NO20090270L - Cinnamoyl-piperazinederivater og deres anvendelse som PAR-I-antagonister - Google Patents
Cinnamoyl-piperazinederivater og deres anvendelse som PAR-I-antagonisterInfo
- Publication number
- NO20090270L NO20090270L NO20090270A NO20090270A NO20090270L NO 20090270 L NO20090270 L NO 20090270L NO 20090270 A NO20090270 A NO 20090270A NO 20090270 A NO20090270 A NO 20090270A NO 20090270 L NO20090270 L NO 20090270L
- Authority
- NO
- Norway
- Prior art keywords
- par
- antagonists
- cinnamoyl
- halogen
- piperazine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Den foreliggende oppfinnelsen angår forbindelser med den generelle formel (I) hvor Ri representerer halogen, CN eller NO2, R2 representerer hydrogen eller halogen; n representerer 1 eller 2; R3 representerer fenyl substituert med ett eller flere halogenatomer eller Ci-C6-alkylgruppeer; eller en sykloheksylgruppe; så vel som de farmasøytisk akseptable saltene og solvatene av disse. Disse forbindelsene kan brukes som proteaseaktiverte reseptor-1 (par-1) antagonister, da spesielt ved behandlingen av trombose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0605419A FR2902426B1 (fr) | 2006-06-19 | 2006-06-19 | Derives de cinnamoyl-piperazine |
PCT/EP2007/056086 WO2007147824A1 (en) | 2006-06-19 | 2007-06-19 | Cinnamoyl-piperazine derivatives and their use as par- i antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20090270L true NO20090270L (no) | 2009-03-03 |
NO341389B1 NO341389B1 (no) | 2017-10-30 |
Family
ID=37846050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20090270A NO341389B1 (no) | 2006-06-19 | 2009-01-16 | Cinnamoyl-piperazinederivater og deres anvendelse som PAR-I-antagonister |
Country Status (32)
Country | Link |
---|---|
US (2) | US8217046B2 (no) |
EP (1) | EP2041104B1 (no) |
JP (1) | JP5356222B2 (no) |
KR (1) | KR101468752B1 (no) |
CN (1) | CN101472907B (no) |
AR (1) | AR061520A1 (no) |
AT (1) | ATE478059T1 (no) |
AU (1) | AU2007263051B2 (no) |
BR (1) | BRPI0713132B8 (no) |
CA (1) | CA2655527C (no) |
CR (1) | CR10509A (no) |
DE (1) | DE602007008572D1 (no) |
EC (1) | ECSP099065A (no) |
ES (1) | ES2349324T3 (no) |
FR (1) | FR2902426B1 (no) |
GE (1) | GEP20115201B (no) |
HK (1) | HK1127353A1 (no) |
IL (1) | IL195972A (no) |
MA (1) | MA30756B1 (no) |
MX (1) | MX2008016447A (no) |
MY (1) | MY144461A (no) |
NO (1) | NO341389B1 (no) |
NZ (1) | NZ573764A (no) |
PL (1) | PL2041104T3 (no) |
PT (1) | PT2041104E (no) |
RU (1) | RU2440997C2 (no) |
SA (1) | SA07280330B1 (no) |
TN (1) | TNSN08522A1 (no) |
TW (1) | TWI404710B (no) |
UA (1) | UA96947C2 (no) |
WO (1) | WO2007147824A1 (no) |
ZA (1) | ZA200900303B (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3014693B1 (fr) * | 2013-12-16 | 2016-01-08 | Pf Medicament | Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
US10028999B2 (en) | 2014-05-11 | 2018-07-24 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | PAR-1 based therapeutic conjugates and uses thereof |
WO2016066789A1 (fr) * | 2014-10-31 | 2016-05-06 | Pierre Fabre Medicament | Utilisation d'antagonistes par-1 pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
CN104496879A (zh) * | 2015-01-13 | 2015-04-08 | 佛山市赛维斯医药科技有限公司 | 一种含腈基苯和二烯氟代金刚烷结构的化合物和用途 |
