AR064319A1 - Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otros - Google Patents
Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otrosInfo
- Publication number
- AR064319A1 AR064319A1 ARP070105586A ARP070105586A AR064319A1 AR 064319 A1 AR064319 A1 AR 064319A1 AR P070105586 A ARP070105586 A AR P070105586A AR P070105586 A ARP070105586 A AR P070105586A AR 064319 A1 AR064319 A1 AR 064319A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- occurrence
- independently
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula (1) o una sal farmacéuticamente aceptable de este; caracterizado porque: m es un entero de 0 a 4; n es un entero de 0 a 2; p es un entero de 0 a 1; q es un entero de 1 a 2; v es un entero de 0 a 2; X es C(R11)2, N(R12), O, o S(O)v; Y es C(R11)2, N(R12), O (2); R1 es arilo sustituido con 0-3 R5 o heteroarilo sustituido con 0-3 R5; R2 es H, alquilo C1-6 recto o ramificado, cicloalquilo C3-6, o arilalquilo C1-6 en donde dicha porcion arilo se sustituye con 0-3 R6; R3 es H, alquilo C1-6 recto o ramificado, alcanol C1-6, cicloalquilo C3-6, o arilalquilo C1-6 en donde dicha porcion arilo se sustituye con 0-3 R7; o R2 y R3, junto con el nitrogeno al cual ellos se adhieren, forman un anillo mono- o bicíclico heterocíclico de 3 a 12 átomos en el anillo, en donde un carbono se puede reemplazar opcionalmente con N, O, S, o SO2, y en donde cualquier átomo de carbono en el anillo se puede sustituir opcionalmente con alquilo C1-4, F, o CF3 o en donde cualquier átomo de N adicional se puede sustituir opcionalmente con alquilo C1-4 con la condicion que si Y es O o N(R12), q no es 2; R4 es H, alquilo C1-6 recto o ramificado, arilo sustituido con 0-3 R8, arilalquilo C1-6 en donde dicha porcion arilo se sustituye con -3 R8, heteroarilo sustituido con 0-3 r8, o heteroarilalquilo C1-6 en donde dicha porcion heteroarilo se sustituye con 0-3 R8; R5 es, independientemente en cada ocurrencia, alquilo C1-6, alcoxi, halo, CF3, OCF3, hidroxi, alcanoiloxi, nitro, nitrilo, alquenilo, alquinilo, arilo sustituido con 0-3 R5 o heteroarilo sustituido con 0-3 R5; R6 es, independientemente en cada ocurrencia, alquilo C1-4, halo o H; R7 es, independientemente en cada ocurrencia, alquilo C1-4, halo o H; R8 es, independientemente en cada ocurrencia, alquilo C1-4, halo o H; R9 es, independientemente en cada ocurrencia, alquilo C1-6, alcoxi, halo, H, CF3, OCF3, hidroxi, alcanoiloxi, nitro, nitrilo, alquenilo, alquinilo, arilo sustituido con 0-3 R10, heteroarilo sustituido con 0-3 R10, alquilsulfoxido, alquilsulfona, alquilsulfonamida, fenilsulfonamida sustituida con 0-3 R10, alquilamido, o arilamido sustituido con -3 R10; o dos R9 adyacentes, junto con los átomos en el anillo a los cuales ellos se adhieren, forman un anillo fusionado de 5 o 6 átomos en el anillo; R10 es, independientemente en cada ocurrencia, H, alquilo C1-6, o halo; R11 es independientemente en cada ocurrencia, H, alquilo C1-6, halo, hidroxi, O- (alquilo C1-6), o arilo sustituido con 0-3 R8; R12 es, independientemente en cada ocurrencia, H, alquilo C1-6, o arilo sustituido con 0-3 R8; R13 es, independientemente en cada ocurrencia, H, alquilo C1-6, haluro, hidroxi, o arilo sustituido con 0-3 R16 o haluro; R15 es, independientemente en cada ocurrencia, H, alquilo C1-4 o haluro; R16 es, independientemente en cada ocurrencia, H, alquilo C1-4, o halo; R17 es, independientemente en cada ocurrencia, H, o alquilo C1.4, en donde el anillo A es fenilo, naftilo, piridilo, pirimidinilo, tienilo, tiazolilo, o pirrolilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86964206P | 2006-12-12 | 2006-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR064319A1 true AR064319A1 (es) | 2009-03-25 |
Family
ID=39345330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105586A AR064319A1 (es) | 2006-12-12 | 2007-12-12 | Compuestos y composiciones farmaceuticas derivadas de sulfonamida ciclicos, proceso de preparacion y usos en el tratamiento de trastornos vasomotrices, sexuales, gastrointestinales y otros |
Country Status (6)
Country | Link |
---|---|
US (1) | US20080171737A1 (es) |
AR (1) | AR064319A1 (es) |
CL (1) | CL2007003591A1 (es) |
PE (1) | PE20081577A1 (es) |
TW (1) | TW200831476A (es) |
WO (1) | WO2008073956A2 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005079726A1 (en) | 2004-02-23 | 2005-09-01 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
