CO6251263A2 - Derivados de bencimidazol e indol sustutuidos por oxadiazol y oxazol como inhibidores de dgat1 - Google Patents

Derivados de bencimidazol e indol sustutuidos por oxadiazol y oxazol como inhibidores de dgat1

Info

Publication number
CO6251263A2
CO6251263A2 CO10045481A CO10045481A CO6251263A2 CO 6251263 A2 CO6251263 A2 CO 6251263A2 CO 10045481 A CO10045481 A CO 10045481A CO 10045481 A CO10045481 A CO 10045481A CO 6251263 A2 CO6251263 A2 CO 6251263A2
Authority
CO
Colombia
Prior art keywords
amino
substituted
unsubstituted
alkyl
lower alkyl
Prior art date
Application number
CO10045481A
Other languages
English (en)
Inventor
Young-Shin Kwak
Gary Mark Coppola
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO6251263A2 publication Critical patent/CO6251263A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1.- Un compuesto que tiene la siguiente estructura: A-Q-B-C-Den donde: A es un alquilo sustituido o insustituido, alcoxilo sustituido o insustituido, cicloalquilo sustituido o insustituido, amino opcionalmente sustituido, arilo sustituido o insustituido, hetero-arilo sustituido o insustituido o a sustituido o heterociclilo insustituido; Q es un heterociclo o hetero-arilo de cinco miembros divalente o trivalente; B es un grupo hetero-arilo divalente sustituido o insustituido seleccionado a partir de uno de los siguientes grupos: en donde:X1 y X2' se seleccionan independientemente a partir de O, NH, NR9 o S, en donde R9 se selecciona a partir de alquilo inferior, alquilo inferior-amino, alcoxilo inferior-alquilo, hidroxilo inferior- alquilo, X1', X2, X3 y X4 se seleccionan independientemente a partir de N, o CH, C es:en donde: - R1 se selecciona a partir de hidrógeno, ciano, alquilo inferior-sulfonil-amino, alcanoil-amino, halógeno, alquilo inferior, trifluoro-metilo, alcoxilo inferior, alquilo inferior-amino, dialquilo inferior-amino, y NO2, - R'1, R2 y R'2 se seleccionan independientemente a partir de hidrógeno, halógeno, trifluoro-metilo, ariloxilo, alquilo inferior, alcoxilo inferior, alquilo inferior-amino, dialquilo inferior- amino, y NO2, o - C también puede ser un grupo arilo o hetero-arilo bicíclico sustituido o insustituido, - D se selecciona a partir de hidrógeno, halógeno, hidroxilo, ciano, alcanoil-amino, carboxilo, carbamoílo, -O-L2-E, -S- L2-E', -C(O)-O- L2-E, -L2-E'', y -NR6-L2-E', -L2 es -(CH2)n(CR6R5)p'-(CH2)m'- -E es alquilo, acilo, alcoxi-carbonilo, ....
CO10045481A 2007-09-28 2010-04-19 Derivados de bencimidazol e indol sustutuidos por oxadiazol y oxazol como inhibidores de dgat1 CO6251263A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97606407P 2007-09-28 2007-09-28

Publications (1)

Publication Number Publication Date
CO6251263A2 true CO6251263A2 (es) 2011-02-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CO10045481A CO6251263A2 (es) 2007-09-28 2010-04-19 Derivados de bencimidazol e indol sustutuidos por oxadiazol y oxazol como inhibidores de dgat1

Country Status (27)

Country Link
US (2) US7879850B2 (es)
EP (1) EP2205595B1 (es)
JP (1) JP5675359B2 (es)
KR (1) KR101616133B1 (es)
CN (1) CN101932576B (es)
AR (1) AR066169A1 (es)
AU (1) AU2008303541B2 (es)
BR (1) BRPI0817272A2 (es)
CA (1) CA2701053C (es)
CL (1) CL2008002871A1 (es)
CO (1) CO6251263A2 (es)
CR (1) CR11261A (es)
CU (1) CU20100049A7 (es)
EA (1) EA019347B1 (es)
EC (1) ECSP10010051A (es)
ES (1) ES2525703T3 (es)
IL (1) IL203797A (es)
MA (1) MA31707B1 (es)
MX (1) MX2010003264A (es)
MY (1) MY151551A (es)
NZ (1) NZ583285A (es)
PE (1) PE20090774A1 (es)
TN (1) TN2010000096A1 (es)
TW (1) TWI429642B (es)
UA (1) UA99305C2 (es)
WO (1) WO2009040410A1 (es)
ZA (1) ZA201000829B (es)

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JP2022507958A (ja) 2018-11-27 2022-01-18 ノバルティス アーゲー 代謝障害の治療用のプロタンパク質転換酵素サブチリシン／ケキシン９型（ｐｃｓｋ９）阻害薬としての環状四量体化合物
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UY31863A (es) 2008-06-05 2010-01-05 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
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