CN104529860B (zh) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一种含硝基苯和二烯氟代金刚烷结构的化合物及制备方法 |
CN104496924B (zh) * | 2015-01-13 | 2016-04-13 | 佛山市赛维斯医药科技有限公司 | 卤苯二烯四氮唑类化合物、其制备方法和用途 |
CN104496922B (zh) * | 2015-01-13 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 腈基苯二烯四氮唑类化合物、其制备方法和用途 |
CN105949116A (zh) * | 2016-06-08 | 2016-09-21 | 青岛理工大学 | 酰基哌嗪类化合物及其制备方法和用途 |
EP3278802A1 (en) | 2016-08-04 | 2018-02-07 | Metabolys | New treatment for the non alcoholic steatohepatitis and fibrosis |
RU2662308C1 (ru) * | 2017-12-25 | 2018-07-25 | Феркат Адельзянович Халиуллин | Средство для лечения и профилактики тромбоза |
EP3787661B1 (en) | 2018-05-02 | 2023-10-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Combination of temozolomide and a par-1 conjugate for treating glioblastoma |
FR3090317B1 (fr) | 2018-12-19 | 2021-05-07 | Cvasthera | Utilisation d’un antagoniste de par-1 pour le traitement d’une maladie inflammatoire chronique intestinale |
KR20230046343A (ko) * | 2021-09-29 | 2023-04-06 | 주성수 | 피페론구민계 화합물을 유효성분으로 포함하는 혈관질환 예방 또는 치료용 약학적 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61106564A (ja) * | 1984-10-30 | 1986-05-24 | Terumo Corp | 不飽和脂肪酸アミド誘導体およびこれを含有する血小板凝集抑制剤 |
US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
WO2002076965A1 (en) * | 2001-03-23 | 2002-10-03 | John Matsoukas | Non peptide mimetics based on the active sequence s42fllr46 of the thrombin receptor for the treatment of thrombosis and cancer |
CN1775762A (zh) * | 2005-12-06 | 2006-05-24 | 山东大学 | 川芎嗪酰基哌嗪衍生物、制备方法和药物组合物与应用 |
FR2917622B1 (fr) * | 2007-06-19 | 2009-10-23 | Pierre Fabre Medicament Sa | Utilisation d'un antagoniste par1 dans le traitement de la fibrillation atriale. |
-
2006
- 2006-06-19 FR FR0605419A patent/FR2902426B1/fr not_active Expired - Fee Related
-
2007
- 2007-06-19 CN CN200780022674XA patent/CN101472907B/zh not_active Expired - Fee Related
- 2007-06-19 DE DE602007008572T patent/DE602007008572D1/de active Active
- 2007-06-19 ES ES07786761T patent/ES2349324T3/es active Active
- 2007-06-19 JP JP2009515860A patent/JP5356222B2/ja not_active Expired - Fee Related
- 2007-06-19 PL PL07786761T patent/PL2041104T3/pl unknown
- 2007-06-19 US US12/305,584 patent/US8217046B2/en active Active
- 2007-06-19 AR ARP070102685A patent/AR061520A1/es active IP Right Grant
- 2007-06-19 SA SA07280330A patent/SA07280330B1/ar unknown
- 2007-06-19 UA UAA200900373A patent/UA96947C2/ru unknown
- 2007-06-19 MY MYPI20085203A patent/MY144461A/en unknown
- 2007-06-19 AU AU2007263051A patent/AU2007263051B2/en not_active Ceased
- 2007-06-19 NZ NZ573764A patent/NZ573764A/en not_active IP Right Cessation
- 2007-06-19 WO PCT/EP2007/056086 patent/WO2007147824A1/en active Application Filing
- 2007-06-19 AT AT07786761T patent/ATE478059T1/de not_active IP Right Cessation
- 2007-06-19 EP EP07786761A patent/EP2041104B1/en active Active
- 2007-06-19 BR BRPI0713132A patent/BRPI0713132B8/pt not_active IP Right Cessation
- 2007-06-19 GE GEAP200711058A patent/GEP20115201B/en unknown
- 2007-06-19 KR KR1020097000946A patent/KR101468752B1/ko active IP Right Grant
- 2007-06-19 CA CA2655527A patent/CA2655527C/en not_active Expired - Fee Related