ES2703450T3 (es) | 2004-04-02 | 2019-03-08 | Fisher & Paykel Healthcare Ltd | Aparato de asistencia a la respiración |
DE202007019687U1 (de) | 2006-07-14 | 2015-07-14 | Fisher & Paykel Healthcare Ltd. | Atemhilfsgerät |
US10258757B2 (en) | 2008-05-12 | 2019-04-16 | Fisher & Paykel Healthcare Limited | Patient interface and aspects thereof |
US10792451B2 (en) | 2008-05-12 | 2020-10-06 | Fisher & Paykel Healthcare Limited | Patient interface and aspects thereof |
US11660413B2 (en) | 2008-07-18 | 2023-05-30 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
US9901700B2 (en) | 2008-10-10 | 2018-02-27 | Fisher & Paykel Healthcare Limited | Nasal pillows for a patient interface |
EP3741418B1 (en) | 2009-11-18 | 2024-05-08 | Fisher & Paykel Healthcare Limited | Nasal interface |
EP3406287B1 (en) | 2010-10-08 | 2022-04-27 | Fisher & Paykel Healthcare Limited | Respiratory mask assembly for breathing assistance apparatus |
CN102464627A (zh) * | 2010-11-10 | 2012-05-23 | 上海药明康德新药开发有限公司 | 丙烯基-1,3-磺内酰胺的制备方法 |
WO2012120052A1 (de) * | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120057A1 (de) * | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120055A1 (de) * | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US10603456B2 (en) | 2011-04-15 | 2020-03-31 | Fisher & Paykel Healthcare Limited | Interface comprising a nasal sealing portion |
AU2012241516B2 (en) | 2011-04-15 | 2016-06-16 | Fisher & Paykel Healthcare Limited | Interface comprising a rolling nasal bridge portion |
SG11201407402TA (en) | 2012-05-11 | 2014-12-30 | Reset Therapeutics Inc | Carbazole-containing sulfonamides as cryptochrome modulators |
CN104602745B (zh) | 2012-08-08 | 2017-09-26 | 费雪派克医疗保健有限公司 | 用于患者接口的头帽 |
US9950130B2 (en) | 2012-09-04 | 2018-04-24 | Fisher & Paykel Healthcare Limited | Valsalva mask |
CN104812382A (zh) | 2012-09-20 | 2015-07-29 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
WO2016032343A1 (en) | 2014-08-25 | 2016-03-03 | Fisher & Paykel Healthcare Limited | Respiratory mask and related portions, components or sub-assemblies |
WO2016188806A1 (de) | 2015-05-22 | 2016-12-01 | Basf Se | Beta-naphtholethersulfonate, verfahren zu deren herstellung und deren verwendung als glanzverbesserer |
WO2018007323A1 (en) * | 2016-07-04 | 2018-01-11 | Bayer Cropscience Aktiengesellschaft | Benzosultams and analogues and their use as fungicides |
USD824020S1 (en) | 2017-02-23 | 2018-07-24 | Fisher & Paykel Healthcare Limited | Cushion assembly for breathing mask assembly |
USD823454S1 (en) | 2017-02-23 | 2018-07-17 | Fisher & Paykel Healthcare Limited | Cushion assembly for breathing mask assembly |
USD823455S1 (en) | 2017-02-23 | 2018-07-17 | Fisher & Paykel Healthcare Limited | Cushion assembly for breathing mask assembly |
CN111559990B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种小分子噁噻嗪类衍生物及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3041336A (en) * | 1958-10-01 | 1962-06-26 | Norwich Pharma Co | 3-oxo-1.2.6-thiadiazine-1.1-dioxides |
US3303190A (en) * | 1965-03-11 | 1967-02-07 | Smith Kline French Lab | Novel dihydro-2, 1-benzothiazine-2, 2-dioxide compounds |
DE1811717A1 (de) * | 1968-11-29 | 1970-06-11 | Bayer Ag | 2,4-Dicyano-6-nitrophenyl-Derivate |
GB2362381A (en) * | 2000-05-18 | 2001-11-21 | Lilly Co Eli | Pharmaceutically active indolyl-piperidines |
US7414052B2 (en) * | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
WO2006000902A1 (en) * | 2004-06-25 | 2006-01-05 | Pfizer Products Inc. | Dihydrobenzofuran compounds and uses thereof |
WO2006121922A1 (en) * | 2005-05-06 | 2006-11-16 | Neurocrine Biosciences, Inc. | Monoamine re-uptake inhibitors and methods relating thereto |
-
2007
- 2007-12-11 CL CL200703591A patent/CL2007003591A1/es unknown
- 2007-12-12 US US11/954,466 patent/US20080171737A1/en not_active Abandoned
- 2007-12-12 PE PE2007001770A patent/PE20081577A1/es not_active Application Discontinuation
- 2007-12-12 AR ARP070105586A patent/AR064319A1/es unknown
- 2007-12-12 WO PCT/US2007/087171 patent/WO2008073956A2/en active Application Filing
- 2007-12-12 TW TW096147428A patent/TW200831476A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008073956A2 (en) | 2008-06-19 |
PE20081577A1 (es) | 2008-11-28 |
WO2008073956A3 (en) | 2008-07-24 |
US20080171737A1 (en) | 2008-07-17 |
CL2007003591A1 (es) | 2008-02-29 |
TW200831476A (en) | 2008-08-01 |
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