MA31707B1 - Dérivés de benzimidazole et d'indole substitués par de l'oxadiazole et oxazole comme inhibiteurs de dgat1 - Google Patents

Dérivés de benzimidazole et d'indole substitués par de l'oxadiazole et oxazole comme inhibiteurs de dgat1

Info

Publication number
MA31707B1
MA31707B1 MA32702A MA32702A MA31707B1 MA 31707 B1 MA31707 B1 MA 31707B1 MA 32702 A MA32702 A MA 32702A MA 32702 A MA32702 A MA 32702A MA 31707 B1 MA31707 B1 MA 31707B1
Authority
MA
Morocco
Prior art keywords
dgat1
benzimidazole
indole derivatives
oxadiazole
oxazole
Prior art date
Application number
MA32702A
Other languages
Arabic (ar)
English (en)
Inventor
Young-Shin Kwak
Gary Mark Coppola
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA31707B1 publication Critical patent/MA31707B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La présente invention porte sur des dérivés de benzimidazole et d'indole substitués par de l'oxadiazolyle utiles pour traiter des états ou des troubles associés à l'activité de la dgat1 chez l'animaux, en particulier l'être humain.
MA32702A 2007-09-28 2010-03-17 Dérivés de benzimidazole et d'indole substitués par de l'oxadiazole et oxazole comme inhibiteurs de dgat1 MA31707B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97606407P 2007-09-28 2007-09-28
PCT/EP2008/062900 WO2009040410A1 (fr) 2007-09-28 2008-09-26 Dérivés de benzimidazole et d'indole substitués par de l'oxadiazole et oxazole comme inhibiteurs de dgat1

Publications (1)

Publication Number Publication Date
MA31707B1 true MA31707B1 (fr) 2010-09-01

Family

ID=39971086

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32702A MA31707B1 (fr) 2007-09-28 2010-03-17 Dérivés de benzimidazole et d'indole substitués par de l'oxadiazole et oxazole comme inhibiteurs de dgat1

Country Status (27)

