-14 2010-02-18 Amgen Inc. Modulateurs d’aurora kinase et procédés d'utilisation
CA3017886A1 (fr) 2008-11-19 2010-05-27 Envivo Pharmaceuticals, Inc. Traitement de troubles cognitifs par la (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide et les sels de qualite pharmaceutique de celle-ci
MX2011011972A (es) * 2009-05-11 2011-12-08 Envivo Pharmaceuticals Inc Tratamiento de trastornos cognitivos con determinados receptores de acido nicotinico alfa-7 en combinacion con inhibidores de acetilcolinesterasa.
DK3029039T3 (en) 2010-05-17 2017-12-04 Forum Pharmaceuticals Inc PHARMACEUTICAL FORMS CONTAINING CRYSTALLINIC FORMS OF (R) -7-CHLOR-N- (QUINUCLIDIN-3-YL) BENZO (B) THIOPHEN-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE
WO2013169646A1 (fr) 2012-05-08 2013-11-14 Envivo Pharmaceuticals, Inc. Procédés de maintien, de traitement ou d'amélioration de la fonction cognitive
FR3080620B1 (fr) * 2018-04-27 2021-11-12 Univ Paris Sud Composes a activite inhibitrice de la polymerisation de la tubuline et aux proprietes immunomodulatrices
CN113648307B (zh) * 2021-09-23 2022-09-30 河南大学 MII-tt-DTT及其在制备抗结直肠癌药物中的应用

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DE3277623D1 (en) 1981-07-31 1987-12-17 Sloan Kettering Inst Cancer Anti-leukemic beta-glycosyl c-nucleosides
EP0364598A4 (en) 1988-03-02 1992-01-15 Yoshitomi Pharmaceutical Industries, Ltd. 3,4-dihydrothieno 2,3-d¨pyrimidine compounds and pharmaceutical application thereof
JPH02256667A (ja) * 1988-12-27 1990-10-17 Masatoshi Yamato 縮合キノリン系化合物およびその製造方法
CA2039411A1 (fr) 1990-03-30 1991-10-01 Ronnie Gerald Edie Derives de la thienopyrimidine
US5187168A (en) 1991-10-24 1993-02-16 American Home Products Corporation Substituted quinazolines as angiotensin II antagonists
WO1993017021A1 (fr) 1992-02-19 1993-09-02 Pfizer, Inc. Composes heterocycliques ameliorant l'activite antitumorale
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
CA2223081C (fr) 1995-06-07 2001-03-06 Pfizer Inc. Derives de pyrimidine heterocycliques a noyaux condenses
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
ATE243697T1 (de) 1995-12-08 2003-07-15 Pfizer Substitutierte heterozyclische derivate als crf antagonisten
PT882051E (pt) 1996-02-07 2002-04-29 Janssen Pharmaceutica Nv Tiofenopirimidinas
IL129825A0 (en) 1996-11-27 2000-02-29 Pfizer Fused bicyclic pyrimidine derivatives
ZA986729B (en) * 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
EP1028964A1 (fr) * 1997-11-11 2000-08-23 Pfizer Products Inc. Derives de thienopyrimidine et thienopyridine utiles comme agents anticancereux

Also Published As

Publication number Publication date
AR032621A1 (es) 2003-11-19
EP1287001A1 (fr) 2003-03-05
MXPA02012034A (es) 2003-04-25
WO2001094353A1 (fr) 2001-12-13
ATE277933T1 (de) 2004-10-15
DOP2001000170A (es) 2002-05-15
PE20011373A1 (es) 2002-01-18
US20020042409A1 (en) 2002-04-11
PA8518701A1 (es) 2002-09-17
UY26750A1 (es) 2002-01-31
CA2411084A1 (fr) 2001-12-13
DE60106022D1 (de) 2004-11-04
TR200402656T4 (tr) 2004-11-22
DE60106022T2 (de) 2006-03-09
ECSP014097A (es) 2003-02-06
JP2003535867A (ja) 2003-12-02
GT200100104A (es) 2002-01-31
EP1287001B1 (fr) 2004-09-29
BR0111377A (pt) 2003-06-03
PT1287001E (pt) 2004-12-31
ES2223827T3 (es) 2005-03-01
AU2001252463A1 (en) 2001-12-17
SV2002000478A (es) 2002-07-03
US6964961B2 (en) 2005-11-15

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