ES2036178T3 - Procedimiento para preparar nuevas benzamidas. - Google Patents

Procedimiento para preparar nuevas benzamidas.

Info

Publication number
ES2036178T3
ES2036178T3 ES198686402796T ES86402796T ES2036178T3 ES 2036178 T3 ES2036178 T3 ES 2036178T3 ES 198686402796 T ES198686402796 T ES 198686402796T ES 86402796 T ES86402796 T ES 86402796T ES 2036178 T3 ES2036178 T3 ES 2036178T3
Authority
ES
Spain
Prior art keywords
alkyl
procedure
prepare new
new benzamides
alkynyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686402796T
Other languages
English (en)
Inventor
Jacques Acher
Jean-Claude Monier
Jean-Paul Schmitt
Renee Gardaix-Luthereau
Brenda Dr. Costall
Robert Dr. Naylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Delagrange SA
Original Assignee
Laboratoires Delagrange SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Delagrange SA filed Critical Laboratoires Delagrange SA
Application granted granted Critical
Publication of ES2036178T3 publication Critical patent/ES2036178T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/28—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA INVENCION CONCIERNE A NUEVAS BENZAMIDAS SUSTITUIDAS DE FORMULA GENERAL (I) SUS ISOMEROS OPTICOS Y SUS SALES FISIOLOGICAMENTE ACEPTABLES. ESTOS COMPUESTOS SON UTILES COMO AGENTES ACTIVADORES DEL SISTEMA NERVIOSO CENTRAL. LEYENDA DE LA FORMULA (IV): 1) A = ALQUILO, ALQUENILO, DIETILAMINOETILO; 2) R1, R2 = H, ALQUILO, ALQUENILO; R3,R4,R5,R6 = H, ALQUILO 3) X = HALOGENO; Y = H, HALOGENO; Z = NH, OXIGENO O AZUFRE.
ES198686402796T 1985-12-19 1986-12-15 Procedimiento para preparar nuevas benzamidas. Expired - Lifetime ES2036178T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8518829A FR2592042B1 (fr) 1985-12-19 1985-12-19 Nouveaux ortho-anisamides, leur procede d'obtention, et leurs applications therapeutiques

Publications (1)

Publication Number Publication Date
ES2036178T3 true ES2036178T3 (es) 1993-05-16

Family

ID=9325965

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686402796T Expired - Lifetime ES2036178T3 (es) 1985-12-19 1986-12-15 Procedimiento para preparar nuevas benzamidas.

Country Status (37)

Country Link
US (2) US4835172A (es)
EP (1) EP0236646B1 (es)
JP (1) JPS62246553A (es)
KR (1) KR930004653B1 (es)
CN (1) CN1018454B (es)
AR (1) AR242193A1 (es)
AT (1) ATE57376T1 (es)
AU (1) AU586057B2 (es)
CA (2) CA1298301C (es)
CH (1) CH671396A5 (es)
CS (1) CS274285B2 (es)
DD (1) DD260495A5 (es)
DE (2) DE3674916D1 (es)
DK (1) DK612886A (es)
ES (1) ES2036178T3 (es)
FI (1) FI865190A (es)
FR (1) FR2592042B1 (es)
GB (1) GB2184723B (es)
GR (1) GR3002524T3 (es)
HU (1) HU196794B (es)
IE (1) IE59212B1 (es)
IL (1) IL81010A (es)
IN (1) IN163130B (es)
IS (1) IS1448B6 (es)
MA (1) MA20835A1 (es)
NO (1) NO168176C (es)
NZ (1) NZ218675A (es)
OA (1) OA08564A (es)
PH (2) PH24365A (es)
PL (1) PL148408B1 (es)
PT (1) PT83982B (es)
SU (1) SU1496632A3 (es)
TN (1) TNSN86165A1 (es)
YU (1) YU44796B (es)
ZA (1) ZA869560B (es)
ZM (1) ZM10686A1 (es)
ZW (1) ZW24886A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE82124T1 (de) * 1987-06-17 1992-11-15 Delagrange Lab Anwendung von n-(2-(diaethylamino)aethyl>-2-methoxy-4((1-h-4,5ihydro-2-imidazolyl)amino>-5- chlorobenzamid als anxiolytisches und antipsychotisches mittel.
FR2640139A1 (fr) * 1988-12-14 1990-06-15 Delagrange Laboratoires Application de benzamides substitues comme gastromoteurs
FR2640507A1 (fr) * 1988-12-20 1990-06-22 Delagrange Laboratoires Application de benzamides substitues comme anxiolytiques et anti-psychotiques
FR2645742A1 (fr) * 1989-04-12 1990-10-19 Delagrange Laboratoires Application de derives de 2-methoxy 4-(4,5-dihydro 2-imidazolyl (ou 2-oxazolyl) amino) 5-chloro benzamide dans le traitement des troubles de la fonction cognitive
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
US20050140688A1 (en) * 2003-12-29 2005-06-30 Kim Pallister Method and mechanism for programmable filtering of texture map data in 3D graphics subsystems

