CO6251317A2 - Procedimiento para sintetizar sal diclorhidrato de ((1s)-1-(((2s) sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil - Google Patents

Procedimiento para sintetizar sal diclorhidrato de ((1s)-1-(((2s) sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil

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Publication number
CO6251317A2
CO6251317A2 CO10009492A CO10009492A CO6251317A2 CO 6251317 A2 CO6251317 A2 CO 6251317A2 CO 10009492 A CO10009492 A CO 10009492A CO 10009492 A CO10009492 A CO 10009492A CO 6251317 A2 CO6251317 A2 CO 6251317A2
Authority
CO
Colombia
Prior art keywords
imidazol
pirrolidinil
salt
alkyl
synthesizing
Prior art date
Application number
CO10009492A
Other languages
English (en)
Inventor
Shawn K Pack
Peng Geng
Michael Smith
Jason Hamm
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39865546&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6251317(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO6251317A2 publication Critical patent/CO6251317A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

La presente revelación se refiere de forma general a un procedimiento para sintetizar sal diclorhidrato de ((1S)-1-(((2S)-2-(5-(4'-(2-((2S)-1-((2S)-2- ((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil) carbonil)-2-metilpropicarbamato de metilo. La presente revelación también se refiere de forma general a intermedios útiles en este procedimiento. 1.- Un procedimiento para preparar un compuesto de fórmula (7)o una de sus sales farmacéuticamente aceptable; en la quen es 0,1 ó 2; s es 0, 1, 2, 3 ó 4; u y v se selecciona cada uno independientemente de 0, 1, 2 ó 3; X se selecciona de O, S, S(O), SO2, CH2, CHR5 y C(R5)2; con la condición de que cuando n es 0, X se selecciona de CH2, CHR5 y C(R5)2; R1 y R2 se selecciona cada uno independientemente de alcoxi, alquilo y halo; y cuando s es 2, 3 ó 4, cada R5 en el anillo se selecciona independientemente de alcoxi, alquilo y arilo, donde el alquilo puede formar opcionalmente un anillo condensado de tres a seis miembros con un átomo de carbono adyacente, estando el anillo de tres a seis miembros opcionalmente sustituido con uno o dos grupos alquilo; con la condición de que los dos anillos heterocíclicos que sustituyen los anillos imidazol son idénticos;comprendiendo el procedimiento: (a) hacer reaccionar un compuesto de fórmula (3)en la que u, v, R1 y R2 son como se describen para la fórmula (7); y ...
CO10009492A 2007-08-08 2010-01-29 Procedimiento para sintetizar sal diclorhidrato de ((1s)-1-(((2s) sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil CO6251317A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95459507P 2007-08-08 2007-08-08

Publications (1)

Publication Number Publication Date
CO6251317A2 true CO6251317A2 (es) 2011-02-21

Family

ID=39865546

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10009492A CO6251317A2 (es) 2007-08-08 2010-01-29 Procedimiento para sintetizar sal diclorhidrato de ((1s)-1-(((2s) sal diclorhidrato de ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil

Country Status (25)

Country Link
US (1) US7728027B2 (es)
EP (1) EP2178863B1 (es)
JP (2) JP5324574B2 (es)
KR (1) KR101528542B1 (es)
CN (1) CN101778841B (es)
AR (2) AR067896A1 (es)
AU (1) AU2008284097B2 (es)
BR (1) BRPI0815611B1 (es)
CA (1) CA2695711C (es)
CL (1) CL2008002355A1 (es)
CO (1) CO6251317A2 (es)
CY (1) CY1113547T1 (es)
DK (1) DK2178863T3 (es)
EA (1) EA017173B1 (es)
ES (1) ES2396267T3 (es)
HK (1) HK1137454A1 (es)
HR (1) HRP20120990T1 (es)
IL (1) IL203685A (es)
MX (1) MX2010001415A (es)
PE (1) PE20090611A1 (es)
PL (1) PL2178863T3 (es)
PT (1) PT2178863E (es)
SI (1) SI2178863T1 (es)
TW (1) TWI423963B (es)
WO (1) WO2009020825A1 (es)

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JP2013231072A (ja) 2013-11-14
EP2178863B1 (en) 2012-10-24
HRP20120990T1 (hr) 2012-12-31
SI2178863T1 (sl) 2013-02-28
WO2009020825A1 (en) 2009-02-12
JP5324574B2 (ja) 2013-10-23
JP2010535784A (ja) 2010-11-25
BRPI0815611B1 (pt) 2018-08-21
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US7728027B2 (en) 2010-06-01
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BRPI0815611A2 (pt) 2015-03-24
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EA017173B1 (ru) 2012-10-30
CN101778841B (zh) 2015-07-22
AR067896A1 (es) 2009-10-28
KR101528542B1 (ko) 2015-06-15
CA2695711C (en) 2014-09-09
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