HRP20120624T1 - Spojevi fenilpropionamida i njihova uporaba - Google Patents
Spojevi fenilpropionamida i njihova uporaba Download PDFInfo
- Publication number
- HRP20120624T1 HRP20120624T1 HRP20120624TT HRP20120624T HRP20120624T1 HR P20120624 T1 HRP20120624 T1 HR P20120624T1 HR P20120624T T HRP20120624T T HR P20120624TT HR P20120624 T HRP20120624 T HR P20120624T HR P20120624 T1 HRP20120624 T1 HR P20120624T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- 6alkyl
- 6alkynyl
- 6alkenyl
- aryl
- Prior art date
Links
- DOZZSWAOPDYVLH-UHFFFAOYSA-N 2-phenylpropanamide Chemical class NC(=O)C(C)C1=CC=CC=C1 DOZZSWAOPDYVLH-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 66
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 25
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract 22
- 125000000217 alkyl group Chemical group 0.000 claims abstract 22
- 125000003118 aryl group Chemical group 0.000 claims abstract 22
- 150000001875 compounds Chemical class 0.000 claims abstract 20
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 14
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 10
- -1 nitro, amino, ureido Chemical group 0.000 claims abstract 8
- 125000001424 substituent group Chemical group 0.000 claims abstract 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 239000012453 solvate Substances 0.000 claims abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 4
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims abstract 4
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims abstract 4
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims abstract 4
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 4
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 4
- 150000003573 thiols Chemical class 0.000 claims abstract 4
- 208000002193 Pain Diseases 0.000 claims 20
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 102000003840 Opioid Receptors Human genes 0.000 claims 3
- 108090000137 Opioid Receptors Proteins 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 102000051367 mu Opioid Receptors Human genes 0.000 claims 2
- 208000004296 neuralgia Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000020431 spinal cord injury Diseases 0.000 claims 2
- 108020001612 μ-opioid receptors Proteins 0.000 claims 2
- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 229940125714 antidiarrheal agent Drugs 0.000 claims 1
- 239000003793 antidiarrheal agent Substances 0.000 claims 1
- 239000002111 antiemetic agent Substances 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 229940125684 antimigraine agent Drugs 0.000 claims 1
- 239000002282 antimigraine agent Substances 0.000 claims 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 1
- VMWLQTUUMNDKAI-UHFFFAOYSA-N n-[1-(3,3-diphenylpropyl)piperidin-4-yl]-n-phenylpropanamide Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC(C=1C=CC=CC=1)C1=CC=CC=C1 VMWLQTUUMNDKAI-UHFFFAOYSA-N 0.000 claims 1
- CDXQVQPFRQLXCB-UHFFFAOYSA-N n-[1-(3-cyano-3,3-diphenylpropyl)piperidin-4-yl]-n-phenylpropanamide Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 CDXQVQPFRQLXCB-UHFFFAOYSA-N 0.000 claims 1
- WFSYLDUKRIPQAT-UHFFFAOYSA-N n-[1-(4-oxo-3,3-diphenyl-4-pyrrolidin-1-ylbutyl)piperidin-4-yl]-n-phenylpropanamide Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C(=O)N1CCCC1 WFSYLDUKRIPQAT-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85582606P | 2006-11-01 | 2006-11-01 | |
| PCT/IB2007/003411 WO2008053352A2 (en) | 2006-11-01 | 2007-10-31 | Phenylpropionamide compounds and the use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120624T1 true HRP20120624T1 (hr) | 2012-08-31 |
Family
ID=39185788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120624TT HRP20120624T1 (hr) | 2006-11-01 | 2012-07-31 | Spojevi fenilpropionamida i njihova uporaba |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8481743B2 (ru) |
| EP (2) | EP2384768B1 (ru) |
| JP (1) | JP5087629B2 (ru) |
| KR (2) | KR101154544B1 (ru) |
| CN (1) | CN101553256B (ru) |
| AU (1) | AU2007315859B2 (ru) |
| BR (1) | BRPI0716327A2 (ru) |
| CA (1) | CA2666750C (ru) |
| CY (1) | CY1113102T1 (ru) |
| DK (1) | DK2079485T3 (ru) |
| EA (1) | EA017471B1 (ru) |
| ES (2) | ES2389456T3 (ru) |
| HK (2) | HK1163545A1 (ru) |
| HR (1) | HRP20120624T1 (ru) |
| IL (1) | IL198010A (ru) |
| MX (1) | MX2009004822A (ru) |
| NZ (1) | NZ575939A (ru) |
| PL (1) | PL2079485T3 (ru) |
| PT (1) | PT2079485E (ru) |
| RS (1) | RS52451B (ru) |
| SI (1) | SI2079485T1 (ru) |
| TW (1) | TWI381838B (ru) |
| UA (1) | UA96777C2 (ru) |
| WO (1) | WO2008053352A2 (ru) |
| ZA (1) | ZA200902189B (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110009449A1 (en) * | 2007-12-19 | 2011-01-13 | Dan Peters | N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20110046180A1 (en) * | 2007-12-19 | 2011-02-24 | Neurosearch A/S | N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as opioid receptor ligands |
| JP5648216B2 (ja) | 2008-06-06 | 2015-01-07 | ファーマ ツゥ ビー リミテッド | パーキンソン病治療医薬組成物 |
