IL127304A - Indoline derivatives, process for their preparation, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating anxiety and depression - Google Patents
Indoline derivatives, process for their preparation, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating anxiety and depressionInfo
- Publication number
- IL127304A IL127304A IL12730497A IL12730497A IL127304A IL 127304 A IL127304 A IL 127304A IL 12730497 A IL12730497 A IL 12730497A IL 12730497 A IL12730497 A IL 12730497A IL 127304 A IL127304 A IL 127304A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- medicaments
- depression
- pharmaceutical compositions
- treating anxiety
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9612885.5A GB9612885D0 (en) | 1996-06-20 | 1996-06-20 | Novel compounds |
| PCT/EP1997/003157 WO1997048700A1 (en) | 1996-06-20 | 1997-06-16 | Indoline derivatives useful as 5-ht-2c receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127304A0 IL127304A0 (en) | 1999-09-22 |
| IL127304A true IL127304A (en) | 2003-07-06 |
Family
ID=10795577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12730497A IL127304A (en) | 1996-06-20 | 1997-06-16 | Indoline derivatives, process for their preparation, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating anxiety and depression |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6313145B1 (es) |
| EP (1) | EP0912556B1 (es) |
| JP (1) | JP2000512644A (es) |
| KR (1) | KR20040101563A (es) |
| CN (1) | CN1147485C (es) |
| AR (1) | AR008244A1 (es) |
| AT (1) | ATE196766T1 (es) |
| AU (1) | AU718000B2 (es) |
| BR (1) | BR9709982A (es) |
| CA (1) | CA2258559A1 (es) |
| CO (1) | CO4870758A1 (es) |
| CZ (1) | CZ289799B6 (es) |
| DE (1) | DE69703242T2 (es) |
| DK (1) | DK0912556T3 (es) |
| ES (1) | ES2152682T3 (es) |
| GB (1) | GB9612885D0 (es) |
| GR (1) | GR3034847T3 (es) |
| HK (1) | HK1019744A1 (es) |
| HU (1) | HUP9903480A3 (es) |
| IL (1) | IL127304A (es) |
| NO (1) | NO316756B1 (es) |
| NZ (1) | NZ332840A (es) |
| PL (1) | PL186885B1 (es) |
| PT (1) | PT912556E (es) |
| TR (1) | TR199802552T2 (es) |
| TW (1) | TW360650B (es) |
| WO (1) | WO1997048700A1 (es) |
| ZA (1) | ZA975416B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9710523D0 (en) * | 1997-05-23 | 1997-07-16 | Smithkline Beecham Plc | Novel compounds |
| AU3030899A (en) * | 1998-02-25 | 1999-09-15 | Smithkline Beecham Plc | Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives |
| GB0019950D0 (en) * | 2000-08-12 | 2000-09-27 | Smithkline Beecham Plc | Compounds |
| US20030008880A1 (en) * | 2001-05-02 | 2003-01-09 | Pfizer Inc. | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity |
| MXPA04005151A (es) | 2001-11-28 | 2004-08-11 | Upjohn Co | Compuestos terapeuticos. |
| GB0200283D0 (en) * | 2002-01-08 | 2002-02-20 | Smithkline Beecham Plc | Compounds |
| AU2003217817A1 (en) | 2002-03-04 | 2003-09-22 | Pharmacia And Upjohn Company | Pyridinyloxy derivatives as 5-ht receptor ligands |
| DE60326223D1 (de) * | 2002-04-19 | 2009-04-02 | Glaxo Group Ltd | Verbindungen mit affinität zum 5ht2c-rezeptor und deren therapeutische verwendung |
| GB0305024D0 (en) * | 2003-03-05 | 2003-04-09 | Glaxo Group Ltd | Compounds |
| GB0305553D0 (en) * | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Compounds |
| KR101062376B1 (ko) * | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| CN102348798A (zh) | 2009-01-16 | 2012-02-08 | 麻省理工学院 | 孤独症谱系障碍的诊断和治疗 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4704693A (en) * | 1992-08-20 | 1994-03-15 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT-2C and 5HT-2B antagonists |
| GB9313913D0 (en) | 1993-07-06 | 1993-08-18 | Smithkline Beecham Plc | Novel compounds |
| WO1996023769A2 (en) | 1995-02-02 | 1996-08-08 | Smithkline Beecham Plc | Heterocyclic compounds possessing 5ht2c receptor antagonist activity |
| CZ294097B6 (cs) * | 1995-02-02 | 2004-10-13 | Smithklineábeechamáplc | Indolový derivátŹ způsob jeho přípravy a farmaceutická kompozice s jeho obsahem |
| GB9607219D0 (en) | 1996-04-04 | 1996-06-12 | Smithkline Beecham Plc | Novel compounds |
| US6028055A (en) | 1996-10-22 | 2000-02-22 | Genetech, Inc. | Receptor selective BNP |
-
1996
- 1996-06-20 GB GBGB9612885.5A patent/GB9612885D0/en active Pending
-
1997
- 1997-06-16 BR BR9709982A patent/BR9709982A/pt not_active Application Discontinuation
- 1997-06-16 PT PT97929202T patent/PT912556E/pt unknown
- 1997-06-16 IL IL12730497A patent/IL127304A/xx not_active IP Right Cessation
- 1997-06-16 DE DE69703242T patent/DE69703242T2/de not_active Expired - Fee Related
- 1997-06-16 CZ CZ19984204A patent/CZ289799B6/cs not_active IP Right Cessation
- 1997-06-16 CN CNB971955395A patent/CN1147485C/zh not_active Expired - Fee Related
- 1997-06-16 DK DK97929202T patent/DK0912556T3/da active
- 1997-06-16 EP EP97929202A patent/EP0912556B1/en not_active Expired - Lifetime
- 1997-06-16 KR KR10-2004-7017304A patent/KR20040101563A/ko active IP Right Grant
