PE20050999A1 - Cetoamidas novedosas con p4 ciclicos como inhibidores de ns3 serina proteasa del virus de hepatitis c - Google Patents

Cetoamidas novedosas con p4 ciclicos como inhibidores de ns3 serina proteasa del virus de hepatitis c

Info

Publication number
PE20050999A1
PE20050999A1 PE2005000218A PE2005000218A PE20050999A1 PE 20050999 A1 PE20050999 A1 PE 20050999A1 PE 2005000218 A PE2005000218 A PE 2005000218A PE 2005000218 A PE2005000218 A PE 2005000218A PE 20050999 A1 PE20050999 A1 PE 20050999A1
Authority
PE
Peru
Prior art keywords
ketoamides
virus
inhibitors
cyclic
serine protease
Prior art date
Application number
PE2005000218A
Other languages
English (en)
Inventor
F George Njoroge
Viyyoor M Girijavalllabahn
Kevin X Chen
Latha G Nair
Bancha Vibulbhan
Ashok Arasappan
Frank Bennett
Stephane L Bogen
Srikanth Venkatraman
Weiying Yang
Mousumi Sannigrahi
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34919371&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20050999(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20050999A1 publication Critical patent/PE20050999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, A SUS ENANTIOMEROS, ESTEREOISOMEROS, ROTAMEROS, TAUTOMEROS Y RACEMATOS, UNA SAL, SOLVATO O ESTER, DONDE R1 ES H, OH, NH2, ENTRE OTROS; A Y M SON CADA UNO H, OH, NH2, ENTRE OTROS; L Y E SON CADA UNO CH, CH2CH, C-ARIL, ENTRE OTROS; M-L-E-A TAMBIEN PUEDEN ESTAR JUNTOS; R2 Y R3 SON CADA UNO H, ALQUIL, ALQUENIL, ENTRE OTROS; Y ES a, b, c, ENTRE OTROS; R15, R16, R17, R18, R19 Y R20 SON CADA UNO H, ALQUILO C1-C10, HETEROALQUILO C1-C10, ENTRE OTROS. DICHAS CETOAMIDAS CON P4 CICLICOS COMO INHIBIDORES DE NS3 SERINA PROTEASA SON UTILES EN EL TRATAMIENTO DEL VIRUS DE HEPATITS C (VHC)
PE2005000218A 2004-02-27 2005-02-24 Cetoamidas novedosas con p4 ciclicos como inhibidores de ns3 serina proteasa del virus de hepatitis c PE20050999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54850604P 2004-02-27 2004-02-27

Publications (1)

Publication Number Publication Date
PE20050999A1 true PE20050999A1 (es) 2005-12-01

Family

ID=34919371

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000218A PE20050999A1 (es) 2004-02-27 2005-02-24 Cetoamidas novedosas con p4 ciclicos como inhibidores de ns3 serina proteasa del virus de hepatitis c

Country Status (18)

Country Link
US (2) US7173057B2 (es)
EP (1) EP1730142B1 (es)
JP (1) JP4874227B2 (es)
KR (1) KR20070026394A (es)
CN (1) CN1946718A (es)
AR (1) AR048023A1 (es)
AT (1) ATE514691T1 (es)
AU (1) AU2005219824B2 (es)
BR (1) BRPI0508217A (es)
CA (1) CA2557304C (es)
EC (1) ECSP066792A (es)
IL (1) IL177628A0 (es)
NO (1) NO20064355L (es)
PE (1) PE20050999A1 (es)
RU (1) RU2006134000A (es)
TW (1) TW200529822A (es)
WO (1) WO2005085242A1 (es)
ZA (1) ZA200607048B (es)

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Also Published As

Publication number Publication date
CN1946718A (zh) 2007-04-11
EP1730142A1 (en) 2006-12-13
US7619094B2 (en) 2009-11-17
CA2557304A1 (en) 2005-09-15
ECSP066792A (es) 2006-11-16
RU2006134000A (ru) 2008-04-10
AR048023A1 (es) 2006-03-22
ATE514691T1 (de) 2011-07-15
KR20070026394A (ko) 2007-03-08
US20050222047A1 (en) 2005-10-06
EP1730142B1 (en) 2011-06-29
TW200529822A (en) 2005-09-16
US20070093430A1 (en) 2007-04-26
NO20064355L (no) 2006-11-24
CA2557304C (en) 2013-08-06
JP4874227B2 (ja) 2012-02-15
IL177628A0 (en) 2006-12-31
ZA200607048B (en) 2008-06-25
US7173057B2 (en) 2007-02-06
AU2005219824A1 (en) 2005-09-15
BRPI0508217A (pt) 2007-07-17
AU2005219824B2 (en) 2007-11-29
WO2005085242A1 (en) 2005-09-15
JP2007525518A (ja) 2007-09-06

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