FR3014693B1 - Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales - Google Patents
Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perinealesInfo
- Publication number
- FR3014693B1 FR3014693B1 FR1362682A FR1362682A FR3014693B1 FR 3014693 B1 FR3014693 B1 FR 3014693B1 FR 1362682 A FR1362682 A FR 1362682A FR 1362682 A FR1362682 A FR 1362682A FR 3014693 B1 FR3014693 B1 FR 3014693B1
- Authority
- FR
- France
- Prior art keywords
- pelvi
- propenone
- piperazin
- fluoro
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Abstract
La présente invention concerne l'utilisation de la 3- (2-Chloro-phényl ) -1- [4- (4-fluoro-benzyl) -pipérazin-1-yl ] -propénone ou l'un de ses sels pharmaceutiquement acceptables pour la prévention et/ou le traitement des pathologies fonctionnelles pelvi-périnéales, notamment du syndrome de la vessie douloureuse.
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1362682A FR3014693B1 (fr) | 2013-12-16 | 2013-12-16 | Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
TN2016000196A TN2016000196A1 (fr) | 2013-12-16 | 2014-10-31 | Utilisation d'antagonistes par-1 pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales. |
AU2014365665A AU2014365665B2 (en) | 2013-12-16 | 2014-10-31 | Use of PAR-1 antagonists for preventing and/or treating pelvi-perineal functional pathological conditions |
US15/101,170 US9980970B2 (en) | 2013-12-16 | 2014-10-31 | Use of PAR-1 antagonists for preventing and/or treating pelvi-perineal functional pathological conditions |
UAA201607312A UA120603C2 (uk) | 2013-12-16 | 2014-10-31 | Застосування антагоністів, що активуються протеазою рецепторів 1 (par1), для профілактики та/або лікування функціональних патологічних станів в області таза і промежини |
MX2016007795A MX370061B (es) | 2013-12-16 | 2014-10-31 | Uso de antagonistas del par-1 para prevenir y/o tratar condiciones patologicas funcionales pelviperineales. |
MA39072A MA39072A1 (fr) | 2013-12-16 | 2014-10-31 | Utilisation d'antagonistes par-1 pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
CA2931161A CA2931161A1 (fr) | 2013-12-16 | 2014-10-31 | Utilisation d'antagonistes par-1 pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
RU2016127158A RU2678309C1 (ru) | 2013-12-16 | 2014-10-31 | Применение антагонистов активируемых протеазой рецепторов 1 (par-1) для профилактики и/или лечения функциональных патологических состояний в области таза и промежности |
KR1020167017262A KR20160089518A (ko) | 2013-12-16 | 2014-10-31 | 골반-회음부 기능의 병리학적 병태들을 예방하고/거나 치료하기 위한 par-1 길항제들의 용도 |
CN201480068095.9A CN105813642B (zh) | 2013-12-16 | 2014-10-31 | Par-1拮抗剂用于预防和/或治疗骨盆-会阴功能病状的用途 |
EP14793086.1A EP3082818A1 (fr) | 2013-12-16 | 2014-10-31 | Utilisation d'antagonistes par-1 pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
JP2016540042A JP6612233B2 (ja) | 2013-12-16 | 2014-10-31 | 骨盤・会陰部機能の病的状態を予防および/または治療するためのpar−1アンタゴニストの使用 |
PCT/EP2014/073453 WO2015090705A1 (fr) | 2013-12-16 | 2014-10-31 | Utilisation d'antagonistes par-1 pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
IL246216A IL246216A0 (en) | 2013-12-16 | 2016-06-14 | Use of par-1 antagonists for the prevention and/or treatment of functional and pathological conditions of the pelvic-perianal |
SA516371348A SA516371348B1 (ar) | 2013-12-16 | 2016-06-16 | استعمال مضادات par-1 للوقاية من و/أو علاج الحالات المرضيه الوظيفية لمنطقة الحوض والعِجان |
HK16110155.2A HK1221913A1 (zh) | 2013-12-16 | 2016-08-25 | 拮抗劑用於預防和/或治療骨盆-會陰功能病狀的用途 |
US15/962,837 US10265322B2 (en) | 2013-12-16 | 2018-04-25 | Use of PAR-1 antagonists for preventing and/or treating pelvi-perineal functional pathological conditions |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1362682A FR3014693B1 (fr) | 2013-12-16 | 2013-12-16 | Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3014693A1 FR3014693A1 (fr) | 2015-06-19 |
FR3014693B1 true FR3014693B1 (fr) | 2016-01-08 |
Family
ID=50424483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1362682A Expired - Fee Related FR3014693B1 (fr) | 2013-12-16 | 2013-12-16 | Utilisation de la 3-(2-chloro-phenyl)-1-[4-(4-fluoro-benzyl)-piperazin-1-yl]-propenone pour la prevention et/ou le traitement des pathologies fonctionnelles pelvi-perineales |