Country Link
US (2) US7879850B2 (fr)
EP (1) EP2205595B1 (fr)
JP (1) JP5675359B2 (fr)
KR (1) KR101616133B1 (fr)
CN (1) CN101932576B (fr)
AR (1) AR066169A1 (fr)
AU (1) AU2008303541B2 (fr)
BR (1) BRPI0817272A2 (fr)
CA (1) CA2701053C (fr)
CL (1) CL2008002871A1 (fr)
CO (1) CO6251263A2 (fr)
CR (1) CR11261A (fr)
CU (1) CU20100049A7 (fr)
EA (1) EA019347B1 (fr)
EC (1) ECSP10010051A (fr)
ES (1) ES2525703T3 (fr)
IL (1) IL203797A (fr)
MA (1) MA31707B1 (fr)
MX (1) MX2010003264A (fr)
MY (1) MY151551A (fr)
NZ (1) NZ583285A (fr)
PE (1) PE20090774A1 (fr)
TN (1) TN2010000096A1 (fr)
TW (1) TWI429642B (fr)
UA (1) UA99305C2 (fr)
WO (1) WO2009040410A1 (fr)
ZA (1) ZA201000829B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ587106A (en) 2004-12-14 2012-03-30 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
AR058562A1 (es) 2005-12-22 2008-02-13 Astrazeneca Ab Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1
WO2007138311A1 (fr) 2006-05-30 2007-12-06 Astrazeneca Ab Acides 5-phénylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phénoxy-cyclohexane carboxyliques substitués en tant qu'inhibiteurs de l'acétyl coenzyme a diacylglycérol acyltransférase
AR066169A1 (es) * 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
WO2009112445A1 (fr) * 2008-03-10 2009-09-17 Novartis Ag Procédé d’accroissement de phosphatidyl-choline des cellules par l’inhibition de la dgat1
CA2755253A1 (fr) * 2009-03-18 2010-09-23 Schering Corporation Composes bicycliques en tant qu'inhibiteurs de la diacylglycerol acyltransferase
CN102781915A (zh) 2009-12-31 2012-11-14 皮拉马尔有限公司 二酰甘油酰基转移酶抑制剂
EP2552441B1 (fr) 2010-03-30 2016-05-04 Novartis AG Utilisations d'inhibiteurs de dgat1
WO2012044567A2 (fr) * 2010-09-30 2012-04-05 Merck Sharp & Dohme Corp. Dérivés d'imidazole
WO2012064569A1 (fr) * 2010-11-08 2012-05-18 Merck Sharp & Dohme Corp. Dérivés d'imidazole
PT2729142T (pt) 2011-07-08 2018-10-01 Novartis Ag Método de tratamento de aterosclerose em sujeitos com nível elevado de triglicéridos
WO2013074387A1 (fr) * 2011-11-14 2013-05-23 Merck Sharp & Dohme Corp. Dérivés d'imidazole
WO2013169648A1 (fr) 2012-05-07 2013-11-14 Novartis Ag Combinaisons pharmaceutiques comprenant un inhibiteur de dgat1 et un médicament abaissant la teneur en triglycérides
WO2014054053A1 (fr) 2012-10-03 2014-04-10 Advinus Therapeutics Limited Composés spirocycliques et leurs compositions et applications médicinales
WO2014081996A1 (fr) * 2012-11-23 2014-05-30 Glaxosmithkline Llc Nouveaux composés en tant qu'inhibiteurs de diacylglycérol acyltransférase
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
PE20150967A1 (es) * 2012-11-23 2015-06-25 Glaxosmithkline Llc Compuestos novedosos como inhibidores de diacilglicerol aciltransferasa
CN103087045B (zh) * 2013-01-11 2015-08-12 上海交通大学 一种苯并咪唑类杂环化合物、药物组合物及其用途
CN104610152A (zh) * 2015-02-13 2015-05-13 佛山市赛维斯医药科技有限公司 一类环丙基酰肼类gpr119激动剂、制备方法及其用途
CN104672144A (zh) * 2015-02-13 2015-06-03 佛山市赛维斯医药科技有限公司 一种环丙基酰肼和硝基苯类gpr119激动剂、制备方法及其用途
WO2020110008A1 (fr) 2018-11-27 2020-06-04 Novartis Ag Composés pentamères cycliques servant d'inhibiteurs de proprotéine convertase subtilisine/kexine de type 9 (pcsk9) pour le traitement d'un trouble métabolique
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
JP2022509184A (ja) * 2018-11-27 2022-01-20 ノバルティス アーゲー 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド
WO2023084449A1 (fr) 2021-11-12 2023-05-19 Novartis Ag Dérivés diaminocyclopentylpyridines pour le traitement d'une maladie ou d'un trouble

