UA96777C2 - Фенилпропионамидные соединения и их применение как опиоидных агонистов - Google Patents
Фенилпропионамидные соединения и их применение как опиоидных агонистовInfo
- Publication number
- UA96777C2 UA96777C2 UAA200905600A UAA200905600A UA96777C2 UA 96777 C2 UA96777 C2 UA 96777C2 UA A200905600 A UAA200905600 A UA A200905600A UA A200905600 A UAA200905600 A UA A200905600A UA 96777 C2 UA96777 C2 UA 96777C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compounds
- opioid agonists
- phenylpropionamide compounds
- formula
- phenylpropionamide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Изобретение касается фенилпропионамидных соединений формулы I: EMBED MDLDrawOLE.MDLDrawObject.1 \s и их фармацевтически приемлемых солей, пролекарств и сольватов, где А, В, R1, R2, R3, R4 и R5 имеют такие значения, как указано в описании. Изобретение также касается применения соединения формулы I для лечения, предупреждения или улучшения состояния расстройств, чувствительного к активации опиоидных рецепторов, в частности (-опиоидных рецепторов. Соединения данного изобретения являются очень эффективными для лечения боли.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85582606P | 2006-11-01 | 2006-11-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA96777C2 true UA96777C2 (ru) | 2011-12-12 |
Family
ID=39185788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200905600A UA96777C2 (ru) | 2006-11-01 | 2007-10-31 | Фенилпропионамидные соединения и их применение как опиоидных агонистов |
Country Status (25)
Country | Link |
---|---|
US (1) | US8481743B2 (ru) |
EP (2) | EP2079485B1 (ru) |
JP (1) | JP5087629B2 (ru) |
KR (2) | KR20120031245A (ru) |
CN (1) | CN101553256B (ru) |
AU (1) | AU2007315859B2 (ru) |
BR (1) | BRPI0716327A2 (ru) |
CA (1) | CA2666750C (ru) |
CY (1) | CY1113102T1 (ru) |
DK (1) | DK2079485T3 (ru) |
EA (1) | EA017471B1 (ru) |
ES (2) | ES2389456T3 (ru) |
HK (2) | HK1131922A1 (ru) |
HR (1) | HRP20120624T1 (ru) |
IL (1) | IL198010A (ru) |
MX (1) | MX2009004822A (ru) |
NZ (1) | NZ575939A (ru) |
PL (1) | PL2079485T3 (ru) |
PT (1) | PT2079485E (ru) |
RS (1) | RS52451B (ru) |
SI (1) | SI2079485T1 (ru) |
TW (1) | TWI381838B (ru) |
UA (1) | UA96777C2 (ru) |
WO (1) | WO2008053352A2 (ru) |
ZA (1) | ZA200902189B (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009077584A1 (en) * | 2007-12-19 | 2009-06-25 | Neurosearch A/S | N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as opioid receptor ligands |
US20110009449A1 (en) * | 2007-12-19 | 2011-01-13 | Dan Peters | N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
NO2303330T3 (ru) | 2008-06-06 | 2018-04-14 | ||
US9212139B2 (en) | 2010-06-16 | 2015-12-15 | Purdue Pharma, L.P. | Aryl substituted indoles and their use as blockers of sodium channels |
JP5977240B2 (ja) | 2010-09-21 | 2016-08-24 | パーデュー、ファーマ、リミテッド、パートナーシップ | ブプレノルフィン類似体 |
EP3333156A3 (en) | 2012-11-09 | 2018-09-26 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
US9175000B2 (en) | 2012-12-07 | 2015-11-03 | Purdue Pharma L.P. | Buprenorphine analogs |
CA2900023A1 (en) | 2013-01-31 | 2014-08-07 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
EP3087078B1 (en) | 2013-12-26 | 2019-05-15 | Purdue Pharma LP | 7-beta-alkyl analogs of orvinols |
US9656962B2 (en) | 2013-12-26 | 2017-05-23 | Purdue Pharma L.P. | Ring-contracted morphinans and the use thereof |
US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
EP3086790A4 (en) | 2013-12-27 | 2017-07-19 | Purdue Pharma LP | 6-substituted and 7-substituted morphinan analogs and the use thereof |
US10030021B2 (en) | 2014-05-27 | 2018-07-24 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