- 2007-06-19 MX MX2008016447A patent/MX2008016447A/es active IP Right Grant
- 2007-06-19 PT PT07786761T patent/PT2041104E/pt unknown
- 2007-06-19 RU RU2008152247/04A patent/RU2440997C2/ru active
- 2007-06-20 TW TW096122073A patent/TWI404710B/zh not_active IP Right Cessation
-
2008
- 2008-12-16 CR CR10509A patent/CR10509A/es unknown
- 2008-12-16 IL IL195972A patent/IL195972A/en active IP Right Grant
- 2008-12-16 TN TNP2008000522A patent/TNSN08522A1/en unknown
-
2009
- 2009-01-09 MA MA31560A patent/MA30756B1/fr unknown
- 2009-01-13 EC EC2009009065A patent/ECSP099065A/es unknown
- 2009-01-14 ZA ZA2009/00303A patent/ZA200900303B/en unknown
- 2009-01-16 NO NO20090270A patent/NO341389B1/no not_active IP Right Cessation
- 2009-08-05 HK HK09107160.0A patent/HK1127353A1/xx not_active IP Right Cessation
-
2012
- 2012-05-21 US US13/476,487 patent/US8513258B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20090270L (no) | Cinnamoyl-piperazinederivater og deres anvendelse som PAR-I-antagonister | |
NO20085060L (no) | Triazolpyrazinderivater anvendelige som anti-cancermidler | |
NO20091409L (no) | Pyridin-3-yl-derivater som immunmodulerende midler | |
NO20052493L (no) | Selekterte CGRP antagonister, fremgangsmater for fremstilling derav og deres anvendelse som farmasoytiske sammensetninger. | |
NO20072689L (no) | Tetrasykliske indolderivater som antivirale midler | |
NO20064166L (no) | Utvalgte CGRP-antagonister, deres fremstilling og deres anvendelse som medikanmenter | |
NO20076680L (no) | Utvalgte CGRP-antagonister, metoder for fremstilling av disse og deres anvendelse som medikamenter | |
IS8503A (is) | Azatvíhringja heteróhringir sem kannabínóníð-viðtakastillar | |
TW200606151A (en) | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions | |
GEP20125437B (en) | New sulfonamide derivatives as bradykinin antagonists | |
TW200800962A (en) | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | |
AR056321A1 (es) | COMBINACIONES TERAPÉUTICAS PARA EL TRATAMIENTO O LA PREVENCIoN DE TRASTORNOS PSICoTICOS | |
ATE553106T1 (de) | Heteroarylpyrrolopyridinone als kinaseinhibitoren | |
TW200833324A (en) | Sulfonamide derivatives | |
CY1113911T1 (el) | Παραγωγα sf5 ως αναστολεις par1, η παρασκευη τους και η χρηση τους ως φαρμακα | |
ATE476431T1 (de) | Piperidin- und azetidinderivate als glyt1- inhibitoren | |
NO20062533L (no) | 5-fluor, 5-klor- og cyanopyridin-2-yl-tetrazoler som ligander for den metabotrofe glutamatreseptor-5 | |
NO20072089L (no) | Benzimidazolderivater, sammensetninger som inneholder dem, fremstilling derav og anvendelse derav | |
NO20080110L (no) | Benzimidazolderivativer som 5-HT6,5-HT24 | |
NO20055749L (no) | Sulfamat benzotiofenderivater som steroid sulfatase inhibitorer | |
UY29012A1 (es) | "oxazolididonas y composiciones y metodos relacionados" | |
NO20064074L (no) | Pyrrolokinolin- og piperidinokinolinderivater, fremstilling derav, sammensetninger inneholdende disse og anvendelse derav | |
NO20062307L (no) | Spirofuropyridinarylderivater | |
NO20053876D0 (no) | Karbonylaminosubstituerte acylfenylurederivater, fremgangsmate for deres fremstilling samt anvendelse derav | |
NO20081529L (no) | Naftyridinderivater |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |