EA201270359A1 - Терапевтическое средство от расстройств настроения - Google Patents

Терапевтическое средство от расстройств настроения

Info

Publication number
EA201270359A1
EA201270359A1 EA201270359A EA201270359A EA201270359A1 EA 201270359 A1 EA201270359 A1 EA 201270359A1 EA 201270359 A EA201270359 A EA 201270359A EA 201270359 A EA201270359 A EA 201270359A EA 201270359 A1 EA201270359 A1 EA 201270359A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mood disorders
therapeutic means
therapeutic
pharmaceutically acceptable
general formula
Prior art date
Application number
EA201270359A
Other languages
English (en)
Other versions
EA030333B1 (ru
Inventor
Кодзи Ямада
Томоюки Канда
Original Assignee
Киова Хакко Кирин Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43649339&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201270359(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Киова Хакко Кирин Ко., Лтд. filed Critical Киова Хакко Кирин Ко., Лтд.
Publication of EA201270359A1 publication Critical patent/EA201270359A1/ru
Publication of EA030333B1 publication Critical patent/EA030333B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описывается терапевтическое и/или профилактическое средство от расстройств настроения, которое содержит в качестве активного ингредиента производное тиазола, представленное общей формулой (I) (где Rпредставляет собой арильную группу или аналогичные и Rпредставляет пиридильную группу или аналогичные), или его фармацевтически приемлемую соль.
EA201270359A 2009-09-02 2010-09-02 Способ лечения и/или предотвращения расстройств настроения EA030333B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009202893 2009-09-02
PCT/JP2010/064988 WO2011027805A1 (ja) 2009-09-02 2010-09-02 気分障害治療剤

Publications (2)

Publication Number Publication Date
EA201270359A1 true EA201270359A1 (ru) 2012-09-28
EA030333B1 EA030333B1 (ru) 2018-07-31

Family

ID=43649339

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270359A EA030333B1 (ru) 2009-09-02 2010-09-02 Способ лечения и/или предотвращения расстройств настроения

Country Status (31)

Country Link
US (1) US9249135B2 (ru)
EP (1) EP2474543B1 (ru)
JP (1) JP5663484B2 (ru)
KR (1) KR101762981B1 (ru)
CN (1) CN102482272A (ru)
AU (1) AU2010290423B2 (ru)
BR (1) BR112012004851B8 (ru)
CA (1) CA2772920C (ru)
CL (1) CL2012000534A1 (ru)
CY (1) CY1119118T1 (ru)
DK (1) DK2474543T3 (ru)
DO (1) DOP2012000058A (ru)
EA (1) EA030333B1 (ru)
ES (1) ES2633538T3 (ru)
GE (1) GEP20156224B (ru)
HR (1) HRP20171137T1 (ru)
HU (1) HUE033690T2 (ru)
IL (1) IL218321A (ru)
LT (1) LT2474543T (ru)
MA (1) MA33618B1 (ru)
ME (1) ME02804B (ru)
MX (1) MX2012002528A (ru)
NZ (1) NZ598750A (ru)
PL (1) PL2474543T3 (ru)
PT (1) PT2474543T (ru)
RS (1) RS56345B1 (ru)
SI (1) SI2474543T1 (ru)
TN (1) TN2012000092A1 (ru)
UA (1) UA110097C2 (ru)
WO (1) WO2011027805A1 (ru)
ZA (1) ZA201202346B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3002283T3 (en) * 2003-12-26 2017-07-10 Kyowa Hakko Kirin Co Ltd THIAZOLE DERIVATIVES.
UA113383C2 (xx) * 2009-09-02 2017-01-25 Терапевтичний агент для лікування тривожних розладів
MA41090A (fr) * 2014-12-03 2017-10-10 H Lundbeck As Antagoniste de a2a faiblement dosé pour le traitement du tdah et de la maladie de parkinson
JOP20200093A1 (ar) * 2015-01-09 2017-06-16 Kyowa Kirin Co Ltd طريقة لإنتاج مشتق ثيازول
JO3544B1 (ar) * 2015-03-19 2020-07-05 Kyowa Kirin Co Ltd عامل علاجي للاختلال الوظيفي في الفص الجبهي
TW201803869A (zh) 2016-04-27 2018-02-01 健生藥品公司 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑
WO2019244001A1 (en) 2018-06-18 2019-12-26 Janssen Pharmaceutica Nv 6-aminopyridin-3-yl pyrazoles as modulators of roryt
CA3103929A1 (en) 2018-06-18 2019-12-26 Janssen Pharmaceutica Nv Phenyl substituted pyrazoles as modulators of roryt
CA3103932A1 (en) 2018-06-18 2019-12-26 Janssen Pharmaceutica Nv Pyridinyl pyrazoles as modulators of roryt
ES2929140T3 (es) 2018-06-18 2022-11-25 Janssen Pharmaceutica Nv Imidazoles sustituidos con fenilo y piridinilo como moduladores de RORgammat
WO2023201267A1 (en) 2022-04-13 2023-10-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0628311T3 (da) 1992-07-08 2002-07-22 Kyowa Hakko Kogyo Kk Xanthinderivater som antidepressive midler
EP1666041A3 (en) 1997-09-05 2008-04-02 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives for treating neurodegenerative disorders
CA2459304A1 (en) * 2001-09-13 2003-03-20 Schering Corporation Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic
US6620811B2 (en) 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
JP4778894B2 (ja) 2003-06-10 2011-09-21 協和発酵キリン株式会社 不安障害の治療方法
DK3002283T3 (en) 2003-12-26 2017-07-10 Kyowa Hakko Kirin Co Ltd THIAZOLE DERIVATIVES.
WO2005095357A2 (en) 2004-03-30 2005-10-13 Taisho Pharmaceutical Co., Ltd. Pyrimidine derivatives and methods of treatment related to the use thereof
JPWO2006137527A1 (ja) * 2005-06-23 2009-01-22 協和発酵キリン株式会社 チアゾール誘導体
DK1921077T3 (en) 2005-08-02 2017-10-23 Kyowa Hakko Kirin Co Ltd Means for treating and / or preventing sleep disorders

Also Published As

Publication number Publication date
MX2012002528A (es) 2012-04-11
LT2474543T (lt) 2017-08-25
PL2474543T3 (pl) 2017-09-29
GEP20156224B (en) 2015-01-26
JP5663484B2 (ja) 2015-02-04
HUE033690T2 (hu) 2017-12-28
UA110097C2 (uk) 2015-11-25
BR112012004851A2 (pt) 2016-04-05
HRP20171137T1 (hr) 2017-10-06
RS56345B1 (sr) 2017-12-29
DOP2012000058A (es) 2012-06-30
DK2474543T3 (en) 2017-08-14
KR20120047310A (ko) 2012-05-11
NZ598750A (en) 2014-08-29
EP2474543B1 (en) 2017-05-03
CY1119118T1 (el) 2018-02-14
US20120184554A1 (en) 2012-07-19
EP2474543A4 (en) 2013-05-29
CL2012000534A1 (es) 2012-09-14
MA33618B1 (fr) 2012-09-01
CN102482272A (zh) 2012-05-30
EP2474543A1 (en) 2012-07-11
KR101762981B1 (ko) 2017-07-28
CA2772920A1 (en) 2011-10-03
JPWO2011027805A1 (ja) 2013-02-04
US9249135B2 (en) 2016-02-02
PT2474543T (pt) 2017-08-03
EA030333B1 (ru) 2018-07-31
AU2010290423B2 (en) 2015-10-29
IL218321A0 (en) 2012-04-30
WO2011027805A1 (ja) 2011-03-10
AU2010290423A1 (en) 2012-04-19
CA2772920C (en) 2018-07-31
ZA201202346B (en) 2015-11-25
ME02804B (me) 2018-01-20
BR112012004851B1 (pt) 2021-03-02
IL218321A (en) 2016-10-31
ES2633538T3 (es) 2017-09-21
SI2474543T1 (sl) 2017-08-31
BR112012004851B8 (pt) 2021-05-25
TN2012000092A1 (en) 2013-09-19

Similar Documents

Publication Publication Date Title
EA201270359A1 (ru) Терапевтическое средство от расстройств настроения
EA201390908A1 (ru) Производные бицикло[3.2.1]октиламида и их применение
WO2011058474A8 (en) N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
EA201170872A1 (ru) Ингибиторы протеинкиназы
TW200728307A (en) Novel spirochromanone derivatives
AU2009258496A8 (en) Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity
EA201390885A1 (ru) Азаиндолы в качестве противовирусных агентов против респираторного синцитиального вируса
RS53617B1 (en) NEW UNITS USEFUL FOR TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
CY1112429T1 (el) Υποκατεστημενα παραγωγα σουλφοναμιδιου
EA201391486A1 (ru) Способы и композиции для лечения болезни паркинсона
RS53613B1 (en) COMPOUNDS, COMPOSITIONS, AND PROCEDURES FOR TREATMENT OF BETA-AMYLOID DISEASES AND SYNUCLEINOPATHY
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
NZ596362A (en) Therapeutic agent for motor disorders
RS52108B (en) 3-SUBSTITUTED [1,2,3] -BENZOTRIAZINONE UNIT TO INCREASE GLUTAMATERGIC SYNAPTIC ANSWERS
PH12016502246B1 (en) Carboxamide derivatives
MX341341B (es) Derivados de benzamida y su uso como inhibidores de proteina de choque termico 90 kda (hsp90).
TN2016000491A1 (en) Carboxamide derivatives.
WO2011159124A3 (ko) Ｉｎｔｅｒｌｅｕｋｉｎ-６ 억제 작용을 갖는 신규한 벤즈옥사졸 유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물
CY1119483T1 (el) Θεραπευτικος παραγων για τις αγχωδεις διαταραχες
EA201070367A1 (ru) Производное 6-пиримидинилпиримид-4-она
MX2012012410A (es) Agente terapeutico y agente preventivo para enfermedad de alzheimer.
WO2013062332A3 (ko) 시링가레시놀을 포함하는 혈관 노화 억제용 조성물
WO2011102660A3 (en) A novel 5-membered heterocycle derivatives and manufacturing process thereof
WO2012125663A3 (en) Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
EA200901085A1 (ru) Производные циклогексиламида арилкарбоновой кислоты

Legal Events

Date Code Title Description
TC4A Change in name of a patent proprietor in a eurasian patent