EP3154972A4 (en) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
BR112017017619A2 (pt) | 2015-02-19 | 2018-05-08 | Purdue Pharma Lp | métodos e composições para diminuir esvaziamento gástrico |
US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
US3763168A (en) * | 1968-09-09 | 1973-10-02 | Sterling Drug Inc | N-(3-quinuclidinyl) acylanilides |
BE775611A (fr) | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
US3679690A (en) * | 1971-03-18 | 1972-07-25 | Sterling Drug Inc | Certain n-(pyridyl) propionanilides |
US4801615A (en) * | 1987-12-31 | 1989-01-31 | The Boc Group, Inc. | 4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds |
ATE301457T1 (de) | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
TW504510B (en) | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
SK13082000A3 (sk) * | 1998-03-06 | 2001-03-12 | Janssen Pharmaceutica N. V. | Inhibítory prenosu glycínu, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
TWI245763B (en) | 1998-04-02 | 2005-12-21 | Janssen Pharmaceutica Nv | Biocidal benzylbiphenyl derivatives |
CA2324330A1 (en) | 1999-11-08 | 2001-05-08 | Ssp Co., Ltd. | 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same |
AU4274401A (en) | 2000-03-24 | 2001-10-03 | Meiji Seika Kaisha | Diphenylalkylamine derivatives useful as opioid delta receptor agonists |
AU2002226000A1 (en) | 2000-11-13 | 2002-05-21 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
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2007
- 2007-10-31 EA EA200900615A patent/EA017471B1/ru not_active IP Right Cessation
- 2007-10-31 MX MX2009004822A patent/MX2009004822A/es active IP Right Grant
- 2007-10-31 RS RS20120375A patent/RS52451B/en unknown
- 2007-10-31 JP JP2009533981A patent/JP5087629B2/ja not_active Expired - Fee Related
- 2007-10-31 PL PL07825628T patent/PL2079485T3/pl unknown
- 2007-10-31 US US12/447,758 patent/US8481743B2/en active Active
- 2007-10-31 AU AU2007315859A patent/AU2007315859B2/en not_active Ceased
- 2007-10-31 CN CN2007800406352A patent/CN101553256B/zh not_active Expired - Fee Related
- 2007-10-31 KR KR1020127005526A patent/KR20120031245A/ko not_active Application Discontinuation
- 2007-10-31 SI SI200730992T patent/SI2079485T1/sl unknown
- 2007-10-31 KR KR1020097011344A patent/KR101154544B1/ko not_active IP Right Cessation
- 2007-10-31 WO PCT/IB2007/003411 patent/WO2008053352A2/en active Application Filing
- 2007-10-31 EP EP07825628A patent/EP2079485B1/en active Active
- 2007-10-31 BR BRPI0716327-4A2A patent/BRPI0716327A2/pt not_active IP Right Cessation
- 2007-10-31 ES ES07825628T patent/ES2389456T3/es active Active
- 2007-10-31 PT PT07825628T patent/PT2079485E/pt unknown
- 2007-10-31 UA UAA200905600A patent/UA96777C2/ru unknown
- 2007-10-31 TW TW096140980A patent/TWI381838B/zh not_active IP Right Cessation
- 2007-10-31 ES ES11176434T patent/ES2433118T3/es active Active
- 2007-10-31 NZ NZ575939A patent/NZ575939A/en not_active IP Right Cessation
- 2007-10-31 DK DK07825628.6T patent/DK2079485T3/da active
- 2007-10-31 EP EP11176434.6A patent/EP2384768B1/en active Active
- 2007-10-31 CA CA2666750A patent/CA2666750C/en not_active Expired - Fee Related
-
2009
- 2009-03-27 ZA ZA2009/02189A patent/ZA200902189B/en unknown
- 2009-04-05 IL IL198010A patent/IL198010A/en not_active IP Right Cessation
- 2009-12-21 HK HK09112025.5A patent/HK1131922A1/xx not_active IP Right Cessation
- 2009-12-21 HK HK12104350.2A patent/HK1163545A1/xx not_active IP Right Cessation
-
2012
- 2012-07-31 HR HRP20120624TT patent/HRP20120624T1/hr unknown
- 2012-09-10 CY CY20121100812T patent/CY1113102T1/el unknown
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