ES2152682T3 - Derivados de indolina utiles como antagonistas del receptor 5ht-2c. - Google Patents

Derivados de indolina utiles como antagonistas del receptor 5ht-2c.

Info

Publication number
ES2152682T3
ES2152682T3 ES97929202T ES97929202T ES2152682T3 ES 2152682 T3 ES2152682 T3 ES 2152682T3 ES 97929202 T ES97929202 T ES 97929202T ES 97929202 T ES97929202 T ES 97929202T ES 2152682 T3 ES2152682 T3 ES 2152682T3
Authority
ES
Spain
Prior art keywords
indolina
antagonists
receiver
derivatives useful
rent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97929202T
Other languages
English (en)
Inventor
Steven M Bromidge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2152682T3 publication Critical patent/ES2152682T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

LA INVENCION SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (I), O A UNA SAL DE LOS MISMOS, EN LA QUE R 1 ES HI DROGENO O ALQUILO C 1-6 ; LOS GRUPOS R 2 , R 3 Y R 4 SON, INDEPENDIENTEMENTE, HIDROGENO, HALOGENO O ALQUILO C 16 OPCIONALMENTE SUSTITUIDO POR UNO O MAS ATOMOS DE FLUOR, QUE POSEEN UNA ACTIVIDAD FARMACOLOGICA, A PROCEDIMIENTOS PARA SU PREPARACION, A COMPOSICIONES QUE LOS CONTIENEN Y A SU USO EN EL TRATAMIENTO DE TRASTORNOS DEL SNC TALES COMO LA ANSIEDAD.
ES97929202T 1996-06-20 1997-06-16 Derivados de indolina utiles como antagonistas del receptor 5ht-2c. Expired - Lifetime ES2152682T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9612885.5A GB9612885D0 (en) 1996-06-20 1996-06-20 Novel compounds

Publications (1)

Publication Number Publication Date
ES2152682T3 true ES2152682T3 (es) 2001-02-01

Family

ID=10795577

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97929202T Expired - Lifetime ES2152682T3 (es) 1996-06-20 1997-06-16 Derivados de indolina utiles como antagonistas del receptor 5ht-2c.

Country Status (28)

Country Link
US (2) US6313145B1 (es)
EP (1) EP0912556B1 (es)
JP (1) JP2000512644A (es)
KR (1) KR20040101563A (es)
CN (1) CN1147485C (es)
AR (1) AR008244A1 (es)
AT (1) ATE196766T1 (es)
AU (1) AU718000B2 (es)
BR (1) BR9709982A (es)
CA (1) CA2258559A1 (es)
CO (1) CO4870758A1 (es)
CZ (1) CZ289799B6 (es)
DE (1) DE69703242T2 (es)
DK (1) DK0912556T3 (es)
ES (1) ES2152682T3 (es)
GB (1) GB9612885D0 (es)
GR (1) GR3034847T3 (es)
HK (1) HK1019744A1 (es)
HU (1) HUP9903480A3 (es)
IL (1) IL127304A (es)
NO (1) NO316756B1 (es)
NZ (1) NZ332840A (es)
PL (1) PL186885B1 (es)
PT (1) PT912556E (es)
TR (1) TR199802552T2 (es)
TW (1) TW360650B (es)
WO (1) WO1997048700A1 (es)
ZA (1) ZA975416B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9710523D0 (en) * 1997-05-23 1997-07-16 Smithkline Beecham Plc Novel compounds
WO1999043650A2 (en) * 1998-02-25 1999-09-02 Smithkline Beecham Plc Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
US20030008880A1 (en) * 2001-05-02 2003-01-09 Pfizer Inc. 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity
AU2002346507A1 (en) 2001-11-28 2003-06-10 Pharmacia And Upjohn Company Benzazepine derivatives and their use as 5-ht ligands
GB0200283D0 (en) * 2002-01-08 2002-02-20 Smithkline Beecham Plc Compounds
CA2475254A1 (en) 2002-03-04 2003-09-18 Pharmacia & Upjohn Company Pyridinyloxy derivatives as 5-ht receptor ligands
EP1497265B1 (en) * 2002-04-19 2009-02-18 Glaxo Group Limited Compounds having affinity at 5ht2c receptor and use thereof in therapy
GB0305024D0 (en) * 2003-03-05 2003-04-09 Glaxo Group Ltd Compounds
GB0305553D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
KR101062376B1 (ko) * 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
WO2010083044A1 (en) 2009-01-16 2010-07-22 Massachusetts Institute Of Technology Diagnosis and treatment of autism spectrum disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ254785A (en) * 1992-08-20 1995-09-26 Smithkline Beecham Plc Heterocyclically-condensed indoles and medicaments
GB9313913D0 (en) 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
PL184490B1 (pl) * 1995-02-02 2002-11-29 Smithkline Beecham Plc Nowe pochodne indolu jako antagonista receptora T
US5972937A (en) 1995-02-02 1999-10-26 Smithkline Beecham P.L.C. Heterocyclic compounds possessing 5HT2C receptor antagonist activity
GB9607219D0 (en) 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
US6028055A (en) 1996-10-22 2000-02-22 Genetech, Inc. Receptor selective BNP

Also Published As

Publication number Publication date
NO985970L (no) 1998-12-18
EP0912556A1 (en) 1999-05-06
DE69703242T2 (de) 2001-03-08
IL127304A0 (en) 1999-09-22
HUP9903480A3 (en) 2002-12-28
PL186885B1 (pl) 2004-03-31
NO985970D0 (no) 1998-12-18
CZ420498A3 (cs) 1999-05-12
TW360650B (en) 1999-06-11
AU3339697A (en) 1998-01-07
AU718000B2 (en) 2000-04-06
CA2258559A1 (en) 1997-12-24
TR199802552T2 (xx) 1999-02-22
CZ289799B6 (cs) 2002-04-17
DE69703242D1 (de) 2000-11-09
US20020035134A1 (en) 2002-03-21
DK0912556T3 (da) 2001-01-22
PT912556E (pt) 2001-02-28
ZA975416B (en) 1999-01-25
IL127304A (en) 2003-07-06
PL330708A1 (en) 1999-05-24
CO4870758A1 (es) 1999-12-27
US6313145B1 (en) 2001-11-06
GB9612885D0 (en) 1996-08-21
BR9709982A (pt) 1999-08-10
NO316756B1 (no) 2004-04-26
GR3034847T3 (en) 2001-02-28
HK1019744A1 (en) 2000-02-25
KR20040101563A (ko) 2004-12-02
HUP9903480A2 (en) 2000-07-28
CN1222152A (zh) 1999-07-07
ATE196766T1 (de) 2000-10-15
EP0912556B1 (en) 2000-10-04
AR008244A1 (es) 1999-12-29
JP2000512644A (ja) 2000-09-26
NZ332840A (en) 2000-05-26
WO1997048700A1 (en) 1997-12-24
CN1147485C (zh) 2004-04-28

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