BRPI0517792A - macrolonas - quinolonas amino-substituìdas - Google Patents

macrolonas - quinolonas amino-substituìdas

Info

Publication number
BRPI0517792A
BRPI0517792A BRPI0517792-8A BRPI0517792A BRPI0517792A BR PI0517792 A BRPI0517792 A BR PI0517792A BR PI0517792 A BRPI0517792 A BR PI0517792A BR PI0517792 A BRPI0517792 A BR PI0517792A
Authority
BR
Brazil
Prior art keywords
macrolones
amino substituted
substituted quinolones
quinolones
quinolonas
Prior art date
Application number
BRPI0517792-8A
Other languages
English (en)
Inventor
Desmond John Best
John Stephen Elder
Andrea Fajdetic
Andrew Keith Forrest
Robert John Sheppard
Original Assignee
Glaxosmithkline Zagreb
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb, Glaxo Group Ltd filed Critical Glaxosmithkline Zagreb
Publication of BRPI0517792A publication Critical patent/BRPI0517792A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

MACROLONAS - QUINOLONAS AMINO-SUBSTITUìDAS. São propostos compostos da fórmula (I) ou derivados seus farmaceuticamente aceitáveis tendo atividade anti-microbiana, assim como processos para a sua preparação, composições que os contêm e seus usos em medicina.
BRPI0517792-8A 2004-11-11 2005-11-09 macrolonas - quinolonas amino-substituìdas BRPI0517792A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0424959A GB0424959D0 (en) 2004-11-11 2004-11-11 Novel compounds
PCT/EP2005/012038 WO2006050942A1 (en) 2004-11-11 2005-11-09 Macrolones - amino substituted quinolones

Publications (1)

Publication Number Publication Date
BRPI0517792A true BRPI0517792A (pt) 2008-10-21

Family

ID=33523587

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517792-8A BRPI0517792A (pt) 2004-11-11 2005-11-09 macrolonas - quinolonas amino-substituìdas

Country Status (19)

Country Link
US (2) US7718621B2 (pt)
EP (1) EP1824870A1 (pt)
JP (1) JP2008519788A (pt)
KR (1) KR20070085919A (pt)
CN (1) CN101098881A (pt)
AR (1) AR053311A1 (pt)
AU (1) AU2005303961A1 (pt)
BR (1) BRPI0517792A (pt)
CA (1) CA2587413A1 (pt)
GB (1) GB0424959D0 (pt)
IL (1) IL182978A0 (pt)
MA (1) MA29213B1 (pt)
MX (1) MX2007005776A (pt)
NO (1) NO20072939L (pt)
PE (1) PE20061137A1 (pt)
RU (1) RU2007121581A (pt)
TW (1) TW200630378A (pt)
WO (1) WO2006050942A1 (pt)
ZA (1) ZA200703603B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
EP1879904A1 (en) * 2005-05-10 2008-01-23 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 4" amino linked macrolides useful for the treatment of microbial infections
WO2007054296A1 (en) * 2005-11-09 2007-05-18 Glaxo Group Limited Macrolones
PE20070802A1 (es) * 2005-11-09 2007-10-19 Glaxo Group Ltd Derivados de eritromicina 4''-sustituidos como agentes antimicrobianos
EP2201010B1 (en) 2007-09-14 2013-11-06 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
CN102245195B (zh) 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
AU2011255464C1 (en) 2010-05-20 2017-02-23 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
EP2830632A4 (en) 2012-03-27 2015-10-21 Cempra Pharmaceuticals Inc PARENTERAL FORMULATIONS FOR THE ADMINISTRATION OF MACROLIDE ANTIBIOTICS
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN106589023A (zh) * 2016-11-22 2017-04-26 宜昌东阳光药业股份有限公司 一种罗红霉素杂质及其合成方法
WO2018178041A1 (en) 2017-03-30 2018-10-04 F. Hoffmann-La Roche Ag Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
GB0127349D0 (en) * 2001-11-14 2002-01-02 Glaxo Group Ltd Macrolides
GB0225384D0 (en) 2002-10-31 2002-12-11 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
EP1824870A1 (en) 2007-08-29
RU2007121581A (ru) 2008-12-20
IL182978A0 (en) 2007-08-19
JP2008519788A (ja) 2008-06-12
WO2006050942A1 (en) 2006-05-18
PE20061137A1 (es) 2006-12-13
KR20070085919A (ko) 2007-08-27
US20080090773A1 (en) 2008-04-17
NO20072939L (no) 2007-08-08
MX2007005776A (es) 2007-07-16
GB0424959D0 (en) 2004-12-15
CN101098881A (zh) 2008-01-02
ZA200703603B (en) 2008-07-30
US20080269146A1 (en) 2008-10-30
AU2005303961A1 (en) 2006-05-18
TW200630378A (en) 2006-09-01
CA2587413A1 (en) 2006-05-18
MA29213B1 (fr) 2008-02-01
AR053311A1 (es) 2007-05-02
US7718621B2 (en) 2010-05-18

Similar Documents

Publication Publication Date Title
BRPI0517792A (pt) macrolonas - quinolonas amino-substituìdas
ECSP045519A (es) Nuevos derivados de quinuclidina-amida
ECSP056194A (es) Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de quinasa
BRPI0508540A (pt) composto, composição farmacêutica, e, uso de um composto
BRPI0413427A (pt) derivados de piridilpirrol ativos como inibidores da cinase
NO20091893L (no) Nye 1,4-benzotiepin-1,1-dioksidderivater som er substituert med benzylgrupper, fremgangsmater for fremstilling av medisiner inneholdende forbindelsene og anvendelse derav.
UY30759A1 (es) Compuestos quimicos
DK2324008T3 (da) Diarylpyrazol som protein kinase inhibitorer
BR0312464A (pt) Inibidores de tirosina quinases
ATE514699T1 (de) Substituierte pyrrolopyrazolderivate als kinaseinhibitoren
BR122019010008B8 (pt) derivados de pirimidina, seu uso, e composição e combinação farmacêuticas
EA201070167A1 (ru) Замещенные производные индазола, активные как ингибиторы киназы
CU23208A3 (es) Oxazolidinonas sustituidas y su uso en el campo de la coagulacion sanguinea
ATE452129T1 (de) N-phenyl-2-pyrimidine-amine derivatives
BRPI0821004A8 (pt) Composto derivado de aminopirazol, composição farmacêutica que o contem e uso deste
BRPI0713132B8 (pt) compostos derivados de cinamoil-piperazina, método de preparação dos referidos compostos, composições farmacêuticas, seus usos como antagonistas de par-i e produtos
BRPI0519398A2 (pt) compostos de piridina para o tratamento de doenÇas mediadas por prostaglandina
NO20085087L (no) Nye heterocykliske forbindelser
BRPI0512986A (pt) novos derivados de hidantoìna
BRPI0413094A (pt) derivados de quinolina e seu uso em terapia
BRPI0519351A2 (pt) medicamentos para o tratamento ou prevenÇço de doenÇas fibràticas
UY29892A1 (es) Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
BRPI0414780A (pt) composto, uso do mesmo, composição farmacêutica, e, métodos para a terapia da dor em um animal de sangue quente, e para preparar um composto
SE0301701D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0301699D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.