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ324834A (en) 1995-12-28 2001-11-30 Fujisawa Pharmaceutical Co Benzimidazole derivatives and their use in reducing blood sugar or as inhibitors of PDE5 activity
WO2002072549A1 (fr) 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Heterocycles fonctionnalises en tant que modulateurs de la fonction du recepteur de chimiokines et procedes de mise en oeuvre
KR100979988B1 (ko) 2001-08-13 2010-09-03 얀센 파마슈티카 엔.브이. 2-아미노-4,5-삼치환 티아졸릴 유도체
EP1562956A4 (fr) 2002-11-22 2007-10-10 Japan Tobacco Inc Heterocycles contenant de l'azote bicyclique fusionne
CA2509042A1 (fr) 2002-12-11 2004-06-24 Eli Lilly And Company Nouveaux antagonistes du recepteur de l'hormone de concentration en melanine
CA2513102C (fr) 2003-01-27 2011-03-22 Merck & Co., Inc. Pyrazoles substitues, compositions contenant de tels composes et procedes d'utilisation
AR044152A1 (es) 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
JP3878625B2 (ja) * 2003-06-20 2007-02-07 松下電器産業株式会社 振幅調整回路、モータ駆動制御装置、振幅調整方法、及びモータ駆動制御方法
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
JP2007501801A (ja) * 2003-08-07 2007-02-01 日本たばこ産業株式会社 ピロロ［１，２−ｂ］ピリダジン誘導体
WO2005035526A1 (fr) 2003-10-09 2005-04-21 Argenta Discovery Ltd. Composes bicycliques et leur utilisation therapeutique
WO2005080371A1 (fr) 2004-02-12 2005-09-01 Merck & Co., Inc. Composes amino heterocycliques modulateurs de l'activite des recepteurs de chimiokines
WO2005108370A1 (fr) * 2004-04-16 2005-11-17 Ajinomoto Co., Inc. Composés du benzène
WO2005121132A1 (fr) 2004-06-11 2005-12-22 Shionogi & Co., Ltd. Composé hétérocyclique fondu ayant un effet anti-vhc
US20070249620A1 (en) 2004-07-02 2007-10-25 Hitoshi Kurata Urea Derivative
ATE492542T1 (de) 2004-10-15 2011-01-15 Bayer Healthcare Llc Herstellung und anwendung von biphenyl-4-yl- carbonylaminosäurederivaten zur behandlung von obesitas
CN101052618A (zh) 2004-10-29 2007-10-10 默克公司 用作治疗阿尔茨海默氏病的β－分泌酶抑制剂的2－氨基吡啶化合物
NZ587106A (en) 2004-12-14 2012-03-30 Astrazeneca Ab Oxadiazole derivatives as dgat inhibitors
EP1845081A4 (fr) 2005-02-01 2009-03-25 Takeda Pharmaceutical Composé amide
MX2007013049A (es) 2005-04-19 2008-01-11 Bayer Pharmaceuticals Corp Preparacion y uso de derivados de aril alquil acido para el tratamiento de la obesidad.
JP2008540485A (ja) 2005-05-10 2008-11-20 エフ．ホフマン−ラ ロシュ アーゲー ジアシルグリセロールアシルトランスフェラーゼ阻害剤
US20090215779A1 (en) 2005-06-11 2009-08-27 Roger John Butlin Oxadiazole derivatives as dgat inhibitors
EP1912634A4 (fr) 2005-07-29 2010-06-09 Bayer Healthcare Llc Preparation et utilisation de derives aminoacides biphenyle pour traiter l'obesite
CN101282929A (zh) 2005-08-15 2008-10-08 Irm责任有限公司 用作tpo模拟物的化合物和组合物
EP2298770A1 (fr) 2005-11-03 2011-03-23 ChemBridge Corporation Composés hétérocycliques en tant que modulateurs de TrkA
US7714126B2 (en) 2005-11-28 2010-05-11 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
AR058562A1 (es) 2005-12-22 2008-02-13 Astrazeneca Ab Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1
WO2007137107A2 (fr) 2006-05-19 2007-11-29 Abbott Laboratories Inhibiteurs de l'enzyme diacylglycerol o-acyltransférase de type 1
WO2007137103A2 (fr) 2006-05-19 2007-11-29 Abbott Laboratories Inhibiteurs de l'enzyme diacylglycérol o-acyltransférase de type 1
WO2007138311A1 (fr) 2006-05-30 2007-12-06 Astrazeneca Ab Acides 5-phénylamino-1,3,4-oxadiazol-2-ylcarbonylamino-4-phénoxy-cyclohexane carboxyliques substitués en tant qu'inhibiteurs de l'acétyl coenzyme a diacylglycérol acyltransférase
AU2007266890B2 (en) 2006-05-30 2011-02-17 Astrazeneca Ab 1, 3, 4 -oxadiazole derivatives as DGAT1 inhibitors
CN101460469A (zh) 2006-06-06 2009-06-17 阿斯利康(瑞典)有限公司 化合物
MX2008015725A (es) 2006-06-08 2009-02-13 Astrazeneca Ab Benzimidazolas y su uso para el tratamiento de diabetes.
GB0611507D0 (en) 2006-06-10 2006-07-19 Astrazeneca Ab Chemical compounds
GB0611506D0 (en) 2006-06-10 2006-07-19 Astrazeneca Ab Chemical compounds
GB0611552D0 (en) 2006-06-12 2006-07-19 Astrazeneca Ab Chemical compounds
US20120065196A1 (en) 2006-07-21 2012-03-15 Shuji Kitamura Amide compounds
EP2044055A4 (fr) 2006-07-21 2011-03-23 Takeda Pharmaceutical Composés amidés
CA2669884A1 (fr) 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc Nouveaux 2-(2-hydroxyphenyl)benzimidazoles utilises pour traiter l'obesite et le diabete
ES2421326T3 (es) 2006-11-29 2013-08-30 Abbvie Inc. Inhibidores de la enzima diacilglicerol O-aciltransferasa de tipo 1
WO2008099221A1 (fr) 2007-02-15 2008-08-21 Prosidion Limited Dérivés d'amide et d'urée pour le traitement de maladies métaboliques
GB0707662D0 (en) 2007-04-20 2007-05-30 Astrazeneca Ab Chemical compounds
EP2452937A1 (fr) 2007-04-30 2012-05-16 Abbott Laboratories Inhibiteurs de l'enzyme diacylglycérol o-acyltransférase de type 1
WO2008134690A1 (fr) 2007-04-30 2008-11-06 Abbott Laboratories Inhibiteurs d'enzyme diacylglycérol o-acyltransférase de type 1
US8115011B2 (en) 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
MX2009012285A (es) 2007-05-22 2009-12-15 Via Pharmaceuticals Inc Inhibidores de diacilglicerol aciltransferasa.
US8153644B2 (en) 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8058299B2 (en) 2007-05-22 2011-11-15 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
ES2483898T3 (es) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Derivados de piperidina/piperazina
US8835437B2 (en) 2007-06-08 2014-09-16 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
PA8783601A1 (es) 2007-06-08 2009-01-23 Janssen Pharmaceutica Nv Derivados de piperidina/piperazina
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
WO2009011285A1 (fr) 2007-07-13 2009-01-22 Taisho Pharmaceutical Co., Ltd. Composés hétéroarylbenzènes
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
WO2009024821A2 (fr) 2007-08-17 2009-02-26 Astrazeneca Ab Composés chimiques 979
US20090076275A1 (en) 2007-09-19 2009-03-19 David Robert Bolin Diacylglycerol acyltransferase inhibitors
AR066169A1 (es) * 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
WO2009071483A1 (fr) 2007-12-07 2009-06-11 Via Pharmaceuticals, Inc. 1-(indazol-5-yl)urées comme inhibiteurs de diacylglycérol acyltransférase
EP2234978B1 (fr) 2007-12-20 2015-02-25 AstraZeneca AB Composés carbamoyles comme inhibiteurs de dgat1 190
JP4531127B2 (ja) 2008-03-26 2010-08-25 第一三共株式会社 新規テトラヒドロイソキノリン誘導体
US9107946B2 (en) 2008-06-05 2015-08-18 Janssen Pharmaceutica Nv Drug combinations comprising a DGAT inhibitor and a PPAR-agonist
EP2349484A2 (fr) * 2008-07-15 2011-08-03 Novartis AG Dérivés d'hétéroaryles comme inhibiteurs de dgat1

