CU20120071A7 - DERIVADOS DE N1-PIRAZOLOESPIROCETONA ÚTILES COMO INHIBIDORES DE ACETIL-CoA CARBOXILASA - Google Patents

DERIVADOS DE N1-PIRAZOLOESPIROCETONA ÚTILES COMO INHIBIDORES DE ACETIL-CoA CARBOXILASA

Info

Publication number
CU20120071A7
CU20120071A7 CU2012000071A CU20120071A CU20120071A7 CU 20120071 A7 CU20120071 A7 CU 20120071A7 CU 2012000071 A CU2012000071 A CU 2012000071A CU 20120071 A CU20120071 A CU 20120071A CU 20120071 A7 CU20120071 A7 CU 20120071A7
Authority
CU
Cuba
Prior art keywords
useful
pirazoloespirocetone
acetil
derivatives
coa carboxylase
Prior art date
Application number
CU2012000071A
Other languages
English (en)
Other versions
CU24077B1 (es
Inventor
Scott William Bagley
David Andrew Griffith
Daniel Wei-Shung Kung
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20120071A7 publication Critical patent/CU20120071A7/es
Publication of CU24077B1 publication Critical patent/CU24077B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La invención proporciona un compuesto de Fórmula (1): ESPACIO PARA LA FÓRMULA en la que R1, R2, R3 y R4 son como se describen en el presente documento; los cuales son útiles en el tratamiento de enfermedades, afecciones o trastornos modulados por la inhibición de una(s) enzima(s) acetil-CoA carboxilasa(s) en un animal.
CU2012000071A 2009-11-10 2010-10-29 DERIVADOS DE N1-PIRAZOLOESPIROCETONA ÚTILES COMO INHIBIDORES DE ACETIL-CoA CARBOXILASA CU24077B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25982309P 2009-11-10 2009-11-10
PCT/IB2010/054908 WO2011058474A1 (en) 2009-11-10 2010-10-29 N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors

Publications (2)

Publication Number Publication Date
CU20120071A7 true CU20120071A7 (es) 2013-05-31
CU24077B1 CU24077B1 (es) 2015-03-30

Family

ID=43357094

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2012000071A CU24077B1 (es) 2009-11-10 2010-10-29 DERIVADOS DE N1-PIRAZOLOESPIROCETONA ÚTILES COMO INHIBIDORES DE ACETIL-CoA CARBOXILASA

Country Status (39)

Country Link
US (4) US8288405B2 (es)
EP (3) EP2676958B1 (es)
JP (1) JP5114610B1 (es)
KR (2) KR101478517B1 (es)
CN (1) CN102695708B (es)
AP (1) AP3283A (es)
AR (1) AR078944A1 (es)
AU (1) AU2010317501B2 (es)
BR (1) BR112012011072A2 (es)
CA (1) CA2778886C (es)
CL (1) CL2012000999A1 (es)
CO (1) CO6541569A2 (es)
CR (1) CR20120190A (es)
CU (1) CU24077B1 (es)
DK (1) DK2499139T3 (es)
DO (1) DOP2012000128A (es)
EA (1) EA020153B1 (es)
EC (1) ECSP12011880A (es)
ES (1) ES2444543T3 (es)
GE (1) GEP20146169B (es)
HK (1) HK1173724A1 (es)
HN (1) HN2012000973A (es)
HR (1) HRP20140025T1 (es)
IL (1) IL219373A (es)
MA (1) MA33734B1 (es)
MX (1) MX2012005429A (es)
NI (1) NI201200089A (es)
NZ (1) NZ599815A (es)
PE (1) PE20121469A1 (es)
PL (1) PL2499139T3 (es)
PT (1) PT2499139E (es)
RS (1) RS53156B (es)
SI (1) SI2499139T1 (es)
TN (1) TN2012000192A1 (es)
TW (1) TWI394756B (es)
UA (1) UA102336C2 (es)
UY (1) UY33020A (es)
WO (1) WO2011058474A1 (es)
ZA (1) ZA201204231B (es)

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Also Published As

Publication number Publication date
EA020153B1 (ru) 2014-09-30
KR101478517B1 (ko) 2015-01-02
JP2013510192A (ja) 2013-03-21
ZA201204231B (en) 2013-02-27
US20130296319A1 (en) 2013-11-07
WO2011058474A1 (en) 2011-05-19
US8288405B2 (en) 2012-10-16
RS53156B (en) 2014-06-30
MA33734B1 (fr) 2012-11-01
BR112012011072A2 (pt) 2017-06-20
TN2012000192A1 (fr) 2013-12-12
PE20121469A1 (es) 2012-11-01
JP5114610B1 (ja) 2013-01-09
WO2011058474A8 (en) 2012-04-26
GEP20146169B (en) 2014-09-25
CA2778886C (en) 2014-01-07
HK1173724A1 (en) 2013-05-24
CU24077B1 (es) 2015-03-30
EP2499139B1 (en) 2013-12-11
KR20120099460A (ko) 2012-09-10
NI201200089A (es) 2012-08-20
US8507681B2 (en) 2013-08-13
PL2499139T3 (pl) 2014-04-30
US9139587B2 (en) 2015-09-22
DOP2012000128A (es) 2012-08-31
CO6541569A2 (es) 2012-10-16
AP2012006269A0 (en) 2012-06-30
CA2778886A1 (en) 2011-05-19
EP2676958A1 (en) 2013-12-25
EP2947082A1 (en) 2015-11-25
ECSP12011880A (es) 2012-07-31
EA201290191A1 (ru) 2012-12-28
KR101550557B1 (ko) 2015-09-04
US20140288111A1 (en) 2014-09-25
ES2444543T3 (es) 2014-02-25
SI2499139T1 (sl) 2014-01-31
US20110111046A1 (en) 2011-05-12
HN2012000973A (es) 2015-03-02
US8802690B2 (en) 2014-08-12
TW201127838A (en) 2011-08-16
AU2010317501A1 (en) 2012-05-17
IL219373A (en) 2014-04-30
KR20140034919A (ko) 2014-03-20
CN102695708A (zh) 2012-09-26
NZ599815A (en) 2013-04-26
AR078944A1 (es) 2011-12-14
TWI394756B (zh) 2013-05-01
DK2499139T3 (da) 2014-01-27
US20130030181A1 (en) 2013-01-31
CN102695708B (zh) 2014-10-15
HRP20140025T1 (hr) 2014-02-14
EP2676958B1 (en) 2015-07-01
CL2012000999A1 (es) 2012-07-20
UA102336C2 (uk) 2013-06-25
AU2010317501B2 (en) 2013-06-06
AP3283A (en) 2015-05-31
IL219373A0 (en) 2012-06-28
UY33020A (es) 2011-06-30
PT2499139E (pt) 2014-02-10
CR20120190A (es) 2012-05-24
MX2012005429A (es) 2012-06-19
EP2499139A1 (en) 2012-09-19

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