MX2010001170A - Derivados de imidazolona, metodo de preparacion de los mismos y uso biologico de los mismos. - Google Patents
Derivados de imidazolona, metodo de preparacion de los mismos y uso biologico de los mismos.Info
- Publication number
- MX2010001170A MX2010001170A MX2010001170A MX2010001170A MX2010001170A MX 2010001170 A MX2010001170 A MX 2010001170A MX 2010001170 A MX2010001170 A MX 2010001170A MX 2010001170 A MX2010001170 A MX 2010001170A MX 2010001170 A MX2010001170 A MX 2010001170A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- aryl
- same
- alkyl
- imidazolone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a derivados de imidazolona y el uso de los mismos como fármacos, que tienen la fórmula (l), en donde: R1 = H, alquilo en C1 a C5, arilo, o un grupo heterocíclico con 5 o 6 elementos; Ar1 = arilo, opcionalmente sustituido, o un heterociclo aromático; R = R2-S-, R3-HN-, R4COHN o Ar2, con- R2 = un radical alquilo en C1-C5, vinilo o alquil-vinilo en C1-C5, nitrilo o alquilnitrilo en Cl-C5, arilo, bencilo, los cuales son opcionalmente sustituidos; -R3 = según se define anteriormente; y -Ar2 = arilo sustituido o no sustituido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0705632A FR2919608B1 (fr) | 2007-08-01 | 2007-08-01 | Derives d'imidazolones,procede de preparation et applications biologiques |
PCT/FR2008/001152 WO2009050352A2 (fr) | 2007-08-01 | 2008-08-01 | Derives d'imidazolones, procede de preparation et applications biologiques |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010001170A true MX2010001170A (es) | 2010-06-25 |
Family
ID=39323606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010001170A MX2010001170A (es) | 2007-08-01 | 2008-08-01 | Derivados de imidazolona, metodo de preparacion de los mismos y uso biologico de los mismos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US8563588B2 (es) |
EP (1) | EP2185547B1 (es) |
JP (1) | JP5926885B2 (es) |
KR (1) | KR20100051698A (es) |
CN (1) | CN101784542B (es) |
BR (1) | BRPI0814457A2 (es) |
CA (1) | CA2694377A1 (es) |
ES (1) | ES2644087T3 (es) |
FR (1) | FR2919608B1 (es) |
MX (1) | MX2010001170A (es) |
RU (1) | RU2491283C2 (es) |
WO (1) | WO2009050352A2 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010096584A1 (en) | 2009-02-18 | 2010-08-26 | Cornell University | Coupled recognition/detection system for in vivo and in vitro use |
EP2281824A1 (en) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders |
US11453646B2 (en) | 2011-07-27 | 2022-09-27 | Cornell University | Methods for RNA detection and quantification |
CA3006139C (en) * | 2012-07-30 | 2020-06-02 | Kyoto University | Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor |
FR3002044A1 (fr) * | 2013-02-08 | 2014-08-15 | Centre Nat Rech Scient | Marqueur dyrk1a pour la maladie d'alzheimer |
WO2015031718A1 (en) * | 2013-08-29 | 2015-03-05 | Mcquade D Tyler | Methods of making 2-halonicotinonitriles |
US9664676B2 (en) | 2013-09-06 | 2017-05-30 | Cornell University | RNA sequences that induce fluorescence of small molecule fluorophores |
CN104370891B (zh) * | 2014-10-17 | 2016-09-07 | 中国农业大学 | 一种5-(丁烯内酯-3-亚乙基)-2-氨基咪唑啉酮类化合物、制备方法及其应用 |
RU2730550C1 (ru) * | 2019-05-15 | 2020-08-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Производное 2-селеноксо-тетрагидро-4н-имидазол-4-она, способ его получения и применения |
CN114502161B (zh) * | 2019-12-14 | 2024-03-29 | 上海市东方医院(同济大学附属东方医院) | 具有心肌细胞增殖活性的杂环衍生物在治疗心脏病中的用途 |
WO2021114314A1 (en) * | 2019-12-14 | 2021-06-17 | Tongji University | Novel heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases |
KR102491260B1 (ko) * | 2019-12-26 | 2023-01-27 | 연세대학교 산학협력단 | 피롤리딘 유도체 및 이를 포함하는 베타-아밀로이드 또는 타우 단백질 관련 질병의 예방 또는 치료용 약학 조성물 |
CA3174844A1 (en) | 2020-04-30 | 2021-11-04 | Perha Pharmaceuticals | New imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
EP3904354A1 (en) | 2020-04-30 | 2021-11-03 | Perha Pharmaceuticals | New imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
EP4173673A1 (en) | 2021-10-26 | 2023-05-03 | Perha Pharmaceuticals | Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
EP4173674A1 (en) | 2021-10-26 | 2023-05-03 | Perha Pharmaceuticals | Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
EP4173675A1 (en) | 2021-10-26 | 2023-05-03 | Perha Pharmaceuticals | Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1038050B (de) * | 1955-11-17 | 1958-09-04 | Farmaceutici Italia S A Soc | Verfahren zur Herstellung von 5-(3', 4'-Dioxybenzyliden)-Derivaten heterocyclischer Verbindungen |
DD95843A5 (es) * | 1971-01-21 | 1973-02-20 | ||
US4431656A (en) * | 1981-02-05 | 1984-02-14 | Kanegafuchi Chemical Industry Company Limited | 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient |
GR79384B (es) * | 1982-08-20 | 1984-10-22 | Hoechst Uk Ltd | |
IE940525L (en) * | 1988-05-25 | 1989-11-25 | Warner Lambert Co | Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents |
DE69007413T2 (de) * | 1989-10-09 | 1994-07-21 | Toshiba Kawasaki Kk | Organisches Material für die nichtlineare Optik und nichtlineare optische Vorrichtung. |
US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
EP0526598B1 (en) * | 1990-04-27 | 1996-12-18 | Orion-Yhtymà Oy | New pharmacologically active catechol derivatives |
JP3015702B2 (ja) * | 1995-02-21 | 2000-03-06 | 株式会社アラクス | イミダゾール誘導体及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれらを有効成分とする抗潰瘍剤 |
US6218437B1 (en) * | 1996-09-30 | 2001-04-17 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
PL187019B1 (pl) * | 1997-02-19 | 2004-04-30 | Univ Jagiellonski Collegium Me | Nowe związki, pochodne 5-arylideno-4-okso-2-imidazolidynoglicyny |
EG21566A (en) * | 1999-09-21 | 2001-12-31 | Hosny Hamed Hoharam | Synthesis of 5-(4-dimethylaminobenzli-dene)-2-phenylhydrozino (1,3-h) imidazole-4-one (iii) |
EP1569653A1 (en) * | 2002-12-06 | 2005-09-07 | Warner-Lambert Company LLC | Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k |
FR2855755B1 (fr) * | 2003-06-05 | 2007-09-07 | Oreal | Utilisation d'au moins un filtre de la lumiere bleue pour preserve le capital de carotenoides endogenes de la peau; nouveaux filtres de la lumiere bleue; compositions cosmetiques |
DE602004022170D1 (de) * | 2003-07-28 | 2009-09-03 | Merck Serono Sa Coinsins | 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren |
JP2008516905A (ja) * | 2004-10-14 | 2008-05-22 | エフ.ホフマン−ラ ロシュ アーゲー | Cdk1抗増殖活性を有する1,5−ナフチリジンアゾリジノン |
US20090299063A1 (en) * | 2005-03-29 | 2009-12-03 | Paul Shapiro | Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and Uses Therefor |
US7304074B2 (en) * | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
JP2007063444A (ja) * | 2005-08-31 | 2007-03-15 | Tdk Corp | 錯化合物及びこれを用いた光記録媒体 |
US7371862B2 (en) * | 2005-11-11 | 2008-05-13 | Pfizer Italia S.R.L. | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
WO2007065261A1 (en) * | 2005-12-07 | 2007-06-14 | American Diagnostica Inc. | Plasminogen activator inhibitor-1 inhibitors |
-
2007
- 2007-08-01 FR FR0705632A patent/FR2919608B1/fr active Active
-
2008
- 2008-08-01 JP JP2010518711A patent/JP5926885B2/ja active Active
- 2008-08-01 WO PCT/FR2008/001152 patent/WO2009050352A2/fr active Application Filing
- 2008-08-01 US US12/452,940 patent/US8563588B2/en active Active
- 2008-08-01 ES ES08838929.1T patent/ES2644087T3/es active Active
- 2008-08-01 CA CA2694377A patent/CA2694377A1/fr not_active Abandoned
- 2008-08-01 KR KR1020107004568A patent/KR20100051698A/ko not_active Application Discontinuation
- 2008-08-01 BR BRPI0814457-5A2A patent/BRPI0814457A2/pt not_active IP Right Cessation
- 2008-08-01 CN CN200880103961.8A patent/CN101784542B/zh active Active
- 2008-08-01 EP EP08838929.1A patent/EP2185547B1/fr active Active
- 2008-08-01 MX MX2010001170A patent/MX2010001170A/es active IP Right Grant
- 2008-08-01 RU RU2010107262/04A patent/RU2491283C2/ru active
Also Published As
Publication number | Publication date |
---|---|
US20100216855A1 (en) | 2010-08-26 |
CA2694377A1 (fr) | 2009-04-23 |
EP2185547A2 (fr) | 2010-05-19 |
KR20100051698A (ko) | 2010-05-17 |
FR2919608B1 (fr) | 2012-10-05 |
CN101784542A (zh) | 2010-07-21 |
CN101784542B (zh) | 2014-04-02 |
FR2919608A1 (fr) | 2009-02-06 |
JP5926885B2 (ja) | 2016-05-25 |
BRPI0814457A2 (pt) | 2015-01-06 |
JP2010535180A (ja) | 2010-11-18 |
EP2185547B1 (fr) | 2017-07-19 |
WO2009050352A2 (fr) | 2009-04-23 |
ES2644087T3 (es) | 2017-11-27 |
US8563588B2 (en) | 2013-10-22 |
RU2010107262A (ru) | 2011-09-10 |
RU2491283C2 (ru) | 2013-08-27 |
WO2009050352A3 (fr) | 2009-07-23 |
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Legal Events
Date | Code | Title | Description |
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FG | Grant or registration |