Also Published As

Publication number Publication date
BRPI0817272A2 (pt) 2015-06-16
EP2205595A1 (fr) 2010-07-14
UA99305C2 (ru) 2012-08-10
JP5675359B2 (ja) 2015-02-25
US20110077277A1 (en) 2011-03-31
TW200914449A (en) 2009-04-01
JP2011501735A (ja) 2011-01-13
CU23901B1 (fr) 2013-06-28
CA2701053A1 (fr) 2009-04-02
CN101932576A (zh) 2010-12-29
AU2008303541B2 (en) 2012-06-07
KR20100071048A (ko) 2010-06-28
MX2010003264A (es) 2010-04-01
CO6251263A2 (es) 2011-02-21
US8217065B2 (en) 2012-07-10
EA019347B1 (ru) 2014-03-31
CA2701053C (fr) 2016-08-23
KR101616133B1 (ko) 2016-04-27
CL2008002871A1 (es) 2009-05-15
TN2010000096A1 (en) 2011-09-26
ES2525703T3 (es) 2014-12-29
NZ583285A (en) 2012-05-25
AU2008303541A1 (en) 2009-04-02
EP2205595B1 (fr) 2014-09-10
CU20100049A7 (es) 2011-09-21
TWI429642B (zh) 2014-03-11
ECSP10010051A (es) 2010-04-30
CR11261A (es) 2010-04-26
WO2009040410A1 (fr) 2009-04-02
CN101932576B (zh) 2014-09-10
US7879850B2 (en) 2011-02-01
AR066169A1 (es) 2009-07-29
IL203797A (en) 2014-01-30
US20090186891A1 (en) 2009-07-23
MY151551A (en) 2014-06-13
ZA201000829B (en) 2010-12-29
EA201000428A1 (ru) 2010-10-29
PE20090774A1 (es) 2009-07-17

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