NO993372L - Substituerte 4-(6-fluor-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridin for behandling av CNS-forstyrrelser - Google Patents

Substituerte 4-(6-fluor-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridin for behandling av CNS-forstyrrelser

Info

Publication number
NO993372L
NO993372L NO993372A NO993372A NO993372L NO 993372 L NO993372 L NO 993372L NO 993372 A NO993372 A NO 993372A NO 993372 A NO993372 A NO 993372A NO 993372 L NO993372 L NO 993372L
Authority
NO
Norway
Prior art keywords
treatment
tetrahydropyridine
indol
fluoro
substituted
Prior art date
Application number
NO993372A
Other languages
English (en)
Other versions
NO993372D0 (no
Inventor
John Fairhurst
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO993372D0 publication Critical patent/NO993372D0/no
Publication of NO993372L publication Critical patent/NO993372L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En farmasøytisk forbindelse med formel (I), hvori R1 er hydrogen, C,_ alkyl, CM alkoksy eller halogen, og R2 er hydrogen, CM alkyl eller CM alkoksy; eller et salt derav. Forbindelsene ifølge oppfinnelsen og deres farmasøytisk akseptable salter er indikert for anvendelse ved behandling av forstyrrelser i sentralnervesystemet.
NO993372A 1997-01-17 1999-07-08 Substituerte 4-(6-fluor-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridin for behandling av CNS-forstyrrelser NO993372L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9700895.7A GB9700895D0 (en) 1997-01-17 1997-01-17 Pharmaceutical compounds
PCT/GB1998/000113 WO1998031686A1 (en) 1997-01-17 1998-01-14 Substituted 4-(6-fluoro-(1h)-indol-3-yl)-1,2,3,6-tetrahydropyridine for the treatment of cns-disorders

Publications (2)

Publication Number Publication Date
NO993372D0 NO993372D0 (no) 1999-07-08
NO993372L true NO993372L (no) 1999-07-08

Family

ID=10806121

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993372A NO993372L (no) 1997-01-17 1999-07-08 Substituerte 4-(6-fluor-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridin for behandling av CNS-forstyrrelser

Country Status (29)

Country Link
US (1) US20010053783A1 (no)
EP (1) EP0854146B1 (no)
JP (1) JPH10204090A (no)
KR (1) KR20000070221A (no)
AR (1) AR011422A1 (no)
AT (1) ATE190617T1 (no)
AU (1) AU5569298A (no)
CA (1) CA2227132A1 (no)
CZ (1) CZ290318B6 (no)
DE (1) DE69800092T2 (no)
DK (1) DK0854146T3 (no)
EA (1) EA001469B1 (no)
ES (1) ES2144888T3 (no)
GB (1) GB9700895D0 (no)
GR (1) GR3033316T3 (no)
HU (1) HUP0000854A3 (no)
ID (1) ID21920A (no)
IL (1) IL129647A (no)
NO (1) NO993372L (no)
NZ (1) NZ335493A (no)
PE (1) PE99399A1 (no)
PL (1) PL334569A1 (no)
PT (1) PT854146E (no)
SI (1) SI0854146T1 (no)
SV (1) SV1998000088A (no)
TR (1) TR199901583T2 (no)
TW (1) TW396156B (no)
WO (1) WO1998031686A1 (no)
ZA (1) ZA98300B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8743098A (en) * 1997-08-22 1999-03-16 Eli Lilly And Company Limited Benzothiadiazinyl-indole derivatives and their use as serotonin receptor ligands
GB9825413D0 (en) 1998-11-19 1999-01-13 Lilly Co Eli Pharmaceutical compounds
GB9903784D0 (en) * 1999-02-18 1999-04-14 Lilly Co Eli Pharmaceutical compounds
AR028945A1 (es) * 2000-06-19 2003-05-28 Lundbeck & Co As H Derivados de indol
KR101165996B1 (ko) 2010-04-23 2012-07-18 주식회사 녹십자 프탈라지논 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
CN105949190B (zh) * 2016-07-04 2018-06-29 烟台凯博医药科技有限公司 一种制备1，8-萘啶及衍生物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2662696A2 (fr) * 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
FR2675801A1 (fr) * 1991-04-24 1992-10-30 Rhone Poulenc Rorer Sa Piperidines, leur preparation et les medicaments les contenant.
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
SV1998000088A (es) 2000-10-10
CZ151099A3 (cs) 1999-09-15
PT854146E (pt) 2000-08-31
HUP0000854A2 (hu) 2000-11-28
AU5569298A (en) 1998-08-07
EA001469B1 (ru) 2001-04-23
IL129647A (en) 2002-02-10
JPH10204090A (ja) 1998-08-04
EP0854146A1 (en) 1998-07-22
KR20000070221A (ko) 2000-11-25
PE99399A1 (es) 1999-11-11
NO993372D0 (no) 1999-07-08
NZ335493A (en) 2000-09-29
GR3033316T3 (en) 2000-09-29
EP0854146B1 (en) 2000-03-15
PL334569A1 (en) 2000-03-13
WO1998031686A1 (en) 1998-07-23
CA2227132A1 (en) 1998-07-17
CZ290318B6 (cs) 2002-07-17
DE69800092T2 (de) 2000-09-14
AR011422A1 (es) 2000-08-16
SI0854146T1 (en) 2000-10-31
ZA98300B (en) 1998-09-10
DE69800092D1 (de) 2000-04-20
US20010053783A1 (en) 2001-12-20
DK0854146T3 (da) 2000-06-05
ATE190617T1 (de) 2000-04-15
ES2144888T3 (es) 2000-06-16
TW396156B (en) 2000-07-01
HUP0000854A3 (en) 2002-06-28
GB9700895D0 (en) 1997-03-05
IL129647A0 (en) 2000-02-29
ID21920A (id) 1999-08-12
TR199901583T2 (xx) 1999-11-22
EA199900667A1 (ru) 2000-02-28

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