BR112012011072A2 - inibidores de n1-pirazolospirocetona acetil-coa carboxilase - Google Patents

inibidores de n1-pirazolospirocetona acetil-coa carboxilase

Info

Publication number
BR112012011072A2
BR112012011072A2 BR112012011072A BR112012011072A BR112012011072A2 BR 112012011072 A2 BR112012011072 A2 BR 112012011072A2 BR 112012011072 A BR112012011072 A BR 112012011072A BR 112012011072 A BR112012011072 A BR 112012011072A BR 112012011072 A2 BR112012011072 A2 BR 112012011072A2
Authority
BR
Brazil
Prior art keywords
pyrazolospyrocetone
coa carboxylase
carboxylase inhibitors
acetyl coa
compound
Prior art date
Application number
BR112012011072A
Other languages
English (en)
Inventor
Weishung Kung Daniel
Andrew Griffith David
William Bagley Scott
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR112012011072A2 publication Critical patent/BR112012011072A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

inibidores de acetil-coa carboxilase n1-pirazolospirocetona. a presente invenção proporciona um composto de fórmula (i) ou um sal farmaceuticamente aceitável do composto, em que r~ 1~,r~ 2~.r~ 3~ e r~ 4~ são como descrito aqui; composições farmacêuticas dos mesmo; e o uso dos mesmos no tratamento de doenças, condições ou desordens moduladas pela inibição de uma enzima(s) acetil-co a carboxilase em um animal.
BR112012011072A 2009-11-10 2010-10-29 inibidores de n1-pirazolospirocetona acetil-coa carboxilase BR112012011072A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25982309P 2009-11-10 2009-11-10
PCT/IB2010/054908 WO2011058474A1 (en) 2009-11-10 2010-10-29 N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors

Publications (1)

Publication Number Publication Date
BR112012011072A2 true BR112012011072A2 (pt) 2017-06-20

Family

ID=43357094

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012011072A BR112012011072A2 (pt) 2009-11-10 2010-10-29 inibidores de n1-pirazolospirocetona acetil-coa carboxilase

Country Status (39)

Country Link
US (4) US8288405B2 (pt)
EP (3) EP2499139B1 (pt)
JP (1) JP5114610B1 (pt)
KR (2) KR101550557B1 (pt)
CN (1) CN102695708B (pt)
AP (1) AP3283A (pt)
AR (1) AR078944A1 (pt)
AU (1) AU2010317501B2 (pt)
BR (1) BR112012011072A2 (pt)
CA (1) CA2778886C (pt)
CL (1) CL2012000999A1 (pt)
CO (1) CO6541569A2 (pt)
CR (1) CR20120190A (pt)
CU (1) CU24077B1 (pt)
DK (1) DK2499139T3 (pt)
DO (1) DOP2012000128A (pt)
EA (1) EA020153B1 (pt)
EC (1) ECSP12011880A (pt)
ES (1) ES2444543T3 (pt)
GE (1) GEP20146169B (pt)
HK (1) HK1173724A1 (pt)
HN (1) HN2012000973A (pt)
HR (1) HRP20140025T1 (pt)
IL (1) IL219373A (pt)
MA (1) MA33734B1 (pt)
MX (1) MX2012005429A (pt)
NI (1) NI201200089A (pt)
NZ (1) NZ599815A (pt)
PE (1) PE20121469A1 (pt)
PL (1) PL2499139T3 (pt)
PT (1) PT2499139E (pt)
RS (1) RS53156B (pt)
SI (1) SI2499139T1 (pt)
TN (1) TN2012000192A1 (pt)
TW (1) TWI394756B (pt)
UA (1) UA102336C2 (pt)
UY (1) UY33020A (pt)
WO (1) WO2011058474A1 (pt)
ZA (1) ZA201204231B (pt)

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Also Published As

Publication number Publication date
TWI394756B (zh) 2013-05-01
IL219373A (en) 2014-04-30
NI201200089A (es) 2012-08-20
MA33734B1 (fr) 2012-11-01
HN2012000973A (es) 2015-03-02
CA2778886A1 (en) 2011-05-19
US8802690B2 (en) 2014-08-12
US9139587B2 (en) 2015-09-22
KR20120099460A (ko) 2012-09-10
PL2499139T3 (pl) 2014-04-30
KR101478517B1 (ko) 2015-01-02
MX2012005429A (es) 2012-06-19
CL2012000999A1 (es) 2012-07-20
CU20120071A7 (es) 2013-05-31
TN2012000192A1 (fr) 2013-12-12
TW201127838A (en) 2011-08-16
US8288405B2 (en) 2012-10-16
JP2013510192A (ja) 2013-03-21
US20130296319A1 (en) 2013-11-07
KR20140034919A (ko) 2014-03-20
KR101550557B1 (ko) 2015-09-04
HRP20140025T1 (hr) 2014-02-14
GEP20146169B (en) 2014-09-25
RS53156B (en) 2014-06-30
AP2012006269A0 (en) 2012-06-30
SI2499139T1 (sl) 2014-01-31
CO6541569A2 (es) 2012-10-16
CU24077B1 (es) 2015-03-30
JP5114610B1 (ja) 2013-01-09
DK2499139T3 (da) 2014-01-27
WO2011058474A1 (en) 2011-05-19
AR078944A1 (es) 2011-12-14
EA201290191A1 (ru) 2012-12-28
HK1173724A1 (en) 2013-05-24
CR20120190A (es) 2012-05-24
EP2676958A1 (en) 2013-12-25
EP2676958B1 (en) 2015-07-01
US8507681B2 (en) 2013-08-13
US20110111046A1 (en) 2011-05-12
IL219373A0 (en) 2012-06-28
PT2499139E (pt) 2014-02-10
NZ599815A (en) 2013-04-26
WO2011058474A8 (en) 2012-04-26
US20130030181A1 (en) 2013-01-31
DOP2012000128A (es) 2012-08-31
EP2499139B1 (en) 2013-12-11
UY33020A (es) 2011-06-30
UA102336C2 (uk) 2013-06-25
CN102695708B (zh) 2014-10-15
AP3283A (en) 2015-05-31
EP2499139A1 (en) 2012-09-19
EP2947082A1 (en) 2015-11-25
EA020153B1 (ru) 2014-09-30
ECSP12011880A (es) 2012-07-31
AU2010317501B2 (en) 2013-06-06
CN102695708A (zh) 2012-09-26
AU2010317501A1 (en) 2012-05-17
CA2778886C (en) 2014-01-07
PE20121469A1 (es) 2012-11-01
ZA201204231B (en) 2013-02-27
US20140288111A1 (en) 2014-09-25
ES2444543T3 (es) 2014-02-25

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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