| US9212139B2 (en) | 2010-06-16 | 2015-12-15 | Purdue Pharma, L.P. | Aryl substituted indoles and their use as blockers of sodium channels |
| PE20140020A1 (es) | 2010-09-21 | 2014-01-31 | Purdue Pharma Lp | Analogos de buprenorfina |
| WO2014072809A2 (en) | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| TW201434842A (zh) | 2012-12-07 | 2014-09-16 | Purdue Pharma Lp | 丁基原啡因（ｂｕｐｒｅｎｏｒｐｈｉｎｅ）類似物類 |
| US9056836B2 (en) | 2013-01-31 | 2015-06-16 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
| US9988392B2 (en) | 2013-12-26 | 2018-06-05 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| WO2015100174A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Ring-contracted morphinans and the use thereof |
| WO2015097545A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| EP3086790A4 (en) | 2013-12-27 | 2017-07-19 | Purdue Pharma LP | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| US10030021B2 (en) | 2014-05-27 | 2018-07-24 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| MA40171A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés d'azamophinan et leur utilisation |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| CA2977367A1 (en) | 2015-02-19 | 2016-08-25 | Purdue Pharma L.P. | Methods and compositions for decreasing gastric emptying |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
| US3763168A (en) * | 1968-09-09 | 1973-10-02 | Sterling Drug Inc | N-(3-quinuclidinyl) acylanilides |
| BE775611A (fr) | 1970-11-24 | 1972-03-16 | Synthelabo | Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent |
| US3679690A (en) * | 1971-03-18 | 1972-07-25 | Sterling Drug Inc | Certain n-(pyridyl) propionanilides |
| US4801615A (en) * | 1987-12-31 | 1989-01-31 | The Boc Group, Inc. | 4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds |
| EP0833622B8 (en) | 1995-06-12 | 2005-10-12 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor |
| US6573282B1 (en) | 1995-09-12 | 2003-06-03 | Adolor Corporation | Peripherally active anti-hyperalgesic opiates |
| US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| TW504510B (en) | 1996-05-10 | 2002-10-01 | Janssen Pharmaceutica Nv | 2,4-diaminopyrimidine derivatives |
| SK13082000A3 (sk) | 1998-03-06 | 2001-03-12 | Janssen Pharmaceutica N. V. | Inhibítory prenosu glycínu, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
| TWI245763B (en) | 1998-04-02 | 2005-12-21 | Janssen Pharmaceutica Nv | Biocidal benzylbiphenyl derivatives |
| CA2324330A1 (en) | 1999-11-08 | 2001-05-08 | Ssp Co., Ltd. | 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same |
| WO2001070689A1 (fr) | 2000-03-24 | 2001-09-27 | Meiji Seika Kaisha, Ltd. | DERIVES DE LA DIPHENYLALKYLAMINE UTILES COMME AGONISTES DU RECEPTEUR DE L'OPIOIDE $g(d) |
| WO2002038185A2 (en) | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
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2007
- 2007-10-31 WO PCT/IB2007/003411 patent/WO2008053352A2/en active Application Filing
- 2007-10-31 UA UAA200905600A patent/UA96777C2/ru unknown
- 2007-10-31 NZ NZ575939A patent/NZ575939A/en not_active IP Right Cessation
- 2007-10-31 EP EP11176434.6A patent/EP2384768B1/en active Active
- 2007-10-31 US US12/447,758 patent/US8481743B2/en active Active
- 2007-10-31 CN CN2007800406352A patent/CN101553256B/zh not_active Expired - Fee Related
- 2007-10-31 EP EP07825628A patent/EP2079485B1/en active Active
- 2007-10-31 KR KR1020097011344A patent/KR101154544B1/ko not_active IP Right Cessation
- 2007-10-31 ES ES07825628T patent/ES2389456T3/es active Active
- 2007-10-31 DK DK07825628.6T patent/DK2079485T3/da active
- 2007-10-31 TW TW096140980A patent/TWI381838B/zh not_active IP Right Cessation
- 2007-10-31 JP JP2009533981A patent/JP5087629B2/ja not_active Expired - Fee Related
- 2007-10-31 MX MX2009004822A patent/MX2009004822A/es active IP Right Grant
- 2007-10-31 SI SI200730992T patent/SI2079485T1/sl unknown
- 2007-10-31 PT PT07825628T patent/PT2079485E/pt unknown
- 2007-10-31 AU AU2007315859A patent/AU2007315859B2/en not_active Ceased
- 2007-10-31 BR BRPI0716327-4A2A patent/BRPI0716327A2/pt not_active IP Right Cessation
- 2007-10-31 RS RS20120375A patent/RS52451B/en unknown
- 2007-10-31 ES ES11176434T patent/ES2433118T3/es active Active
- 2007-10-31 CA CA2666750A patent/CA2666750C/en not_active Expired - Fee Related
- 2007-10-31 PL PL07825628T patent/PL2079485T3/pl unknown
- 2007-10-31 EA EA200900615A patent/EA017471B1/ru not_active IP Right Cessation
- 2007-10-31 KR KR1020127005526A patent/KR20120031245A/ko not_active Application Discontinuation
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2009
- 2009-03-27 ZA ZA2009/02189A patent/ZA200902189B/en unknown
- 2009-04-05 IL IL198010A patent/IL198010A/en not_active IP Right Cessation
- 2009-12-21 HK HK12104350.2A patent/HK1163545A1/xx not_active IP Right Cessation
- 2009-12-21 HK HK09112025.5A patent/HK1131922A1/xx not_active IP Right Cessation
-
2012
- 2012-07-31 HR HRP20120624TT patent/HRP20120624T1/hr unknown
- 2012-09-10 CY CY20121100812T patent/CY1113102T1/el unknown
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