EA201200863A1 - Ингибиторы сфингозинкиназы - Google Patents
Ингибиторы сфингозинкиназыInfo
- Publication number
- EA201200863A1 EA201200863A1 EA201200863A EA201200863A EA201200863A1 EA 201200863 A1 EA201200863 A1 EA 201200863A1 EA 201200863 A EA201200863 A EA 201200863A EA 201200863 A EA201200863 A EA 201200863A EA 201200863 A1 EA201200863 A1 EA 201200863A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- sphingozinkinase
- inhibitors
- tautomers
- prodrugs
- solvates
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/4965—Non-condensed pyrazines
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- C07D213/72—Nitrogen atoms
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Abstract
Изобретение относится к соединениям формулы (I)в которой R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, M, M, М, М, Y, Y, V, W, n, m и о имеют значения, приведенные в п.1, и их физиологически приемлемым солям, производным, пролекарствам, сольватам, таутомерам и стереоизомерам, включая их смеси во всех соотношениях, пригодным для применения для лечения заболеваний, на которые оказывает влияние ингибирование Sph киназы 1.
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EP09015422 | 2009-12-14 | ||
EP09015754 | 2009-12-18 | ||
PCT/EP2010/007057 WO2011072791A1 (de) | 2009-12-14 | 2010-11-22 | Inhibitoren der sphingosinkinase |
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EA201200863A1 true EA201200863A1 (ru) | 2013-01-30 |
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EA201200863A EA201200863A1 (ru) | 2009-12-14 | 2010-11-22 | Ингибиторы сфингозинкиназы |
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US (1) | US9062015B2 (ru) |
EP (1) | EP2513057B1 (ru) |
JP (1) | JP2013513628A (ru) |
KR (1) | KR20120093428A (ru) |
CN (1) | CN102666489B (ru) |
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AU (1) | AU2010333338A1 (ru) |
BR (1) | BR112012014164A2 (ru) |
CA (1) | CA2784075A1 (ru) |
EA (1) | EA201200863A1 (ru) |
ES (1) | ES2438509T3 (ru) |
IL (1) | IL220187A0 (ru) |
MX (1) | MX2012006776A (ru) |
SG (1) | SG181570A1 (ru) |
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Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201020161D0 (en) * | 2010-11-26 | 2011-01-12 | Almac Discovery Ltd | Pharmaceutical compounds |
JP6454549B2 (ja) * | 2011-12-19 | 2019-01-16 | サウディ ベーシック インダストリーズ コーポレイション | メタロセン錯体を調製するプロセス |
JP6454548B2 (ja) * | 2011-12-19 | 2019-01-16 | サウディ ベーシック インダストリーズ コーポレイション | メタロセン錯体を調製するプロセス |
EP3085700B1 (en) * | 2013-12-20 | 2018-10-31 | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China | Novel piperidine carboxamide compound, preparation method, and usage thereof |
JP6902040B2 (ja) | 2016-01-28 | 2021-07-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 免疫チェックポイント阻害剤の効力を増強する方法 |
EA201990001A1 (ru) | 2016-06-07 | 2019-05-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
US10988466B2 (en) | 2017-03-23 | 2021-04-27 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
CN108079303A (zh) * | 2017-12-14 | 2018-05-29 | 广东药科大学 | 鞘氨醇激酶抑制剂在制备治疗肝纤维化药物中的应用 |
WO2019162325A1 (en) | 2018-02-21 | 2019-08-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of sk1 as biomarker for predicting response to immunecheckpoint inhibitors |
PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
WO2022040002A1 (en) | 2020-08-17 | 2022-02-24 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
SK285141B6 (sk) | 1996-02-13 | 2006-07-07 | Astrazeneca Uk Limited | Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje |
EP0885198B1 (en) | 1996-03-05 | 2001-12-19 | AstraZeneca AB | 4-anilinoquinazoline derivatives |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
DE69839887D1 (de) * | 1997-10-02 | 2008-09-25 | Eisai R&D Man Co Ltd | Kondensierte pyridinderivate |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
DE19945594A1 (de) * | 1999-09-23 | 2001-03-29 | Boehringer Ingelheim Pharma | Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
MXPA02011770A (es) | 2000-05-31 | 2003-04-10 | Astrazeneca Ab | Derivados de indol con actividad de dano vascular. |
IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
WO2002008213A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
EP1357104A4 (en) * | 2000-12-26 | 2004-07-28 | Res Found Itsuu Lab | TROPOLONE DERIVATIVE |
US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
EP1485381B8 (en) | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazine as inhibitors of protein kinases |
DE60332433D1 (de) | 2002-03-15 | 2010-06-17 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
EP1485376B1 (en) | 2002-03-15 | 2007-06-27 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
UA77526C2 (en) | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
AU2003291403A1 (en) | 2002-11-08 | 2004-06-03 | Neurogen Corporation | 3-substituted-6-aryl pyridined as ligands of c5a receptors |
US7220734B2 (en) | 2002-12-20 | 2007-05-22 | Merck & Co., Inc. | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists |
AU2004269892B2 (en) | 2003-09-09 | 2010-03-11 | F. Hoffmann-La Roche Ag | 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
CA2545296C (en) * | 2003-12-08 | 2012-10-16 | Galderma Research & Development, S.N.C. | Biphenyl derivatives useful as ligands that activate the rar receptors, process for preparing them and use thereof in human medicine and in cosmetics |
EP1701934B1 (en) | 2003-12-26 | 2009-02-25 | Allergan, Inc. | DISUBSTITUTED CHALCONE OXIMES HAVING RAR(Gamma)-RETINOID RECEPTOR ANTAGONIST ACTIVITY |
US7476673B2 (en) | 2003-12-30 | 2009-01-13 | Allergan, Inc. | Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors |
MX2007015863A (es) * | 2005-06-17 | 2008-04-02 | Apogee Biotechnology Corp | Inhibidores de esfingosina cinasa. |
EP1928848A2 (en) | 2005-08-04 | 2008-06-11 | Apogee Biothechnology Corporation | Sphingosine kinase inhibitors and methods of their use |
US7250510B2 (en) * | 2005-08-24 | 2007-07-31 | Total Synthesis, Ltd. | Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations |
JP2009528280A (ja) | 2006-02-16 | 2009-08-06 | シェーリング コーポレイション | Erkインヒビターとしてのピロリジン誘導体 |
US20090030012A1 (en) | 2006-02-23 | 2009-01-29 | Adams Alan D | Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators |
JP5734655B2 (ja) * | 2007-09-17 | 2015-06-17 | アッヴィ・バハマズ・リミテッド | 抗感染症ピリミジンおよびその使用 |
WO2009146112A1 (en) | 2008-04-02 | 2009-12-03 | University Of Virginia Patent Foundation | Compositions and methods for inhibiting sphingosine kinase |
GB0822425D0 (en) * | 2008-12-09 | 2009-01-14 | Glaxo Group Ltd | Compounds |
WO2012012320A1 (en) * | 2010-07-19 | 2012-01-26 | Millenium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
GB201020161D0 (en) * | 2010-11-26 | 2011-01-12 | Almac Discovery Ltd | Pharmaceutical compounds |
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ES2438509T3 (es) | 2014-01-17 |
AR079448A1 (es) | 2012-01-25 |
US20120252789A1 (en) | 2012-10-04 |
BR112012014164A2 (pt) | 2016-05-17 |
WO2011072791A1 (de) | 2011-06-23 |
KR20120093428A (ko) | 2012-08-22 |
EP2513057A1 (de) | 2012-10-24 |
ZA201205237B (en) | 2013-03-27 |
JP2013513628A (ja) | 2013-04-22 |
CA2784075A1 (en) | 2011-06-23 |
AU2010333338A1 (en) | 2012-08-02 |
EP2513057B1 (de) | 2013-09-04 |
MX2012006776A (es) | 2012-10-05 |
IL220187A0 (en) | 2012-07-31 |
US9062015B2 (en) | 2015-06-23 |
CN102666489A (zh) | 2012-09-12 |
CN102666489B (zh) | 2014-07-23 |
SG181570A1 (en) | 2012-07-30 |
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