CU20100049A7 - Derivados de bencimidazol e indol sustituidos por oxadiazol y oxasol como inhibidores de dgat1 - Google Patents

Derivados de bencimidazol e indol sustituidos por oxadiazol y oxasol como inhibidores de dgat1

Info

Publication number
CU20100049A7
CU20100049A7 CU2010000049A CU20100049A CU20100049A7 CU 20100049 A7 CU20100049 A7 CU 20100049A7 CU 2010000049 A CU2010000049 A CU 2010000049A CU 20100049 A CU20100049 A CU 20100049A CU 20100049 A7 CU20100049 A7 CU 20100049A7
Authority
CU
Cuba
Prior art keywords
dgat1
oxasol
bencimidazol
oxadiazol
inhibitors
Prior art date
Application number
CU2010000049A
Other languages
English (en)
Other versions
CU23901B1 (es
Inventor
Young-Shin Kwak
Gary Mark Coppola
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20100049A7 publication Critical patent/CU20100049A7/es
Publication of CU23901B1 publication Critical patent/CU23901B1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención proporciona derivados de bencimidazol e indol sustituidos por oxadiazolilo que son útiles para el tratamiento de las condiciones o los tratornos asociados con la actividad de DGAT1 en animales, en particular en seres humanos.
CU2010000049A 2007-09-28 2010-03-17 Derivados de bencimidazol e indol sustituidos por oxadiazol y oxasol como inhibidores de dgat1 CU20100049A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97606407P 2007-09-28 2007-09-28
PCT/EP2008/062900 WO2009040410A1 (en) 2007-09-28 2008-09-26 Oxadiazole- and oxazole-substituted benzimidazole- and indole-derivatives as dgat1 inhibitors

Publications (2)

Publication Number Publication Date
CU20100049A7 true CU20100049A7 (es) 2011-09-21
CU23901B1 CU23901B1 (es) 2013-06-28

Family

ID=39971086

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2010000049A CU20100049A7 (es) 2007-09-28 2010-03-17 Derivados de bencimidazol e indol sustituidos por oxadiazol y oxasol como inhibidores de dgat1

Country Status (27)

Country Link
US (2) US7879850B2 (es)
EP (1) EP2205595B1 (es)
JP (1) JP5675359B2 (es)
KR (1) KR101616133B1 (es)
CN (1) CN101932576B (es)
AR (1) AR066169A1 (es)
AU (1) AU2008303541B2 (es)
BR (1) BRPI0817272A2 (es)
CA (1) CA2701053C (es)
CL (1) CL2008002871A1 (es)
CO (1) CO6251263A2 (es)
CR (1) CR11261A (es)
CU (1) CU20100049A7 (es)
EA (1) EA019347B1 (es)
EC (1) ECSP10010051A (es)
ES (1) ES2525703T3 (es)
IL (1) IL203797A (es)
MA (1) MA31707B1 (es)
MX (1) MX2010003264A (es)
MY (1) MY151551A (es)
NZ (1) NZ583285A (es)
PE (1) PE20090774A1 (es)
TN (1) TN2010000096A1 (es)
TW (1) TWI429642B (es)
UA (1) UA99305C2 (es)
WO (1) WO2009040410A1 (es)
ZA (1) ZA201000829B (es)

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Publication number Publication date
CL2008002871A1 (es) 2009-05-15
TW200914449A (en) 2009-04-01
ZA201000829B (en) 2010-12-29
CN101932576B (zh) 2014-09-10
CN101932576A (zh) 2010-12-29
TN2010000096A1 (en) 2011-09-26
CU23901B1 (es) 2013-06-28
CO6251263A2 (es) 2011-02-21
AU2008303541B2 (en) 2012-06-07
EA201000428A1 (ru) 2010-10-29
TWI429642B (zh) 2014-03-11
MA31707B1 (fr) 2010-09-01
EP2205595B1 (en) 2014-09-10
EP2205595A1 (en) 2010-07-14
MY151551A (en) 2014-06-13
JP5675359B2 (ja) 2015-02-25
JP2011501735A (ja) 2011-01-13
PE20090774A1 (es) 2009-07-17
UA99305C2 (ru) 2012-08-10
NZ583285A (en) 2012-05-25
CA2701053A1 (en) 2009-04-02
KR101616133B1 (ko) 2016-04-27
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