SU1496632A3 - Cпocoб пoлучehия зameщehhыx бehзamидob - Google Patents
Cпocoб пoлучehия зameщehhыx бehзamидob Download PDFInfo
- Publication number
- SU1496632A3 SU1496632A3 SU864028722A SU4028722A SU1496632A3 SU 1496632 A3 SU1496632 A3 SU 1496632A3 SU 864028722 A SU864028722 A SU 864028722A SU 4028722 A SU4028722 A SU 4028722A SU 1496632 A3 SU1496632 A3 SU 1496632A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- day
- substituted benzamides
- producing substituted
- nmol
- diphenin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Description
Изобретение относится к медицине, а именно к гинекологии.
Целью изобретения является предупреждение побочного действия от введения лекарственных средств.
Пример. Больная Н., 43 лет, обратилась с жалобами на боли в нижних отделах живота, больна в течение 6 лет. Диагноз при поступлении: миома матки. При обследовании размер образования соответствует 8-недельному сроку беременности, количество лимфоцитов 1782, Т-лимфоцитов 56%, содержание дофамина в суточной моче 1453 нмоль/сут; норадреналина 163,2 нмоль/сут, адреналина 74,2 нмоль/сут, серотонина 1,82 мкмоль/л, адаптационная реакция тренировки. Назначено: дифенин по 2 таблетки в день, настойка элеутерококка по 20 капель 2 раза в день, с 10-го дня очередного менструального цикла дигидроэрготамин по 15 капель 2 раза в день до 19 дня цикла включительно; лечение дифенином и настойкой элеутерококка продолжалось непрерывно в течение 2 мес., дигидроэрготамин повторно добавлен с 10-го дня второго менструального цикла на 10 дней.
После проведения курса лечения при обследовании размеры матки соответствуют 6-7-недельному сроку беременности, боли отсутствуют, количество лимфоцитов 1830, Т-лимфоцитов 62%, уровень экскретируемого дофамина 1605,1 нмоль/сут; норадреналина 136,1 нмоль/сут, адреналина 48,3 нмоль/сут, серотонина 1,1 мкмоль/л.
Способ лечения апробирован на 72 больных с различным клиническим течением миомы матки. После лечения у всех больных установлена нормализация психоэмоционального состояния и ликвидация болей; снижение менструальной кровопотери у 94,4%, стабилизация и уменьшение размеров матки у 95,8% больных.
Claims (1)
- Формула изобретения511 „149В7НУСпособ лечения миомы матки путем введения лекарственных средств, отличающийся тем, что, с целью предупреждения побочного действия, вводят дифенин, настойку элеутерококка и дигидроэрготамин в течение двух месяцев, при этом дифенин и настойку элеутерококка вводят ежедневно, а дигидроэрготамин в середине менструального цикла в течение 10 дней.1496799Соетавнтс.тк ,Ί. : [урышева
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8518829A FR2592042B1 (fr) | 1985-12-19 | 1985-12-19 | Nouveaux ortho-anisamides, leur procede d'obtention, et leurs applications therapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1496632A3 true SU1496632A3 (ru) | 1989-07-23 |
Family
ID=9325965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU864028722A SU1496632A3 (ru) | 1985-12-19 | 1986-12-18 | Cпocoб пoлучehия зameщehhыx бehзamидob |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US4835172A (ru) |
| EP (1) | EP0236646B1 (ru) |
| JP (1) | JPS62246553A (ru) |
| KR (1) | KR930004653B1 (ru) |
| CN (1) | CN1018454B (ru) |
| AR (1) | AR242193A1 (ru) |
| AT (1) | ATE57376T1 (ru) |
| AU (1) | AU586057B2 (ru) |
| CA (2) | CA1298301C (ru) |
| CH (1) | CH671396A5 (ru) |
| CS (1) | CS274285B2 (ru) |
| DD (1) | DD260495A5 (ru) |
| DE (2) | DE3674916D1 (ru) |
| DK (1) | DK612886A (ru) |
| ES (1) | ES2036178T3 (ru) |
| FI (1) | FI865190A (ru) |
| FR (1) | FR2592042B1 (ru) |
| GB (1) | GB2184723B (ru) |
| GR (1) | GR3002524T3 (ru) |
| HU (1) | HU196794B (ru) |
| IE (1) | IE59212B1 (ru) |
| IL (1) | IL81010A (ru) |
| IN (1) | IN163130B (ru) |
| IS (1) | IS1448B6 (ru) |
| MA (1) | MA20835A1 (ru) |
| NO (1) | NO168176C (ru) |
| NZ (1) | NZ218675A (ru) |
| OA (1) | OA08564A (ru) |
| PH (2) | PH24365A (ru) |
| PL (1) | PL148408B1 (ru) |
| PT (1) | PT83982B (ru) |
| SU (1) | SU1496632A3 (ru) |
| TN (1) | TNSN86165A1 (ru) |
| YU (1) | YU44796B (ru) |
| ZA (1) | ZA869560B (ru) |
| ZM (1) | ZM10686A1 (ru) |
| ZW (1) | ZW24886A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3782651T2 (de) * | 1987-06-17 | 1993-03-25 | Delagrange Lab | Anwendung von n-(2-(diaethylamino)aethyl)-2-methoxy-4((1-h-4,5-dihydro-2-imidazolyl)amino)-5-chlorobenzamid als anxiolytisches und antipsychotisches mittel. |
| FR2640139A1 (fr) * | 1988-12-14 | 1990-06-15 | Delagrange Laboratoires | Application de benzamides substitues comme gastromoteurs |
| FR2640507A1 (fr) * | 1988-12-20 | 1990-06-22 | Delagrange Laboratoires | Application de benzamides substitues comme anxiolytiques et anti-psychotiques |
| FR2645742A1 (fr) * | 1989-04-12 | 1990-10-19 | Delagrange Laboratoires | Application de derives de 2-methoxy 4-(4,5-dihydro 2-imidazolyl (ou 2-oxazolyl) amino) 5-chloro benzamide dans le traitement des troubles de la fonction cognitive |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| US20050140688A1 (en) * | 2003-12-29 | 2005-06-30 | Kim Pallister | Method and mechanism for programmable filtering of texture map data in 3D graphics subsystems |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
| FR1539104A (fr) * | 1967-07-31 | 1968-09-13 | Ile De France | Nouveaux benzamides et leur procédé de préparation |
| US3682968A (en) * | 1969-06-25 | 1972-08-08 | Merck & Co Inc | Anti-inflammatory salicylic acid derivatives |
| DE1963193A1 (de) * | 1969-12-17 | 1971-06-24 | Bayer Ag | N-substituierte 2-Arylimino-oxazolidine,Verfahren zu ihrer Herstellung und ihre Verwendung als Ektoparasiticide |
| FR2432513A1 (fr) * | 1977-10-24 | 1980-02-29 | Merieux Inst | Nouveaux derives de la thiazoline et leur application comme medicaments |
| DE2905883A1 (de) * | 1979-02-16 | 1980-08-28 | Boehringer Sohn Ingelheim | Radioimmuntest fuer clonidin |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| CA1201066A (en) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure |
| DE3514351A1 (de) * | 1985-04-20 | 1986-11-06 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte 2-(n-alkinyl-n-phenyl)amino)-imidazolinderivate, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| JPS6341471A (ja) * | 1986-08-08 | 1988-02-22 | Nippon Soda Co Ltd | オキサ（チア）ゾリジン誘導体、その製造法及び殺ダニ剤 |
| US4826990A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
-
1985
- 1985-12-19 FR FR8518829A patent/FR2592042B1/fr not_active Expired
-
1986
- 1986-12-15 EP EP86402796A patent/EP0236646B1/fr not_active Expired - Lifetime
- 1986-12-15 DE DE8686402796T patent/DE3674916D1/de not_active Expired - Lifetime
- 1986-12-15 ES ES198686402796T patent/ES2036178T3/es not_active Expired - Lifetime
- 1986-12-15 IE IE327086A patent/IE59212B1/en not_active IP Right Cessation
- 1986-12-15 AT AT86402796T patent/ATE57376T1/de active
- 1986-12-16 CH CH4997/86A patent/CH671396A5/fr not_active IP Right Cessation
- 1986-12-16 IN IN983/MAS/86A patent/IN163130B/en unknown
- 1986-12-17 MA MA21067A patent/MA20835A1/fr unknown
- 1986-12-17 IL IL81010A patent/IL81010A/xx not_active IP Right Cessation
- 1986-12-17 DD DD86297795A patent/DD260495A5/de not_active IP Right Cessation
- 1986-12-17 DE DE19863643103 patent/DE3643103A1/de not_active Withdrawn
- 1986-12-17 NZ NZ218675A patent/NZ218675A/xx unknown
- 1986-12-17 PH PH34606A patent/PH24365A/en unknown
- 1986-12-17 AR AR86306202A patent/AR242193A1/es active
- 1986-12-17 GB GB8630143A patent/GB2184723B/en not_active Expired
- 1986-12-17 IS IS3178A patent/IS1448B6/is unknown
- 1986-12-17 HU HU865271A patent/HU196794B/hu not_active IP Right Cessation
- 1986-12-18 AU AU66687/86A patent/AU586057B2/en not_active Ceased
- 1986-12-18 NO NO865148A patent/NO168176C/no unknown
- 1986-12-18 DK DK612886A patent/DK612886A/da not_active Application Discontinuation
- 1986-12-18 SU SU864028722A patent/SU1496632A3/ru active
- 1986-12-18 YU YU2179/86A patent/YU44796B/xx unknown
- 1986-12-18 KR KR1019860010868A patent/KR930004653B1/ko not_active IP Right Cessation
- 1986-12-18 CN CN86108972A patent/CN1018454B/zh not_active Expired
- 1986-12-18 CA CA000525719A patent/CA1298301C/fr not_active Expired - Lifetime
- 1986-12-18 OA OA59022A patent/OA08564A/xx unknown
- 1986-12-18 PL PL1986263078A patent/PL148408B1/pl unknown
- 1986-12-18 ZM ZM106/86A patent/ZM10686A1/xx unknown
- 1986-12-18 FI FI865190A patent/FI865190A/fi not_active Application Discontinuation
- 1986-12-19 ZW ZW248/86A patent/ZW24886A1/xx unknown
- 1986-12-19 CS CS960386A patent/CS274285B2/cs unknown
- 1986-12-19 US US06/943,708 patent/US4835172A/en not_active Expired - Fee Related
- 1986-12-19 ZA ZA869560A patent/ZA869560B/xx unknown
- 1986-12-19 JP JP61305136A patent/JPS62246553A/ja active Pending
- 1986-12-19 PT PT83982A patent/PT83982B/pt not_active IP Right Cessation
- 1986-12-19 TN TNTNSN86165A patent/TNSN86165A1/fr unknown
-
1988
- 1988-02-17 PH PH36522A patent/PH24469A/en unknown
-
1989
- 1989-03-13 US US07/322,122 patent/US4914117A/en not_active Expired - Fee Related
-
1990
- 1990-10-22 CA CA000615908A patent/CA1299579C/fr not_active Expired - Lifetime
- 1990-11-13 GR GR90400910T patent/GR3002524T3/el unknown
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