Country Status (17)
Country | Link |
---|---|
US (2) | US9980970B2 (fr) |
EP (1) | EP3082818A1 (fr) |
JP (1) | JP6612233B2 (fr) |
KR (1) | KR20160089518A (fr) |
CN (1) | CN105813642B (fr) |
AU (1) | AU2014365665B2 (fr) |
CA (1) | CA2931161A1 (fr) |
FR (1) | FR3014693B1 (fr) |
HK (1) | HK1221913A1 (fr) |
IL (1) | IL246216A0 (fr) |
MA (1) | MA39072A1 (fr) |
MX (1) | MX370061B (fr) |
RU (1) | RU2678309C1 (fr) |
SA (1) | SA516371348B1 (fr) |
TN (1) | TN2016000196A1 (fr) |
UA (1) | UA120603C2 (fr) |
WO (1) | WO2015090705A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3090317B1 (fr) * | 2018-12-19 | 2021-05-07 | Cvasthera | Utilisation d’un antagoniste de par-1 pour le traitement d’une maladie inflammatoire chronique intestinale |
CN110393718B (zh) * | 2019-08-20 | 2022-10-04 | 青岛海洋生物医药研究院 | 阿托帕沙溴酸作为新型jak-stat3信号通路抑制剂的用途和研究方法 |
FR3109089B1 (fr) * | 2020-04-08 | 2023-04-14 | Cvasthera | Composition pharmaceutique pour le traitement des maladies inflammatoires intestinales |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003089428A1 (fr) | 2002-04-16 | 2003-10-30 | Schering Corporation | Antagonistes tricycliques du recepteur de thrombine |
JP2008519039A (ja) * | 2004-11-04 | 2008-06-05 | ニュー イングランド メデカル センター ホスピタルズ インク | Gタンパク質共役型受容体アゴニストおよびアンタゴニストならびに使用方法 |
FR2902426B1 (fr) * | 2006-06-19 | 2008-09-05 | Pierre Fabre Medicament Sa | Derives de cinnamoyl-piperazine |
EP2709630A4 (fr) * | 2011-05-12 | 2014-10-22 | UNIVERSITé LAVAL | Inhibiteurs de par1 destinés à être utilisés dans le traitement ou la prévention d'infections par paramyxoviridae |
RU2468759C1 (ru) * | 2011-09-23 | 2012-12-10 | Ольга Викторовна Тарабанова | Способ лечения нарушений анатомических соотношений органов малого таза у женщин с атрофией мышц, поднимающих задний проход, и/или множественными дефектами ректо-вагинальной фасции |
-
2013
- 2013-12-16 FR FR1362682A patent/FR3014693B1/fr not_active Expired - Fee Related
-
2014
- 2014-10-31 KR KR1020167017262A patent/KR20160089518A/ko not_active Application Discontinuation
- 2014-10-31 RU RU2016127158A patent/RU2678309C1/ru not_active IP Right Cessation
- 2014-10-31 CA CA2931161A patent/CA2931161A1/fr not_active Abandoned
- 2014-10-31 TN TN2016000196A patent/TN2016000196A1/fr unknown
- 2014-10-31 WO PCT/EP2014/073453 patent/WO2015090705A1/fr active Application Filing
- 2014-10-31 AU AU2014365665A patent/AU2014365665B2/en not_active Ceased
- 2014-10-31 CN CN201480068095.9A patent/CN105813642B/zh not_active Expired - Fee Related
- 2014-10-31 EP EP14793086.1A patent/EP3082818A1/fr not_active Withdrawn
- 2014-10-31 US US15/101,170 patent/US9980970B2/en not_active Expired - Fee Related
- 2014-10-31 MA MA39072A patent/MA39072A1/fr unknown
- 2014-10-31 UA UAA201607312A patent/UA120603C2/uk unknown
- 2014-10-31 MX MX2016007795A patent/MX370061B/es active IP Right Grant
- 2014-10-31 JP JP2016540042A patent/JP6612233B2/ja not_active Expired - Fee Related
-
2016
- 2016-06-14 IL IL246216A patent/IL246216A0/en unknown
- 2016-06-16 SA SA516371348A patent/SA516371348B1/ar unknown
- 2016-08-25 HK HK16110155.2A patent/HK1221913A1/zh unknown
-
2018
- 2018-04-25 US US15/962,837 patent/US10265322B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN105813642A (zh) | 2016-07-27 |
JP6612233B2 (ja) | 2019-11-27 |
JP2016540799A (ja) | 2016-12-28 |
CA2931161A1 (fr) | 2015-06-25 |
AU2014365665B2 (en) | 2019-08-29 |
FR3014693A1 (fr) | 2015-06-19 |
US10265322B2 (en) | 2019-04-23 |
EP3082818A1 (fr) | 2016-10-26 |
HK1221913A1 (zh) | 2017-06-16 |
US20160287603A1 (en) | 2016-10-06 |
AU2014365665A1 (en) | 2016-07-14 |
WO2015090705A1 (fr) | 2015-06-25 |
KR20160089518A (ko) | 2016-07-27 |
US20180311253A1 (en) | 2018-11-01 |
MA39072A1 (fr) | 2017-05-31 |
UA120603C2 (uk) | 2020-01-10 |
MX370061B (es) | 2019-11-29 |
MX2016007795A (es) | 2016-09-07 |
CN105813642B (zh) | 2019-05-03 |
RU2678309C1 (ru) | 2019-01-25 |
US9980970B2 (en) | 2018-05-29 |
IL246216A0 (en) | 2016-07-31 |
SA516371348B1 (ar) | 2019-11-10 |
TN2016000196A1 (fr) | 2017-10-06 |
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