- 1997-06-16 PL PL97330708A patent/PL186885B1/pl not_active IP Right Cessation
- 1997-06-16 WO PCT/EP1997/003157 patent/WO1997048700A1/en active IP Right Grant
- 1997-06-16 AT AT97929202T patent/ATE196766T1/de not_active IP Right Cessation
- 1997-06-16 CA CA002258559A patent/CA2258559A1/en not_active Abandoned
- 1997-06-16 ES ES97929202T patent/ES2152682T3/es not_active Expired - Lifetime
- 1997-06-16 HU HU9903480A patent/HUP9903480A3/hu not_active Application Discontinuation
- 1997-06-16 TR TR1998/02552T patent/TR199802552T2/xx unknown
- 1997-06-16 US US09/202,772 patent/US6313145B1/en not_active Expired - Fee Related
- 1997-06-16 JP JP10502260A patent/JP2000512644A/ja not_active Ceased
- 1997-06-16 AU AU33396/97A patent/AU718000B2/en not_active Ceased
- 1997-06-16 NZ NZ332840A patent/NZ332840A/xx unknown
- 1997-06-18 AR ARP970102675A patent/AR008244A1/es active IP Right Grant
- 1997-06-19 ZA ZA975416A patent/ZA975416B/xx unknown
- 1997-06-19 TW TW086108550A patent/TW360650B/zh active
- 1997-06-20 CO CO97034433A patent/CO4870758A1/es unknown
-
1998
- 1998-12-18 NO NO19985970A patent/NO316756B1/no unknown
-
1999
- 1999-11-02 HK HK99104963A patent/HK1019744A1/xx not_active IP Right Cessation
-
2000
- 2000-11-14 GR GR20000402536T patent/GR3034847T3/el not_active IP Right Cessation
-
2001
- 2001-09-06 US US09/948,289 patent/US20020035134A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP9901556A0 (en) | Sulpponamide derivatives process for their preparation and their use as medicaments | |
| HUP9900974A3 (en) | Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them | |
| EE9900075A (et) | 7a-( -aminoalküül)östratrieenid, nende valmistamise meetod, 7a-( -aminoalküül)östratrieene sisaldavad farmatseutilised preparaadid ja nende kasutamine ravimite valmistamiseks | |
| HUP0001508A3 (en) | 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them | |
| HUP0200309A2 (en) | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression, process for their preparation and pharmaceutical compositions containing them | |
| HUP9700358A3 (en) | New oxazolidinon derivatives, process for their preparation and pharmaceutical compositions containing them | |
| EE9700153A (et) | Heterotsükliga kondenseerunud püridiinid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid | |
| EE9700060A (et) | 2-arüül-asendatud püridiinid,nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid | |
| HUP9602122A3 (en) | Camptothecin derivatives, process for the preparation thereof and pharmaceutical compositions containing them | |
| HUT76286A (en) | Quinoline derivatives, pharmaceutical compositions containing them, process for producing them and their use | |
| IL131163A (en) | Heteroaryl-hexanoic acid amide derivatives, their use in the preparation of medicaments, and pharmaceutical compositions comprising them | |
| HUP0203542A3 (en) | 3(5)-amino-pyrazole derivatives, process for their preparation, their use and pharmaceutical compositions containing the same | |
| IL127798A (en) | N-substituted indol-3-glyoxylamides, process for their preparation and pharmaceutical compositions comprising them | |
| HUP0001555A3 (en) | Tetrahydro-imidazo-naphthyridine derivatives, pharmaceutical compositions thereof and process for their preparation | |
| HUP0000426A3 (en) | Novel benzonaphthyridines, pharmaceutical compositions and use thereof and process for their preparation | |
| IL133784A (en) | Dolastatin 15 derivatives, pharmaceutical compositions comprising them and their use in medicaments for treating cancer | |
| HUP0002404A3 (en) | Amino acid derivatives, pharmaceutical compositions comprising thereof, process for preparation them and their use | |
| HUP9800781A3 (en) | Propanolamine derivatives, process for producing them, pharmaceutical compositions containing them and their use | |
| HUP0002300A3 (en) | Quinoline-4-carboxamide derivatives, process for producing them, pharmaceutical compositions containing them and their use | |
| HUP0002952A3 (en) | Benzimidazole derivatives, process for producing them, their use and pharmaceutical compositions containing them | |
| IL127304A (en) | Indoline derivatives, process for their preparation, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating anxiety and depression | |
| HUP9901485A3 (en) | Heterocyclylcarboxamide derivatives, pharmaceutical compositions containing the same, process for their preparation and their use | |
| CZ63895A3 (en) | 5-vinyl-quinolone-carboxylic, 5-vinyl-naphthyridon-carboxylic, +5-ethinyl-quinolone-carboxylic and 5-ethinyl-naphthyridon-carboxylic acids, process of their preparation, medicaments in which said compounds are comprised and their use | |
| HUP9901434A3 (en) | Substituted benzylamines and their use for the preparation of medicaments for treating depression | |
| CZ92295A3 (en) | Boronpeptide derivatives, process of their preparation and pharmaceutical composition containing thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |