ES2438509T3 - Inhibidores de la esfingosina quinasa - Google Patents

Inhibidores de la esfingosina quinasa Download PDF

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ES2438509T3
ES2438509T3 ES10782202.5T ES10782202T ES2438509T3 ES 2438509 T3 ES2438509 T3 ES 2438509T3 ES 10782202 T ES10782202 T ES 10782202T ES 2438509 T3 ES2438509 T3 ES 2438509T3
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atoms
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nr18r18
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Frank Stieber
Dirk Wienke
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

Compuestos según la fórmula (I) en la que representan, independiente entre sí: R1, R2, R3, R4, R5, R6 , R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 H, D (Deuterio), A, OR18, CN, F, Cl y NR18R18'; donde R1 y R2, R3 y R4, R5 y R6, R10 y R11, R12 y R13, R14 y R15, R16 y R17 pueden formar en cada casotambién >=O (oxígeno carbonílico); donde R9 y R1, R1 y R2, R2 y R3, R3 y R4, R4 y R5, R5 y R6, R6 y R7, R7 y R8, R10 y R11, R11 y R12, R12 y R13 ,R14 y R15, R15 y R16, R16 y R17 pueden formar en cada caso también alquilos cíclicos con 3, 4, 5, 6 o 7átomos de C o Het con 3, 4, 5, 6 o 7 átomos en el anillo; donde R10 y R19, si Y1 >= CR19, R11 y R12, R13 y R19, si Y2 >= CR19, R14 y R19, si Y1 >= CR19, R15 y R16, R17 yR19, si Y2 >= CR19 pueden formar en cada caso también con el enlace sencillo y los átomos de C a los quese unen, un doble enlace C>=C; R18, R18' H, D o A; R19, R19' H, D, A, OR18, NR18R18', F, Cl, Br, CN o Het; M1, M2, M3, M4 CR19 o N; Y1, Y2 CR19 o N; V C(R19)(R19'), NR19 o está ausente; W [C(R19)(R19')]pZ, CO-[C(R19)(R19')]pZ, [C(R19)(R19')]pN(R19)-Z, CO-N(R19)-[C(R19)(R19')]pZ, N(R19)-CO-[C(R19)(R19')]pZ, CO-O-[C(R19)(R19')]pZ, C(O)OR18, OR18, H o D; donde V, W y Y2 pueden estar formados en cada caso también por alquilo cíclico con 3, 4, 5, 6 o 7 átomos deC, pudiéndose sustituir preferentemente 1, 2, 3, 4, 5, 6 o 7 átomos de H por F, Cl, Br, CN y/o OH, OR19,OC(O)R19, NR19C(O)OZ, C(O)OR19, C(O)N(R19)(R19') o N(R19)(R19'25 ); o Het con 3, 4, 5, 6 o 7 átomos en elanillo, en el que Het representa preferentemente un heterociclo saturado, insaturado o aromático con 1 a4 átomos de N, O y/o S, que puede no estar sustituido o estarlo una, dos o tres veces por Hal, F, Cl, Br,CN, A, OR18, W, SR18, NO2, N(R19)(R19'), NR18COOZ, OCONHZ, NR18SO2Z, SO2N(R18)Z, S(O)mZ, COZ,CHO, COZ, >=S, >=NH, >=NA, Oxi (-O-) y/o >=O (oxígeno carbonílico); Z Het, Ar o A; A alquilo no ramificado o ramificado con 1, 2, 3, 4, 5, 6, 7, 8, 9 o 10 átomos de C, donde 1, 2, 3, 4, 5, 6 o 7átomos de H pueden estar sustituidos por F, Cl, Br, CN y/o OH, OR19, OC(O)R19, NR19C(O)OZ, C(O)OR19,C(O)N(R19)(R19') o N(R19)(R19'); y/o en el que uno o dos grupos CH2 pueden estar sustituidos por O, S, SO, SO2, CO, COO, NR18,NR18CO, CONR1835 , alquilo cíclico con 3, 4, 5, 6 o 7 átomos de C, CH>=CH y/o grupos CHºCH.
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