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
FR1539104A (fr) * 1967-07-31 1968-09-13 Ile De France Nouveaux benzamides et leur procédé de préparation
US3682968A (en) * 1969-06-25 1972-08-08 Merck & Co Inc Anti-inflammatory salicylic acid derivatives
DE1963193A1 (de) * 1969-12-17 1971-06-24 Bayer Ag N-substituierte 2-Arylimino-oxazolidine,Verfahren zu ihrer Herstellung und ihre Verwendung als Ektoparasiticide
FR2432513A1 (fr) * 1977-10-24 1980-02-29 Merieux Inst Nouveaux derives de la thiazoline et leur application comme medicaments
DE2905883A1 (de) * 1979-02-16 1980-08-28 Boehringer Sohn Ingelheim Radioimmuntest fuer clonidin
CA1201066A (en) * 1981-11-20 1986-02-25 Alcon Laboratories, Inc. N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure
US4461904A (en) * 1981-11-20 1984-07-24 Alcon Laboratories, Inc. 2-(Trisubstituted phenylimino)-imidazolines
DE3514351A1 (de) * 1985-04-20 1986-11-06 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte 2-(n-alkinyl-n-phenyl)amino)-imidazolinderivate, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS6341471A (ja) * 1986-08-08 1988-02-22 Nippon Soda Co Ltd オキサ（チア）ゾリジン誘導体、その製造法及び殺ダニ剤
US4826990A (en) * 1987-09-30 1989-05-02 American Home Products Corporation 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents

Also Published As

Publication number Publication date
DE3674916D1 (de) 1990-11-15
US4914117A (en) 1990-04-03
YU217986A (en) 1987-12-31
SU1496632A3 (ru) 1989-07-23
IE59212B1 (en) 1994-01-26
IS3178A7 (is) 1987-06-20
PH24469A (en) 1990-07-18
PT83982B (pt) 1989-01-17
DD260495A5 (de) 1988-09-28
ATE57376T1 (de) 1990-10-15
GB2184723B (en) 1989-12-28
ZW24886A1 (en) 1987-05-13
NZ218675A (en) 1990-06-26
CA1299579C (fr) 1992-04-28
YU44796B (en) 1991-02-28
FI865190A (fi) 1987-06-20
CN86108972A (zh) 1987-11-18
NO865148D0 (no) 1986-12-18
FR2592042B1 (fr) 1988-03-25
EP0236646B1 (fr) 1990-10-10
FR2592042A1 (fr) 1987-06-26
GB8630143D0 (en) 1987-01-28
GR3002524T3 (en) 1993-01-25
DK612886A (da) 1987-06-20
ZM10686A1 (en) 1987-11-27
CH671396A5 (es) 1989-08-31
AU6668786A (en) 1987-06-25
CA1298301C (fr) 1992-03-31
IL81010A (en) 1991-06-30
NO168176C (no) 1992-01-22
NO168176B (no) 1991-10-14
PT83982A (en) 1987-01-01
US4835172A (en) 1989-05-30
IS1448B6 (is) 1991-01-16
NO865148L (no) 1987-06-22
AU586057B2 (en) 1989-06-29
AR242193A1 (es) 1993-03-31
TNSN86165A1 (fr) 1990-01-01
OA08564A (fr) 1988-09-30
KR870006008A (ko) 1987-07-08
KR930004653B1 (ko) 1993-06-02
PL263078A1 (en) 1988-04-14
IL81010A0 (en) 1987-03-31
DK612886D0 (da) 1986-12-18
CS274285B2 (en) 1991-04-11
PH24365A (en) 1990-06-13
ZA869560B (en) 1987-11-25
CS960386A2 (en) 1990-09-12
GB2184723A (en) 1987-07-01
PL148408B1 (en) 1989-10-31
HUT43844A (en) 1987-12-28
FI865190A0 (fi) 1986-12-18
MA20835A1 (fr) 1987-07-01
EP0236646A1 (fr) 1987-09-16
IN163130B (es) 1988-08-13
CN1018454B (zh) 1992-09-30
DE3643103A1 (de) 1987-06-25
IE863270L (en) 1987-06-19
HU196794B (en) 1989-01-30
JPS62246553A (ja) 1987-10-27

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